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- 저자 : Mutiso, Kinenee wa (검색결과 5 건)
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Physical properties of nanoparticles do matter
Kiio Tony Mutiso,박소연 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.1
Background Nanoparticles (NPs) have been used to enhance pharmaceutical properties of drugs, including cell/tissue penetration, selective biodistribution, circulation half-life, and accumulation at target sites. Rigorous efforts, including chemical modifications using target moieties, have been dedicated to improving their functions. Area covered Optimization of the physical properties of NPs, including size, shape, charge, and elasticity, is suggested to be an important step in the creation of NPs with desirable pharmacokinetic properties for use as drug delivery systems. In this review, we highlight recent findings on the effect of the physical properties of NPs, including the size, shape, surface charge, and elasticity on pharmaceutical functions. Expert opinion Many studies have demonstrated that 30–200 nm NPs facilitate cell uptake and do not trigger the immune response due to their relatively large surface area. Compared to spherical NPs, non-spherical NPs are not only advantageous for cell uptake but also for systemic circulation owing to their multivalent interactions with the cell surface. The slightly negative charges carried by NPs have been considered responsible for the reduced electrostatic interactions with plasma proteins. Importantly, soft NPs enhance cellular uptake, reduce immunogenicity, and enhance tumor accumulation compared to their hard counterparts. Nonetheless, it is not easy to offer unequivocal suggestions regarding the physical properties of NPs during their pharmacokinetic journey; this is due to the multifaceted aspects at each step. Smart NPs that can alter their physical properties by responding to environmental stimuli were developed as alternatives to address this issue. Thus, physical properties do play a very important role in determining the pharmaceutical applications of NPs.
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AFRICAN IMAGES IN KITHAKA WA MBERIA’S POETRY
Samson Ontiri Ongarora,Janes Nyachae Michira,Rayya Timammy,Kineene wa Mutiso 한국외국어대학교 아프리카연구소 2020 Asian Journal of African Studies Vol.- No.49
Africa is a continent endowed with natural resources such as fertile land, minerals, forests, wildlife and a warm tropical climate. Besides, it has communities with diverse cultures which attract tourists from other parts of the world. However, for a long time, the continent has experienced social, political and environmental challenges like political instability, despotic leadership, civil wars, refugees, hunger, poverty and diseases among others. In this article, we apply key principles of postcolonial theory to analyse the various images of Africa as depicted by Kenyan poet Kithaka wa Mberia in his works. We argue that the poet as a committed and critical writer has depicted negative images about Africa as a challenge to Africans and its leadership to address those issues. For instance, he shows African leaders and governments as being corrupt and inept in their governance. As a result, there are rampant cases of corruption, tribalism and dictatorship which create little or no room for equality, democracy, freedom of speech and the rule of law. But on the other hand, the poet portrays some positive images of Africa including the beautiful natural sceneries, mountains, forests, wildlife, rivers, beaches and a conducive climate. We shall draw our examples from Kithaka wa Mberia’s five anthologies namely; Mchezo wa Karata (A Game of Cards), Bara Jingine (Another Continent), Msimu wa Tisa (The Ninth Season), Redio na Mwezi (Radio and the Moon) and Rangi ya Anga (Colour of the Sky).
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Jinsol Choi,Lyndon Bastatas,Eunhee Lee,Kiio Tony Mutiso,박소연 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.113 No.-
Lipid nanoparticles (LNPs) have been widely used in drug delivery systems. Their physicochemical propertiesplay a substantial role in the pharmaceutical functions and therapeutic efficacy of encapsulateddrugs. Although, numerous previous studies have examined the optimal physicochemical propertiesfor drug delivery, the role of LNP mechanical compliance has not yet been established, owing to limitationsimposed by their small size, extreme softness, and complex structures. The aim of this study was todelineate the true topography and the map of elastic moduli of LNPs by analyzing atomic force microscope(AFM) force spectroscopic data based on the modified Hertz model considering the asymptoticapproach. Results reveal a hard core-soft shell structure of LNPs. Additionally, the elastic moduli of thecore of LNPs are modulated from 176 kPa to 599 kPa through the addition of crosslinked alginate. However, a consistent elastic modulus (128 kPa) of outer shells is maintained regardless of core composition. In addition, Transwell assay show that, compared to rigid LNPs, those with soft properties exhibitenhanced permeation. This finding, which delineates the true topography and elastic moduli of LNPs,suggest an alternative for resolving the long-standing issues in AFM force spectroscopic studies.
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