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Y.H. Gad,M.M. Magida,H.H. El-Nahas 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.6
The effect of gamma irradiation on the properties of waste low density polyethylene/ethylene vinyl acetate/bitumen blend was investigated. The variation in tensile strength, elongation at break, hardness and compression set (%) of the prepared blends confirmed the impact of gamma irradiation on the blend microstructure. The best mechanical properties were reported at an integral irradiation dose of 75 kGy at a weight composition ratio of bitumen:EVA:waste LDPE blend, 1:1:1. The influence of ionizing irradiation on the thermal stability and compatibility of the prepared blends, solubility and scanning electron micrographs were investigated. The results suggest that EVA content plays a detrimental role in the ultimate specifications via irradiation. The study offers an elastic product thanks to the controllable radiation crosslinking of EVA beside the introduction of the waste LDPE and bitumen as a possible means of recycling for a likely implementation in expansion joint systems of the concrete moulds. 2010 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
Molluscicidal Activity and Clinico-pathological Effect of Agave lophantha
El-Sayed, M.M.,Abdel-Hadi, M.,El-Nahas, H.A. The Pharmaceutical Society of Korea 1991 Archives of Pharmacal Research Vol.14 No.1
Dry powder and different extracts of Agave lophantha were tested against Biomphalaria alexandrina. The results showed that the butanol extract has high molluscicidal activity. The activity of the dry powder has been found to be stable under the effect of some simulated field conditions. Also the toxicological effect of the plant on mice was tested through determination of certain parameters such as total protein, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and acid phosphatase enzymes as well as histopathological study on liver and kidney.
Carlos Walter Sobrado Júnior,Carlos de Almeida Obregon,Afonso Henrique da Silva e Sousa Júnior,Lucas Faraco Sobrado,Sérgio Carlos Nahas,Ivan Cecconello 대한대장항문학회 2020 Annals of Coloproctolgy Vol.36 No.4
Purpose: Present an updated classification for symptomatic hemorrhoids, which not only guides the treatment of internal hemorrhoids but also the treatment of external components. In addition, this new classification includes new treatment alternatives created over the last few years. Methods: Throughout the past 7 years, the authors developed a method to classify patients with symptomatic hemorrhoids. This study, besides presenting this classification proposal, also retrospectively analyzed 149 consecutive patients treated between March 2011 and November 2013 and aimed to evaluate the association between the management adopted with Goligher classification and our proposed BPRST classification. Results: Both classifications had a statistically significant association with the adopted management strategies. However, the BPRST classification tended to have fewer management discrepancies when each stage of disease was individually analyzed. Conclusion: Although there is much disagreement about how the classification of hemorrhoidal disease should be updated, it is accepted that some kind of revision is needed. The BPRST method showed a strong association with the management that should be adopted for each stage of the disease. Further studies are needed for its validation, but the current results are encouraging.
Naha, A.,Usha, A.N.,Ranjith, A.K.,Musmade, P.,Manoj, K.,Anju, P.,Prasanna, S.,Mutalik, S. 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.2
The objective of the present study was to develop ‘once daily’ sustained release tablets of aceclofenac by direct compression using hydroxypropyl methylcellulose-K4M (HPMC). The solubility studies of aceclofenac were conducted to select suitable dissolution media. The drugexcipient mixtures were subjected to preformulation studies. The tablets were subjected to physicochemical, In vitro drug release and stability studies. Preclinical (anti-inflammatorv, analgesic, pharmacokinetic and toxicity studies) and clinical pharmacokinetic studies were conducted for optimized tablets. Based on the preformulation results, microcrystalline cellulose (MCC), dicalcium phosphate and spray dried lactose (SDL) were selected as directly compressible vehicles. Because of the incompatibility with aceclofenac, SDL was excluded from the study. The physicochemical properties of tablets were found within the limits. By comparing the dissolution profiles with the marketed product, the tablet containing HPMC (45%) and MCC (30%) along with talc and magnesium stearate (1% w/w, each) (tablet B7) was considered as a better formulation. This tablet exhibited almost similar drug release profile in different dissolution media as that of marketed tablet. Tablet B7 was stable in accelerated conditions for 6 months. The composition of this tablet showed almost similar preclinical pharmacological activities compared to marketed tablet composition and did not exhibit any toxicity in rats and mice with respect to tested haematological and biochemical parameters along with bodyweight, food and water intake. The pharmacokinetic study in healthy human volunteers indicated that B7 tablet produced an extended drug release of drug upto 24 h as that of marketed product with almost identical pharmacokinetic parameters.
