영아 천식의 임상적 고찰 : Asthma prospective score에 의한 Based on Asthma Prospective Score

양은석,노영일,문경래,박영봉,박상기,변주남 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

A Clinical study was made on 40 patients for infantile asthma less than 2 years old who had been admitted to the Department of Pediatrics of Chosun University Hospital from January 1997 to December 1998. We evaluated family history of allergic diseases, clinical features, serum IgE level, eosinophilia, chest radiologic findings and response to bronchodilator. The results obtained were as follows ; 1) The male to female ratio of patients studied was 4 : 1. 2) Eighteen of the 40 patients (45.0%) had a family history of allergic diseases, of which 10 patients had maternal allergic diseases. 3) Atopic dermatitis was the most common disease (37.5%) among the associated allergic diseases. 4) Thirty two of the 40 patients (80.0%) showed high serum total 19E levels. 5) Only 5 of the 20 patients who were examined by MAST showed positive reaction. 6) The frequency of chest radiologic findings observed in these patients was as follows ; hyperinflation (52.5%), increased bronchovascular marking(30.0%), no pathologic findings(25.0%), and pneumonic infiltration(25.0%). 7) In response to bronchodilator 28 cases(70.0%) were effective. 8) When we divided the 40 patients into two groups by the diagnostic criteria of Asthma prospective score (AP score), 30 patients(75.0%) were included in a compatible group. On the basis of AP score, family history of major or minor allergic dieases and the responsiveness to bronchodilator were important factors for the diagnosis of asthma.

고등급 이형성을 보인 편평톱니샘종

권경주,정성애,심기남,정정화,강석형,송도경,전승정,김혜인 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.1

Until recently, colorectal polyps were classified predominantly as hyperplastic or adenomatous. While adenomatous polyps are well-characterized precursor lesions of adenocarcinomas, hyperplastic polyps have been considered as benign lesion. However, some hyperplastic polyps with serrated morphology of the crypts have been recognized to have distinctive features and these polyps were termed ‘serrated adenomas’. Recent data show that sessile serrated adenomas (SSA) might be the precursors of serrated colonic cancers, underlining the necessity of identifying them. SSA is approximately 3% of all polyps, commonly appears as flat or sessile and yellowish due to mucus production. In the pathogenesis of SSA, progression to high grade dysplasia or early invasive carcinoma may be associated with serrated neoplasia pathway different from adenoma-carcinoma sequence. We report a case with a colon polyp diagnosed as sessile serrated adenoma with high grade dysplasia after endoscopic submucosal dissection.

마산 수출자유지역공단 근로자들에 대한 사회의학적 조사연구

이영호,정석주,이수일,김응남,맹광호 가톨릭대학산업의학센타 산업의학연구소 1977 韓國의 産業醫學 Vol.16 No.3

Followings are major findings obtained from a study on the socio-medical studus of the manu-facturing workers in the Masan Free Export Zone. This study was planned to find out socio-medical conditions of the workers which seemed to be essential to the better management of the health of the workers and the working environments. For this study, 6978 workers who are equivalent to 26.9% of total workers in Masan Free Export Zone as of the end of 1976 were sampled and they were asked to answer to the pretested questionnaire. 1) General characteristics; (1) 83.9% of sampled workers were female. (2) 84.9% of workers were less than 25 years of age and female workers who entered in this age group were 93.6%. (3) 91.9% of workers had more than junior high school education and those who finished only junior high school occupied the majority with the proportion of 67.7%. (4) 897.1% of workers were un-married and the proportion for the female was 93.2% (5) Majority (89.6%) were from Yongnam area and 5.2% of workers were from Honam area. (6) 49.1% of workers were living separately from their families and 76.9% of them were self-cooking. 2) Working conditions and working history; (1) 78.1% of workers were receiving from 20,000 won 40,000won as their monthly salaries and those who were receiving from 40,000 won to 60,000 won were the next (12.5%). (2) 34.4% of workers had been working in the present plant for from one to three years and those who had been working for less than one year were 31.9%. (3) Most of workers (91.2%) were working 8 hours a day but 25.3% of precision optical instruments manufacturing workers were working about 10 hours a day. (4) Only 6.2% of workers ever changed their working places during the past one year. 89.0% of them changed once and 9.0%, twice. Male workers changed their working places more often (8.7%) than female workers (5.7%). 3) Present and past history of illness; (1) 6.7% of workers had the sick among their family members and cardiovascular diseases were most common (47.8%) (2) Those who had experiences of sickness lasted more than one week were 7.1% and those who had had operations were 3.3%. (3) 42.0% of workers were complainning at least one physical symptom. Those who were complainning "tingling pain on eye ball" were the most (20.5%), and headache, and dizziness were both the next (16.3%). 4) Smoking, drinking habits and drug dependency; (1) Among all workers, 11.7% (male, 69.5%; female, 0.4%) were smoking and 13.1%(male, 71.9%; female, 2.3%) were drinking alchole. Those who were using drug customarily were only 2.3% and the drugs they were using were aspirin (35.0%), antibiotics (12.5%) and others. 5) Present physical conditions found at the periodic physical examinations; (1) Mean height of male workers was 168.3cm and that of female workers was 158.1cm. Mean body weight of male workers was 60.7kg and that of female workers was 51.3kg. (2) Those who had anormal vision were 10.1% and the frequency of self-awared hearing loss was 4.5%.If the visual power of one or both eyes was less than 0.6, we considered this as and abnormal vision. (3) Those who were informed by the physician that they had hypertension were 8.4% and those whe were informed that they had tuberculosis lesion on the chest were only 0.4%.

