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Choi, Myung-Sook,Jung, Un Ju,Kim, Hye-Jin,Do, Gyeong-Min,Jeon, Seon-Min,Kim, Myung-Joo,Lee, Mi-Kyung Institute for Advanced Research in Asian Science a 2008 The American journal of Chinese medicine Vol.36 No.1
<P>This study examined the effect of a Du-zhong (Eucommia ulmoides Oliver) leaf extract (0.175 g/100 g diet) that was supplemented with a high-fat diet (10% coconut oil, 0.2% cholesterol, wt/wt) on hyperlipidemic hamsters. Hamsters fed with Du-zhong leaf extract for 10 weeks showed a smaller size of epididymal adipocytes compared to the control group. The supplementation of the Du-zhong leaf extract significantly lowered the plasma levels of triglyceride, total cholesterol, LDL-cholesterol, non HDL-cholesterol, and free fatty acid, whereas it elevated the HDL-cholesterol/total cholesterol ratio and apolipoprotein A-I levels. The hepatic cholesterol concentration was lower in the Du-zhong group than in the control group. The plasma total cholesterol concentration was positively correlated with hepatic HMG-CoA reductase activity (r = 0.547, p < 0.05) and hepatic cholesterol concentration (r = 0.769, p < 0.001). The hepatic fatty acid synthase and HMG-CoA reductase activities were significantly lowered by a Du-zhong leaf extract supplement in high fat-fed hamsters. Hepatic fatty acid synthase activity was positively correlated with plasma fatty acid concentration (r = 0.513, p < 0.05) that was lower in the Du-zhong group. These results demonstrate that the Du-zhong leaf extract exhibits antihyperlipidemic properties by suppressing hepatic fatty acid and cholesterol biosynthesis with the simultaneous reduction of plasma and hepatic lipids in high fat-fed hamsters.</P>
Building a Causal Loop of Disaster Management Process for Fine Dust Considering a Dynamic Life Cycle
Myung Gi Hong,Yong Un Ban,Nam Hee Choi 위기관리 이론과 실천 2019 Crisisonomy Vol.15 No.6
본 연구의 목적은 시스템 다이나믹스를 활용하여 최근 국내에서 사회적 재난의 하나로 논의되고 있는 미세먼지에 대한 동태적 생애주기 인과지도를 구축하고, 지속가능한 도시 메타볼리즘 패러다 임을 적용한 통합적인 미세먼지 재난관리 틀을 제안하는 것이다. 이러한 목표를 이루기 위해, 본 연구는 미세먼지 및 재난관리와 관련된 이전의 연구들을 통합적으로 검토했다. 결과적으로 본 연구 는 미세먼지 재난의 주요 요인들을 추출하고, 생애주기에 따라 요인 상호 간의 부적 또는 양적 인과 관계를 확인하여 관계가 확인된 변수들을 지속가능 도시메타볼리즘의 주요요소인 경제, 사회, 환경 의 특성 및 새로운 재난 관리단계에 따라 인과지도를 구축하였다. 새롭게 제안하는 재난관리 틀은 기존 재난관리의 단계 틀 보다 분류기준이 명확하고, 재난의 시간적 동태적 특성 및 지속가능성을 반영할 수 있어 미세먼지와 같은 사회적 재난을 미리 예측하고 모니터링하기 용이할 것이며, 이에 따라 정책결정 당국자들이 적절하고 빠르게 재난대응 계획을 수립하고 실행할 수 있게 할 것이다. This study used system dynamics to build a dynamic life-cycle causal loop diagram for fine dust, one of social disasters recently discussed in Korea in order to propose an integrated disaster management framework for fine dust disaster with a sustainable urban metabolism paradigm. To reach this goal, this study reviewed the previous research related to fine dust and disaster management comprehensively. As a result, this study extracted the major factors of fine dust disaster, checked a mutual causal relationship, and then built a causal loop diagram using variables in each factor according to a sustainable urban metabolism paradigm composed of economic, social and environmental characteristics and a new disaster management framework. The proposed disaster management framework has clearer classification criteria than the existing framework and reflects the time-dynamic characteristics of disasters and sustainability, making it easier to predict and monitor fine dust disaster in advance and enabling policy makers and practitioners to prepare action plans and implement them in an appropriate and prompt manner.