Naha, N.,Li, S.P.,Yang, B.C.,Park, T.J.,Kim, M.O. Wiley Subscription Services, Inc., A Wiley Company 2009 Synapse Vol.63 No.10
<P>The correlation of the subcellular localization of dopamine D<SUB>1</SUB> and D<SUB>2</SUB> receptors (DA D<SUB>1</SUB> R, DA D<SUB>2</SUB> R) with nicotine addiction has not been studied. We demonstrated the ultrasubcellular organelle localization of DA D<SUB>1</SUB> and D<SUB>2</SUB> Rs in the caudate-putamen (CPu) area of rat brain in vivo exposed to nicotine (3 mg/day; oral) and passive cigarette smoking (500 ml each; 3 times/day) for 1, 4, and 12 weeks, respectively. Our results revealed DA D<SUB>1</SUB> R localization in the presynaptic and postsynaptic dendrites, endocytic vesicles, and secretory granules, and DA D<SUB>2</SUB> R localization in the presynaptic dendrites and vesicles. DA D<SUB>1</SUB> R immunogold particles were highly decreased in the secretory granules of CPu, and increased in the postsynaptic area and vesicles after prolonged nicotine and smoking exposures, suggesting the strong influence of long time smoking and nicotine exposures on DA D<SUB>1</SUB> R subcellular organelle localization. DA D<SUB>2</SUB> R immunoreactivity was comparatively less changed than that of the DA D<SUB>1</SUB> R. Western blot analysis also showed the differential expression of DA D<SUB>1</SUB> and D<SUB>2</SUB> R proteins upon nicotine and smoking exposures as compared to the untreated controls. Taken together, the results for the first time suggests the execution of addictive behavior of nicotine through modulation of mesolimbic dopaminergic system targeting subcellular organelle of DA D<SUB>1</SUB> and D<SUB>2</SUB> Rs in the CPu of adult rat brain that may lead to novel therapeutic approaches related to nicotine's neuropsychological disorders including drug addiction. Synapse 63:847–854, 2009. © 2009 Wiley-Liss, Inc.</P>
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김나혜 ( Nahae Kim ),김주영 ( Juyoung Kim ) 한국공업화학회 2016 공업화학 Vol.27 No.1
In this study, core-crosslinked amphiphilic polymer (CCAP) nanoparticles prepared using a reactive amphiphilic polymer precursor (RARP) were used for preparing some valuable compounds encapsulated polymer nanoparticles with high payload through nanoprecipitation process. Various solvents (acetone, ethanol, and THF) having different polarity and CCAP nanoparticles prepared using different amphiphilicity were used for the preparation of α-tocopherol encapsulated polymer nanoparticles to investigate their effects on the encapsulation efficiency, payload, nanoparticle size, and stability. CCAP dissolved in hydrophobic solvent, THF, could formα-tocopherol encapsulated polymer nanoparticles dispersed in water with the high payload of α-tocopherol and encapsulation efficiency. Because of their physically and chemically robust nano-structure originated from crosslinking of the hydrophobic core, CCAP nanoparticles could encapsulate α-tocopherol with the high payload (33 wt%) and encapsulation efficiency (97%), and form 70 nm-sized stable nanoparticles in water.