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Hong, Dachao,Yamada, Yusuke,Nagatomi, Takaharu,Takai, Yoshizo,Fukuzumi, Shunichi American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.48
<P>Single or mixed oxides of iron and nickel have been examined as catalysts in photocatalytic water oxidation using [Ru(bpy)(3)](2+) as a photosensitizer and S(2)O(8)(2-) as a sacrificial oxidant. The catalytic activity of nickel ferrite (NiFe(2)O(4)) is comparable to that of a catalyst containing Ir, Ru, or Co in terms of O(2) yield and O(2) evolution rate under ambient reaction conditions. NiFe(2)O(4) also possesses robustness and ferromagnetic properties, which are beneficial for easy recovery from the solution after reaction. Water oxidation catalysis achieved by a composite of earth-abundant elements will contribute to a new approach to the design of catalysts for artificial photosynthesis.</P>
Development of a WLAN Based Monitoring System for Group Activity Measurement in Real-Time
Tsunoda, Hiroshi,Nakayama, Hidehisa,Ohta, Kohei,Suzuki, Akihiro,Nishiyama, Hiroki,Nagatomi, Ryoichi,Hashimoto, Kazuo,Waizumi, Yuji,Keeni, Glenn Mansfield,Nemoto, Yoshiaki The Korea Institute of Information and Commucation 2011 Journal of communications and networks Vol.13 No.2
In recent years, there has been a rise in epidemiological evidence suggesting the health benefits of a physically active lifestyle. However, it is not always easy for individuals to personally recognize the optimal conditions for exercise and physical activity. Wearable acceleration-based pedometers have become widely used in estimating the amount of physical activity, and to a limited extent, providing information regarding exercise intensity, but they have never been used to assess adaptation to exercise. In order to realize simultaneous activity monitoring for multiple users exercising outdoors, we developed a prototype wireless local area network (WLAN) based system. In our system, a WLAN is deployed outside, and a user wearing a smart phone and monitoring device exercises freely within the coverage area of the wireless network. By doing so, the developed system is able to monitor the activity of each user andmeasures various parameters including those related to exercise adaptation. In a demonstration experiment, the developed system was evaluated and used to monitor users enjoying a Nordic walk, after which users were immediately able to receive their exercise report. In this paper, we discuss the requirements and issues in developing an activity monitoring system and report the findings we obtained through the demonstration experiment.
Ambroxol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells
Mutsuo Yamaya,Hidekazu Nishimura,Lusamba Kalonji Nadine,Chiharu Ota,Hiroshi Kubo,Ryoichi Nagatomi 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4
The mucolytic drug ambroxol hydrochloridereduces the production of pro-inflammatory cytokines andthe frequency of exacerbation in patients with chronicobstructive pulmonary disease (COPD). However, theinhibitory effects of ambroxol on rhinovirus infection, themajor cause of COPD exacerbations, have not been studied. We examined the effects of ambroxol on type 14rhinovirus (RV14) infection, a major RV group, in primarycultures of human tracheal epithelial cells. RV14 infectionincreased virus titers and cytokine content in the supernatantsand RV14 RNA in the cells. Ambroxol (100 nM)reduced RV14 titers and cytokine concentrations of interleukin(IL)-1b, IL-6 and IL-8 in the supernatants and RV14RNA in the cells after RV14 infection, in addition toreducing susceptibility to RV14 infection. Ambroxol alsoreduced the expression of intercellular adhesion molecule-1 (ICAM-1), the receptor for RV14, and the number ofacidic endosomes from which RV14 RNA enters thecytoplasm. In addition, ambroxol reduced the activation ofthe transcription factor nuclear factor kappa B (NF-jB) inthe nucleus. These results suggest that ambroxol inhibitsRV14 infection partly by reducing ICAM-1 and acidicendosomes via the inhibition of NF-jB activation. Ambroxol may modulate airway inflammation by reducingthe production of cytokines in rhinovirus infection.
