http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Min Su You (검색결과 283 건)
- 무료
- 기관 내 무료
- 유료
-
관상 동맥 질환에서 아포 E 지단백 유전자 다형성과 혈청 지질치와의 관계
곽선영,김성구,정호석,이유경,이광희,김철현,최태명,현민수,권영주 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1
Background and aims: The Apolipoprotein E is a ligand of both the protein component LDL receptor as well as the apo E LDL-Receptor related protein (LRP). It modulates the receptor binding of lipoproteins, with the apolipoprotein E found on cell surfaces as its component, thus serving an important role in the lipid metabolism by carrying out the intracellular transport of cholesterol in lipoproteins. The gene for apolipoprotein E is the product of three common genotypes as well as many more rare alleles. The common genotypes are ε2, ε3, and ε4, and are expressed in the three phenotype isoforms of E2, E3, and E4. In the event that E4 is the main component, a rise in the cholesterol level, as the result of down-regulation of the LDL receptor, is observed. Therefore, those samples with E4 genotypes are known to be in much higher risk of coronary artery disease than those with ε3/ε3, while those with ε2 are in low risk (with the exception of hypertiglyceremai Ⅲ). The aim of this study is to analyze in patients with ischemic heart disease the role of aplipoprotein E alleles in order to seek its correlation with coronary artery disease, as well as to seek whether the polymorphism of apo E produces any differences in the severity of coronary artery disease according to plasma lipid levels. Methods: The subjects for study were 273 patients admitted to the Internal Cardiology Division of the Soonchunhyang University Hospital form December 1998 to February 1999. The subjects were divided into the two groups of which one was ischemic heart disease (IHD) experiment group totaling 105 (avg.60.1 years of age, male/female ratio = 69/36) and the control group totaling 168 (avg. 59.7 years of age, male/female = 73:95). The coronary angiogram was given to 127 subjects, and of this total, 94 have developed significant stenosis in the coronary artery. The stages of the analyzing of the apo E phenotype was first, the separation of DNA from the blood samples, subjecting it to the PCR from with 228 base pairs of expanded products were obtained. The band was determined by means of the reverse hybridization principle on the nitrocellulose strip. Results: From the 105 patients the distributions of apo E phenotypes were as follows: ε3/2(5.7%), ε4/2(1.9%), ε3/3(70%), ε4/3(20%), ε4/4(1.9%). The relative frequencies of each allele are as follow: ε2 (0.038), ε3 (0.833), ε4 (0.128). The results show as follows: ⅰ) The IHD experiment group to have a higher occurrence of ε4/3 phenotypes as well as ε4 alleles than the control group. ⅱ) Both the control group and IHD group showed the largest distribution of ε3/3 for phenotypes, and ε4 for alleles. ⅲ) The IHD group showed less ε2/3 phenotypes as well as significantly less allele frequency of ε3 in comparison to the control group. ⅳ) the IHD group showed a much lower level of HDL in comparison to the control group, while the LDL was significantly higher; samples including the apo ε2 showed a significantly higher level of HDL than those without. Among the control group, samples including apo ε2 showed a significantly higher level of TG (triglyceride) than samples without. No significant difference was found between the experiment apo ε4 sample and the control plasma lipid sample. ⅴ) No significant correlation was found between an apo E polynorphism and the number of involved arteries of a coronary angiogram. Conclusion: Between the experiment IHD group and control group were found differences in the frequency of alleles. The polymorphism of apo E alleles may contribute as a risk factor to the development of heart disease by involving itself in the metabolism and modulation of plasma lipids.
