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Mudan Li,Yinsong Wang 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.6
A new frequency coordinated control strategy based on the variable de-loading level for a D-PMSG wind turbine is proposed. First, the D-PMSG wind turbine model and control system model are established. Second, the de-loading control principle of the D-PMSG wind turbine is described, the variable de-loading level control strategy is analyzed according to diff erent wind speeds and additional inertial control is introduced. Then the frequency coordinated control strategy combining variable de-loading level control and additional inertial control is designed for diff erent power reserve areas. Finally, a D-PMSG grid-connected simulation system is built to verify the rationality and accuracy of the frequency coordinated control strategy.
( Mudan Cai ),( Inho Jung ),( Huiyoung Kwon ),( Eunbi Cho ),( Jieun Jeon ),( Jeanho Yun ),( Young Choon Lee ),( Dong Hyun Kim ),( Jong Hoon Ryu ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.2
Hippocampal synaptic dysfunction is a hallmark of Alzheimer’s disease (AD). Many agents regulating hippocampal synaptic plasticity show an ameliorative effect on AD pathology, making them potential candidates for AD therapy. In the present study, we investigated spinosin as a regulating agent of synaptic plasticity in AD. Spinosin attenuated amyloid β (Aβ)-induced long-term potentiation (LTP) impairment, and improved plasmin activity and protein level in the hippocampi of 5XFAD mice, a transgenic AD mouse model. Moreover, the effect of spinosin on hippocampal LTP in 5XFAD mice was prevented by 6-aminocaproic acid, a plasmin inhibitor. These results suggest that spinosin improves synaptic function in the AD hippocampus by regulating plasmin activity.
Mudan Cai,Eun Jin Yang 한국한의학연구원 2019 Integrative Medicine Research Vol.8 No.4
Background: Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease that is characterized by selective motor neuron cell death in the motor cortex, brainstem, and spinal cord. Two drugs for ALS, riluzole and edaravone, have been approved by FDA for the treatment of ALS patients. However, they have many side effects, and riluzole extends the patient’s life by only 2–3 months. Therefore, ALS patients seek an effective therapy for treating the symptoms or delaying the progression of ALS. Based on this, we review the effects of complementary and alternative medicine (CAM) in ALS animals or patients to verify the efficacy of CAM in incurable diseases. Methods: For this review, we searched published papers focusing on the effect of CAM in pre-clinical and clinical study in ALS. The search keywords included amyotrophic lateral sclerosis, acupuncture, herbal medicine, Traditional Chinese medicine, CAM, animals, and clinical study through electronic databases PubMed and Google Scholar from their inception until March 2019. Results: In the ALS animal model, CAM modulated the immune system to increase motor function by reducing the expression levels of neuroinflammatory proteins in the spinal cord. Besides this, ALS patients treated with herbal medicine showed improved disease symptoms, but clinical trials with larger sample sizes are needed to develop a treatment with this herbal medicine. Conclusion: This review shows that CAM may be useful for ALS treatment, but more evidence regarding the efficacy and molecular mechanisms is required to establish CAM as a good therapy for the treatment of ALS patients.
Research of ASW‑FCM‑Based Algorithm for Clustered Wind Turbine Group Equivalent Modeling
Mudan Li,Yinsong Wang,Qunli Sun,Yanyan Liu 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.4
A new dynamic equivalent modeling method for a wind farm composed of direct-drive wind turbines is proposed. Firstly, the efective input wind speed is calculated considering the wake efect and wind direction change between wind turbines, the operating characteristics is analyzed, the efective wind speed, rotor speed, pitch angle and output power that refect the wind turbine operating characteristics are selected as the multi-grouping indicators. Secondly, an adaptive sample weighting fuzzy C-means clustering algorithm (ASW-FCM) considering the diferences and correlations among turbines operating conditions is designed to cluster the wind farm optimally. Then the equivalent model of the clustered wind turbine group is established based on the principle that the output characteristics before and after the equivalence are equal. Finally, an actual wind farm system is used as an example for modeling and simulation to verify the rationality and accuracy of the equivalent modeling method.
최선,Mudan Cai,이준환,정의민 한국뇌신경과학회 2018 Experimental Neurobiology Vol.27 No.1
Cognitive impairment is age-related and manageable only with early diagnosis and prevention. Moxibustion is widely accepted in East Asia as useful for preventing cognitive impairment. This systematic review of animal studies was conducted to verify the efficacy of moxibustion in preventing cognitive impairment and to elucidate the underlying mechanism. Randomized controlled animal trials that established the efficacy of moxibustion in preventing cognitive impairment were included in the analysis. Results of behavioral tests and the signaling pathways elucidated were extracted and a meta-analysis was conducted with the behavioral test results. The risk of bias was evaluated using 9 items, and reporting quality was evaluated using the ARRIVE (Animal Research: Reporting In Vivo Experiments) Guidelines Checklist. Ten trials involving 410 animals met the inclusion criteria. All studies reported the benefit of moxibustion in preventing cognitive deficits caused by Alzheimer’s disease (AD). Among five studies using the Morris water maze test, a significant effect of moxibustion in decreasing the escape time was reported in three studies, increasing the crossing times in four studies, and prolonging the dwelling time in two studies. The effects of moxibustion were demonstrated to be mediated by an increase in the activity of neurotrophins and heat shock protein, modulation of the cell cycle, and suppression of apoptosis and inflammation. However, considering the small number of included studies, the lack of studies investigating entire signaling pathways, and a high risk of bias and low reporting quality, our results need to be confirmed through more detailed studies.
Moxibustion for cognitive impairment: a systematic review and meta-analysis of animal studies
Sungmin Aum,Seon Choe,Mudan Cai,정의민,이준환 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.2
Background: Cognitive impairment is an age-dependent chronic disorder that exponentially worsens with age; however, its treatment is mostly symptomatic. Moxibustion is widely accepted in East Asia as a treatment for cognitive impairment. This systematic review aimed to verify the efficacy and underlying mechanism of moxibustion in treating cognitive impairment. Methods: Sixteen trials involving 324 animals obtained from MEDLINE (PubMed), EMBASE, the Cochrane library, the Chinese National Knowledge Infrastructure, Wan-Fang, Cqvip, the Korean Studies Information Service System, and the Oriental Medicine Advanced Searching Integrated System met the inclusion criteria. We extracted the results of behavioral tests and immunohistochemical biomarkers from the included articles and evaluated the risk of bias and reporting quality. Results: The moxibustion group showed significantly decreased escape latency, increased crossing times, and prolonged dwelling times in the Morris water maze test. There was a significantly enhanced latency period and reduced error time in the step-down test and nerve behavior score. The effects of moxibustion were found to be mediated by suppression of oxidative stress and apoptosis, modulation of inflammation and Aβ genesis activation of vascular endothelial growth factor, and adjustment of metabolites in the tricarboxylic acid cycle and fatty acid metabolism. Conclusion: Our results demonstrated the therapeutic efficacy of moxibustion on cognitive impairment and suggested the putative mechanism. However, considering the small number of included studies, high bias risk, low reporting quality, and the limitations of animal experimentation, our results need to be confirmed by more detailed studies.