http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Choi, Minji,Chaudhari, Harmesh N,Ji, Young Rae,Ryoo, Zae Young,Kim, Sang Woo,Yun, Jong Won Dr. W. Junk B. V. Publishers ; Kluwer Academic Pub 2015 MOLECULAR AND CELLULAR BIOCHEMISTRY - Vol.407 No.1
<P>Prohibitin (PHB) is a ubiquitously expressed and highly conserved protein that participates in diverse cellular processes, and its functions are linked to a variety of diseases. In the present study, to explore transcriptional activation and signaling pathways involved in PHB regulation in response to sex hormone treatment, we investigated the effects of estrogen (17-β-estradiol, E2) on regulation of PHB in several metabolic tissues from male and female rats. Elevated expression of PHB was prominent in white adipose tissue (WAT) and the liver, and E2 stimulated PHB expression in both ND and HFD-fed rats. To further confirm the expression of PHB which was increased in WAT and the liver, we analyzed PHB expression levels in 3T3-L1 and C9 cells after the treatment of E2. Transcription and protein levels of PHB were dose-dependently increased by E2 treatment in both cell types, supporting our in vivo data. To further evaluate the possible role of E2 in elevation of PHB via estrogen receptors (ER), the potent ER inhibitor fulvestrant was treated to 3T3-L1 and C9 cells. Fulvestrant markedly suppressed both transcription and protein levels of PHB, suggesting that PHB expression in both tissues may be regulated through ERs. GeneMANIA, a predictive web interface, was used to show that Phb is regulated via the intracellular steroid hormone receptor signaling pathway, suggesting a role for ERs in expression of Phb as well as other metabolically important genes. Based on these results, we expect that targeting PHB would be a useful therapeutic approach for treatment of obesity.</P>
Choi, Minji,Mukherjee, Sulagna,Kang, Nam Hyeon,Barkat, Jameel Lone,Parray, Hilal Ahmad,Yun, Jong Won Wiley Blackwell (John WileySons) 2018 IUBMB life Vol.70 No.6
<P>Induction of the brown adipocyte-like phenotype in white adipocytes (browning) is considered as a novel strategy to fight obesity due to the ability of brown adipocytes to increase energy expenditure. Here, we report that L-rhamnose induced browning by elevating expression levels of beige-specific marker genes, including Cd137, Cited1, Tbx1, Prdm16, Tmem26, and Ucp1, in 3T3-L1 adipocytes. Moreover, L-rhamnose markedly elevated expression levels of proteins involved in thermogenesis both in 3T3-L1 white and HIB1B brown adipocytes. L-rhamnose treatment in 3T3-L1 adipocytes also significantly elevated protein levels of p-HSL, p-AMPK, ACOX, and CPT1 as well as reduced levels of ACC, FAS, C/EBP, and PPAR, suggesting its possible role in enhancement of lipolysis and lipid catabolism as well as reduced adipogenesis and lipogenesis, respectively. The quick technique of efficient molecular docking provided insight into the strong binding of L-rhamnose to the fat-digesting glycine residue of (3)-adrenergic receptor (AR), indicating strong involvement of L-rhamnose in fat metabolism. Further examination of the molecular mechanism of L-rhamnose revealed that it induced browning of 3T3-L1 adipocytes via coordination of multiple signaling pathways through (3)-AR, SIRT1, PKA, and p-38. To the best of our knowledge, this is the first study to demonstrate that L-rhamnose plays multiple modulatory roles in the induction of white fat browning, activation of brown adipocytes, as well as promotion of lipid metabolism, thereby demonstrating its therapeutic potential for treatment of obesity. (c) 2018 IUBMB Life, 70(6):563-573, 2018</P>
Optimal route selection model for fire evacuations based on hazard prediction data
Choi, Minji,Chi, Seokho Elsevier Science B.V., Amsterdam. 2019 SIMULATION MODELLING PRACTICE AND THEORY Vol.94 No.-
<P><B>Abstract</B></P> <P>Providing accurate information on available evacuation routes is critical during the time-sensitive emergency situation of a building fire, particularly when it occurs in a large-scale facility with a complex layout. Timely access to safe and efficient egress paths helps minimize exposure to hazardous fire effluents such as toxic smoke during evacuation. The following study develops a computational model which uses hazard prediction data to identify optimal evacuation routes, the safest and shortest paths to the nearest exit, during the event of a building fire. It uses the Fire Dynamics Simulator to provide prediction data on smoke propagation inside a structure and the A* algorithm to search for the fastest escape path. The algorithm is modified to consider whether the ensuing nodes in the route are in a normal or hazardous state. The test simulations demonstrate that the model is both accurate and effective in guiding evacuees to a place of safety while minimizing direct exposure to smoke. These results enable a more informed approach to safety management during indoor fires and reduce the likelihood of evacuees impeding the evacuation process by entering a dangerous area unprepared.</P>
( Minji Kim ),( Sir Yeon Hong ),( Yejin Kim ),( Yun Sun Choi ),( Ilyeo Jang ),( Ji Hee Sung ),( Suk Joo Choi ),( Soo Young Oh ),( Cheong Rae Roh ) 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: We compared the maternal and neonatal outcomes between elective labor induction versus spontaneous labor or rupture of membranes in women with non-complicated singleton pregnancies who tried labor after 39 weeks of gestation. Methods: This was a retrospective cohort study of 342 women with singleton pregnancy who tried labor after 39 weeks of gestation in a single institution between 2018 and 2021. Pregnant women who delivered before 39 weeks of gestation, who delivered by elective cesarean section, or with multiple gestation or complicated pregnancy were excluded. Subjects were categorized into two groups: pregnant women who underwent elective labor induction (induction group) and pregnant women who had spontaneous labor or rupture of membranes (spontaneous group). Pregnancy outcomes and neonatal outcomes were reviewed. Subgroup analyses were done in nulliparous and multiparous women. Results: Maternal characteristics were similar in the two groups. Cesarean section rate was significantly higher in the induction group than the spontaneous group (27.0% vs. 14.6%, P=0.005). However, the indications for cesarean delivery were significantly different between the two groups: induction failure (35.4% vs. 0%), failure to progress (64.6% vs. 79.2%), and fetal distress (0% vs. 20.8%) in the induction group and spontaneous group (P<0.001), respectively. Postoperative complications were comparable between the two groups, but postoperative hemoglobin drop more than 10% was significantly more common in the induction group. Neonatal outcomes were similar between the two groups. In nulliparous women, cesarean section rate was significantly higher in the induction group (37.0% vs. 20.2%, P=0.004). Conclusion: Elective labor induction in non-complicated singleton women at 39 weeks of gestation was associated with a higher cesarean section rate than spontaneous labor or rupture of membranes. And this was mostly due to a higher rate of cesarean delivery for induction failure in nulliparous women.