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Moon, Jisu,Moon, Yu Kyung,Park, Do Dam,Choi, Sukyung,You, Youngmin,Cho, Eun Jin American Chemical Society 2019 Journal of organic chemistry Vol.84 No.20
<P>Tri(9-anthryl)borane was successfully applied as an organophotocatalyst for the visible-light-induced trifluoromethylation of unactivated alkenes with CF<SUB>3</SUB>I. The mild reaction conditions tolerated a variety of functional groups, and the reaction could be extended to perfluoroalkylations with C<SUB>3</SUB>F<SUB>7</SUB>I and C<SUB>4</SUB>F<SUB>9</SUB>I. Mechanistic studies revealed that the photoredox catalysis involves an oxidative quenching pathway.</P> [FIG OMISSION]</BR>
Changes in postoperative long-term nutritional status and quality of life after total pancreatectomy
Moon Young Oh,Eun Joo Kim,Hongbeom Kim,Yoonhyeong Byun,Youngmin Han,Yoo Jin Choi,Jae Seung Kang,Wooil Kwon,Jin-Young Jang 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.4
Purpose: Quality of life (QoL) is widely known to be poor after total pancreatectomy (TP) due to the loss of pancreatic function and poor nutritional status, but prospective studies on changes in QoL over time are lacking. The aim of this study was to prospectively evaluate the short- and long-term consequences of pancreatic exocrine insufficiency, changes in nutritional status, and their associated effects on QoL after TP. Methods: Prospective data were collected from patients who underwent TP between 2008 and 2018. Validated questionnaires (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire [EORTC QLQ] Core 30, EORTC QLQ-pancreatic cancer module, and the Mini Nutritional Assessment), measured frequency of bowel movement, relative body weight (RBW), triceps skinfold thickness (TSFT), and serum levels of protein, albumin, transferrin, and hemoglobin A1c were collected serially for 1 year. Results: Thirty patients who underwent TP were eligible for the study. Bowel movement frequency increased over time, and the RBW and TSFT were lowest by 1 year. The global health status score showed no significant difference over time. At 3 months, physical and role function scores as well as symptoms of fatigue, constipation, and digestive difficulties worsened significantly. Most indices recovered after 1 year, but poorer physical function scores, digestive difficulties, and altered bowel habits persisted. Conclusion: Because some symptoms do not recover over time, careful follow-up and supportive postoperative management are needed for TP patients, including nutritional support with pancreatic enzyme replacement and education about medication adherence and diet.
Conversion surgery for initially unresectable extrahepatic biliary tract cancer
Moon Young Oh,Hongbeom Kim,Yoo Jin Choi,Yoonhyeong Byun,Youngmin Han,Jae Seung Kang,Heeju Sohn,Jung Min Lee,Wooil Kwon,Jin-Young Jang 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.3
Backgrounds/Aims: Surgical resection is the only curative treatment for biliary tract cancers; however, most patients undergo palliative chemotherapy because they are contraindicated for surgery. Conversion surgery, a treatment strategy for downsizing chemotherapy and subsequent surgical resection, is feasible for initially unresectable biliary tract cancers following the introduction of effective chemotherapeutic agents. Methods: Patients initially diagnosed with unresectable biliary tract cancers, and treated with conversion surgery after palliative chemotherapy between 2013 and 2019, were reviewed retrospectively. Results: Twelve patients underwent conversion surgery after palliative chemotherapy for initially unresectable biliary tract cancers. The final pathological diagnosis included six perihilar cholangiocarcinomas, four distal common bile duct cancers, and two gallbladder cancers. Different chemotherapy regimens were used, but all the patients were treated with gemcitabine at some point during their treatment. The median overall survival was 28 months, which was longer than that of patients treated with isolated palliative chemotherapy in previous studies. Conclusions: Conversion surgery represents a therapeutic alternative for specific cases of unresectable biliary tract cancers. Palliative chemotherapy for initially unresectable biliary tract cancers is recommended for downsizing the tumor and expanding the indications for surgery. Further studies and clinical trials are required to develop new and effective chemotherapeutic regimens.
Comparison of Perioperative and Postoperative Long- Term Quality of Life after Total Pancreatectomy
( Moon Young Oh ),( Eun Joo Kim ),( Wooil Kwon ),( Hongbeom Kim ),( Yoon Hyeong Byun ),( Yoo Jin Choi ),( Jae Seung Kang ),( Youngmin Han ),( Jin-young Jang ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Quality of Life (QoL) is widely known to be poor after total pancreatectomy. This study was designed to evaluate the short-term and long-term consequences of endocrine and exocrine insufficiency and their associated effects on QoL and nutritional status. Methods: Prospective data was collected from patients who underwent total pancreatectomy at Seoul National University Hospital during an interval of 4 years and followed up for at least 1 year. QoL, and nutritional status were assessed by administering validated questionnaires (EORTC QLQ C-30, PAN26, GIQLI, MNA), preoperatively and 3, 12 months postoperatively. Results: A total of 30 patients were eligible for the study. 3 months after receiving total pancreatectomy, the global heath score (GHS) showed no significant difference (preoperatively 57.2 vs. 3 months postoperatively 68.3; P=0.119). By the 1st postoperative year, the GHS still showed no significant difference (preoperatively 57 vs. 1 year postoperatively 52.4; P=0.2) and there was no significant differences in most of the QoL categories. However, poor physical function (79.2 vs. 67.6; P=0.01), digestive difficulties (14.9 vs. 36.9; P=0.03) and altered bowel habits (9.2 vs. 25.6; P=0.03) continued even 1 year after surgery. Conclusions: The overall QoL score after total pancreatectomy was comparable to the preoperative QoL score. Some symptoms after total pancreatectomy significantly worsen after 3 months postoperatively, but then improve to a comparable level 1 year after surgery. Because some symptoms persist even after time has passed, supportive management is needed for total pancreatectomy patients, including nutritional support with pancreatic enzyme replacement and education for diabetes and diet.