Hygro-thermo-mechanical vibration and buckling of exponentially graded nanoplates resting on elastic foundations via nonlocal elasticity theory

Sobhy, Mohammed Techno-Press 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.63 No.3

In this article, hygro-thermo-mechanical vibration and buckling of exponentially graded (EG) nanoplates resting on two-parameter Pasternak foundations are studied using the four-unknown shear deformation plate theory. The material properties are presumed to change only in the thickness direction of the EG nanoplate according to two exponential laws distribution. The boundary conditions of the nanoplate may be simply supported, clamped, free or combination of them. To consider the small scale effect on forced frequencies and buckling, Eringen's differential form of nonlocal elasticity theory is employed. The accuracy of the present study is investigated considering the available solutions in literature. A detailed analysis is executed to study the influences of the plate aspect ratio, side-to-thickness ratio, temperature rise, moisture concentration and volume fraction distributions on the vibration and buckling of the nanoplates.

Vibration analysis of functionally graded graphene platelet-reinforced composite doubly-curved shallow shells on elastic foundations

Mohammed Sobhy,Ashraf M. Zenkour 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.33 No.2

Based on a four-variable shear deformation shell theory, the free vibration analysis of functionally graded graphene platelet-reinforced composite (FGGPRC) doubly-curved shallow shells with different boundary conditions is investigated in this work. The doubly-curved shells are composed of multi nanocomposite layers that are reinforced with graphene platelets. The graphene platelets are uniformly distributed in each individual layer. While, the volume faction of the graphene is graded from layer to other in accordance with a novel distribution law. Based on the suggested distribution law, four types of FGGPRC doubly-curved shells are studied. The present shells are assumed to be rested on elastic foundations. The material properties of each layer are calculated using a micromechanical model. Four equations of motion are deduced utilizing Hamilton's principle and then converted to an eigenvalue problem employing an analytical method. The obtained results are checked by introducing some comparison examples. A detailed parametric investigation is performed to illustrate the influences of the distribution type of volume fraction, shell curvatures, elastic foundation stiffness and boundary conditions on the vibration of FGGPRC doubly-curved shells.

Efficacy of Nile tilapia (Oreochromis niloticus) juveniles and spinosyns bioinsecticides against aquatic stages of Culex pipiens: An experimental study

Mohamed Ibrahim A.,Fathy Mohamed,Farghal Ahmed I.A.,Temerak Sobhy A.H.,Sayed Alaa El-Din H. 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.1

The mosquito Culex pipiens is the most widely distributed dipteran species in all regions of Egypt and the principal vector of Wuchereria bancrofti and certain arboviruses in human beings. For controlling C. pipiens vector, biological tools (e.g., larvivorous fish and bioinsecticides) are more potent and safer options to the environment, human beings, and beneficial organisms than chemical pesticides. The efficiency of O. niloticus juveniles as predatory fish species and two bioinsecticides, spinosad 24% and spinetoram 12%, was investigated against the C. pipiens developmental stages in the laboratory. The first trial evaluated the predatory efficacy of small-sized O. niloticus (2.1–2.6 cm; 250–315 mg) and large-sized O. niloticus (2.5–3.2 cm; 250–315 mg) against the 3rd larvae and pupae of C. pipiens. This is the first report in Egypt confirming the predation potential of O. niloticus as efficient predatory fish against the immature C. pipiens. Large-sized O. niloticus predated a greater number of 3rd of C. pipiens larvae and pupae than the small-sized ones. Furthermore, the daily consumption of C. pipiens larvae by small- and large-sized O. niloticus was significantly higher than the pupae. The second trial assessed the toxicity efficacy of spinosad 24% and spinetoram 12% against C. pipiens larvae and pupae. The results confirmed that the tested bioinsecticides showed higher potency toward C. pipiens larvae than pupae after exposure for 24 h and 48 h. Spinosad was more toxic toward 3rd C. pipiens larvae (LC 50 = 0.013 and 0.003 mg/L) and pupae (LC 50 = 320.69 and 44.28 mg/L) than spinetoram after 24 and 48 h. Herein, O. niloticus juveniles (as promising native predatory fish) and spinosyns bioinsecticides were more effective against C. pipiens in the larval stage than in the pupal stage. In conclusion, Nile tilapia juveniles and biorational compounds, spinosad 24% and spinetoram 12%, might be considered as promising and favorable environmental biological agents for controlling C. pipiens in Egypt. However, further trials are needed to investigate the potential of these agents in the control of this mosquito vector under field conditions.

