Advances in Gel Propulsion Technology

Mohan Varma 한국추진공학회 2012 한국추진공학회 학술대회논문집 Vol.2012 No.11

Transgressive Segregation for Yield Traits in Oryza sativa IR58025B ${\times}$ Oryza meridionalis Ng. $Bc_2F_3$ Population under Irrigated and Aerobic Conditions

Varma, Chejerla Mohan Kumar,Gouda, Patil Kalmeshwer,Saikumar, Surapaneni,Shenoy, Vinay,Shashidhar, Halagappa Eshwarappa,Neelamraju, Sarla 한국작물학회 2012 Journal of crop science and biotechnology Vol.15 No.3

Wild species of the genus Oryza are a good source of beneficial alleles for enhancing rice yield under normal and adverse conditions. $Bc_2F_3$ population was derived from a cross between Oryza sativa IR58025B and Oryza meridionalis Ng. (2n = 24, AA) a heat tolerant wild species to evaluate 12 yield traits under irrigated and aerobic conditions. Analysis of variance and genetic estimates indicated there is substantial genetic variation among progenies under both conditions. Grain yield had high heritability (61.9%) and genetic advance (36.4%) under irrigated conditions but moderate heritability (49.6%) and genetic advance (13.3%) under aerobic conditions indicating that selection for yield will be effective under both conditions. Panicle number, grain number, spikelet fertility, and test weight showed significant positive correlation with grain yield under both conditions. Families out-performing IR58025B for yield under both conditions were obtained providing evidence that phenotypically inferior O. meridionalis contributed to yield increase. This species can be a novel source of natural genetic variation for the improvement of rice under irrigated as well as under aerobic condition.

Monitoring of Virtual Machines in the Eucalyptus Cloud

( Mohan Krishna Varma Nandimandalam ),( Eunmi Choi ) 한국정보처리학회 2013 한국정보처리학회 학술대회논문집 Vol.20 No.2

Cloud computing provides access to big volumes of data and computational resources through various services. Cloud computing also supports to process these volumes of data using set of computers. Cloud computing can satisfy resource requirements through virtualization technology. Eucalyptus is an open source cloud computing environment helps the users to setup their own private cloud based on virtualization. In this paper, monitoring of virtual machines is explained with the eucalyptus cloud setup.

Transgressive Segregation forYield Traits in Oryza sativa IR58025B X Oryza meridionalis Ng. Bc2F3Population under Irrigated and Aerobic Conditions

Chejerla Mohan Kumar Varma,Patil Kalmeshwer Gouda,Surapaneni Saikumar,Vinay Shenoy,Halagappa Eshwarappa,Sarla Neelamraju 한국작물학회 2012 Journal of crop science and biotechnology Vol.15 No.3

Wild species of the genus Oryza are a good source of beneficial alleles for enhancing rice yield under normal and adverse conditions. BC2F3 population was derived from a cross between Oryza sativa IR58025B and Oryza meridionalis Ng. (2n = 24, AA) a heat tolerant wild species to evaluate 12 yield traits under irrigated and aerobic conditions. Analysis of variance and genetic estimates indicated there is substantial genetic variation among progenies under both conditions. Grain yield had high heritability (61.9%) and genetic advance (36.4%) under irrigated conditions but moderate heritability (49.6%) and genetic advance (13.3%) under aerobic conditions indicating that selection for yield will be effective under both conditions. Panicle number, grain number, spikelet fertility,and test weight showed significant positive correlation with grain yield under both conditions. Families out-performing IR58025B for yield under both conditions were obtained providing evidence that phenotypically inferior O. meridionalis contributed to yield increase. This species can be a novel source of natural genetic variation for the improvement of rice under irrigated as well as under aerobic condition

Development of simvastatin electrospun fibers: a novel approach for sustained drug delivery

Sudheer Betha,B. Pamula Reddy,M. Mohan Varma,D. Basava Raju,Venkata Ramana Murthy Kolapalli 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.1

