Effects on solid complex fertilizer for biomass increase of benthic microalgae in manila clam Ruditapes philippinarum bed

Mi Ryung Oh,Kyeong-Ah Seong,Jung-Rae Rho,Yeong-Doo Yoo,Hyung Seop Kim,Wonho Yih 한국수산해양기술학회(구 한국어업기술학회) 2016 한국수산해양기술학회 학술발표대회 Vol.2016 No.10

Effects on solid complex fertilizer for biomass increase of benthic microalgae in manila clam Ruditapes philippinarum bed

Mi Ryung Oh,Kyeong-Ah Seong,Jung-Rae Rho,Yeong-Doo Yoo,Hyung Seop Kim,Wonho Yih 한국수산과학회 양식분과 2016 한국수산과학회 양식분과 학술대회 Vol.2016 No.10

Role of Mitofusin-2 gene as prognostic biomarker for cutaneous squamous cell carcinoma recurrence

( Mi Yeon Cho ),( Xianglan Zhang ),( Yeongjoo Oh ),( Byung Ho Oh ),( Kee Yang Chung ),( Mi Ryung Roh ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Although vast amount of research has been done on genes related to cancers, it remains unclear whether Mitofusin-2 (MFN2) functions as a tumor suppressor or oncogene in cancer progression. The impact of MFN2 on carcinogenesis is likely to be more complicated than expected, so further research is needed. In this study, we aimed to investigate the effect of MFN2 on the pathogenesis of cutaneous squamous cell carcinoma (cSCC). Objectives: The objective of the study was to evaluate the expression of MFN2 in cSCC tissue and to investigate the influence of MFN2 expression on the biological behavior of cSCC. Methods: MFN2 expression was detected in a cSCC cohort consisting 111 samples of patients with long-term follow-up by immunohistochemistry. The influence of MFN2 on biological behavior of cSCC cells was investigated in vitro. Results: Increased MFN2 abundance was found in 76 (68.5%) of cSCC patients. In multivariate analysis using age, gender, lesion site, MFN2 as cofactors, MFN2 expression was an independent risk factor for recurrence of cSCC with a hazard ratio of 3.47 (95% confidence invterval, 2.31-15.03; P=0.001). The proliferative, migratory, and invasive abilitiesof the cells were 2.1-, 2.8-, and 3.1 fold decreased after MFN2-knockdown than control cells (all P<0.001). Conclusion: MFN2 may act as an oncogene by affecting the development of cSCC and can be used as a biomarker to predict the prognosis of cSCC.

외상성 두부 손상 아동의 인지기능 특성 및 어머니의 양육스트레스에 관한 예비연구

오미령 ( Mi-ryung Oh ),심규원 ( Kyu-won Shim ),김동석 ( Dong-seok Kim ),박은경 ( Eun-kyung Park ),염인선 ( In-sun Yeom ),신의진 ( Yee-jin Shin ),엄소용 ( So-yong Eom ) 한국영유아아동정신건강학회 2012 영유아아동정신건강연구 Vol.5 No.1

본 연구의 목적은 외상성 두부 손상 아동의 인지 기능과 양육스트레스에 대한 임상적 특성을 파악 하는 것이었다. 이를 위해 한국판 웩슬러 아동용 지능검사, Rey-Kim 아동용 기억검사, 전산화된 주의력장애 진단 시스템(시각), 한국판 부모양육 스트레스검사를 사용하였다. 서울소재 대학병원에 외 상성 두부 손상을 주호소로 내원한 만 6세에서 15세에 해당하는 아동 중 심리평가에 의뢰된 아동 66명과 보호자 66명을 대상으로 자료를 수집하여 분석한 결과, 두부 손상으로 내원한 아동의 지능 평균은 평균 수준에 해당하였고, 기억 능력 평균은 평균하 상단 수준에 해당하고 있어 지능수준에 비해 통계학적으로 유의미한 수준의 저하가 시사되었다. 주의력의 경우 부주의, 충동성, 반응시간 표준편차의 영역의 평균 자체가 비정상 범위에 속하고 있으며, 과반수이상이 비정상 범위에 포함 되는 것으로 나타났다. 의식 소실의 유무로 집단을 나누어 비교해본 결과 의식 소실 경험의 아동은 전체 지능 및 동작성 지능에서 유의미한 저하를 보였으나 기타 영역에서는 두 집단의 차이가 나타나지 않았다. 어머니의 양육 스트레스 검사 결과 과반수이상이 정상 범위를 벗어나는 스트레스에 해당하고 있어 임상적으로 도움이 필요한 스트레스를 경험하고 있는 것으로 나타났다. 하위 영역 중 양육 유능감, 아동에 대한 기대, 자녀와의 애착, 역할의 제한의 영역에서 상대적으로 증가된 스트레스를 보이고 있었다. 의식 소실의 여부에 따라서는 통계적으로 의미 있는 차이를 보이지는 않았다. 이러한 두부 손상 아동들의 특성을 고려하여, 의학적 서비스와 더불어 학습 치료적 개입, 부모교육 프로그램 등과 같은 심리학적 서비스의 통합적 개입 계획 수립이 필요함이 시사되었다. The purpose of this study is to investigate the clinical characteristics of cognitive function and parenting stress found in children with traumatic brain injuries. This study was conducted using Korean-Wechsler Intelligence Scale for Children, Rey-Kim Memory Test for children, attention deficit hyperactivity disorder diagnostic system, and Korean Parenting Stress Index. Subjects were 66 children with traumatic brain injuries at the age of six to fifteen who had visited hospitals in Seoul and their guardians. The result showed that intelligence of the children with traumatic brainin juries was at the average level and their memory function was lower than the average level, indicating that memory function might relatively decline. In the case of visual attention, the standard deviation of inattention, impulsivity, and reaction time was higher than the T score. The result also showed that more than half of the subjects were placed in the higher threshold. The subjects were divided into two groups based on whether they had ever experienced loss of consciousness. Comparison of the two groups found that the children who had experienced loss of consciousness showed significantly lower levels of Full Scale Intelligence Quotient and Performance Intelligence Quotient. However, no significant difference was found in the remaining domains. More than half of the subjects’ mothers experienced parenting stress that was higher than the normal level. Considering the characteristic of the children with traumatic brain injury, it is required that an integrated intervention plan for psychological services such as supportive therapy for family and programs for parent education should be provided in addition to medical services.

