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Molecular Cloning and Expression of Inositol 1,4,5 - Triphosphate 3 Kinase
Moon, Kyung Ho,Kim, Jae Won,Rhee, Sue Goo,KIM, HA KUN,Lee, Sang Yeol,Choi, Kwan Yong,Chung, Hong Keun,Sin, Sang Soo 한국유전학회 1990 Genes & Genomics Vol.12 No.4
Department of Life Science, Pohang Institute of Science and Technology, Pohang, Korea, *^Department of Biochemistry, Kyongsang National University, Chinju, Korea, (**)^Department of Biochemistry, Kyongsung University, Pusan, Korea, (++)^Department of Biochemistry, College of Medicine, Seoul National University, Seoul, Korea, +^Laboratory of Biochemistry, NHLBI, N.I.H., Bethesda, MD 20892, U.S.A.
Design and Implementation of the RF Systems for Bi-directional Wireless Capsule Endoscopes
Moon, Yeon-Kwan,Lee, Jyung-Hyun,Park, Hee-Joon,Lee, Ju-Gab,Ryu, Jae-Jong,Lee, Wu-Seong,Woo, Sang-Hyo,Won, Chul-Ho,Cho, Jin-Ho,Choi, Hyun-Chul Korea Multimedia Society 2006 멀티미디어학회논문지 Vol.9 No.12
This paper explains that the RF systems for hi-directional wireless capsule endoscopes were designed and implemented. The designed RF systems for a capsule endoscope can transmit the images of intestines from the inside to the outside of a body and the behavior of the capsules can be controlled by an external controller simultaneously. The hi-directional wireless capsule endoscope consists of a CMOS image sensor, FPGA, LED, battery, DC to DC Converter, transmitter, receiver, and antennas. The transmitter and receiver which were used in the hi-directional capsule endoscope, were designed and fabricated with $10mm(diameter){\times}3.2mm(thickness)$ dimensions taking into the MPE, power consumption, system size, signal to noise ratio and modulation method. The RF systems designed and implemented for the hi-directional wireless capsule endoscopes system were verified by in-vivo experiments. As a result, the RF systems for the hi-directional wireless capsule endoscopes satisfied the design specifications.
Unit Commitment by Separable Augmented Lagrangian Relaxation
Moon, Guk-Hyun,Joo, Sung-Kwan,Lee, Ki-Sung,Choi, Jae-Seok The Korean Institute of Electrical Engineers 2008 Journal of Electrical Engineering & Technology Vol.3 No.4
The non-separable quadratic penalty terms create an inherent difficulty when applying the standard augmented Lagrangian relaxation(ALR) method for decomposing the unit commitment problem into independent subproblems. This paper presents a separable augmented Lagrangian relaxation method for solving the unit commitment problem. The proposed method is designed to have a separable structure by introducing the quadratic terms with additional auxiliary terms in the augmented Lagrangian function. Numerical results are presented to validate the effectiveness of the proposed method.
The effect of implant shape and bone preparation on primary stability
Moon, Sang-Hyun,Um, Heung-Sik,Lee, Jae-Kwan,Chang, Beom-Seok,Lee, Min-Ku Korean Academy of Periodontology 2010 Journal of Periodontal & Implant Science Vol.40 No.5
Purpose: The purpose of this study was to evaluate the effects of implant shape and bone preparation on the primary stability of the implants using resonance frequency analysis. Methods: Sixty bovine rib blocks were used for soft and hard bone models. Each rib block received two types of dental implant fixtures; a straight-screw type and tapered-screw type. Final drilling was done at three different depths for each implant type; 1 mm under-preparation, standard preparation, and 1 mm over-preparation. Immediately after fixture insertion, the implant stability quotient (ISQ) was measured for each implant. Results: Regardless of the bone type, the ISQ values of the straight-screw type and tapered-screw type implants were not significantly different (P>0.05). Depth of bone preparation had no significant effect on the ISQ value of straight-screw type implants (P>0.05). For the tapered-screw type implants, under-preparation significantly increased the ISQ value (P<0.05), whereas overpreparation significantly decreased the ISQ value (P<0.05). Conclusions: Within the limitations of this study, it is concluded that bone density seemed to have a prevailing effect over implant shape on primary stability. The primary stability of the tapered-screw type implants might be enhanced by delicate surgical techniques.
Application of Hot Start PCR Method in PCR-based Preimplantation Genetic Diagnosis
Sung Ah Kim,Moon Joo Kang,Hee Sun Kim,Sun Kyung Oh,Seung-yup Ku,Young Min Choi,Jong Kwan Jun,Shin Yong Moon 대한의학유전학회 2012 대한의학유전학회지 Vol.9 No.1
Purpose: To determine a method to improve the efficacy and accuracy of preimplantation genetic diagnosis (PGD)-polymerase chain reaction (PCR), we compared hot start PCR and conventional multiplex nested PCR. Materials and Methods: This study was performed with single lymphocyte isolated from whole blood samples that were obtained from two couples with osteogenesis imperfecta (OI). We proceeded with conventional multiplex nested PCR and hot start PCR in which essential reaction components were physically removed, and we compared the amplification rate, allele dropout rate and nonspecific products. Afterward, we used selective method for PGD. Results: In the two couples, the respective amplification rate were 93.5% and 80.0% using conventional multiplex nested PCR and 95.5% and 92.0% using hot start PCR. The respective mean allele dropout rates for the two couples were 42.0% and 14.0% with conventional multiplex nested PCR and 36.0% and 6.0% with hot start PCR. Conclusion: The results demonstrate that the hot start PCR procedure provides higher amplification rates and lower allele dropout rate than the conventional method and that it decreased the nonspecific band in multiplex nested PCR. The hot start method is more efficient for analyzing a single blastomere in clinical PGD.