In the present investigation simvastatin electrospunfibers were developed using electrospinningapparatus with drug–polymer w/w ratios of 1:1, 1:2, 1:3and 1:4. Also solid mixtures were prepared with sameratios by employing kneading technique as conventionalapproach for comparison in drug release rate. Polyethyleneoxide WSR coagulant 301, a hydrophilic matrix formingpolymer, was used as carrier for sustained release of simvastatin. The ability of polyethylene oxide to control thedrug release rate in both the formulations was also investigated. Studies were performed to characterize the optimizeddosage form. Drug was crystalline in pure form. SEM surface morphology studies as well as powder X-raydiffractometry studies to developed fibers reveals that thecrystalline drug was converted into amorphous form afterfiber development. No physical incompatibility was foundin FTIR and DSC studies of pure drug and physical mixtureof drug, polymer. In vitro studies were performed insodium phosphate buffer (pH 7.0) containing 0.5 % SLS. Simvastatin release was sustained over a period of 12 h inelectrospinning fibers developed with drug to polymer w/wratio 1:4 and 98.86 ± 0.42 % drug release was observed,interestingly with the same ratio there was a burst releaseof drug was obtained in case of solid mixtures ‘‘within spanof 1 h’’. Polyethylene oxide showed vast difference in drugrelease rate due to the techniques chosen to prepare formulations. The stability studies were also performed to theoptimized product and no significant variance wasobserved in all the evaluation parameters. From the variousmathematical models the drug release kinetics was estimatedand found that the drug release followed zero orderrelease rate kinetics with non fickian process as drugrelease mechanism.

Effect of thickness variation of hole injection and hole blocking layers on the performance of fluorescent green organic light emitting diodes

K. Narayan,S. Varadharajaperumal,G. Mohan Rao,M. Manoj Varma,T. Srinivas 한국물리학회 2013 Current Applied Physics Vol.13 No.1

In this paper we present the effect of thickness variation of hole injection and hole blocking layers on the performance of fluorescent green organic light emitting diodes (OLEDs). A number of OLED devices have been fabricated with combinations of hole injecting and hole blocking layers of varying thicknesses. Even though hole blocking and hole injection layers have opposite functions, yet there is a particular combination of their thicknesses when they function in conjunction and luminous efficiency and power efficiency are maximized. The optimum thickness of CuPc (Copper(II) phthalocyanine) layer, used as hole injection layer and BCP (2,9 dimethyl-4,7-diphenyl-1,10-phenanthroline) used as hole blocking layer were found to be 18 nm and 10 nm respectively. It is with this delicate adjustment of thicknesses, charge balancing is achieved and luminous efficiency and power efficiency were optimized. The maximum luminous efficiency of 3.82 cd/A at a current density of 24.45 mA/cm2 and maximum power efficiency of 2.61 lm/W at a current density of 5.3 mA/cm2 were achieved. We obtained luminance of 5993 cd/m2 when current density was 140 mA/cm2. The EL spectra was obtained for the LEDs and found that it has a peaking at 524 nm of wavelength.

Dose calculation, design and development of nateglinide matrix tablets using quality by design approach and its pharmacokinetic evaluation in animal model

Sudheer Betha,B. Pamula Reddy,P. V. Swamy,M. Mohan Varma,D. Basava Raju,Venkata Ramana Murthy Kolapalli 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.6

The present work deals with design of zero order sustained release nateglinide matrix tablets by application of statistical design using response surface methodology as a tool. Central composite design was used to investigate the effect of two independent formulation variables (at three levels) such as Kollidon SR (X1), PVP K 30 (X2) on dependent variables viz. time required to release 30 % (T30, Y1), percentage drug released at 6th hour (DR6, Y2) and time required to release 90 % (T90, Y3) of drug. Wet granulation technique was employed for tablets preparation. The result showed that release pattern of the optimized formulation was almost equal to the statistically predicted values. There was no chemical interaction observed between drug and polymer based up on FTIR and DSC results. In vitro release studies were performed in 0.1 N HCl containing 0.5 % SLS for first 2 h followed by pH 6.8 phosphate buffer containing 0.5 % SLS. Stability studies were performed to statistically optimized formulation. The release pattern from statistically optimized formulation was followed zero order kinetics with non- Fickian process as drug release mechanism. Pharmacokinetic studies were performed to optimized formulation in comparison with nateglinide suspension in rabbit as animal model. The results of in vivo studies revealed the % relative bioavailability of statistically optimized formulation was found to be 68.87 %.