비복신경이식을 이용한 긴 거리의 말초신경 결손부 수복

이종호,이세영,김명진,이은진,안강민,김성민,최원재,명훈,황순정,서병무,최진영,정필훈 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2

The surgery of oral and maxillofacial area poses the risk of cranial nerve damage such as trigeminal nerve or facial nerve. Inferior alveolar nerve is prone to damage in the third molar extraction, implant installation, orthognathic surgery, open reduction and rigid fixation, and tumor ablation surgery. On the other hands,facial nerve is likely to be damaged or sacrificed with trauma or parotidectomy. In case of inferior alveolar nerve injury, the incidence is reported to be about 1.3%. The nerve function will almost recover in minimal damage, but it won't recover at last in total damage of a part of nerve unit. In latter cases, nerve regeneration in intended by allograft as nerve substitute or various route of merve condit. But the recovery with autograft is believed to be most relialbe mrthod in the rapair of long-span(longer than 15㎜)nerve defect. We have performed autologous sural nerve graft in the repair of nerve defect, which is caused by resection of benign or malignant tumor. Hereby we report the method of nerve harvesting, recovery of defected peripheral nerve and the complications of donor site with the discussion of sural nerve anatomy.

백서 척수후근절로부터 슈반세포의 효과적인 체외 배양법

김성민,이종호,김남열,안강민,최원재,최시호,차미주,이주영,황순정,장정원,명훈,최진영,서병무,정필훈,김명진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4

Schwann cells(SCs), an important component of the peripheral nervous system, intract with nerous to mutually support growth and replication for the peripheral nerve regentation. Recently, ading SCs to the lumen of guidance channel is widely tried to improve regeneration or to make regeneration possible over otherwise irreparable gaps. however, it is not easy to isolate and multiplicate SCs as much as enough to help the axonal regeneration. For the allogeneic SCs source for tubular nerve guidance, we developed a little bit improved technique of harvesting and multiplicating SCs. by culturing dispersed dorsal root ganglia in specially designed medium with growth factors and serial processing, we repeatedlly generate relatively homogenous SC cultures. Our technique was compared with other methods of literature using immunostaining methods such as GFAP, S100, BDNF and the total SC count assessment at different time interval after primary culture.

가상기준점측량을 이용한 도시기준점 분석

최석근, 안원태, 박명진 충북대학교 건설기술연구소 2008 충북대학교 건설기술연구소 논문집 Vol.27 No.1

Realtime Kinematic(RTK) method make decision to correct position by calculating correction value of rover and transmitting to rover data from GPS base station. However. this method has many problems as it required base station and rover. Also lots of time for setting, commit workers and many equipment were needed. Therefore, in this study, we made system using virtual reference station and analysed the accuracy of urban control point through VRS RTK method without limited time and distance. As result of this study, two control points were obtained with good results in expected accuracy, therefore it was good method for management of urban control point. Also, it was useful to reconstruct control point immediately and to build urban information system.

Goretex를 이용한 융비술

최진영,민철기,명훈,황순정,서병무,이종호,정필순,김명진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4

융비술시 실리콘 고무는 다루기 쉽고 조직 반응이 적어 현대 많이 돌출의 합병증이 생길 수 있다. 저자등은 이러한 실리콘의 단점을 보완할 수 있는 goretex를 사용하여 융비술을 시행하고 비첨에 대해서 자가연골을 이식하여 만족할 만한 결과를 얻었기에 goretex가 안면부 연조직의 증강을 위한 이식재료로 적합하다고 생각되어 문헌고찰과 함께 보고하는 바이다. Many different materials have been used to provide augmentation of the nasal dorsum. this include both autogenous and homogenous materials,as well as allografts. Silicone among the artificial materials has been most widely used. The silicone has some advantages and disadvantages. Goretex(expanded polytetra-fluoroethylene) which has widely used in vascular surgery and abdominal surgery can be used for facial soft tissue augmentation. The author presemts 2 cases of nasal augmentaion using goretex with literature review.

하악골 골절후의 골치유과정에 있어서 방사선학적 추적조사

최진영,김명호,허경희,서병무,이종호,정필훈,김명진 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The results of radiographic study of healing of fractured mandible are often inconsistent with clinical evaluation of bone healing pattern of it. In addition, there is inconsistency between radiographic studies. We think if such inconsistency is resolved, clinical assessment combined with radiologic evidence can be used to guide to more accurate clinical management. The purpose of this study is to evaluate radiological healing pattern of mandible, and to apply its result to clinical use. Panoramic view was used to analyze the change of radiographic finding in 35 patients (27 male, 8 female, ranging 17 to 53 years old) treated for mandibular fracture at the department of oral & maxillofacial surgery, SNUH in the period 1991 to 1998, Patients are all treated by rigid internal fixation using monocortical miniplate. Within 9 weeks, no change is observed at fracture site. Osteogenic change is observed at various time interval (3 to 21 weeks). We have found radiographic change of healing is observed 4 to 6 weeks later to clinical healing, According to this result, we recommend radiographic follow-up at 4 week, 10 week, 10 month.