Clinical outcome of high-dose-rate interstitial brachytherapy in patients with oral cavity cancer
Sung Uk Lee,MD,Kwan Ho Cho,MD,Sung Ho Moon,MD,Sung Weon Choi,MD,Sung Uk Lee,MD,Kwan Ho Cho,MD,Sung Ho Moon,MD,Sung Weon Choi,MD 대한방사선종양학회 2014 Radiation Oncology Journal Vol.32 No.4
Purpose: To evaluate the clinical outcome of high-dose-rate (HDR) interstitial brachytherapy (IBT) in patients with oral cavity cancer. Materials and Methods: Sixteen patients with oral cavity cancer treated with HDR remote-control afterloading brachytherapy using 192Ir between 2001 and 2013 were analyzed retrospectively. Brachytherapy was administered in 11 patients as the primary treatment and in five patients as salvage treatment for recurrence after the initial surgery. In 12 patients, external beam radiotherapy (50–55 Gy/25 fractions) was combined with IBT of 21 Gy/7 fractions. In addition, IBT was administered as the sole treatment in three patients with a total dose of 50 Gy/10 fractions and as postoperative adjuvant treatment in one patient with a total of 35 Gy/7 fractions. Results: The 5-year overall survival of the entire group was 70%. The actuarial local control rate after 3 years was 84%. All five recurrent cases after initial surgery were successfully salvaged using IBT ± external beam radiotherapy. Two patients developed local recurrence at 3 and 5 months, respectively, after IBT. The acute complications were acceptable (≤grade 2). Three patients developed major late complications, such as radio-osteonecrosis, in which one patient was treated by conservative therapy and two required surgical intervention. Conclusion: HDR IBT for oral cavity cancer was effective and acceptable in diverse clinical settings, such as in the cases of primary or salvage treatment.
Moon, Yeon-Hee,Kwon, Seong-Min,Kim, Hyo-Jun,Jung, Kwan-Young,Park, Jong-Hwan,Kim, Soo-A,Kim, Yong-Chul,Ahn, Sang-Gun,Yoon, Jung-Hoon Spandidos Publications 2009 ONCOLOGY REPORTS Vol.22 No.5
<P>Photodynamic therapy (PDT) is currently being used as an alternative therapeutic modality for a variety of malignant tumors. This study was performed to show an efficient preparation of second generation of photosensitizer chlorin e6 (Ce6) with high yield and purity, and to test antitumor activity of Ce6-induced PDT (Ce6-PDT) both in vitro and in vivo using a rat tumor model. Three-week-old male Sprague-Dawley (SD) rats were inoculated s.c. on the right flank with 5x10(6) RK3E-ras cells. The animals were administered i.v. with Ce6 (10 mg/kg) and 24 h later, PDT was performed using a laser diode at a light dose of 100 J/cm2. Ce6-PDT generated reactive oxygen species and led to significant growth inhibition in RK3E-ras cell. In addition, Ce6-PDT induced apoptosis through the activation of caspase-3 and its downstream target, PARP cleavage. The protein level of anti-apoptotic bcl-2 was also reduced by Ce6-PDT in RK3E-ras cells. In in vivo experiments, application of Ce6-PDT led to a significant reduction of tumor size. PCNA immunostaining and TUNEL assay revealed that Ce6-PDT inhibited tumor cell proliferation and increased apoptosis. These findings suggest that the newly purified Ce6-PDT can effectively arrest tumor growth by inhibiting cell proliferation and inducing apoptosis.</P>
Stochastic Integrated Generation and Transmission Planning Incorporating Electric Vehicle Deployment
Moon, Guk-Hyun,Kong, Seong-Bae,Joo, Sung-Kwan,Ryu, Heon-Su,Kim, Tae-Hoon The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.1
The power industry is currently facing many challenges, due to the new environment created by the introduction of smart grid technologies. In particular, the large-scale deployment of electric vehicles (EVs) may have a significant impact on demand for electricity and, thereby, influence generation and transmission system planning. However, it is difficult to deal with uncertainties in EV charging loads using deterministic planning methods. This paper presents a two-stage stochastic decomposition method with Latin-hyper rectangle sampling (LHRS) to solve the integrated generation and transmission planning problem incorporating EV deployment. The probabilistic distribution of EV charging loads is estimated by Latin-hyper rectangle sampling (LHRS) to enhance the computational performance of the proposed method. Numerical results are presented to show the effectiveness of the proposed method.