가관카뉼라가 삽입된 소아에서의 기관재건술을 위한 마취

오흥근,최령,윤덕미,엄대자 대한마취과학회 1982 Korean Journal of Anesthesiology Vol.15 No.2

The anesthetist plays an important role in recognizing and managing the problems during surgery as well as postoperatively in patients having transurethral resection. As the number of transurethral resections increase in Korea, we are facing more cardiovascular and respiratory problems as well as other problems. During the 5 year period from 1974 to 1979, 230 cases of T.U.R.'s which were performed under various anesthesia, were recorded at the Dongsan Medical Center. We have observed the problems and the pitfalls according to the following classification in tables Ⅰ and Ⅱ. Underlying diseases in patients for T.U.R. operation time, distribution of patients according to ASA classification, age and sex distribution, preoperative problems, classification of anesthesia and anesthetics, sedatives used during regional anesthesia and post T.U.R. complications were listed in Tables Ⅱ through XI. 1) The age of these cases ranged from 20 to 80 years old and the sixth decade was most common. 2) The preoperative problems are listed in Table Ⅶ. i.e., cardiovascular abnormalities (35.7%), pulmonary problems (10%), metabolic and endocrine nutritional disorders in that order. 3) Major underlying diseases are listed in Table Ⅲ. i.e., bladder tumor, BPH and prostate carcinoma in that order of incidence. 4) Postoperative complications are listed in Table Ⅶ. i.e., bleeding, infection, extravasation, fluid absorption toxicity in that order of incidence. 5) The sedatives(pentothal, nembutal, valium) were used in 35.9% of the total cases during the regional analgesia for T.U.R. 6) The low spinal anesthesia is considered to be the best technique for anesthesia in T.U.R. procedures after reviewing the problems, pitfalls and complications.

Long-term outcomes of laser treatment for congenital melanocytic nevus

( Yeongjoo Oh ),( Si-hyung Lee ),( Jungmin Lim ),( Kee Yang Chung ),( Mi Ryung Roh ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Although various laser treatments have been tried for CMNs, only small retrospective studies with short-term follow-up had been done to assess outcomes. Objectives: We analyzed the long-term outcomes of laser treatment for CMN and compared the outcomes with the combination treatment of partial excisions followed by laser treatments. Methods: Patients with CMN treated with lasers and followed-up for more than 1 year were retrospectively reviewed and patients with more than 3-year follow-up were grouped as the long-term follow-up group. Results: A total of 67 cases of CMN were reviewed. 52 patients were treated with laser only, and 15 patients were treated with combination treatment of partial excision followed by laser treatments. Among 20 patients (20/52, 38.5%) with nearly total clearance during laser-only treatment, 11 patients were in long-term follow-up group and 5 of them showed repigmentation. 15 patients showed repigmentation regardless of clearance, and the mean period until repigmentation was 3.93 years from the initial treatment. Patients with combination treatment of partial excision and lasers showed higher Investigator’s Global Assessment (IGA) scores, less number of laser treatments and shorter treatment period compared to patients with laser-only treatment. Conclusion: More than 4 years of follow-up is required to evaluate the efficacy of lasers in CMN and combination treatment of partial excision and lasers can be an effective treatment option.