2자유도를 갖는 3차원 운동 시뮬레이터 연구

최명환,김영진 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.A

In this work, we have developed a 2 degrees of freedom(DOF) motion simulator that can generate the sensation of motion in a 6 DOF space. The motion base has the DOF of roll and pitch, and the purpose of the motion base is to create the sensation of riding a vehicle in a 3D space by controlling the motion base. The dynamics of the mechanism was analysed and the optimal design of the motion base mechanism has been reached. The prototype motion base mechanism was developed and tested. The multi-axis motion controller(MMC) was used to control the two AC servo meters that drive the roll and pitch motion.

1~2기 본태성 고혈압 환자들에서 Imidapril 대 Enalapril의 항고혈압 효과를 평가하기 위한 무작위, 이중맹검 임상시험

최영진,손대원,김용진,이홍자,채인호,김효수,김철호,오병희,이명묵,박영배,채윤식,이영우 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.11

투기, 구기, 라켓경기 선수의 피하지방 두께와 근질량 비교분석

최명진,안세옥 경희대학교 사회체육연구소 1996 體育科學論叢 Vol.- No.9

The purpose of this study was to discriminate the characteristics of muscle mass and skinfold thickness in made cdlesiate athletes 120 athletes from three parts of sport events who were 20∼22 years old (mean 21 age years). with ape of 21 years ANOVA. swbjects were 120 1. The maximal upper arm girth means corrected for the tricep skinfold thickness were ranged from 26.05 for the taekwondo to 31.41 for the judo. Judo was one of the greatest maximal upper arm girth means corrected for the tricep skinfold thickness in all sports (rugby, table tennis, handball, badminton, taekwondo). By scheffe test, judo and rugby is different from other sports. 2. The maximal forearm girth means were ranged from 26.13 for the taekwondo to 29.28 for the judo. Judo was one of the greatest maximal forearm arm girth means corrected for the tricep skinfold thickness in all sports (rugby, table tennis, handball, badminton, taekwondo). By scheffe test, rugby was different from taekwondo, Judo was different from taekwondo, handball, badminton, table tennis. 3. The mid thigh girth means corrected for the front thigh skinfold thickness were ranged from 50.75 for the table tennis to 57.09 for the rugby. Rugby was one of the greatest maximal mid thigh girth means corrected for the tricep skinfold thickness in all sports (rugby, table tennis, handball, badminton, taekwondo). By scheffe test, judo was different from table tennis. Rugby was different from taekwondo, handball, badminton, table tennis. 4. The maximal calf girth means corrected for the calf skinfold thickness were ranged from 34.69 for the Table tennis to 39.61 for the rugby, Rugby was one of the greatest maximal calf girth means corrected for the tricep skinfold thickness in all sports (rugby, table tennis, handball, badminton, taekwondo). By scheffe test, rugby was different from badminton. judo different from taekwondo, handball, badminton, table tennis. 5. The muscle mass were ranged from 41.88 for the table tennis to 53.07 for the rugby. Rugby had significantly greater muscle mass than other sports (judo, handball, taekwondo, badminton, table tennis). By scheffe test, rugby was different from taekwondo and judo was different from other sports (handball, taekwondo, badminton, table tennis). 6. The percentage of body mass was ranged from 61.29 for the Judo to 64.34 or the handball. Handball had significantly greater a percentage of body mass than other sports (badminton, taekwondo, rugby, table tennis, judo). By scheffe test, fudo is only different from handball. 7. The sum of skinfold thickness was ranged from 24.9mm for the taekwondo to 36.9mm for the judo. Judo had significantly greater the sum of skinfold thickness than other sports (rugby, badminton, table tennis, handball, taekwondo). By scheffe test, Judo is different from taekwondo and handball.

