Expansin으로 형질전환 된 담배의 생장 특성

신하정, 성현정, 백승준, 김보미, 엄유리, 조은정, 정찬문, 이이 충북대학교 연초연구소 2008 煙草硏究 Vol.21 No.-

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전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

Effect of Reboxetine Pretreatment on the Forced Swimming Test-induced Gene Expression Profile in the Rat Lateral Septum

Moon, Bo-Hyun,Kang, Seung-Woo,Kim, Hyun-Ju,Shin, Seung-Keon,Choi, Sang-Hyun,Lee, Min-Soo,Kim, Myeung-Kon,Shin, Kyung-Ho The Korean Society of Toxicogenomics and Toxicopro 2008 Molecular & cellular toxicology Vol.4 No.1

The forced swim test (FST) is the most widely used model for assessing potential antidepressant activity. Although it has been shown that lateral septum is involved with the FST-related behavior, it is not clear whether antidepressant treatments could alter the FST-induced gene expression profile in the lateral septum. In the present study, the gene expression profiles in response to FST and reboxetine pretreatment were observed in the lateral septum of rats. Reboxetine is known as a most selective serotonin norepinephrine reuptake inhibitor. In addition, we compared the changes in gene expression profile between reboxetine response and nonresponse groups, which were determined by counting FST-related behavior. After FST, lateral septum from controls and reboxetine pretreated group were dissected and gene expression profiles were assessed using an Affymetrix microarray system containing 15,923 genes. Various genes with different functions were changed in reboxetine response group compared with reboxetine nonresponse group, In particular, pleiotrophin, orexin receptor 2, serotonin 2A receptor, neuropeptide Y5 receptor and thyroid hormone receptor $\beta$ were decreased in reboxetine response group, but Lim motif-containing protein kinase 1 (Limk1) and histone deacetylase 1 (HDAC1) were increased. Although further studies are required for direct roles of these genes in reboxetine response, the microarray may provide tools to find out potential target genes and signaling pathways in antidepressant response.

P190 : Clinicopathologic study of 14 cases of eccrine poroma

( Seung Hyun Moon ),( Taekgeun Lee ),( Hyun Hwang Bo ),( Taegwang Kwon ),( Hyunho Son ),( Sookkyung Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Eccrine poroma is benign skin appendageal tumor, arising from the eccrine sweat duct. Clinicopathologic studies of eccrine poroma are limited in Korea. Objectives: To analyze the clinicopathological characteristics of eccrine poroma. Methods: We reviewed the medical records, photographs and histopathological slides of 14 patients diagnosed with eccrine poroma at our clinic between 2001 and 2014. Results: The mean age of the tumors is 62.8 years old. The mean duration is 24.7 months. The average size was 0.8 cm. The most frequent location was sole and foot, followed by scalp, palm, trunk. The most common clinical feature was erythematous or flesh solitary nodule without symptom. Initial impressions on the first visit were poroma(n=3), verruca(n=3), soft fibroma(n=3), seborrheic keratosis(n=1), melanoma(n=1), melanocytic nevus(n=1), hemangioma(n=1), Bowen disease(n=1). Histopathologically, the majority of the cases showed highly vascular stroma, uniform cuboidal epithelial cells with clear cytoplasm and focal ductal differentiation. Cystic degenerations were seen in 3 cases, peritumoral cleft in 4 cases, melanin pigmentation in 5 cases, underlying dermal duct tumor in 1 case. Conclusion: Eccrine poroma should be included in differential diagnosis when patients show solitary erythematous or flesh nodule on sole and foot smaller than 2cm size without symptom. The matrix may contains highly vascular stroma with some clear cells, in addition to general feature of eccrine poroma.

Dokhwaljihwang-tang inhibits LPS-induced inflammatory cytokine production in peripheral blood mononuclear cells.

