Timing and tectonic settings of the Late Paleozoic intrusions in the Zhusileng, northern Alxa: implication for the metallogeny

Mingming Fei,Mao Pan,Chunlin Xie,Jianhui Wang,Hansen Zhao 한국지질과학협의회 2019 Geosciences Journal Vol.23 No.1

The Zhusileng–Hangwula tectonic zone, located in the northern Alxa area, is a key site for understanding the evolution of the Paleo-Asian Ocean (PAO) and related mineral formation. We report the major and trace elements and zircon U-Pb ages of newly discovered mafic and intermediate to felsic intrusive rocks in the Zhusileng area. LA-ICP-MS zircon U-Pb analyses of the Echenghei diabase and Haierhan and Heipingshan granites yielded crystallization ages of 305 Ma, 284 Ma, and 271 Ma, respectively. The Late Carboniferous mafic rocks have high MgO and Fe2O3T contents and low K2O and TiO2 contents, and are characterized by depletion of HREEs and notably negative Nb-Ta anomalies, with enrichment of Rb, Ba, and U, which indicate an enriched mantle source. The Early Permian granites of the Zhusileng area are highly differentiated I-type granitoids sourced from mixing of mantle and crust, are high-K calc-alkaline and enriched in LREEs, and exhibit moderately to strongly negative Eu anomalies. All the intrusive rocks formed in a post-collisional extensional environment, which indicates that the branch of the PAO in the northern Alxa area had closed before the Early Permian. The Cu-Mo/Au mineralization in the Zhusileng area formed in the Middle to Late Permian and is genetically linked to the Late Paleozoic post-collisional rifting magmatism from after the closure of the Paleo-Asian Ocean.

Thermal history of the Jurassic marine sequences in the Qiangtang Basin, northern Tibetan Plateau: implication for the hydrocarbon preservation

Mingming Fei,Licheng Wang,Yalin Li,Yushuai Wei 한국지질과학협의회 2016 Geosciences Journal Vol.20 No.4

The Jurassic marine sequences of the Qiangtang Basin in the northern part of the Tibet Plateau have the best petroleum exploration prospect. The prototype basin has undergone multi-stage and complicated tectonic events since the Cretaceous, especially the mid-Cretaceous tectonic event and the Cenozoic uplift of Tibetan Plateau. However, little information about the impact of these tectonic events on petroleum preservation has been done. In this paper, the burial and thermal histories modeling using vitrinite reflectance (Ro) are used to characterize the impact. The results showed that there is a regional falling of palaeotemperature in the Qiangtang Basin during the mid-Cretaceous indicating a regional tectonic event caused by the collision between Lhasa and Qiangtang blocks. However, the Cenozoic tectonic event caused by the uplift of Tibetan Plateau since 30 Ma was only recorded in the Southern Qiangtang Depression and not obvious in the Northern Qiangtang Depression, which indicates that uplift-denudation caused by the mid-Cretaceous tectonic event was extensive in whole Qiangtang Basin and more significant to the hydrocarbon accumulation than those in the Cenozoic. The event could damage the previously formed hydrocarbon traps and caused the leaking of cap-rocks for the dramatically denudation especially in the Southern Qiangtang Depression. We speculated that the Northern Qiangtang Depression has the lower thickness of denudation and barely influenced by the Cenozoic tectonic events and thus is primary exploration target for gas or gas hydrate.

An Induced Hesitant Linguistic Aggregation Operator and Its Application for Creating Fuzzy Ontology

( Mingming Kong ),( Fangling Ren ),( Doo-soon Park ),( Fei Hao ),( Zheng Pei ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.10

An induced hesitant linguistic aggregation operator is investigated in the paper, in which, hesitant fuzzy linguistic evaluation values are associated with probabilistic information. To deal with these hesitant fuzzy linguistic information, an induced hesitant fuzzy linguistic probabilistic ordered weighted averaging (IHFLPOWA) operator is proposed, monotonicity, boundary and idempotency of IHFLPOWA are proved. Then andness, orness and the entropy of dispersion of IHFLPOWA are analyzed, which are used to characterize the weighting vector of the operator, these properties show that IHFLPOWA is extensions of the induced linguistic ordered weighted averaging operator and linguistic probabilistic aggregation operator. In this paper, IHFLPOWA is utilized to gather linguistic information and create fuzzy ontologies, and a movie fuzzy ontology as an illustrative case study is used to show the elaboration of the proposed method and comparison with the existing linguistic aggregation operators, it seems that the IHFLPOWA operator is an useful and alternative operator for dealing with hesitant fuzzy linguistic information with probabilistic information.

