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      • Surface-Mediated Solidification of a Semiconducting Polymer during Time-Controlled Spin-Coating

        Na, Jin Yeong,Kang, Boseok,Lee, Seung Goo,Cho, Kilwon,Park, Yeong Don American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.11

        <P>Spin-casting a polymer semiconductor solution over a short period of only a few seconds dramatically improved the molecular ordering, and charge transport properties of the resulting semiconductor thin films. In this process, it was quite important to halt spinning before the drying line propagation had begun. Here, we elucidated the effects of the substrate surface characteristics on the drying kinetics during spin-coating, systematically investigated the microstructural evolution during semiconducting polymer solidification, and evaluated the performances of the resulting polymer field-effect transistors. We demonstrated that the spin time required to enhance the molecular ordering and electrical properties of the polythiophene thin films was strongly correlated with the solidification onset time, which was altered by surface treatments introduced onto the substrate surfaces.</P>

      • SCIESCOPUSKCI등재

        Enhancement of a Liver Form of Cytosolic Phospholipase A2 Activity by Methylmercury

        Na, Doe Sun,Kang, Mi Sun,Kim, Dae Kyong,Huh, Don Haeng,Sohn, Dong Hun 생화학분자생물학회 1999 BMB Reports Vol.31 No.2

        Methylmercury (MeHg), which is widely distributed in the environment, is well known for both its acute and chronic poisoning effects on the human health; however, the precise biochemical mechanisms by which this compound elicits its toxicity in a cellular level are still poorly understood. To examine whether MeHg-induced liver injury involves activation of Phospholipase A₂ (PLA₂), the PLA₂ activity of control and MeHg-administrated livers was measured. MeHg stably enhanced a liver form of cytosolic PLA₂ activity, which exhibited several biochemical properties similar to those of the 100 kDa cPLA₂, except in its elution profile of a DEAE-5PW HPLC, and it migrated as a molecular weight of 80 kDa in Western blot analysis. This blotting analysis also indicated that the MeHg-induced enhancement of the activity could be due to the increase in the amount of the enzyme protein rather than a stable modification of the enzyme such as phosphorylation. Our data also showed the higher myeloperoxidase activity in MeHg-administrated liver than in the control, suggesting that this increase in the amounts of the 80 kDa PLA₂ and its activity may be resulted from infiltration of neutrophils into the liver during a, hepatic injury process such as MeHg-induced inflammation. Taken together, these data suggest that MeHg-induced liver injury may be mediated by activation of the 80 kDa form of liver cytosolic PLA₂.

      • Effects of Bisphenol A on Sex Differentiation and Gonadal Development of Medaka, Oryzias latipes

        Na, Oh-Soo,Lee, Young-Don,Baek, Hea-Ja,Kim, Hyung-Bae The Korean Society for Integrative Biology 2002 Korean journal of biological sciences Vol.6 No.1

        A study on the effects of bisphenol A (BPA) on sex differentiation and gonadal development in medaka, Oryzias latipes, was investigated by histological examination. The fish were exposed to aqueous solutions of BPA at nominal concentrations of 50, 100, and 200 $\mu\textrm{g}$/L from newly-hatched larvae stage to 70 d. The ovaries of female fish were composed of oocytes at the chromatin nucleolus and peri-nucleolus stages at 20 d after the exposure. The testes contained a number of spermatogonia and spermatocytes at 30 d. In the process of sex differentiation. gonadal development was not different in all experimental groups until 30 d after the exposure. At 70 d after the exposure, however, advanced development of oocytes in the ovary and inhibition of spermatogenesis in the testis were observed in the BPA-treated groups compared to the non-treated controls. More females than males were identified in the 50 and 100 $\mu\textrm{g}$/L BPA-treated groups, in comparison to the 200 $\mu\textrm{g}$/L BPA-treated group and non-treated controls. Medaka exposed to 200 $\mu\textrm{g}$/L BPA were bigger compared to other experimental groups. The present study suggests that BPA may lead to problems in either mating or sexual behavior due to the difference in growth and disparity of sexual maturation between male and female fish.

      • SCIESCOPUSKCI등재

        Attention Circuits Mediate the Connection between Emotional Experience and Expression within the Emotional Circuit

        Na Rae Won,Young-Don Son,Sun Mi Kim,Sujin Bae,Jeong Hee Kim,Jong-Hoon Kim,Doug Hyun Han 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.4

        Objective: Most affective neuroscience studies use pictures from the International Affective Picture System or standard facial expressions to elicit emotional experiences. The attention system, including the prefrontal cortex, can mediate emotional regulation in response to stimulation with emotional faces. We hypothesized that emotional experience is associated with brain activity within the neocortex. In addition, modification within the neocortex may be associated with brain activity within the attention system. Methods: Thirty-one healthy adult participants were recruited to be assessed for emotional expression using clinical scales of happiness, sadness, anxiety, and anger as and for emotional experience using brain activity in response to pictures of facial emotional expressions. The attention system was assessed using brain activity in response to the go-no-go task. Results: We found that emotional experience was associated with brain activity within the frontotemporal cortices, while emotional expression was associated with brain activity within the temporal and insular cortices. In addition, the association of brain activity between emotional experiences and expressions of sadness and anxiety was affected by brain activity within the anterior cingulate gyrus in response to the go-no-go task. Conclusion: Emotional expression may be associated with brain activity within the temporal cortex, whereas emotional experience may be associated with brain activity within the frontotemporal cortices. In addition, the attention system may interfere with the connection between emotional expression and experience.