Genetic population diversity of European eel Anguilla anguilla elvers in two Egyptian water bodies, Rosetta (Rachid) estuary and Burullus Lake

Sobhy El‑Sayed Hassab El‑Nabi,Marwa Said El‑Desoky,Khaled Mohammed‑Geba 한국유전학회 2017 Genes & Genomics Vol.39 No.10

The European eel Anguilla anguilla is a species of great economic importance for Egypt. Its long trans- Atlantic migrations for semelparous spawning then larval homing provides a possible way for worldwide mixing of populations. Its natural habitats in Egypt, as in other Mediterranean countries, are under heavy load of pollution due to anthropogenic activities. Hence, a major priority should be given to assess the genetic diversity within/among eels’ populations as a step towards revealing populations’ status, identification of possible conservation units, and, subsequently, implementation of proper conservation and management strategies for them. For this, A. anguilla elvers were collected from Rosetta estuary and Burullus coastal lagoon in the North of Egypt. Sequencing of the barcode region of the cytochrome c oxidase subunit 1 gene (COI) was carried out for all collected elvers. The sequences were analyzed using various genetic, phylogenetic, and population analyses to assess their variability. A total of 33 haplotypes were identified, 14 of which were unique to Burullus Lake, and 11 to Rosetta estuary. Very low fixation (Fst = 0–0.04) was found for A. anguilla populations in Egypt and worldwide, except for the Turkish and Czech ones (Fst = 0.47–0.62 and 0.18–0.41, respectively). Both Egyptian populations showed signs of recent populations’ expansion, besides low, non-significant raggedness values. The results suggested Burullus Lake and Rosetta estuary as separate conservation units for A. anguilla in Egypt. These units require special attention for proper protection and management of the existing eel diversity and permitting sustainability in the activities dealing with eel’s fishing and aquaculture.

Immunohistochemical expression of programmed death-ligand 1 and CD8 in glioblastomas

Dina Mohamed El Samman,Manal Mohamed El Mahdy,Hala Sobhy Cousha,Zeinab Abd El Rahman Kamar,Khaled Abdel Karim Mohamed,Hoda Hassan Abou Gabal 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.6

Background: Glioblastoma is the most aggressive primary malignant brain tumor in adults and is characterized by poor prognosis. Immune evasion occurs via programmed death-ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) interaction. Some malignant tumors have responded to PD-L1/PD-1 blockade treatment strategies, and PD-L1 has been described as a potential predictive biomarker. This study discussed the expression of PD-L1 and CD8 in glioblastomas.Methods: Thirty cases of glioblastoma were stained immunohistochemically for PD-L1 and CD8, where PD-L1 expression in glioblastoma tumor tissue above 1% is considered positive and CD-8 is expressed in tumor infiltrating lymphocytes. The expression of each marker was correlated with clinicopathologic parameters. Survival analysis was conducted to correlate progression-free survival (PFS) and overall survival (OS) with PD-L1 and CD8 expression.Results: Diffuse/fibrillary PD-L1 was expressed in all cases (mean expression, 57.6%), whereas membranous PD-L1 was expressed in six of 30 cases. CD8-positive tumor-infiltrating lymphocytes (CD8+ TILs) had a median expression of 10%. PD-L1 and CD8 were positively correlated (p = .001). High PD-L1 expression was associated with worse PFS and OS (p = .026 and p = .001, respectively). Correlation of CD8+ TILs percentage with age, sex, tumor site, laterality, and outcomes were statistically insignificant. Multivariate analysis revealed that PD-L1 was the only independent factor that affected prognosis.Conclusions: PD-L1 expression in patients with glioblastoma is robust; higher PD-L1 expression is associated with lower CD8+ TIL expression and worse prognosis.

Facile route for the decoration of Nickel Hydroxide sheets as antibacterial nanocomposite for Cellulose Acetate Butyrate Films

( Emad Sobhy Mohamed Goda ),( Sang. E. Hong ),( In. S. Kim ),( Su. B. Lee ),( Kuk. R. Yoon ) 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.1

Synthesis of a new series of angiotensin II receptor antagonists and antibacterial agents

Farghaly, Thoraya A.,Gomha, Sobhi M.,Abdalla, Mohamed M. 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

2-(Arylmethylenehydrazono)-4,4-diphenyl-1H-imidazol-5(4H)-one 3 underwent regioselective cyclization upon treatment with bromine in acetic acid containing sodium acetate to give the respective 3-substituted-6,6-diphenyl-6,7-dihydro-imidazo[2,1-c][1,2,4]triazole-5-one 4 in overall good yields and not the isomeric structure 5. In addition, compound 4 was synthesized by alternative method via reaction of compound 1 with different acids in acetic acid. The synthesized hydrazone derivatives were screened for their angiotensin II receptor antagonists activity and the results showed promising activity. Also, imidazo[2,1-c][1,2,4]triazole-5-ones 4 were screened for the antibacterial activity and the result revealed that two derivatives have excellent activity.

