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Mirela Zec,Damir Roje,Martina Matovinovic,Vesna Anti cevic,Ljubica Librenjak Skare,Ana Jeron cic,Livia Puljak,Sanja Madunic,Zoran Mestrovic 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.10
Vitamin B12 plays an important role in cell division and is of vital importance during pregnancy. Iron and B12 deficiency increase the risk of neonatal morbidity and the outcome of the overall pregnancy. The aim of our study was to analyze whether the use of vitamin B12, with standard supplements of folic acid and iron among nonanemic pregnant women, will result in improvements of hemogram parameters in terms of hematological and biochemical markers. Study participants were 200 healthy pregnant women, randomized into an intervention group and a control group, recruited from gynecological primary care practices in Split, Croatia. In addition to standard supplementation (350 mg/day ferrous iron, 5 mg folic acid), participants in the intervention group were given 5 μg of vitamin B12 each morning for 100 days. Both biochemical and hematological measurings were conducted in two intervals: 8th–10th week of gestation and then again in the 34th–36th week of gestation. Participants in the control group were given only standard-of-care iron and folic acid supplementation. Significantly lower values of haptoglobin postintervention, compared with baseline, were found only in the intervention group; for erythrocytes, significantly lower values postintervention were found only in the control group. For parameter hematocrit, we found decreased values postintervention, compared with baseline, in both intervention and control group; however, this decrease was within the reference range for the control group, whereas it was above the reference range for the intervention group. The results of this study indicated that intervention with vitamin B12 in pregnancy reduces possibilities of the onset of anemia, but within reference range.
Blood level of adipokines and nutritional status variables in adolescent pregnancy
Mirela Douradinho Fernandes,Silvia Daher,Luciana Moraes de Sousa,Indiomara Baratto,Thalita Frutuoso Lobo,Edward Araujo Júnior,Cristina Aparecida Falbo Guazzelli 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.6
ObjectiveTo evaluate the serum levels of adiponectin and leptin and their relationship with nutritional variables duringpregnancy in adolescents. MethodsThis prospective cohort study evaluated eutrophic pregnant adolescents (body mass index [BMI], 18.5–24.9 kg/m2) during the 3 gestational trimesters (first, 10–14 weeks; second, 24–28 weeks; and third, 30–34 weeks). Serumadiponectin and leptin concentrations were measured using the enzyme-linked immunosorbent assay method. Therelationship of these adipokines with the pre-gestational BMI, gestational weight gain, weight at the time of samplecollection, and newborn weight were evaluated. Analysis of variance and the Kruskal-Wallis test were used forstatistical analysis. ResultsThe study group comprised 62 pregnant adolescents. The serum concentration of adiponectin showed a significantdifference between the first and third trimesters (P=0.003), which decreased during pregnancy, but unrelated tonutritional variables. Serum leptin levels increased throughout the pregnancy (P<0.0001) and showed a positivecorrelation with pre-gestational BMI, total weight gain, pregnancy weight at the time of sample collection, andnewborns’ weight. ConclusionSerum levels of adiponectin and leptin vary inversely throughout pregnancy. This pattern in adolescents is similar tothat observed in adults. Moreover, leptin concentrations increased throughout pregnancy, and they were positivelycorrelated with all variables evaluated.
( Mirela Anghel ),( Elena Radu Sultanescu ),( Mihai Sandulescu ),( Anca Ioana Anghel ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: Hypertension is one of the most important causes of premature death worldwide. Pre-diabetic state, mainly impaired glucose tolerance (IGT), is a risk factor for coronary artery disease (CAD) and sudden death. Aortic function (AD-aortic distensibility) plays a signifi cant prognostic role for cardiovascular (CV) events. The resistive index (RI) refl ects local wall extensibility and the related vascular resistance. Methods: We enrolled 285 consecutive newly diagnosed hypertensive pre-diabetic (IGT) patients without CAD (according to ESC and EASD). All patients were evaluated by lab tests, ambulatory blood pressure monitoring, carotid Doppler ultrasound (RI), Doppler echocardiography (AD), ECG stress test for non-cardiac or atypical chest symptom, rest ECG and/or cardiac echo abnormalities. We analyzed the association between AD, RI, BP, abnormal exercise ECG, several clinical parameters and cardiac events during a mean follow-up period of 4.5 ± 0.3 years. Results: The mean age of the population was 47.5 ± 14.6 years. Abnormal stress ECG showing inducible ischemia was noticed in 21% pts. Univariate analysis has shown the following parameters signifi cant associated with abnormal exercise testing: age (p<0.01), family history of premature CV events (p<0.02), SBP (p<0.02), dyslipidaemia (p<0.02), AD (p<0.03), carotid RI (p<0.04), and plasma glucose (p<0.04). Multi-adjusted analysis revealed that LDL cholesterol (p<0.01), SBP (p<0.02), higher values ofRI (p<0.02) and lower values of AD (p<0.03) were signifi cant independent predictors of abnormal ECG exercise test. Multivariate Cox proportional analysis revealed that abnormal stress ECG (HR=2.4, 95%CI: 1.5 - 6.1, p=0.032) and post-load glucose (2- hPG) (HR=2.7, 95%CI: 0.8 - 6.5, p=0.039) were good predictors of the cardiac events. Conclusion: Two simple, effective markers of vascular dysfunction - aortic distensibility and resistive index can be extremely useful in every day clinical practice in the initial risk evaluation of newly diagnosed pre-diabetic hypertensive patients without known previous CAD.