Hematological Aspects in A Endotoxemic Young Rabbit Model
Choi, Seok-Cheol,Kwon, Heun-Young,Kim, Jai-Young,Hwang, Soo-Myung,Kim, Tae-Un,Seong, Hee-Kyung,Kim, Yang-Weon,Lee, Won-Jae 대한의생명과학회 2002 Biomedical Science Letters Vol.8 No.3
Gram-negaive septicemia, which continues to be a serious clinical problem, is one of the major causes of morbidity and mortality in hospitalized patients. Endotoxin of gram-negative bacteria is a pivotal pathogen of sepsis. To understand the effect of endotoxin on hematological aspect and the time course in early childhood, this study was designed with experimental septic model of young rabbits (8 week-old). Rabbits were divided into control (n=7) and endotoxin group (0.50 mg/kg of endotoxin). The endotoxin group was subdivided into six groups by the sampling times: 3,6,12,24,48 and 72 hr-group (E-G_3, E-G_6, E-G_12, E-G_24, E-G_48 and E-G_72hrs, each n=7). The evaluation of CBC, activated partial thromboplastin time (APTT), prothrombin time (PT),fibrinogen concentration, coagulation factors and D-dimer were taken from the bloods. The number of leukocytes was lower in E-G_3and E-G_6hrs (due to pantocytopenia), whereas it was higher in E-G_24 and E-G_48hrs (due to neutrophilia and/or lymphophilia) than in control group (p<0.05). Platelet counts in E-G_3, E-G_6, E-G_12, E-G_24 and E-G_48hrs were lover than those of control group (p<0.05). Normoblast counts in E-G_3, E-G_6, E-G_12 and E-G_48hrs were higher than those of control group (p<0.01). APTT in E-G_3, E-G_6, E-G_12, E-G_24 and E-G_72hrs were longer while PT in E-G_3, E-G_6, E-G_48 and E-G_72hrs were higher than those of control group (p<0.05). Fibrinogen concentrations were lover in E-G_3, E-G_6 and E-G_12hrs but higher in E-G_48 and E-G_72hrs than those of control (P<0.05). Intrinsic coagulation factors (XII, XI, IX, VIII) in all endotoxin groups were significantly lower than those of control group (P<0.05). Extrinsic coagulation factors (X, VII, V, II) were lower in E-G_3, E-G_6, E-G_12 and E-G_24hrs whereas they were higher in E-G_48 and E-G_72hrs than in controlgroup (p<0.05). D-dimer concentrations in E-G_48 and E-G_72hrs were higher than those of control group (p<0.001). We concluded that endotoxin led to extensive hematological disturbances including disseminated intravascular coagulation in the young rabbits and that this pathologic condition in the infant and childhood groups will cause the grave results.
The Leaf of Diospyros kaki Thumb Ameliorates Renal Oxidative Damage in Mice with Type 2 Diabetes
Myung-Sook Choi,Mi Ji Jeong,Yong Bok Park,Sang Ryong Kim,Un Ju Jung 한국식품영양과학회 2016 Preventive Nutrition and Food Science Vol.21 No.4
Diabetic kidney disease is the most common and severe chronic complication of diabetes. The leaf of Diospyros kaki Thumb (persimmon) has been commonly used for herbal tea and medicinal purposes to treat a variety of conditions, including hypertension and atherosclerosis. However, the effect of persimmon leaf on kidney failure has not been investigated. This study aimed to examine the role of persimmon leaf in protecting the diabetes-associated kidney damage in a mouse model of type 2 diabetes. Mice were fed either a normal chow diet with or without powered persimmon leaf (5%, w/w) for 5 weeks. In addition to kidney morphology and blood markers of kidney function, we assessed levels of oxidative stress markers as well as antioxidant enzymes activities and mRNA expression in the kidney. Supplementation of the diet with powered persimmon leaf not only decreased the concentration of blood urea nitrogen in the plasma but also improved glomerular hypertrophy. Furthermore, the persimmon leaf significantly decreased the levels of hydrogen peroxide and lipid peroxide in the kidney. The activities of superoxide dismutase, catalase, and glutathione peroxidase and the mRNA expression of their respective genes were also increased in the kidney of persimmon leaf-supplemented db/db mice. Taken together, these results suggest that supplementation with the persimmon leaf may have protective effects against type 2 diabetes-induced kidney dysfunction and oxidative stress.