Synthesis of a new series of angiotensin II receptor antagonists and antibacterial agents

Thoraya A. Farghaly,Sobhi M. Gomha,Mohamed M. Abdalla 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

2-(Arylmethylenehydrazono)-4,4-diphenyl-1Himidazol-5(4H)-one 3 underwent regioselective cyclizationupon treatment with bromine in acetic acid containingsodium acetate to give the respective 3-substituted-6,6-diphenyl-6,7-dihydro-imidazo[2,1-c][1,2,4]triazole-5-one 4in overall good yields and not the isomeric structure 5. Inaddition, compound 4 was synthesized by alternativemethod via reaction of compound 1 with different acids inacetic acid. The synthesized hydrazone derivatives werescreened for their angiotensin II receptor antagonistsactivity and the results showed promising activity. Also,imidazo[2,1-c][1,2,4]triazole-5-ones 4 were screened forthe antibacterial activity and the result revealed that twoderivatives have excellent activity.

Nanoparticles of ZnO/Berberine complex contract COVID-19 and respiratory co-bacterial infection in addition to elimination of hydroxychloroquine toxicity

Ghareeb Doaa A.,Saleh Samar R.,Seadawy Mohamed G.,Nofal Mohammed S.,Abdulmalek Shaymaa A.,Hassan Salma. F.,Khedr Shaimaa M.,AbdElwahab Miral G.,Sobhy Ahmed A.,Abdel-Hamid Ali saber Ali,Yassin Abdelrah 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.6

Purpose A novel coronavirus (COVID-19) that has not been previously identified in humans and has no specific treatment has recently spread. Treatment trials using antiviral and immune-modulating drugs such as hydroxychloroquine (HCQ) were used to control this viral outbreak however several side effects have emerged. Berberine (BER) is an alkaloid that has been reported to reveal some pharmacological properties including antioxidant and antimicrobial activities. Additionally, Zinc oxide nanoparticles (ZnO-NPs) possess potent antioxidant and anti-inflammatory properties. Therefore, this study was undertaken to estimate the efficiency of both BER and synthetic ZnO/BER complex as an anti-COVID-19 therapy. Methods First, the ZnO/BER complex was prepared by the facile mixing method. Then in vitro studies on the two compounds were conducted including VeroE6 toxicity, anti-COVID-19 activity, determination of inhibitory activity towards papain-like proteinase (PL pro) and spike protein- and receptor- binding domain (RBD) as well as assessment of drug toxicity on RBCs. Results The results showed that ZnO/BER complex acts as an anti-COVID-19 by inhibiting spike protein binding with angiotensin-converting enzyme II (ACE II), PL pro activity, spike protein and E protein levels, and expression of both E-gene and RNA dependent RNA polymerase (RdRp) at a concentration lower than that of BER or ZnO-NPs alone. Furthermore, ZnO/BER complex had antioxidant and antimicrobial properties where it prevents the auto oxidation of 2,2-Diphenyl- 1-picrylhydrazyl (DPPH) and the culture of lower respiratory system bacteria that affected Covid 19 patients. The ZnO/BER complex prevented as well the HCQ cytotoxic effect on both RBC and WBC (in vitro) and hepatotoxicity, nephrotoxicity and anemia that occurred after HCQ long administration in vivo. Conclusion The ZnO/BER complex can be accounted as promising anti-COVID 19 candidate because it inhibited the virus entry, replication, and assembly. Furthermore, it could be used to treat a second bacterial infection that took place in hospitalized COVID 19 patients. Moreover, ZnO/BER complex was found to eliminate the toxicity of long-term administration of HCQ in vivo.

Potential therapeutic and pharmacological strategies for SARS-CoV2

Ghareeb Doaa A.,Saleh Samar R.,Nofal Mohammed S.,Kaddah Mohamed M. Y.,Hassan Salma. F.,Seif Inas K.,El-Zahaby Sally A.,Khedr Shaimaa M.,Kenawy Marwa Y.,Masoud Aliaa A.,Soudi Salma A.,Sobhy Ahmed A.,Se 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.3

Background At the end of 2019, the new Coronavirus disease 2019 (COVID-19) strain causing severe acute respiratory syndrome swept the world. From November 2019 till February 2021, this virus infected nearly 104 million, with more than two million deaths and about 25 million active cases. This has prompted scientists to discover effective drugs to combat this pandemic. Area covered Drug repurposing is the magic bullet for treating severe acute respiratory syndrome coronavirus 2 (SARSCoV2). Therefore, several drugs have been investigated in silico, in vitro, as well as through human trials such as anti- SARS-CoV2 agents, or to prevent the complications resulting from the virus. In this review, the mechanisms of action of different therapeutic strategies are summarized. According to the WHO, different classes of drugs can be used, including anti-malarial, antiviral, anti-inflammatory, and anti-coagulant drugs, as well as angiotensin-converting enzyme inhibitors, antibiotics, vitamins, zinc, neutralizing antibodies, and convalescent plasma therapy. Recently, there are some vaccines which are approved against SARS-CoV2. Expert opinion A complete understanding of the structure and function of all viral proteins that play a fundamental role in viral infection, which contribute to the therapeutic intervention and the development of vaccine in order to reduce the mortality rate.