인후두이상감증 환자들에서 인후두역류의 확인에 있어 음성검사의 임상적 적용

허성철,홍석중,송용진,유승주,김상윤,남순열 대한이비인후과학회 2001 대한이비인후과학회지 두경부외과학 Vol.44 No.11

섬록암폐석을 이용한 폴리머 콘크리트의 특성 및 제품 개발

김기락,최동순,연규석,주명기,김남길 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

우리나라에서는 각종 광산으로 부터 폐석이 다량으로 발생되고 있다. 이와같은 폐석의 부가가치를 높일 수 있는 방안의 모색이 절실한 실정이다. 따라서 본 연구에서는 강원도 춘천지역의 섬록암 광산에서 다량으로 발생되고 있는 폐석을 활용하여 고강도이며, 내구성이 우수한 폴리머 콘크리트를 제조하고, 이에 대한 물리·역학적 특성을 실험적으로 구명하였다. 또한 섬록암 폐석을 이용한 폴리머 콘크리트를 사용하여 플륨, 경계석, 보도블럭, 기와 등과 같은 공장제품을 제조하여 이에 대한 효율적 활용 방안을 제시하였다. Large amount of mine waste have been produced and acumulated from various mining works in korea. Mine wastes causes many adverse invironmental impacts and it is urgently required t develop methods to increase its value by resuing in construction materials and other products. The dbjectives of the study were to develop a high strength and durable high quality polymer concrete by using Diorite mine wastes that are produced from mines in Chunchon area, and to experimentally test the physical and mechanical properties of the concrete. Also, effective reuse methods for the Diorite mine wastes were suggested by developing flumes, curb stones, foot path blocks and roof tiles with the polymer concrete.

Involvement of Oxidative Stress and Poly(ADP-ribose) Polymerase Activation in 3-Nitropropionic Acid-induced Cytotoxicity in Human Neuroblastoma Cells

Nam, Eun-Joo,Lee, Young-Jae,Oh, Young-Ah,Jung, Jin-Ah,Im, Hye-In,Koh, Seong-Eun,Maeng, Sung-Ho,Joo, Wan-Seok,Kim, Yong-Sik The Korean Society of Pharmacology 2003 The Korean Journal of Physiology & Pharmacology Vol.7 No.6

3-Nitropropionic acid (3-NP) inhibits electron transport in mitochondria, leading to a metabolic failure. In order to elucidate the mechanism underlying this toxicity, we examined a few biochemical changes possibly involved in the process, such as metabolic inhibition, generation of reactive oxygen species (ROS), DNA strand breakage, and activation of Poly(ADP-ribose) polymerase (PARP). Exposure of SK-N-BE(2)C neuroblastoma cells to 3-NP for 48 h caused actual cell death, while inhibition of mitochondrial function was readily observed when exposed for 24 h to low concentrations (0.2${\sim}$2 mM) of 3-NP. The earliest biochemical change detected with low concentration of 3-NP was an accumulation of ROS (4 h after 3-NP exposure) followed by degradation of DNA. PARP activation by damaged DNA was also detectable, but at a later time. The accumulation of ROS and DNA strand breakage were suppressed by the addition of glutathione or N-acetyl-L-cysteine (NAC), which also partially restored mitochondrial function and cell viability. In addition, inhibition of PARP also reduced the 3-NP-induced DNA strand breakage and cytotoxicity. These results suggest that oxidative stress and activation of PARP are the major factors in 3-NP-induced cytotoxicity, and that the inhibition of these factors may be useful in protecting neuroblastoma cells from 3-NP-induced toxicity.