LncRNA PVT1 influences breast cancer cells glycolysis through sponging miR-145-5p

Qu Huan,Li Xingxing,Chen Fei,Zhang Min,Lu Xun,Gu Yun,Lv Mingming,Lu Cheng 한국유전학회 2023 Genes & Genomics Vol.45 No.5

Background Long-non-coding RNA PVT1 (lncRNA PVT1) can be used as an oncogenic regulatory non-coding RNA (ncRNA) for many cancers. However, its function and mechanism in breast cancer (BRCA) are still not clearly elucidated. Objective We attempt to explain the mechanism of PVT1’s role in breast cancer from different perspectives. Methods We analyzed the expression of PVT1 and its correlation with the breast cancer related clinical data in the The Cancer Genome Atlas (TCGA) database. We used PVT1 overexpression and knockdown lentivirus to infect breast cancer MDA-MB-231 cell line for cell function verification, in vitro using CCK-8 to measure proliferation, flow cytometry to measure apoptosis, transwell test to measure invasion and migration ability, detecting cell extracellular acidification rate (ECAR) to assess glycolysis metabolism and explore the biological functions of PVT1 in breast cancer cells. Transcriptome sequencing was used to analyze the changes of related genes in cells after overexpression of PVT1. In vivo we used a xenograft model to study the effect of PVT1 on breast cancer. Results PVT1 was up-regulated in breast cancer tissues and was positively correlated with the clinical stage of breast cancer patients. Overexpression of PVT1 in vitro promoted cell proliferation, migration and invasion, and promoted tumor growth in vivo. Knockdown of PVT1 led to the opposite biological consequence. Further bioinformatics analysis showed that PVT1 changes the glycolysis metabolism of tumors through regulation of glycolysis-related genes. In addition, the expression of miR-145-5p is negatively correlated with PVT1. We consider the possibility of PVT1 promoting cell proliferation and metastasis by regulating the aerobic glucose metabolism in breast cancer cells through sponging the miR-145-5p. Conclusion Our results reveal a potential pathway for competing endogenous RNA to regulate breast cancer glucose metabolism. PVT1 regulates glycolysis related genes expression by competitively binding to endogenous miR-145-5p in breast cancer cells to change the metabolic phenotype. This may Provide new ideas for precise molecular therapy targets for breast cancer.

Isolation and characterization of heat-responsive gene TaGASR1 from wheat (Triticum aestivum L.)

Liyuan Zhang,Xiaoli Geng,Haiyan Zhang,Chunlei Zhou,Aiju Zhao,Fei Wang,Yue Zhao,Xuejun Tian,Zhaorong Hu,Mingming Xin,Yingyin Yao,Zhongfu Ni;Qixin Sun,Qixin Sun,Huiru Peng 한국식물학회 2017 Journal of Plant Biology Vol.60 No.1

GA-stimulated transcript (GAST) family genes have been identified in numerous plant species. In this paper, we isolated and characterized a heat-responsive gene, TaGASR1, from heat tolerant variety TAM107. The complete ORF of TaGASR1 was cloned, which encoded a 98-kDa protein, and the sequence shared 51.52% similarity to OsGASR1. Analysis of the TaGASR1 promoter region showed that it contained a heat shock element (HSE) and several cis-elements involved in abiotic stress response and hormone signal transduction. Expression patterns of TaGASR1 revealed that it was strongly induced by stress factors, such as high temperature, drought, high salinity and oxidation, as well as the phytohormones, including MeJA, ACC and ABA, which suggested the TaGASR1 gene might participate in these stress and hormone signal transduction pathways. Transient expression of TaGASR1-GFP fusion proteins in onion epidermal cells indicated that TaGASR1 protein was localized to the cell membrane or cytosol. Further analysis showed that ectopic expression of TaGASR1 in Arabidopsis enhanced thermotolerance and reduced the accumulation of reactive oxygen species (ROS) after heat stress. Moreover, we also found that TaGASR1-overexpressing wheat improved tolerance to heat stress and oxidative stress.