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C -11 및 F - 18 표지 콜린의 합성과 체내동태에 관한 연구
전권수,유국현,김상욱,임상무,홍성운,서용섭,양승대,안순혁,허민구 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.3
Objectives: Recently, [methyl-(11)^C]-(β-Hydroxyethyl)trimethylammonium ([(11)^C]choline) has been discovered to be a very effective tracer in imaging various human tumors using positron emission tomography. Because of the short half-life of C-11, it is very difficult to use in a routine imaging procedure and needs a frequent synthesis of [(11)^]choline. This can be supplemented by the substitution of [(11)^Ccholine with [methyS-18]fluorocholine. Here, we would like to report cell uptake and biodistribution of [(11)^Ccholine and [(18)^F]fluorocholine as a basic study. Methods [(11)^C]Choline was prepared by the treatment of [(11)^C]CHzI with N,N-dimethylaminoethanol and [18F]fluorocholine was synthesized from reaction of CHzBr[18F]F with N,N-dimethylaminoethanol. The radiochemical purity was checked by high performance liquid chromatography (HPLC). The biodistribution of [(11)^C]choline and [(18)^F]fluorocholine was determined in balb/c mouse at 5 min, 20 min, 40 min and 80 min. The cell uptake wa measured using glioma (9L) and colon adeocarcinoma (SW620). Results: The radiochemical purity was more than 98% after purification. In the liver, uptake did not change over time the uptake was 20/ID/g for [C]choline and 13%ID/g for [(18)^F]fluorocholine. In the kidney, radioactivity decreased over tirne the uptake was 15%1D/g for [(11)^Ccholine and 20%ID/g for [(18)^F]fluorocholine, 80 min post-injection. The cell uptake of [(11)^Ccholine was 4.93% for glioma (9L) and 18.69F for colon adenocarcinoma (SW620). For [(18)^F]fluorocholine, 1.77% for glioma (9L) and 2.77% for colon adenocarcinoma (SW620). Conclusion: [(11)^CCholine and [(18)^F]fluorocholine showed a different cell uptake tendency, depending on cancer cell line. (Korean J Nucl Med 200135:185-191)
Facile Synthesis and Radioiodine Labeling of Hypericin
Kim, Sang-Wook,Park, Jeong-Hoon,Yang, Seung-Dae,Hur, Min-Goo,Kim, Yu-Seok,Chai, Jong-Seo,Kim, Young-Soon,Yu, Kook-Hyun Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.8
Hypericin (1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione), an antidepressant which is also known to be a potent protein kinase C (PKC) inhibitor was synthesized as a precursor for radioiodine labeling via two step reactions. Malignant glioma cells express higher PKC activity compared to untransformed glial cell. Here we report the synthesis and radioiodine labeling of hypericin as a potential brain tumor imaging radiopharmaceutical. The reference compound, 2-iodohypericin, and its radiolabelled analogues, 2-[$^{123}I$]iodohypericin and 2-[$^{124}I$]iodohypericin have been prepared by the reaction of hypericin with NaI or [$^{123}I$]NaI or [$^{124}I$]NaI. The labeling yield was 60-65% for each analogue and the optimal reaction time was 10 min. The purification and isolation of the labelled products were achieved by a reversed-phase HPLC.
우리나라 강우량 변화 시나리오에 따른 밭토양의 토양 유실량 변화 예측
김민경(Min-Kyeong Kim),허승오(Seong-Oh Hur),권순익(Soon-Ik Kwon),정구복(Goo-Bok Jung),손연규(Yeon-Kyu Sonn),하상건(Sang-Keun Ha),이덕배(Deog-Bae Lee) 한국토양비료학회 2010 한국토양비료학회지 Vol.43 No.6
우리나라의 A1B 기후변화 시나리오에 따르면 21세기 말에는 강우량이 17% 증가하는 것으로 예상되고 있으며, 이에 따라 우리나라 밭토양의 단위면적당 토양 유실량은 2003년 대비 7.6% 증가하고, 총 토양 유실량은 2003년 대비 12.9% 증가하는 것으로 예측되었다. 그러나, 본 연구에서는 우리나라 강우량 변화 시나리오에 따른 토양 침식을 예측에 있어 미래의 작물, 토지이용의 변화 및 지구단위별 지형 변경 등의 인자는 분석에 적용되지 못하였다. 또한, 태풍빈도, 토지피복의 변화 등의 영향은 충분히 반영되지 않아 향후 기후변화에 따른 토양 유실 방지를 위해서는 보다 면밀한 대책이 필요할 것으로 생각된다. 따라서, 앞으로 이러한 문제점을 해결하기 위해서는 본 연구결과를 토대로 하여 적용 인자들을 확대하고, 향후 개선된 연구자료와 방법론으로 보완해야 할 것이다. 또한, 기후변화에 따른 비점오염원 관리정책과 연계하여 농업환경 영향평가, 예측 및 관리방안에 대한 연구가 필요하다고 판단된다. Major impacts of climate change expert that soil erosion rate may increase during the 21<SUP>st</SUP> century. This study was conducted to assess the potential impacts of climate change on soil erosion by water in Korea. The soil loss was estimated for regions with the potential risk of soil erosion on a national scale. For computation, Universal Soil Loss Equation (USLE) with rainfall and runoff erosivity factors (R), cover management factors (C), support practice factors (P) and revised USLE with soil erodibility factors (K) and topographic factors (LS) were used. RUSLE, the revised version of USLE, was modified for Korean conditions and re-evaluate to estimate the national-scale of soil loss based on the digital soil maps for Korea. The change of precipitation for 2010 to 2090s were predicted under A1B scenarios made by National Institute of Meteorological Research in Korea. Future soil loss was predicted based on a change of R factor. As results, the predicted precipitations were increased by 6.7% for 2010 to 2030s, 9.5% for 2040 to 2060s and 190% for 2070 to 2090s, respectively. The total soil loss from uplands in 2005 was estimated approximately 28 × 10<SUP>6</SUP> ton. Total soil losses were estimated as 31 × 10<SUP>6</SUP> ton in 2010 to 2030s, 31 × 10<SUP>6</SUP> ton in 2040 to 2060s and 33 × 10<SUP>6</SUP> ton in 2070 to 2090s, respectively. As precipitation increased by 17% in the end of 21<SUP>st</SUP> century, the total soil loss was increased by 12.9%. Overall, these results emphasize the significance of precipitation. However, it should be noted that when precipitation becomes insignificant, the results may turn out to be complex due to the large interaction among plant biomass, runoff and erosion. This may cause increase or decrease the overall erosion.