Moon, Phil-Dong,Han, Na-Ra,Ko, Seong-Gum,Jeong, Hyun-Ja,Kim, Su-Jin,Lee, Bo-Ra,Kim, Na-Hyung,Choi, In-Young,An, Hyo-Jin,Myung, Noh-Yil,Lee, Hyejung,Kim, Myong-Jo,Kim, Ju-Sung,Hong, Seung-Heon,Kim, Hyu Butterworths [etc.] 2010 Neurological research Vol.32 No.suppl1

<P>OBJECTIVES: Dokhwaljihwang-tang, one of the prescriptions in Four Constitution medicine, has been used to treat neurological disorders. This work was aimed to examine the effect of Dokhwaljihwang-tang on lipopolysaccharide-induced inflammatory cytokine production in peripheral blood mononuclear cells from the lesser yang subjects. METHODS: The inflammatory cytokines, interleukin 1 beta, interleukin 4 and tumor necrosis factor were measured using the ELISA. The interleukin 1 beta mRNA expression was evaluated with reverse transcriptase-polymerase chain reaction. The expression level of nuclear factor kappa B was examined by western blotting. RESULTS: Dokhwaljihwang-tang significantly inhibited interleukin 1 beta and interleukin 4 production (p<0.05). When Dokhwaljihwang-tang was pre-treated at the dose of 1 mg/ml, it not only decreased the interleukin 1 beta mRNA expression, but also inhibited the activation of nuclear factor kappa B. DISCUSSION: These results suggest the potential of Dokhwaljihwang-tang as a source of pharmaceutical acupuncture for neuronal inflammatory diseases.</P>

Treatment with the Pinhole Technique Using Erbium-Doped Yttrium Aluminium Garnet Laser for a Cafe au Lait Macule and Carbon Dioxide Laser for Facial Telangiectasia

( Bo Young Chung ),( Seung Seog Han ),( Hye Rim Moon ),( Mi Woo Lee ),( Sung Eun Chang ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.5

Efficient Bone Marrow Transduction by Gene Transfer with Allogeneic Umbilical Cord Blood Serum and Plasma: An Implication for Clinical Trials

Moon, Noory,Yang, Seung-Jip,Park, Bo-Bae,Chung, Yun-Shin,Lee, Jong-Wook,Oh, Il-Hoan Mary Ann Liebert 2008 Human gene therapy Vol.19 No.7

<P>Low in vivo transduction efficiency and safety concerns have been hurdles for effective hematopoietic stem cell (HSC) gene therapy. Here, we investigate whether the safety and efficiency of retroviral gene transfer into HSCs can be improved by using human allogeneic umbilical cord blood (UCB)-derived supplements instead of fetal bovine serum (FBS). When CD34(+) cells were cultured ex vivo in UCB-derived serum (CBS) or plasma (CBP), comparable or higher maintenance of HSCs was observed than in FBS and serum-free substitution medium (SFM) as assessed by the frequency of positive engraftment and the level of engraftment in NOD/SCID mice after transplantation of cultured cells. CBS and CBP also exhibited higher level stabilization of retroviral particles than SFM during in vitro culture of retrovirus pseudotyped with gibbon ape leukemia virus or vesicular stomatitis virus glycoprotein. Retroviral gene transfer into CD34(+) cells performed with CBS or CBP resulted in increased gene transfer into CD34(+) cells and increased transduction of reconstituted bone marrow cells compared to transfers with SFM or FBS. The increased transduction of bone marrow cells was associated with a larger number of transduced progenitors in the recipient mice. Significant oligoclonality in the transduced progenitors, as determined by ligation-mediated polymerase chain reaction, suggested efficient retroviral targeting of multiple HSCs in the CBS- or CBP-supplemented media. Combined, our results show that allogeneic UCB-derived serum or plasma is a safe and easily accessible serum supplement that can support efficient retroviral gene transfer into HSCs for the clinical-grade manipulation of HSCs.</P>

