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The Orphan Nuclear Receptor SHP Attenuates Renal Fibrosis
Jung, Gwon-Soo,Kim, Mi-Kyung,Choe, Mi Sun,Lee, Kyeong-Min,Kim, Hye-Soon,Park, Young Joo,Choi, Hueng-Sik,Lee, Ki-Up,Park, Keun-Gyu,Lee, In-Kyu American Society of Nephrology 2009 Journal of the American Society of Nephrology Vol.20 No.10
<P>The accumulation of extracellular matrix proteins is a common feature of fibrotic kidney diseases. Accumulating evidence suggests that TGF-beta and plasminogen activator inhibitor type 1 (PAI-1) promote the development of renal fibrosis by stimulating the generation and inhibiting the removal of matrix proteins. The small heterodimer partner (SHP) represses PAI-1 expression in the liver by inhibiting TGF-beta signaling, but whether SHP inhibits renal fibrosis is unknown. Here, unilateral ureteral obstruction (UUO) markedly increased the expression of PAI-1, type I collagen, and fibronectin but decreased SHP gene expression. Moreover, in kidneys of SHP-/- mice, the expression of PAI-1, type I collagen, fibronectin and alpha-smooth muscle actin (alpha-SMA) were higher compared with those in kidneys of wild-type mice. In addition, loss of SHP accelerated renal fibrosis after UUO. Adenovirus-mediated overexpression of SHP in cultured rat mesangial cells and renal tubular epithelial cells inhibited TGF-beta-stimulated expression of PAI-1, type I collagen, and fibronectin. SHP inhibited TGF-beta- and Smad3-stimulated PAI-1 promoter activities as well as TGF-beta-stimulated binding of Smad3 to its consensus response element on the PAI-1 promoter. Similarly, in vivo, adenovirus-mediated overexpression of SHP in the kidney inhibited the expression of UUO-induced PAI-1, type I collagen, fibronectin, and alpha-SMA. In summary, SHP attenuates renal fibrosis in obstructive nephropathy, making its pathway a possible therapeutic target for chronic kidney disease.</P>
Lin28a ameliorates glucotoxicity-induced β-cell dysfunction and apoptosis
( Yeo Jin Hwang ),( Gwon-soo Jung ),( Wonbae Jeon ),( Kyeong-min Lee ) 생화학분자생물학회(구 한국생화학분자생물학회) 2021 BMB Reports Vol.54 No.4
An excessive and prolonged increase in glucose levels causes β-cell dysregulation, which is accompanied by impaired insulin synthesis and secretion, a condition known as glucotoxicity. Although it is known that both Lin28a and Lin28b regulate glucose metabolism, other molecular mechanisms that may protect against glucotoxicity are poorly understood. We investigated whether Lin28a overexpression can improve glucotoxicityinduced β-cell dysregulation in INS-1 and primary rat islet cells. INS-1, a rat insulinoma cell line was cultured and primary rat islet cells were isolated from SD-rats. To define the effect of Lin28a in chronic high glucose-induced β-cell dysregulation, we performed several in vitro and ex-vivo experiments. Chronic exposure to high glucose led to a downregulation of Lin28a mRNA and protein expression, followed by a decrease in insulin mRNA expression and secretion in β-cells. The mRNA and protein expression levels of PDX-1 and BETA2, were reduced; The levels of apoptotic factors, including c-caspase3 and the Bax/Bcl-2 ratio, were increased due to glucotoxicity. Adenovirusmediated Lin28a overexpression in β-cells