Tarantula Toxins Interact with Voltage Sensors within Lipid Membranes
Milescu, Mirela,Vobecky, Jan,Roh, Soung H.,Kim, Sung H.,Jung, Hoi J.,Kim, Jae Il,Swartz, Kenton J. Rockefeller University Press 2007 The Journal of general physiology Vol.130 No.5
<P>Voltage-activated ion channels are essential for electrical signaling, yet the mechanism of voltage sensing remains under intense investigation. The voltage-sensor paddle is a crucial structural motif in voltage-activated potassium (K<SUB>v</SUB>) channels that has been proposed to move at the protein–lipid interface in response to changes in membrane voltage. Here we explore whether tarantula toxins like hanatoxin and SGTx1 inhibit K<SUB>v</SUB> channels by interacting with paddle motifs within the membrane. We find that these toxins can partition into membranes under physiologically relevant conditions, but that the toxin–membrane interaction is not sufficient to inhibit K<SUB>v</SUB> channels. From mutagenesis studies we identify regions of the toxin involved in binding to the paddle motif, and those important for interacting with membranes. Modification of membranes with sphingomyelinase D dramatically alters the stability of the toxin–channel complex, suggesting that tarantula toxins interact with paddle motifs within the membrane and that they are sensitive detectors of lipid–channel interactions.</P>
Generalized two-field <i>α</i>-attractor models from the hyperbolic triply-punctured sphere
Babalic, Elena Mirela,Lazaroiu, Calin Iuliu Elsevier 2018 Nuclear Physics, Section B Vol.937 No.-
<P><B>Abstract</B></P> <P>We study generalized two-field <I>α</I>-attractor models whose rescaled scalar manifold is the triply-punctured sphere endowed with its complete hyperbolic metric, whose underlying complex manifold is the modular curve Y ( 2 ) . Using an explicit embedding into the end compactification, we compute solutions of the cosmological evolution equations for a few globally well-behaved scalar potentials, displaying particular trajectories with inflationary behavior as well as more general cosmological trajectories of surprising complexity. In such models, the orientation-preserving isometry group of the scalar manifold is isomorphic with the permutation group on three elements, acting on Y ( 2 ) as the group of anharmonic transformations. When the scalar potential is preserved by this action, <I>α</I>-attractor models of this type provide a geometric description of two-field “modular invariant <I>j</I>-models” in terms of gravity coupled to a non-linear sigma model with topologically non-trivial target and with a finite (as opposed to discrete but infinite) group of symmetries. The precise relation between the two perspectives is provided by the elliptic modular function <I>λ</I>, which can be viewed as a field redefinition that eliminates almost all of the countably infinite unphysical ambiguity present in the Poincaré half-plane description of such models.</P>
Generalized α-Attractor Models from Elementary Hyperbolic Surfaces
Babalic, Elena Mirela,Lazaroiu, Calin Iuliu Hindawi Limited 2018 Advances in mathematical physics Vol.2018 No.-
<P>We consider generalized α-attractor models whose scalar potentials are globally well-behaved and whose scalar manifolds are elementary hyperbolic surfaces. Beyond the Poincaré disk D, such surfaces include the hyperbolic punctured disk <SUP>D⁎</SUP> and the hyperbolic annuli A(R) of modulus μ=2logR>0. For each elementary surface, we discuss its decomposition into canonical end regions and give an explicit construction of the embedding into the Kerekjarto-Stoilow compactification (which in all three cases is the unit sphere), showing how this embedding allows for a universal treatment of globally well-behaved scalar potentials upon expanding their extension in real spherical harmonics. For certain simple but natural choices of extended potentials, we compute scalar field trajectories by projecting numerical solutions of the lifted equations of motion from the Poincaré half plane through the uniformization map, thus illustrating the rich cosmological dynamics of such models.</P>