Risk factors of recurrence in early-stage cutaneous melanoma without nodal metastasis

( Yeongjoo Oh ),( Sooyie Choi ),( Byung Ho Oh ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Complete removal of primary tumor is only required for localized melanomas, however relapses after removal had been frequently observed which cause poor prognosis. Therefore, predicting the risks of relapse and classifying “high-risk” localized melanomas are essential to define candidates for adjuvant systemic treatments. Objectives: To find out risk factors of recurrence in early-stage melanoma in Korea Methods: In this retrospective study, cutaneous melanoma patients visited and followed-up for more than 6 months at the department of dermatology in Severance hospital from 2000 to 2018, without evidence of nodal or distant metastasis, were retrospectively reviewed. Results: A total of 340 patients diagnosed with cutaneous melanoma and staged as melanoma in situ, stage I or II at Severance Hospital were reviewed. Acral melanoma (239/340) was predominant. 92 patients showed recurrence after the removal of primary melanoma and included 29 local recurrences, 49 regional recurrences (in-transit and regional lymph node metastasis) and 28 distant metastases. Sex(male), Clark level and Breslow thickness deeper than 2mm were correlated with increased risk of recurrence (p<0.05) and shorter relapse-free survival (p<0.05). Conclusion: Sex(male), Clark level and Breslow thickness deeper than 2mm are risk factors for recurrence in Asian early-stage melanoma patients

Two cases of malignant melanoma arising in chronic burn scar

( Yeongjoo Oh ),( Jihee Kim ),( Byung Ho Oh ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Non-melanoma skin cancers are known to frequently arise in chronic burn scar. However, there are only 40 cases of melanoma reported to be arising in burn scar. We report two cases of malignant melanoma arising in extensive chronic burn scar. A 54-year old woman had burn scar from childhood and small area was not healed for more than 1 year. Malignant melanoma was diagnosed on the wound. Another 44-year old woman also had burn scar from childhood and malignant melanoma was diagnosed from the small wound not healed up several months. Mohs micrographic surgery with sentinel lymph node biopsy was done for both patients. The initial image study including PET-CT showed no sign of metastasis. The stage of melanoma was stage IIIB (pT4bN1aM0) and stage IIIA (pT4aN1aM0). Both patients had interferon treatment. After 3months from the surgery, metastasis axillary lymph nodes and newly developed melanoma from the burn scar was found from the first patient and the follow-up PET-CT showed metastatic lesions on bones, lung and liver. The second patient also had newly developed melanoma in situ lesion on the burn scar and metastatic lesions on rib were found through follow-up CT after 4months from the surgery. These two cases had distant metastasis even after Mohs micrographic surgery and we could assume that malignant melanomas arising in chronic burn scar have poor prognosis.

Acral atypical melanosis: A single-centre experience

( Yeongjoo Oh ),( Sooyie Choi ),( Byungho Oh ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Early acral lentiginous melanomas with subtle histopathologic findings are sometimes described as atypical melanocytic proliferation by pathologists. Dermatologists may feel pressure deciding whether to excise the total lesion or not. Objectives: To find out the characteristics and prognosis of the patients with atypical melanocytic proliferation. Methods: This is a retrospective study from single institution. The patients with acral melanocytic lesions described as “atypical melanocytic proliferation” or “atypical melanosis” were included. Results: Acral melanocytic lesions from 38 patients were described as atypical melanocytic proliferation by the pathologists. The lesion was on the nail in 14 patients. After total excision of the lesion, 24 patients were diagnosed as melanoma (18 melanoma in situ and 5 invasive melanoma) and 14 patients showed no malignant portion in the excised lesion. The mean duration between biopsy and excision was longer in melanoma patients (11.68 months vs 7.24 months) which was not statistically significant. Melanoma group showed more parallel ridge patterns than atypical melanosis group on dermoscopy. (9/10 (90%) vs 3/8(37.5%)) Conclusion: Acral atypical melanosis can progress to melanoma and therefore complete excision is recommended.

Prognostic factors of recurrence and validation of staginig systems in cutaneous squamous cell carcinoma removed by Mohs micrographic surgery

( Yeongjoo Oh ),( Byung Ho Oh ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: The prognosis of cutaneous squamous cell carcinoma (cSCC) is associated with recurrence of tumor after the removal and Mohs micrographic surgery (MMS) is considered as the best method for removal of cSCC. Objectives: To find out risk factors of recurrence in cSCC treated after MMS. Methods: In this retrospective study, cSCC patients treated with MMS at the department of dermatology in Severance hospital from 2000 to 2017 were reviewed. Correlation among various clinical factors and recurrence were statistically analyzed. Predictive powers for recurrence of four staging systems for cSCC (AJCC 7th, AJCC 8th, BWH, Breuninger) were analyzed. Results: A total of 241 patients with cSCC treated by MMS were reviewed. A total of 40 patients showed recurrence and 21 showed local recurrences and 19 showed recurrences as distant metastasis. Comorbidity of diabetes, history of preceding Bowens disease and poor differentiation of cSCC were correlated with recurrence. History of trauma on the cSCC site, history of solid organ transplantation and removal of tumor by more than 3 stages of MMS were correlated with local recurrence. Preceding Bowens disease and poor differentiation were correlated with distant metastasis. (all p<0.05) Among four staging systems, AJCC 8th staging system showed highest predictive value. Conclusion: Comorbidity of diabetes, history of preceding Bowen disease and poor differentiation of cSCC are risk factors for recurrence after MMS.