Lee, Min Goo,Jeong, Myung Ho,Ahn, Youngkeun,Chae, Shung Chull,Hur, Seung Ho,Hong, Taek Jong,Kim, Young Jo,Seong, In Whan,Chae, Jei Keon,Rhew, Jay Young,Chae, In Ho,Cho, Myeong Chan,Bae, Jang Ho,Rha, S The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.10
<P>We sought to determine the prevalence of metabolic syndrome (MS) in patients with acute myocardial infarction and its effect on clinical outcomes. Employing data from the Korea Acute Myocardial Infarction Registry, a total of 1,990 patients suffered from acute ST-elevation myocardial infarction (STEMI) between November 2005 and December 2006 were categorized according to the National Cholesterol Education Program-Adult Treatment Panel III criteria of MS. Primary study outcomes included major adverse cardiac events (MACE) during one-year follow-up. Patients were grouped based on existence of MS: group I: MS (n=1,182, 777 men, 62.8±12.3 yr); group II: Non-MS (n=808, 675 men, 64.2±13.1 yr). Group I showed lower left ventricular ejection fraction (LVEF) (<I>P</I>=0.005). There were no differences between two groups in the coronary angiographic findings except for multivessel involvement (<I>P</I>=0.01). The incidence of in-hospital death was higher in group I than in group II (<I>P</I>=0.047), but the rates of composite MACE during one-year clinical follow-up showed no significant differences. Multivariate analysis showed that low LVEF, old age, MS, low high density lipoprotein cholesterol and multivessel involvement were associated with high in-hospital death rate. In conclusion, MS is an important predictor for in-hospital death in patients with STEMI.</P>
한국인 사체 CT 영상에 기초한 대퇴골 골절치료용 금속판의 Concept Design
변태민(Tae-Min Byun),허신구(Shin-Goo Hur),황창윤(Chang-Yun Hwang),김남구(Nam-Gu Kim),강승백(Seung-Baek Kang),한상규(Sang-Kuy Han),고철웅(Cheol-Woong Ko) 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.- No.-
본 연구에서는 대퇴골 골절치료용 금속판 개발을 위하여 한국인 사체의CT 영상을 기초로 대퇴골 형상모델을 재구성하였으며, 형상계측학적 측정을 위하여 대퇴골 측정기준을 설정하였다. 특히, 대퇴골 Isthmus 기준위치를 설정하기 위하여 골수강의 단면형상을 측정하였고, 기준위치로부터 5mm 간격으 로 단면측정을 진행하였다. 한국인 대퇴골 간부 형상에 맞는 대퇴골절치료용 금속판의 Concept Design을 제안하였으며, 이를 기초로 향후 형상기억합금을 이용한 금속판 개발을 검토 예정이다.
형상기억합금 소재의 골절치료용 골고정재의 접촉압 시험에 관한 기초연구
변태민(Tae-Min Byun),고철웅(Cheol-Woong Ko),김남구(Nam-Gu Kim),임신혁(Sin-Hyouk Yim),허신구(Shin-Goo Hur),황창윤(Chang-Yun Hwang),강승백(Seung-Baik Kang) 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.2014 No.2
본 연구에서는 대퇴골 골절치료용 형상기억합금 소재의 고정재 개발을 위하여 골고정재 접촉압 시험 장비를 개발하였다. 개발된 시험장비와 감압지를 이용하여 형상기억합금 소재의 골고정재(직경 25mm, 30mm)와 원형 지지봉(직경 40mm)이 접촉하였을 때 발생하는 접촉압을 측정하였다. 측정된 접촉압 분석 결과, 형상기억합금 소재의 골고정재의 온도 변화에 따른 접촉압 발생 거동을 확인하였고, 향후 생체시험용 Saw-bone을 적용하여 추가적인 접촉압 시험을 수행 예정이다.