reversed the glucotoxicity- induced reduction of insulin secretion and insulin mRNA expression via regulation of β-cell-enriched transcription factors such as PDX-1 and BETA2. Adenovirus-mediated overexpression of Lin28a downregulated the glucotoxicity-induced upregulation of c-caspase3 levels and the Bax/Bcl-2 ratio, while inhibition of endogenous Lin28a by small interfering RNA resulted in their up-regulation. Lin28a counteracted glucotoxicity-induced downregulation of p-Akt and p-mTOR. Our results suggest that Lin28a protects pancreatic β-cells from glucotoxicity through inhibition of apoptotic factors via the PI3 kinase/Akt/mTOR pathway. [BMB Reports 2021; 54(4): 215-220]
흡연이 β-Thromboglobulin, Platelet Factor 4 및 혈소판 응집비에 미치는 영향
신화식,조민구,김소연,이권전,조태봉,조경준,최중호,강남영 대한내과학회 1986 대한내과학회지 Vol.31 No.4
The purpose of this study was to determine whether cigarette smoking acutely increases the plasma beta-thromboglobulin(beta-TG) and platelet factor 4(FF 4) and decreases the platelet aggregate ratio(PAR). Beta-TG, PF4, and PAR were measured before cigarette smoking and 20 minutes after smoking(2 filtered cigarettes) using radioimmunoassay kits, in twenty seven healthy men, aged 21 to 32, abstained from alcohol for 12 hours, from coffee and smoking for at least 8 hours. The results were summarized as follows; 1) In nonsmokers, before smoking plasma beta-TG was 42.9±10.6ng/ml, plasma PF4 7.1±2.7 ng/ml, and PAR 0.98±0.04 and 20 minutes after smoking plasma beta-TG significantly increased to 119. 4±41.6ng/ml, plasma PF 4 to 30.7±9.5ng/ml, and PAR decreased to 0. 86±0.10. 2) In smokers, before smoking plasma beta-TG was 49.3±9.1ng/ml, plasma PF 4 9.47±7.0ng/ ml, and PAR 0. 96+0. 10 and 20 minutes after smoking plasma beta-TG significantly increased to 134.4±43.0ng/ml, plasma PF 4 to 35.1±9.5ng/ml. and PAR decreased to 0.81±0.08. 3) Neither before nor after smoking showed signififcant correlation between nonsmokers and smokers in plasma beta-TG, PF 4, and PAR(p$gt;0.1). However in both groups there were significant difference between plasma beta-TG, PF4, and FAR before and after smoking(p$lt;0.005). In conclusion, there were significant increase in plasma beta-TG and FF 4 and decrease in PAR after smoking. Therefore the effect of cigarette smoking on the platelet activation and number of circulating platelet aggregates were significant.
Song, Pil Sang,Ryu, Dong Ryeol,Kim, Min Jeong,Jeon, Ki-Hyun,Choi, Rak Kyeong,Park, Jin Sik,Song, Young Bin,Hahn, Joo-Yong,Gwon, Hyeon-Cheol,Ahn, Youngkeun,Jeong, Myung Ho,Choi, Seung-Hyuk The Korean Society of Cardiology 2018 Korean Circulation Journal Vol.48 No.6
<P><B>Background and Objectives</B></P><P>A risk prediction is needed even in the contemporary era of acute myocardial infarction (AMI). We sought to develop a risk scoring specific for patients with AMI being treated with guideline-adherent optimal therapies, including percutaneous coronary intervention and all 5 medications (aspirin, thienopyridine, β-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin).</P><P><B>Methods</B></P><P>From registries, 12,174 AMI patients were evaluated. The primary outcome was 1-year all-cause death or AMI. The Korea Working Group in Myocardial Infarction (KorMI) system was compared with the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI), Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC), and Global Registry of Acute Coronary Events scores (GRACE) models.