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- 저자 : ( Mirela Anghel ) (검색결과 2 건)
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( Mirela Anghel ),( Elena Radu Sultanescu ),( Mihai Sandulescu ),( Anca Ioana Anghel ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: Hypertension is one of the most important causes of premature death worldwide. Pre-diabetic state, mainly impaired glucose tolerance (IGT), is a risk factor for coronary artery disease (CAD) and sudden death. Aortic function (AD-aortic distensibility) plays a signifi cant prognostic role for cardiovascular (CV) events. The resistive index (RI) refl ects local wall extensibility and the related vascular resistance. Methods: We enrolled 285 consecutive newly diagnosed hypertensive pre-diabetic (IGT) patients without CAD (according to ESC and EASD). All patients were evaluated by lab tests, ambulatory blood pressure monitoring, carotid Doppler ultrasound (RI), Doppler echocardiography (AD), ECG stress test for non-cardiac or atypical chest symptom, rest ECG and/or cardiac echo abnormalities. We analyzed the association between AD, RI, BP, abnormal exercise ECG, several clinical parameters and cardiac events during a mean follow-up period of 4.5 ± 0.3 years. Results: The mean age of the population was 47.5 ± 14.6 years. Abnormal stress ECG showing inducible ischemia was noticed in 21% pts. Univariate analysis has shown the following parameters signifi cant associated with abnormal exercise testing: age (p<0.01), family history of premature CV events (p<0.02), SBP (p<0.02), dyslipidaemia (p<0.02), AD (p<0.03), carotid RI (p<0.04), and plasma glucose (p<0.04). Multi-adjusted analysis revealed that LDL cholesterol (p<0.01), SBP (p<0.02), higher values ofRI (p<0.02) and lower values of AD (p<0.03) were signifi cant independent predictors of abnormal ECG exercise test. Multivariate Cox proportional analysis revealed that abnormal stress ECG (HR=2.4, 95%CI: 1.5 - 6.1, p=0.032) and post-load glucose (2- hPG) (HR=2.7, 95%CI: 0.8 - 6.5, p=0.039) were good predictors of the cardiac events. Conclusion: Two simple, effective markers of vascular dysfunction - aortic distensibility and resistive index can be extremely useful in every day clinical practice in the initial risk evaluation of newly diagnosed pre-diabetic hypertensive patients without known previous CAD.
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Virgil Radu Enatescu,Ion Papava,Ileana Enatescu,Mirela Antonescu,Andrei Anghel,Edward Seclaman,Ioan Ovidiu Sirbu,Catalin Marian 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.5
ObjectiveaaSignificant progress was made in the understanding etiopathogenic factors related to MDD, including through research on the role of micro RNAs (miRs). We investigated plasma miRs as potential markers for MDD in patients treated with antidepressants. MethodsaaAt the initiation and at the end of twelve weeks of treatment, blood samples were collected and a structured diagnostic interview and a standardized depression rating scale for the presence and severity of major depression were done. The average decrease in HAMD score was 76.89%. Plasma miR expression profiling was performed by real time PCR. The lists of up-regulated (cut-off=2) and down-regulated miRs were imported into the miRWalk2.0 algorithm and used for target predictions. KEGG database pathways analysis was used to retrieve the pathways significantly targeted by at least two of the miRs. ResultsaaOf the 222 miRs detected in plasma samples of MDD patients, 40 were differentially expressed after treatment. Twenty-three miRs were significantly overexpressed with fold changes between 1.85 and 25.42, and 17 miRs were significantly downregulated with fold changes from 0.28 to 0.68. Pathway analysis revealed a list of 29 pathways for up-regulated miRs, and 20 pathways for down-regulated miRs. Six dysregulated miRs are common to all the top five pathways (Wnt signaling, Cancer, Endocytosis, Axon guidance, MAPK signaling): miR-146a-5p, miR-146b-5p, miR-221-3p, miR-24-3p, miR-26a-5p. ConclusionaaOverall, our miRWalk analysis of changes in plasma microRNAs after treatment of patients with major depression might open a new avenue for the understanding of Escitalopram mode of action and for its side effects.
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