Serum CA125 Concentration has Inverse Correlation with Metabolic Syndrome

Joo, Nam-Seok,Kim, Kyu-Nam,Kim, Kyung Soo The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.10

<P>Serum carbohydrate antigen 125 (CA-125) is a marker of ovarian cancer and obesity that is related with an increased risk of ovarian cancer. Obesity is a key factor of metabolic syndrome. We evaluated the relationship between CA-125 concentration and metabolic syndrome. The data from subjects who had any cancer and chronic infection were excluded. The data of 12,196 healthy Korean women were analyzed. After CA-125 concentration was divided by quartiles, the prevalence of metabolic syndrome and its components were compared. The lowest quartile of CA-125 compared with the highest quartile showed elevated values of most of metabolic parameters. In addition, as the quartile of CA-125 increased, metabolic derangement decreased. Increased numbers of metabolic syndrome components showed an inverse association with CA-125 levels (<I>P</I> < 0.001). The odds ratio (OR) for the lowest CA-125 quartile vs the highest CA-125 quartile significantly increased in the presence of metabolic syndrome (OR = 1.202, 95% Confidence Interval [CI] 1.013-1.423), elevated triglyceride (OR = 1.381, 95% CI 1.167-1.633), and low high-density lipoprotein cholesterol (OR = 1.168, 95% CI 1.039-1.312). The presence of metabolic syndrome, elevated triglyceride, or low high-density lipoprotein cholesterol negatively correlates with CA-125 concentration.</P>

Ceramide is Involved in $MPP^+-induced$ Cytotoxicity in Human Neuroblastoma Cells

Nam, Eun-Joo,Lee, Hye-Sook,Lee, Young-Jae,Joo, Wan-Seok,Maeng, Sung-Ho,Im, Hye-In,Park, Chan-Woong,Kim, Yong-Sik The Korean Society of Pharmacology 2002 The Korean Journal of Physiology & Pharmacology Vol.6 No.6

To understand the cytotoxic mechanism of $MPP^+,$ we examined the involvement of ceramide in $MPP^+-induced$ cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to $MPP^+,\;MPP^+$ induced dose-dependent cytotoxicity accompanied by 2-fold elevation of intracellular ceramide levels in SH-SY5Y cells. Three methods were used to test the hypothesis that the elevated intracellular ceramide is related to $MPP^+-induced$ cytotoxicity: $C_2-ceramide$ was directly applied to cells, sphingomyelinase (SMase) was exogenously added, and oleoylethanolamine (OE) was used to inhibit degradation of ceramide. Furthermore, inhibition of ceramide-activated protein phosphatase (CAPP), the effector of ceramide, using okadaic acid (OA) attenuated cell death but treatment of fumonisin $B_1,$ the ceramide synthase inhibitor, did not alter the cytotoxic effect of $MPP^+.$ Based on these, we suggest that the elevation of intracellular ceramide is one of the important mediators in $MPP^+-induced$ cell death.

Short-term Changes in Thyroid-Stimulating Hormone Level after Body Fat Reduction via Partial Meal Replacement

Nam-Kyu Kim,Min-Ah Jung,Seok-Hoon Lee,Nam-Seok Joo 대한가정의학회 2023 Korean Journal of Family Medicine Vol.44 No.1

Background: Serum thyroid-stimulating hormone (TSH) levels change during body weight reduction. However, the changes that occur during short-term body weight control interventions remain controversial. Thus, this study aimed to evaluate the changes in TSH levels according to body fat reduction.Methods: We performed a 3-month intervention study involving partial meal replacement. Forty-nine participants completed the study. Correlations between changes in TSH levels and other body composition parameters were determined. The subjects were divided into two groups according to their body fat reduction (>1 kg, n=20; <1 kg, n=29). The changes in metabolic parameters, including TSH levels, were compared. For significant values, a multi-variate analysis was performed after adjustment to evaluate the relationship between TSH changes and body fat re-duction.Results: The 3-month intervention caused favorable changes in body proportions and metabolic parameters. TSH levels changed significantly only after changes in total body fat, showing a partial correlation. Changes in TSH levels were significantly different between groups (P=0.014). Moreover, the change in TSH levels was significantly differ-ent after adjustment (P=0.012).Conclusion: A body fat reduction, especially >1 kg, can reduce serum TSH concentrations in subjects with meta-bolic syndrome after short-term body weight intervention.

The Influence of Leadership Style on Employee Creativity: Focusing on the Mediating Effect of Self-Efficacy

Joo-Seok Chae,Nam-Gyum Lee,Il-Young Hwang,Soon-Young Park 한국유통과학회 2015 Asian Journal of Business Environment (AJBE) Vol.5 No.4

Purpose – This study investigated the effects of leaders of national universities on faculty creativity. The study examined transformational leadership and creativity theories and investigated self-efficacy, the parameter between transformational leadership and creativity, to examine its moderating effect and provide policy implications for national universities. Research design, data, and methodology – This study built four hypotheses based on the literature review, and tested these using a survey methodology. The collected data were analyzed using SPSS 15.0. Result – At the national universities, the results were as follows: charisma of leaders had a positive influence on member creativity; intellectual stimulus of leaders had a positive influence on member creativity; and, individual consideration of leaders had a positive influence on member creativity. Therefore, leaders’ transformational leadership had a positive influence on member creativity. Conclusion – Creativity is thought to be important for organizational survival and continuous development at rapidly changing education administrations. Educational administration leaders should exercise transformational leadership to develop member creativity. Member self-efficacy, which had a mediating effect on creativity, requires leadership to develop it.