      • 대학부속병원 응급실에 내원한 청소년 정신장애 환자의 특성

        나철,김헌수,민병근,김영돈,이재우,박재선,김민호,이길홍 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.4

        The authors respectively reviewed their records from 100 visits by adolescents and 100 visits by adults chosen by random sampling from all adolescent and adult patients seen during July 1984 and July 1987 in the emergency room of Chung-Ang University, Young-San Hospital.Chi-square statistics were calculated with Yates' correction. The results were as follows: 1. Adolescent patients were tended to be more likely than adults to have been referred by friends. 2. Adolescent patients were more likely than adults to have visited emergency room promptly after symptom oneset, and less likely to have insight about one's mental illness.Adolescent were less likely to receive neuropsychiatric out-patient treatment plan, in spite of psychiatrist's recommendation, because of low insight level. 3. With regard to their symptoms and chief complaints, adolescent patients more pften reported anger, aggressive behavior and sucide attempts, while adults were more likely to have been sucide idea. 4. The precipitant for the current visit was more likely to have been extra-familial difficulties inculding academic problem and bad relationdhip with peer groups for adolescents and intrafamiliai problems such as loss of loved person and primary interpersonal relation difficulties for adults. 5. Both gruops were more likely to be diagnosed as suffering from somatization disorder. Adult patients were mpro likely than adolescents to be diagnosed as affective disorder, especially atypical depression. 6. Both groups frequently abused some substances, with adolescents tending to use dyuga and adults tending to use alcohol. In conclusion frequently patients coming to the emergency room had acute and serious pathology, because anger, aggressive brhavir, self0destructive behavior and sucide attempts were expressed vividly and explosively.

      • Solution Processing with a Good Solvent Additive for Highly Reliable Organic Thin-Film Transistors

        Na, Jin Yeong,Kim, Min,Park, Yeong Don American Chemical Society 2017 The Journal of Physical Chemistry Part C Vol.121 No.25

        <P>High-performance transistors require homogeneous crystalline thin films with high charge carrier mobilities on large substrates. We report a versatile solution process that uses a good solvent additive with a high boiling point. This method enables the fabrication of uniform, large-area, polymer thin films with improved thin film crystallinity and electrical characteristics and high reliability organic transistors. We demonstrate here that the addition of a small amount of a good solvent additive with a high boiling point to the processing solution is highly effective in not only inducing the strong self-assembly of the conjugated polymer during film solidification by increasing the solvent evaporation time but also in ensuring the formation of a uniform film morphology. These characteristics were found to enhance the device performance of a poly(3-hexylthiophene) film processed from a mixed solvent containing chlorobenzene and 1,2,4-trichlorobenzene, which was found to exhibit a highest average field-effect mobility of 0.012 cm(2) V-1 s(-1) with excellent reliability over a 16 device array.</P>

      • 결장직장암 환자의 임상적 고찰 : 조선대학교 부속병원의 10년 간의 결과

        나은종,문성표,장정환,김권천,민영돈,김성환,조현진,김정용,김경종 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

        Background and Objectives: The colorectal cancer rates 4th in the total cancer prevalence in Korea. The clinical patient demographics were considered with the incidence rate of the colon and rectal cancer. The clinicopathological factors were analyzed for the 5 year survival rate. Materials Methods: Of the 282 patients who were operated from Jan. 1, 1992 to Dec. 31, 2001 and diagnosed by pathological biopsy as colo-rectal cancer, 234 patients were followed up. The age, sex, location of the cancer, TNM stage, operation method, histopathological classification, metastatic region, complications after operation and the survival rate were investigated. Results: Of the 234 patients, male and female consisted of 120 cases (51.3%) and 114 cases (46.7%), with an average age of 61.6 years. The average follow up period was 52.3 months and the peri operative mortality was 5.6%. The site of the cancer was most frequent at the rectum with 127 cases (54.3%). The patients were classified according to the TNM stages with 38 cases of stage 1 (16.2%), 98 cases of II (41.9%), 72 cases of III (30.8%) and 26 cases of IV (11.1%). The 5 year survival rate in the age group older than 50 was 63.3 % and 73.5% in the group younger than 50. In regard to the operation type, the 5 year survival rate was 65.4% for elective operation and 65.8% for emergency operation. The 5 year survival rate for well differentiated, moderately differentiated, poorly differentiated cancer, and mucinous adenocarcinoma was 73.7%, 60.2%, 58.3%, and 92.6%, respectively. The 5 year survival rate of each of the TNM stage is 81.1%, 74.8%, 57.0%, and 11.5% for Classes I, II, III, and IV, respectively. Conclusion: The clinical factors were analyzed for the 5 year survival rate with no statistical significance for the age, sex, and location of the cancer. The TNM stage and histopathological differentiation were statistically significant. The colon cancer showed better prognosis compared to the rectal cancer.

      • KCI등재

        블렌딩 오일 시장 확대를 위한 소비자 선호 분석

        최돈우 ( Don Woo Choi ),최홍집 ( Hong Jib Choi ),홍나경 ( Na Kyoung Hong ) 한국식품유통학회 2012 食品流通硏究 Vol.29 No.2

        The number of obese people is on the rise in Korea because of westernized eating habits. Accordingly, consumers` concern about cooking oil also increases as trans fats are known to be the cause of obesity. The purpose of this paper is to investigate consumers` preference for the blending oil on the grounds that there`s ideal blending oil which mix omega 3·6·9 fatty acids in the ratio of 2:1:1. A choice experiment is designed and the aroma and prices of sesame oil, flaxseed oil and blending oil are examined as attributes. 154 Daegu metropolitan consumers were surveyed and a mixed logit model was employed to estimate WTPs. The result shows the highest WTP on the blending oil, the second highest on the flaxseed oil, the third on the sesame oil and the last on the aroma. Consumers have positive attitudes on health functional food or functionality-enhanced blending oil. The result of this paper could contribute to the development of functionality-enhanced blending oil production through transferring agricultural technology and improvement of rural household incomes.

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