완전 방실차단을 동반한 포도상구균 패혈증 1예

승기배,강문원,최규보,이원영,강동헌,나종순,추교영,송호철 대한감염학회 1993 감염 Vol.25 No.4

심근염은 다양한 원인에 의해 유발될 수 있으나 포도상구균에 의한 증례는 국내에 보고된 바가 없었다. 저자들은 포도상구균 패혈증 환자에서 발생된 완전 방실차단을 동반한 심근염을 항생제 및 영구 심장박동 조율기로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Myocarditis, and inflammatory process involving the myocardial wall, may be caused by most infectious agents. Irrespective of its etiology, it presents commonly with evidence of heart failure, hypotension, and various electrocardiographic abnormalities. Patient with myocarditis may be asymptomatic or may have a rapidly progressive fatal disease. Medical management of patients with myocarditis includes specific therapy for underlying infection and control of the complication of myocarditis such as congestive heart failure and arrhythmia. There is hardly any clinical report regarding myocarditis in staphylococcal bacteremia. Recently we had experienced staphylococcal sepsis with myocarditis and complete atrioventricular block in 36-year-old man following furuncle on right flank area. Clinically he had shown complete recovery after administration of antibiotics and insertion of permanent pacemaker, so we report it with review of the literature.

Contemporary Safety Management of Virtual Golf in South Korea

Bo Ra MOON,Seung Min LEE,Won Jae SEO 한국스포츠과학회 2022 스포츠과학연구(JSAS) Vol.6 No.1

Purpose: The purpose of this study is to provide implications for virtual golf safety management in Korea through the literature review of current safety issues of virtual golf industry. Research design, data, and methodology: This study employed a qualitative approach to review prior studies and related documents presenting current safety perspectives of virtual sports facility management. First, the study reviewed the experiences of virtual golf players and safety criteria suggested from previous literatures. Second, two experts in sport facility management reviewed the manuscript including implications and provided their opinions including major implications and insights for virtual sport industry. Views of experts were added to the final manuscript. Results: This study found that installation standards and safety and hygiene standards by industry are enacted for the safety management of sports facilities, however, there is a need for standards to be adjusted because the contents are general, abstract, and lack detail, thus causing difficultly to secure effectiveness. Conclusions: For virtual golf courses, it is necessary to develop a safety inspection checklist that suits the characteristics of indoor virtual golf. In this line, safety criteria need to be developed with the consideration of characteristics of screen golf to establish an efficient safety management system and create a safe use environment.

Cartoon Distribution Environment and Strategies for Sport Webtoon Development

Bo-Ra MOON,Seung-Jin HAN,Won-Jae SEO 한국유통과학회 2020 The Journal of Industrial Distribution & Business( Vol.11 No.11

Purpose: With a rapid advance of communication technology, distributional systems of sport contents continue to show improvements. In particular, a traditional framework in creating sport cartoon has been influenced by the environment of the communication industry. Despite the development of distributional systems, the current sport cartoon industry still lacks in advancement. To this day, various research about sport contents have been conducted; yet, not many studies of the interaction between sport cartoons and communication technology have been done. In this respect, this study is to review the distributional environment of the sport cartoon industry and provide distributional strategies for developing sport cartoon industry. Research design, data, and methodology: In addition to indepth interviews with five practitioners in sport cartoon industry, the study employed case study methodology. Interview data were analyzed by qualitative content analysis. Results: With new environments allowing anyone allowing to create and share webtoons, various genres including sports webtoons appear, and this became a motive to the growth of sports webtoons. Today, sports comics acted as a sports advertisement platform which not only created additional profit but also became an opportunity as a marketing method. On the contrary, the formal attributes of webtoons cause hardship in consistently creating sports webtoons. Hence, it is needed that supporting policies need to be established to nurture sport webtoon expertise. For example, Korea Creative Content Agency allows future webtoon authors to have an opportunity to be educated and equipped in producing creative sport webtoon contents. Moreover, revenue systems should be developed for motivating webtoon authors to involve in sport contents in their works. Conclusions: In order to promote the sports cartoon industry based on the findings, it is first necessary to create sports comics that reflect the formal characteristics of webtoons and the changing consumer environment. Second, it is important to acknowledge the industrial value of sports comics and it is necessary to promote policies regarding sports webtoon production and distribution from a national level. Third, by diversifying profits through OSMU and sports advertisements, it is possible to enhance the work environment and the treatment of authors. Implications and future directions were discussed.