-
Evaluation of improved vaccine for type C Foot-and-Mouth Disease in cattle and pigs
Su-Hwa You(Su-Hwa You),Hye-Eun Jo(Hye-Eun Jo),Joo-Hyung Choi(Joo-Hyung Choi),Mi-Kyeong Ko(Mi-Kyeong Ko),Sung Ho Shin(Sung Ho Shin),Min Ja Lee(Min Ja Lee),Su-Mi Kim(Su-Mi Kim),Byounghan Kim(Byounghan K 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-
-
( Min Su You ),( Sang Hyub Lee ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
A 49-year-old man visited our emergency department because of abdominal pain. The pain developed in the right upper quadrant 5 days ago, and physical examination revealed icteric sclerae. Laboratory tests showed elevation of total bilirubin at 24.5 mg/dL, alkaline phosphatase at 745 IU/L, gamma glutamyltransferase at 1163 IU/L, carbohydrate antigen 19-9 (CA 19-9) at 520 U/mL, and carcinoembryonic antigen (CEA) at 29.6 ng/mL. Enhanced abdominal computed tomography (CT) scans showed irregular gallbladder wall thickening with Bismuth type IIIA biliary obstruction and peritoneal seeding nodules, which was also noticed on positron emission tomography-computed tomography (PET-CT). The laboratory and image findings indicated an inoperable state of the advanced gallbladder cancer. Because of the biliary obstruction, a Y-type bilateral metal stent was inserted via endoscopic retrograde cholangiopancreatography. After the biliary decompression, many courses of cyclic chemotherapy were done; 13 cycles of gemcitabine and cisplatin, 1 cycle of 5-fluorouracil, doxorubicin and mitomycin-C, 3 cycles of 5-fluorouracil and leucovorin, and 6 cycles of tegafur and uracil. Cholangitis occurred repeatedly during a period of cyclic chemotherapy, and several sessions of percutaneous transhepatic biliary drainage as well as endoscopic retrograde biliary drainage had been performed. After 2 years of the first chemotherapy and biliary decompression, image findings showed stable extent of tumors and disappearance of the previous peritoneal seeding. Serum CA 19-9 decreased to 19.2 U/mL, and CEA was less than 0.5 ng/mL. Based on the improvement of the image and laboratory findings, the results of the multidisciplinary team approach suggested that curative resection could be conducted. The patient ultimately underwent extended right hemihepatectomy after right portal vein embolization. The pathologic examinations reported R0 resection with no lymph node metastasis. The patient is now seen periodically on our outpatient clinic. Two years have passed since the operation with no signs of recurrent disease.
-
-
-
You, Su-Yeon,Yang, Ji-Su,Kim, Sung Hyun,Hwang, In Min Hindawi Limited 2017 Journal of food quality Vol.2017 No.-
<P>In this study, the changes in pH, organic acid content, acidity, and salinity of kimchi prepared at 0 days, stored 1–8 weeks at 4 and 10°C, and stored at room temperature for two days were analyzed. Organic acids content was analyzed by using analytical technique of high-performance liquid chromatography (HPLC). This method was also validated using quality assurance parameters of linearity, limits of detection and quantification (LOD and LOQ), precision, and spike recovery experiments. In the analysis of organic acids content (mg/kg), it was found that the kimchi stored for 1–8 weeks at 4 and 10°C showed gradual increase in the organic acids content during storage period. The order of organic acids was lactic acid > acetic acid > citric acid > malic acid > succinic acid > oxalic acid > fumaric acid. The pH values of kimchi stored at 4°C, 10°C, and 25°C were 4.1, 3.6–3.7, and 4.1, respectively.</P>
-
( Min Su You ),( Ji Kon Ryu ),( Young Hoon Choi ),( Jin Ho Choi ),( Gunn Huh ),( Woo Hyun Paik ),( Sang Hyub Lee ),( Yong-tae Kim ) 대한소화기학회 2018 Gut and Liver Vol.12 No.6
Background/Aims: The combination of nab-paclitaxel and gemcitabine (nab-P/Gem) is widely used for treating metastatic pancreatic cancer (MPC). We aimed to evaluate the therapeutic outcomes and prognostic role of treatment-related peripheral neuropathy in patients with MPC treated with nab-P/Gem in clinical practice. Methods: MPC patients treated with nab-P/Gem as the first-line chemotherapy were included. All 88 Korean patients underwent at least two cycles of nab-P/Gem combination chemotherapy (125 and 1,000 mg/㎡, respectively). Treatment-related adverse events were monitored through periodic follow-ups. Overall survival and progression-free survival were estimated by the Kaplan-Meier method, and the Cox proportional hazards regression linear model was applied to assess prognostic factors. To evaluate the prognostic value of treatment-related peripheral neuropathy, the landmark point analysis was