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Kim, Myungsuk,Lim, Sue Ji,Kang, Suk Woo,Um, Byung-Hun,Nho, Chu Won American Chemical Society 2014 Journal of agricultural and food chemistry Vol.62 No.17
<P><I>Aceriphyllum rossii</I> contains an abundant source of natural flavonoids with potential antioxidant, anticancer and anti-inflammatory properties. However, the effect of <I>A. rossii</I> extract (ARE) on immunoglobulin E(IgE)-mediated allergic responses remains unknown. In the present study, the effects of ARE and its active compounds, quercetin and kaempferol, on IgE-mediated rat basophilic leukemia mast cell activation and passive cutaneous anaphylaxis (PCA) were investigated. ARE, quercetin, and kaempferol inhibited secretion of β-hexosaminidase and histamine, and reduced the production and mRNA expression of interleukin-4 and tumor necrosis factor-α. ARE also decreased the production of prostaglandin E<SUB>2</SUB> and leukotriene B<SUB>4</SUB> and expression of cyclooxygenase 2 and 5-lipoxygenase. Furthermore, ARE, quercetin, and kaempferol inhibited IgE-mediated phosphorylation of Syk, phospholipase Cγ, protein kinase C (PKC)μ, and the mitogen-activated protein kinases, extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinase. ARE, quercetin, and kaempferol markedly suppressed mast cell-dependent PCA in IgE-sensitized mice. These results indicate that ARE and its active constituents, quercetin and kaempferol, may be a useful therapy for immediate-type hypersensitivity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2014/jafcau.2014.62.issue-17/jf405486c/production/images/medium/jf-2013-05486c_0001.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf405486c'>ACS Electronic Supporting Info</A></P>
Predicting mating flights through meteorological cues using multi-scale logistic regression
Kim, MyungSuk,Lim, Johan,Wang, Suojin John Wiley Sons, Ltd. 2009 Environmetrics Vol.20 No.3
<P>The red imported fire ant is one of the most destructive animals in the US. Its prolific ability through mating flights has aggravated the situation. Understanding the environmental cues triggering mating flights would be important for a comprehensive control solution. Fire ant colony activities related to mating flights were daily monitored from April 2001 to March 2002, and the associated weather data were documented. The method of logistic regression is used to identify environmental factors associated with mating flight where multi-scale decomposition of the meteorological variables is considered to identify the within and the between cues for mating flights. Our empirical results indicate that ambient temperature, relative humidity, wind speed, barometric pressure, and recent rain are significant factors that trigger or influence fire ant mating flights. Among those factors, the ambient temperature, the change in barometric pressure, relative humidity, wind speed, and recent rain are found to be the macro-scale cues, whereas the ambient temperature is also found to be the micro-scale cues. Copyright © 2008 John Wiley & Sons, Ltd.</P>
Kim, Myungsuk,Lim, Sue Ji,Lee, Hee-Ju,Nho, Chu Won American Chemical Society 2015 Journal of agricultural and food chemistry Vol.63 No.41
<P><I>Cassia tora</I> seed is widely used due to its various biological properties including anticancer, antidiabetic, and anti-inflammatory effects. However, there has been no report of the effects of <I>C. tora</I> seed extract (CTE) on immunoglobulin E (IgE)-mediated allergic responses. In this research, we demonstrated the effects of CTE and its active compound aurantio-obtusin on IgE-sensitized allergic reactions in mast cells and passive cutaneous anaphylaxis (PCA). CTE and aurantio-obtusin suppressed degranulation, histamine production, and reactive oxygen species generation and inhibited the production and mRNA expression of tumor necrosis factor-α and interleukin-4. CTE and aurantio-obtusin also suppressed the prostaglandin E<SUB>2</SUB> production and expression of cyclooxygenase 2. Furthermore, CTE and aurantio-obtusin suppressed IgE-mediated FcεRI signaling such as phosphorylation of Syk, protein kinase Cμ, phospholipase Cγ, and extracellular signal-regulated kinases. CTE and aurantio-obtusin blocked mast cell-dependent PCA in IgE-mediated mice. These results suggest that CTE and aurantio-obtusin are a beneficial treatment for allergy-related diseases.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2015/jafcau.2015.63.issue-41/acs.jafc.5b03836/production/images/medium/jf-2015-03836e_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf5b03836'>ACS Electronic Supporting Info</A></P>