( Myung Woo Choi ),( Jong Hwa Lee ),( Sung Sik Oh ),( Mi Rim Choi ),( Hyun Ju Yang ),( Moon Sik Park ),( Jae Un Lee ),( Shang Hoon Han ),( Young Jae Lee ),( Yong Keun Cho ),( Ji Woong Kim ),( Ji Woong 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: There are various tumorous lesions in pancreas, but it is diffi cult to differenciate these lesions because of the anatomical and clinical characteristics. Through endoscopic-ultrasound(EUS)-guided biopsy, the effort for increasing diagnostic rate is still ongoing. However, Sometimes it is diffi cult to get enough tissue through EUS and to get accurate diagnostic imaging of tumorous lesion. In that case, the defi nitive diagnosis is only obtained after surgical intervention. Authors report one case, which was diagnosed as the pancreatic cancer before the operation and had a pancreaticoduodenectomy, but the lesion was proved to be tumor forming chronic pancreatitis on histological examination of a frozen-section. Case: A 65-years-old male patient presented with indigestion for about 1week and he was found to have a tumorous lesion in pancreas by abdominal-ultrasonography at local. He was a chronic drinker who consumed 100g of alcohol everyday. On initial laboratory evaluation, PT-1. 02, AST/ALT-22/12U/L, ALP-342IU/L, T-bilirubin-0. 2mg/ dL, Amylase-74U/L, lipase-160U/L, CA19-9-9. 13U/mL, CEA-6. 1ng/mL. In Contrast-enhanced abdominal-CT, 6. 4x5. 0x4. 0cm mass was found in the pancreas head, which was low density and little more enhanced than normal pancreas and the boundary was relatively clear. EUS-guided Procore 25G-needle biopsy and Cytology was done, but only normal pancreas tissues were found. However there was FDG uptake (SUVmax- 3. 79) in the head of pancreas on PET-CT. So we diagnosed this case as pancreas- cancer in T3N1 and he underwent pancreaticoduodenectomy. After the operation, fi nal histological diagnosis was mass forming chronic pancreatitis. Conclusion: Chronic pancreatitis can present with a fi brotic mass. If there is a risk factor like chronic alcohol intake in medical history taking and CA 19-9 is normal, it could be the chronic pancreatitis which has a possibility of forming mass rather than pancreatic cancer. In conclusion, it needs more effort of imaging examination and tissue confi rmation for accurate diagnosis.
Association of Age and CKD with Prognosis of Myocardial Infarction
Choi, Joon Seok,Kim, Min Jee,Kang, Yong Un,Kim, Chang Seong,Bae, Eun Hui,Ma, Seong Kwon,Ahn, Young-Keun,Jeong, Myung Ho,Kim, Young Jo,Cho, Myeong Chan,Kim, Chong Jin,Kim, Soo Wan American Society of Nephrology 2013 Clinical journal of the American Society of Nephro Vol.8 No.6
Myung-Sook Choi,Un Ju Jung,Myung-Joo Kim,Jong-Yeon Kim,So-Young Park,Joo-Yeun Jang,Mi-Kyung Lee 한국식품영양과학회 2005 Preventive Nutrition and Food Science Vol.10 No.1
Soy and soy foods are a rich source of isoflavones, which possess several biological activities. The effect of soy isoflavones, genistin and diadzin and their respective aglycones, on glucose uptake in adipocytes isolated from normal or high-fat fed rats was examined. As expected, insulin stimulated glucose uptake in a concentration- dependent manner. However, genistin and daidzin and their aglycones inhibited glucose uptake in a concentration-dependent (25~100 μM) manner. In a time-course response, the aglycones significantly inhibited glucose uptake throughout 3 hr (after 30, 60, 120, 180 min), whereas the glycones only significantly inhibited the glucose uptake after 120 min and 180 min in the isolated rat adipocytes. Thus, the glucosides of genistein and daidzein, i.e. genistin and daidzin, were much less effective in inhibiting glucose uptake than their aglycones. In addition, genistin and daidzin did not significantly affect the insulin-stimulated glucose uptake, whereas genistein and daidzein did significantly inhibited glucose uptake compared to the vehicle control group by 47.5% and 24.8%, respectively (p<0.05). The isoflavones also significantly inhibited glucose uptake in adipocytes isolated from rats fed a high-fat diet (50% of total calorie intake) when compared to the vehicle control. Finally, the isoflavones were found to enhance lipolysis in adipocytes isolated from high-fat fed rats, where the glycerol released by the aglycones was also higher than that released by the glycones. The current results showed that the inhibitory effect of daidzein on glucose uptake was very similar to that of genistein. The aglycones were more potent in inhibiting the uptake of glucose and a more potent stimulator of lypolysis than the glycones in adipocytes isolated from high-fat fed rats.