http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
An Efficient Algorithm for Real-Time 3D Terrain Walkthrough
Hesse, Michael,Gavrilova, Marina L. Society for Computational Design and Engineering 2003 International Journal of CAD/CAM Vol.3 No.1
The paper presents an efficient algorithm based on ROAM for visualization of large scale terrain models in real-time. The quality and smoothness of the terrain data visualization within a 3D interactive environment is preserved, while the complexity of the algorithm is kept on a reasonable level. The main contribution of the paper is an introduction of a number of efficient techniques such as implicit coordinates method within the patch array representing ROAM and the viewpoint dependent triangle rendering method for dynamic level of detail (LOD) updates. In addition, the paper presents experimental comparison of a variety of culling techniques, including a newly introduced method: relational position culling. These techniques are incorporated in the visualization software, which allows to achieve more realistic terrain representation and the real-time level of detail reduction.
Paclitaxel-albumin interaction in view of molecular engineering of polymer-drug conjugates
Hess, Michael,Jo, Byung-Wook,Wunderlich, Stefan De Gruyter 2009 Pure and Applied Chemistry Vol.81 No.3
<P>The interaction of water-soluble polymer conjugates of the anticancer agent paclitaxel and albumin as model protein has been investigated using fluorescence spectroscopy and NMR. Drugs and drug conjugates can enter the hydrophobic core of albumin; the kinetics of the interaction with the fluorophore, however, differs. Given the information about the steric situation of the formed complexes, some aspects of molecular engineering of the drug are discussed.</P>
Van Nguyen, T.,Lee, J.,Sweredoski, Michael J.,Yang, S.J.,Jeon, S.J.,Harrison, Joseph S.,Yim, J.H.,Lee, S.,Handa, H.,Kuhlman, B.,Jeong, J.S.,Reitsma, Justin M.,Park, C.S.,Hess, S.,Deshaies, Raymond J. Cell Press 2016 Molecular cell Vol.61 No.6
<P>Cereblon (CRBN), a substrate receptor for the cullin-RING ubiquitin ligase 4 (CRL4) complex, is a direct protein target for thalidomide teratogenicity and antitumor activity of immunomodulatory drugs (IMiDs). Here we report that glutamine synthetase (GS) is an endogenous substrate of CRL4(CRBN). Upon exposing cells to high glutamine concentration, GS is acetylated at lysines 11 and 14, yielding a degron that is necessary and sufficient for binding and ubiquitylation by CRL4 CRBN and degradation by the proteasome. Binding of acetylated degron peptides to CRBN depends on an intact thalidomide-binding pocket but is not competitive with IMiDs. These findings reveal a feedback loop involving CRL4 CRBN that adjusts GS protein levels in response to glutamine and uncover a new function for lysine acetylation.</P>
Gao, Xingsen,Liu, Lifeng,Birajdar, Balaji,Ziese, Michael,Lee, Woo,Alexe, Marin,Hesse, Dietrich WILEY-VCH Verlag 2009 Advanced Functional Materials Vol.19 No.21
<P>A novel nanopatterning method using pulsed laser deposition through an ultrathin anodic aluminium oxide (AAO) membrane mask is proposed to synthesize well-ordered nanodot arrays of magnetic CoFe<SUB>2</SUB>O<SUB>4</SUB> that feature a wide range of applications like sensors, drug delivery, and data storage. This technique allows the adjustment of the array dimension from ∼35 to ∼300 nm in diameter and ∼65 to ∼500 nm in inter-dot distance. The dot density can be as high as 0.21 Terabit in.<SUP>−2</SUP>. The microstructure of the nanodots is characterized by SEM, TEM, and XRD and their magnetic properties are confirmed by well-defined magnetic force microscopy contrasts and by hysteresis loops recorded by a superconducting quantum interference device. Moreover, the high stability of the AAO mask enables the epitaxial growth of nanodots at a temperature as high as 550 °C. The epitaxial dots demonstrate unique complex magnetic domains such as bubble and stripe domains, which are switchable by external magnetic fields. This patterning method creates opportunities for studying novel physics in oxide nanomagnets and may find applications in spintronic devices.</P> <B>Graphic Abstract</B> <P>Well-ordered arrays of magnetic CoFe<SUB>2</SUB>O<SUB>4</SUB> nanodots are synthesized by a nanopatterning method using pulsed laser deposition through an ultrathin anodic aluminium oxide membrane. This technique allows a wide-range adjustment of array periodicity and dot dimension, as well as epitaxial growth of the nanodots. The epitaxial dots demonstrate complex magnetic domains such as bubble and stripe domains. <img src='wiley_img/1616301X-2009-19-21-ADFM200900422-content.gif' alt='wiley_img/1616301X-2009-19-21-ADFM200900422-content'> </P>
Polymer prodrug approaches applied to paclitaxel
Sohn, Jeong Sun,Jin, Jung Il,Hess, Michael,Jo, Byung Wook Royal Society of Chemistry 2010 Polymer chemistry Vol.1 No.6
<P>Paclitaxel possesses a unique mechanism of drug action as a new class of microtubule stabilizing agent which finally leads to disrupted mitosis and cell death. Recent findings have shown that paclitaxel initiates apoptosis through multiple mechanisms. However, the strong hydrophobicity of paclitaxel drastically limits its use in natural form. In addition, significant toxicity which is mainly ascribed to the non-specific, indiscriminate distribution among the tissues limited the application of paclitaxel in cancer therapy. Therefore, it remains of interest to improve their use by enhancing solubility, selectivity and <I>in vivo</I> delivery by preparing functional prodrugs selectively activable in tumour areas. This article summarizes results and information derived recently from paclitaxel prodrugs based mainly on macromolecular conjugates and their interactions with body fluids. We also explore the potential application of site-specific carriers in the development of tumor-targeting paclitaxel conjugates.</P> <P>Graphic Abstract</P><P>This review summarizes results and information derived recently from paclitaxel prodrugs based mainly on macromolecular conjugates and their interactions with body fluids. We also explore the potential application of site-specific carriers in the development of tumor-targeting paclitaxel conjugates. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b9py00351g'> </P>
Wunderlich, Stefan,Zä,hres, Manfred,Jo, Byung-Wook,Hess, Michael WILEY-VCH Verlag 2007 Macromolecular symposia Vol.258 No.1
<P>Summary: We have used warfarin as a local probe to investigate the orientation of paclitaxel and water soluble polymer conjugates of paxlitaxel in albumin. The relative orientation of warfarin and paclitaxel in a 1:1 complex in solution was investigated by <SUP>1</SUP>H-NMR-spektroskopy (NOESY) and the results are used for the interpretation of the steric situation of paclitaxel respectively the polymer conjugate in albumin.</P>