JAPANESE EDUCATION IN AN INTERNATIONAL PERSPECTIVE

NAKAJIMA, HIROSHI EAST WEST EDUCATION RESEARCH INSTITUTE EWHA WOMANS 1986 East west education Vol.7 No.1

Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma

Hiroshi Nakajima,Koichi Hirose 대한면역학회 2010 Immune Network Vol.10 No.1

Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction,and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate these pathognomonic features of asthma. In addition, we and others have recently shown that IL-17-producing CD4+ T cells (Th17 cells) and IL-23, an IL-12-related cytokine that is essential for survival and functional maturation of Th17 cells,are involved in antigen-induced airway inflammation. In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized.

Smart Health Management Technology

Hiroshi Nakajima 한국지능시스템학회 2010 한국지능시스템학회 학술발표 논문집 Vol.20 No.2

Fuzzy Logic and Causal Analysis in Biomedical Sensing System

Hiroshi Nakajima,Naoki Tsuchiya,Kenta Yamamoto,Yutaka Hata 한국지능시스템학회 2010 한국지능시스템학회 학술발표 논문집 Vol.20 No.2

This article proposes the combination of fuzzy logic and causal analysis regarding biomedical sensing. As one of the applications, a heart rate monitoring system is introduced. It monitors heart rate of human body during sleep or lying on the bed. The system consists of an air pressure sensor and data analysis computation part. Fuzzy logic is employed as a role of filtering heart beat signals from an air pressure sensor data which superimposes vibration signals of heart beat, body movement, and respiration. Causal analysis plays a role of making transparent of calculation flow in heart rate from the extracted heat beat signals. The experiments were conducted to prove the performance of the proposed method. Experimental results were very high correlation coefficient of around 0.85.

Implementation of a COTS Fault Diagnosis System by Using RIA Technologies

Hiroshi Nakajima,A-ram Kim,Jin-Song Roh,Sang-Yong Rhee 한국정보통신학회 2012 2016 INTERNATIONAL CONFERENCE Vol.5 No.1

A Nationwide Study on Optical Analysis for Expecting HEOs to Support Ambulances

Nakajima, Isao,Tsuda, Kazuhide,Juzoji, Hiroshi,Ta, Masuhisa,Nakajima, Atsushi Korea Multimedia Society 2019 The journal of multimedia information system Vol.6 No.2

This paper deals with actual optical data from rural as well as urban areas in a nationwide study captured with Fisheye cameras. Simultaneously data was collected (of the receiving power density) from the mobile communications satellite N-STAR. The visibility of the satellite is easily determined by checking the value of the pixels in the binarized fisheye image of its position. The process of determining the visible satellite is automatically performed. Based on the analyses of the field data measured in Japan, we are expecting HEOs (Highly inclined Elliptical Orbiters) that would reduce blockage in the extreme northern region of Wakkanai City well as in the most crowded urban area, in Tokyo Ginza. In case of HEOs operation, the elevation angle will improve from 37 with N-STAR GEO to 75 degrees. HEOs could replace 5G/Ka-band or support in rural areas where broadband circuit is not available. We are proposing combination operations with HEOs and 5G/Ka-band to solve blockage problems, because HEOs can keep line-of-sight propagation with high elevation angle for long duration. In such operations, the communications profile on the vehicle based on actual optical data will be very useful to predict blockages and to select/switch a suitable circuit.

Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma

Nakajima, Hiroshi,Hirose, Koichi The Korean Association of Immunobiologists 2010 Immune Network Vol.10 No.1

Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate these pathognomonic features of asthma. In addition, we and others have recently shown that IL-17-producing $CD4^+$ T cells (Th17 cells) and IL-23, an IL-12-related cytokine that is essential for survival and functional maturation of Th17 cells, are involved in antigen-induced airway inflammation. In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized.