</P><P><B>Results</B></P><P>Ten predictors were identified: left ventricular dysfunction (hazard ratio [HR], 2.3), bare-metal stent (HR, 2.0), Killip class ≥II (HR, 1.9), renal insufficiency (HR, 1.8), previous stroke (HR, 1.6), regional wall-motion- score >20 on echocardiography (HR, 1.5), body mass index ≤24 kg/m<SUP>2</SUP> (HR, 1.4), age ≥70 years (HR, 1.4), prior coronary heart disease (HR, 1.4), and diabetes (HR, 1.4). Compared with the previous models, the KorMI system had good discrimination (time-dependent C statistic, 0.759) and showed reasonable goodness-of-fit by Hosmer-Lemeshow test (p=0.84). Moreover, the continuous-net reclassification improvement varied from −27.3% to −19.1%, the integrated discrimination index varied from −2.1% to −0.9%, and the median improvement in risk score was from −1.0% to −0.4%.</P><P><B>Conclusions</B></P><P>The KorMI system would be a useful tool for predicting outcomes in survivors treated with guideline-adherent optimal therapies after AMI.</P>
레이놀드 수에 따른 색소 젯트의 특성 및 색소레이저의 출력변화
김성호,고도경,이종민,임권,조재흥,장수,Kim, Sung Ho,Ko, Do-Kyeong,Lee, Jong-Min,Lim, Gwon,Jo, Jae-Heung,Chang, Soo 한국광학회 1994 한국광학회지 Vol.5 No.4
레이놀드 수에 따른 색소 젯트의 공간적인 편평도를 마이켈슨 간섭계를 이용하여 분석하였다. 레이놀드 수 600(유속 12m/s)일 때 색소 젯트의 편평도는 최적 조건을 보였다. 이러한 색소 젯트의 최적 조건하에서 종펌핑 Littman형 색소레이저 빔은 펌프 에너지 0.5-1.0mJ/pulse의 범위에서 단일 종모우드로 발진되었다. 이 때의 선폭은 470MHz이었고, 변환 효율과 빔 발산각은 각각 4.7%, 3mrad이었다. The spatial flatness of dye jet depending on the Reynold's number has analyzed by using a Michelson interferometer. When the Reynold's number of dye jet was 600, the flatness of the flow was the best. Under this condition, the dye laser with Littman-type configuration has been operated in a single longitudinal mode at the pumping energy of 0.5~1.0 mJ/pulse. The conversion efficiency and beam divergence were 4.7% and 3 mrad, respectively. ively.
Surveillance of sporadic and subtropical insect pests in Jeonbuk province
Su Ji Jang,Ju Hee Kim,In Young Choi,Min Kyeong Choi,Ju Kim,Hyeong Gwon Chon 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
농작물의 재배기술이 발전하면서 다양한 작물의 재배가 가능해지고, 지구 온난화에 따른 겨울철 기온 상승으로 해충 종의 다양화와 발생이 증가하고 있는 추세이다. 전북지역에 발생하는 돌발 해충과 남방해충의 발생 상황을 파악하기 위해 지대별로 구분하여 4개 시군에서 정점 조사하였다. 조사 결과, 갈색날개매미충의 30 ㎝ 당 난괴 밀도는 0.8개, 약충 밀도는 6월 상순 0.19마리, 6월 하순 0.21마리로 작년보다 밀도가 낮은 것으로 조사되었다. 미국선녀벌레는 산간지인 장수에서 밀도가 높았으며, 먹노린재는 평야지에서 20주당 평균 3마리 발생하였다. 애멸구는 6월 상순 평야지인 부안에서 발생을 확인하였으며, 볼록총채벌레는 5월 중순부터 발생하기 시작하여 7월 초순에서 8월 초순까지 발생이 많았다.
Control effects of environment-friendly materials on Metcalfa pruinosa
Su Ji Jang,Ju Hee Kim,Ju Kim,In Young Choi,Min Kyeong Choi,Hyeong Gwon Chon 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
전북지역에 발생하는 미국선녀벌레는 2017년 익산시 여산면에 식재된 밤나무에 자연 발생되어 피해가 발생했으며 특히, 유기농 농경지의 밤나무, 블루베리, 배나무 등에 피해를 주고 있다. 유기농 재배지에서 피해를 경감시키기 위해 친환경자재 선발 실험을 실시하였다. 미국선녀벌레의 약충과 성충을 대상으로 친환경자재 500배액을 경엽 살포한 결과, 약충 방제효과는 님오일 82.9%, 계피유 69.5%, 햄프시드 65.3%, 데리스 65.1%, 편백유 56.8%, 녹차씨유 45.1%로 나타났다. 성충 방제효과는 님오일 75.7%, 계피유 68.7%, 햄프시드 67.4%, 데리스 62.1%, 편백유 26.7%, 녹차씨유 44.2%로 조사되었다. 님오일은 미국선녀벌레 약충과 성충에서 방제가가 가장 높았으며 약해도 발생하지 않았다. 유기농 재배지에서 미국선녀벌레를 방제하기 위해서는 님오일을 처리하는 것이 효과적일 것으로 기대된다.