면양을 이용한 돼지 지방세포 원형질막 단백질 특이 항체의 생산

최창본,권은진,이명진 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1998 Journal of biomedical laboratory sciences Vol.4 No.1

본 연구는 돼지 지방세포 원형질막 단백질에 대한 항체를 면양에서 생산하고 생산된 항체의 역가 및 조직특이성을 조사하기 위하여 실시되었다. 지방세포, 뇌, 심장, 신장, 간장 및 비장으로부터 원형질막 단백질을 추출하였으며, 그중 지방세포로부터 분리한 원형질막 단백질을 면양(체중 40㎏)에 3주 간격으로 3회 면역접종시켰다. 면역접종 전, 3차 면역접종 후 10일 (AS-1), 12일 (AS-2) 및 14일 (AS-3)째에 각각 면양의 경정맥으로부터 혈액을 채취하여 혈청을 채취하여 혈청을 분리하였다. 항체의 역가 및 기타 조직과의 교차반응성은 enzyme-linked immunosorbent assay (ELISA)로 측정하였다. 면양에서 생산된 돼지 지방세포 원형질막 단백질에 대한 항혈청은 지방세포 원형질막 단백질과 강한 항원-항체 반응을 나타내었다. 항혈청의 교차반응성을 조사한 결과, 기타 조직의 원형질막 단백질과는 매우 미약한 반응을 나타낸 반면 지방세포 원형질막 단백질과는 강한 반응을 나타내었다. 이러한 항혈청의 지방세포 원형질막 단백질과의 조직특이적인 반응은 anti-sheep immunoglobulin Ghorseradish peroxidase conjugate를 2차 항체로 이용한 immunoblot에 의해서도 재확인 되었다. 이상의 결과, 면양으로부터 생산된 돼지 지방세포 원형질막 단백질에 대한 항체는 높은 역가를 지니고 있었으며, 지방세포 원형질막 단백질에 특이적으로 작용함을 알 수 있었다. The objectives of this study were to produce polyclonal antibody to adipocyte plasma membrane (APM) proteins isolated from pig, and to investigate its tissue specificity. Plasma membrane proteins from adipocyte, brain, heart, kidney, liver and spleen were isolated using a self-forming Percoll gradient. Sheep (40㎏) was immunized three times at three week interval with the purified APM proteins. Blood was taken from non-immunized sheep (NS) and from immunized sheep at 10 (AS-1), 12 (AS-2), and 14 (AS-3) days after the third immunization. Antisera titers and cross-reactivity against other tissues were determined by enzyme-linked immunosorbent assay (ELISA). Antisera reacted strongly to APM proteins showing detectable amounts of antibody at 1:81,000 dilution. And antisera showed much stronger reactivity to APM proteins than any other tissue plasma membrane proteins. Furthermore, tissue specificity of antisera against APM was reconfirmed by immunoblotting using anti-sheep immunoglobulin Ghorseradish peroxidase conjugate as a secondary antibody. Antisera to APM proteins showed adipocyte specificity compared with other tissues. In conclusion, polyclonal antibody against APM proteins isolated from pig was developed successfully in our laboratory, and these antisera showed tissue specificity with APM.

진행된 HIV 감염 환자에서 십이지장의 미란성 병변으로 발현한 Mycobacterium genavense 감염 1예

진상만,박종선,김홍빈,오명돈,최강원,김희연,국윤호,김남중 대한감염학회 2007 감염과 화학요법 Vol.39 No.4

Mycobacterium genauense는 최근에 알려진 미코박테륨으로서, 식욕 부진, 체중 감소, 설사, 림프절 병증 등 파종성 Myocobacterium avium-intracellulare complex 감염과 유사한 임상상을 보이며, 위장관 침범을 잘 하는 것으로 알려져 있으나 아직 국내에서 증례는 보고된 바가 없다. 저자들은 진행된 HIV 감염 환자에서 십이지장의 미란성 병변으로 발현한 Mycobacterium genavense 감염 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. 환자는 상복부 동통과 발열, 설사로 내원하였다. 십이지장의 미란성 병변에서 시행한 조직검사에서 항산균이 가득 차있는 거품세포가 관찰되었으며, 이 검체에서 16S rRNA 유전자의 중합연쇄반응 검사를 시행하여 Mycobacterium genavense를 확인하였다. Mycobacterium genavense, first identified in 1990, is known as a pathogen that mimics disseminated Myocobacterium avium-intracellulare complex (MAC) infection with particular propensity for the gastrointestinal tract. In Korea, no case with the organism has been reported. Herein we report a case of Mycobacterium genavense infection that manifested with erosive lesion of duodenum in a patient with acquired immune deficiency syndrome. The patient presented with epigastric pain and fever, diarrhea. Duodenal biopsy showed histiocytic infiltration with numerous acid-fast bacilli. Identification of the mycobacterial isolate by the polymerase chain reaction restriction analysis of 16S rRNA gene revealed Mycobacterium genavense.