Development of a WLAN Based Monitoring System for Group Activity Measurement in Real-Time
Hiroshi Tsunoda,Hidehisa Nakayama,Kohei Ohta,Akihiro Suzuki,Hiroki Nishiyama,Ryoichi Nagatomi,Kazuo Hashimoto,Yuji Waizumi,Glenn Mansfield Keeni,Yoshiaki Nemoto 한국통신학회 2011 Journal of communications and networks Vol.13 No.2
In recent years, there has been a rise in epidemiological evidence suggesting the health benefits of a physically active lifestyle. However, it is not always easy for individuals to personally recognize the optimal conditions for exercise and physical activity. Wearable acceleration-based pedometers have become widely used in estimating the amount of physical activity, and to a limited extent,providing information regarding exercise intensity, but they have never been used to assess adaptation to exercise. In order to realize simultaneous activity monitoring for multiple users exercising outdoors, we developed a prototype wireless local area network (WLAN) based system. In our system, a WLAN is deployed outside, and a user wearing a smart phone and monitoring device exercises freely within the coverage area of the wireless network. By doing so, the developed system is able to monitor the activity of each user andmeasures various parameters including those related to exercise adaptation. In a demonstration experiment, the developed system was evaluated and used to monitor users enjoying a Nordic walk, after which users were immediately able to receive their exercise report. In this paper, we discuss the requirements and issues in developing an activity monitoring system and report the findings we obtained through the demonstration experiment.
Ambroxol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells
Yamaya, Mutsuo,Nishimura, Hidekazu,Nadine, Lusamba Kalonji,Ota, Chiharu,Kubo, Hiroshi,Nagatomi, Ryoichi 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4
The mucolytic drug ambroxol hydrochloride reduces the production of pro-inflammatory cytokines and the frequency of exacerbation in patients with chronic obstructive pulmonary disease (COPD). However, the inhibitory effects of ambroxol on rhinovirus infection, the major cause of COPD exacerbations, have not been studied. We examined the effects of ambroxol on type 14 rhinovirus (RV14) infection, a major RV group, in primary cultures of human tracheal epithelial cells. RV14 infection increased virus titers and cytokine content in the supernatants and RV14 RNA in the cells. Ambroxol (100 nM) reduced RV14 titers and cytokine concentrations of interleukin (IL)-$1{\beta}$, IL-6 and IL-8 in the supernatants and RV14 RNA in the cells after RV14 infection, in addition to reducing susceptibility to RV14 infection. Ambroxol also reduced the expression of intercellular adhesion molecule-1 (ICAM-1), the receptor for RV14, and the number of acidic endosomes from which RV14 RNA enters the cytoplasm. In addition, ambroxol reduced the activation of the transcription factor nuclear factor kappa B (NF-${\kappa}B$) in the nucleus. These results suggest that ambroxol inhibits RV14 infection partly by reducing ICAM-1 and acidic endosomes via the inhibition of NF-${\kappa}B$ activation. Ambroxol may modulate airway inflammation by reducing the production of cytokines in rhinovirus infection.
Mutsuo Yamaya,Kazuhiro Nomura,Kazuya Arakawa,Mitsuru Sugawara,Xue Deng,Nadine Lusamba Kalonji,Hidekazu Nishimura,Mitsuhiro Yamada,Ryoichi Nagatomi,Tetsuaki Kawase 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.5
Rhinoviral infection is associated with anincreased risk of asthma attacks. The macrolide clarithromycindecreases cytokine production in nasopharyngealaspirates from patients with wheezing, but the effectsof macrolides on cytokine production in nasal epithelialcells obtained from asthmatic subjects remain unclear. Here, human nasal epithelial cells were infected with type-14 rhinovirus (RV14), a major RV group. Titers and RNAof RV14 and cytokine concentrations, including IL-1b andIL-6, were higher in the supernatants of the cells obtainedfrom subjects with bronchial asthma (asthmatic group) thanin those from the non-asthmatic group. Pretreatment withclarithromycin decreased RV14 titers, viral RNA andcytokine concentrations, and susceptibility to RV14infection. Pretreatment with clarithromycin also decreasedIL-33 production, which was detected after infection. Pretreatment with clarithromycin decreased the expressionof intercellular adhesion molecule-1, the receptor forRV14, after infection, the number and fluorescence intensityof the acidic endosomes through which RV RNAenters the cytoplasm, and the activation of nuclear factorkappa-B proteins in nuclear extracts. These findings suggestedthat RV replication and cytokine production may beenhanced in nasal epithelial cells obtained from subjectswith bronchial asthma and may be modulated byclarithromycin.