used. Results: Patients underwent a mean of 6.7±4.2 cycles during 6.3±4.4 months. The median overall survival and progression-free survival rates were 14.2 months (95% confidence interval [CI], 11.8 to 20.3 months) and 8.4 months (95% CI, 7.1 to 13.2 months), respectively. The disease control rate was 84.1%; a partial response and stable disease were achieved in 30 (34.1%) and 44 (50.0%) patients, respectively. Treatment-related peripheral neuropathy developed in 52 patients (59.1%), and 13 (14.8%) and 16 (18.2%) patients experienced grades 2 and 3 neuropathy, respectively. In the landmark model, at 6 months, treatment-related peripheral neuropathy did not have a significant correlation with survival (p=0.089). Conclusions: Nab-P/Gem is a reasonable choice for treating MPC, as it shows a considerable disease control rate while the treatment-related peripheral neuropathy was tolerable. The prognostic role of treatment-related neuropathy was limited. (Gut Liver 2018;12:728-735)
-
Su-Jin Park(Su-Jin Park),You-Jeong Kim(You-Jeong Kim),Oh-Hyeok Kwon(Oh-Hyeok Kwon),Jeong-Min Lee(Jeong-Min Lee) 대한미용의학회 2023 대한미용의학회지 Vol.7 No.1
Background: Owing to the COVID-19 pandemic, consumers’ interest in the environment has increased. This has also led to increased interest in eco-friendly products and cosmetics. To increase consumers’ purchase intention of eco-friendly cosmetics, this study explores the influence of consumer innovativeness and cosmetic selection attributes on their purchase intention of eco-friendly cosmetics. Objective: This study aims to provide practical marketing data for eco-friendly cosmetic companies and contribute to increasing consumers’ purchase intention. Methods: This study collected data through self-administered surveys and analyzed the collected data using SPSS ver. 24.0. Results: Our statistical analysis shows that the functional, hedonic, cognitive, and social innovativeness of consumer innovativeness and the brand, quality, and price of cosmetic selection attributes positively (+) influence purchase intention of eco-friendly cosmetics. Conclusion: Our statistical results show that consumer innovativeness and cosmetic selection attributes positively influence the purchase intention of eco-friendly cosmetics. We expect that targeting consumers who have high consumer innovativeness and favor brand-, quality-, and price-centered marketing can increase consumers’ positive purchase intention.
-
-
( Min Su You ),( Sang Hyub Lee ),( Jinwoo Kang ),( Young Hoon Choi ),( Jin Ho Choi ),( Bang-sup Shin ),( Gunn Huh ),( Woo Hyun Paik ),( Ji Kon Ryu ),( Yong-tae Kim ),( Dong Kee Jang ),( Jun Kyu Lee ) 대한간학회 2019 Gut and Liver Vol.13 No.3
Background/Aims: Recurrent pyogenic cholangitis (RPC) is a chronic progressive disease frequently accompanied by cholangiocarcinoma (CCA). This study aimed to investigate the natural course of RPC and identify factors associated with CCA. Methods: From January 2005 to December 2016, 310 patients diagnosed with RPC at Seoul National University Hospital were included. Complications and management during follow-up were recorded. CCA-free probability was estimated by Kaplan-Meier method, and risk factors associated with CCA were analyzed using log-rank test and Cox’s proportional hazard regression model. Results: Mean age at diagnosis was 59.1±10.9 years and mean follow-up duration was 84.0±64.1 months. An intrahepatic duct stone was found in 253 patients (81.6%). Liver atrophy was identified in 185 patients (59.7%) and most commonly located at the left lobe (65.4%). Acute cholangitis, liver abscesses, cirrhotic complications, and CCA developed in 41.3%, 19.4%, 9.7%, and 7.4%, respectively. During follow-up, complete resolution rate after hepatectomy, biliary bypass surgery, and choledocholithotomy with T-tube insertion reached 82.3%, 55.2%, and 42.1%, respectively. None of the patients who maintained complete resolution by the last follow-up day developed CCA. In univariate analysis, female, both-sided intrahepatic duct stones, and liver atrophy at any location were associated with increased risk of CCA. Multivariate analysis revealed that both-sided atrophy significantly increased risk of CCA (hazard ratio, 4.56; 95% confidence interval, 1.48 to 14.09; p=0.008). In 21 patients who developed intrahepatic CCA, tumor was located mostly in the atrophied lobe (p=0.023). Conclusions: In RPC patients, acute cholangitis, liver abscess, cirrhotic complications, and CCA frequently developed. Both-sided liver atrophy was a significant risk factor for developing CCA. (Gut Liver 2019;13:373-379)
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