Communications Protocol Used in the Wireless Token Rings for Bird-to-Bird

Nakajima, Isao,Juzoji, Hiroshi,Ozaki, Kiyoaki,Nakamura, Noboru Korea Multimedia Society 2018 The journal of multimedia information system Vol.5 No.3

We developed a multicast communication packet radio protocol using a time-sharing tablet system ("wireless token ring") to achieve the efficient exchange of files among packet radio terminals attached to swans. This paper provides an overview of the system and the protocol of the packet communications. The packet device forming the main part of the transceiver developed is the Texas Instruments CC2500. This device consists of one call-up channel and one data transmission channel and could improve error frame correction using FEC (forward error correction) with 34.8 kbps MSK and receiving power of at least -64 dBm (output 1 dBm at distance of 200 m using 3 dBi antenna). A time-sharing framework was determined for the wireless token ring using call sign ordinals to prevent transmission right loss. Tests using eight stations showed that resend requests with the ARQ (automatic repeat request) system are more frequent for a receiving power supply of -62 dBm or less. A wireless token ring system with fixed transmission times is more effective. This communication protocol is useful in cases in which frequency resources are limited; the energy consumed is not dependent on the transmission environment (preset transmission times); multiple terminals are concentrated in a small area; and information (position data and vital data) is shared among terminals under circumstances in which direct communication between a terminal and the center is not possible. The method allows epidemiological predictions of avian influenza infection routes based on vital data and relationships among individual birds based on the network topology recorded by individual terminals. This communication protocol is also expected to have applications in the formation of multiple in vivo micromachines or terminals that are inserted into living organisms.

Cancer Cell Cytotoxicity of Extracts and Small Phenolic Compounds from Chaga [Inonotus obliquus (persoon) Pilat]

Nakajima, Yuki,Nishida, Hiroshi,Matsugo, Seiichi,Konishi, Tetsuya The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3

Previously, we studied the antioxidant potential of Chaga mushroom [Inonotus obliquus (persoon) Pilat] extracts and isolated several small (poly)phenolic compounds as the major antioxidant components in the 80% methanol (MeOH) extract. In the present study, these isolated phenolic ingredients together with several other types of Chaga extracts were examined for cytotoxic effects against normal (IMR90) and cancer (A549, PA-1, U937, and HL-60) cell lines. Results revealed decoctions from both the fruiting body (FB) and sclerotium (ST) parts of Chaga, especially the ST part, showed considerable cytotoxicity toward tumor cells, but the cytotoxicity appeared to be stronger against normal cells than cancer cells. The 80% MeOH ST extract also showed the same trend. On the other hand, the 80% MeOH extract of FB showed significant cytotoxicity towards tumor cell lines without affecting normal cells, for example, the 50% lethal dose was $49.4\;{\pm}\;2.9\;{\mu}g/mL$ for PA-1 cells versus $123.6\;{\pm}\;13.8\;{\mu}g/mL$ for normal cells. The phenolic components isolated from the 80% MeOH extracts had markedly greater cancer cell toxicity than the extracts themselves. In particular, two out of seven compounds showed strong cytotoxicity towards several tumor cell lines without giving rise to significant cell toxicity toward normal cells. For example, the 50% lethal dose for 3,4-dihydroxybenzalacetone was $12.2\;{\mu}mmol/L$ in PA-1 cells but was $272.8\;{\mu}mmol/L$ in IMR90 cells. Fluorescence-activated cell sorting analysis further revealed these phenolic ingredients have high potentiality for apoptosis induction in PA-1 cells.

Creation of 3D Maps for Satellite Communications to Support Ambulatory Rescue Operations

Nakajima, Isao,Nawaz, Muhammad Naeem,Juzoji, Hiroshi,Ta, Masuhisa Korea Multimedia Society 2019 The journal of multimedia information system Vol.6 No.1

A communications profile is a system that acquires information from communication links to an ambulance or other vehicle moving on a road and compiles a database based on this information. The equipment (six sets of HDTVs, fish-eye camera, satellite antenna with tracking system, and receiving power from the satellite beacon of the N-star) mounted on the roof of the vehicle, image data were obtained at Yokohama Japan. From these data, the polygon of the building was actually produced and has arranged on the map of the Geographical Survey Institute of a 50 m-mesh. The optical study (relationship between visibility rate and elevation angle) were performed on actual data taken by fish-eye lens, and simulated data by 3D-Map with polygons. There was no big difference. This 3D map system then predicts the communication links that will be available at a given location. For line-of-sight communication, optical analysis allows approximation if the frequency is sufficiently high. For non-line-of-sight communication, previously obtained electric power data can be used as reference information for approximation in certain cases when combined with predicted values calculated based on a 3D map. 3D maps are more effective than 2D maps for landing emergency medical helicopters on public roadways in the event of a disaster. Using advanced imaging technologies, we have produced a semi-automatic creation of a high-precision 3D map at Yokohama Yamashita Park and vicinity and assessed its effectiveness on telecommunications and ambulatory merits.