Relative importance of symptoms, cognition, and other multilevel variables for psychiatric disease classifications by machine learning

Walsh-Messinger, Julie,Jiang, Haoran,Lee, Hyejoo,Rothman, Karen,Ahn, Hongshik,Malaspina, Dolores Elsevier/North Holland Biomedical Press 2019 Psychiatry Research Vol. No.

<P><B>Abstract</B></P> <P>This study used machine-learning algorithms to make unbiased estimates of the relative importance of various multilevel data for classifying cases with schizophrenia (<I>n</I> = 60), schizoaffective disorder (<I>n</I> = 19), bipolar disorder (<I>n</I> = 20), unipolar depression (<I>n</I> = 14), and healthy controls (<I>n</I> = 51) into psychiatric diagnostic categories. The Random Forest machine learning algorithm, which showed best efficacy (92.9% SD: 0.06), was used to generate variable importance ranking of positive, negative, and general psychopathology symptoms, cognitive indexes, global assessment of function (GAF), and parental ages at birth for sorting participants into diagnostic categories. Symptoms were ranked most influential for separating cases from healthy controls, followed by cognition and maternal age. To separate schizophrenia/schizoaffective disorder from bipolar/unipolar depression, GAF was most influential, followed by cognition and paternal age. For classifying schizophrenia from all other psychiatric disorders, low GAF and paternal age were similarly important, followed by cognition, psychopathology and maternal age. Controls misclassified as schizophrenia cases showed lower nonverbal abilities, mild negative and general psychopathology symptoms, and younger maternal or older paternal age. The importance of symptoms for classification of cases and lower GAF for diagnosing schizophrenia, notably more important and distinct from cognition and symptoms, concurs with current practices. The high importance of parental ages is noteworthy and merits further study.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Machine-learning algorithms estimated importance of multilevel data for diagnostic classification. </LI> <LI> Symptoms were most influential for differentiating psychiatric cases from healthy controls. </LI> <LI> Function was most important for separating the schizophrenias from affective disorder cases. </LI> <LI> Function and paternal age were equally important for separating schizophrenia from all other cases. </LI> <LI> Misclassified controls had mild symptoms, lower cognition, and/or younger mothers/older fathers. </LI> </UL> </P>

Bounding the Search Number of Graph Products

Clarke, Nancy Ellen,Messinger, Margaret-Ellen,Power, Grace Department of Mathematics 2019 Kyungpook mathematical journal Vol.59 No.1

In this paper, we provide results for the search number of the Cartesian product of graphs. We consider graphs on opposing ends of the spectrum: paths and cliques. Our main result determines the pathwidth of the product of cliques and provides a lower bound for the search number of the product of cliques. A consequence of this result is a bound for the search number of the product of arbitrary graphs G and H based on their respective clique numbers.

Fit in cause-related marketing: An integrative retrospective

John W. Pracejus,Qian (Claire) Deng,G. Douglas Olsen,Paul R. Messinger 한국마케팅과학회 2020 마케팅과학연구 Vol.30 No.2

Thirteen years ago, “The role of brand-cause fit in the effectiveness of cause-related marketing campaigns” was published in the Journal of Business Research. Since then it has been cited over 400 times according to Google Scholar, making it among the top 100 most cited articles published by that journal. The paper’s contribution and impact may be explained by the fact that it demonstrated for the first time that fit in cause-related marketing can impact choice. In addition, the paper used a methodology (choice conjoint) that was, at the time, somewhat novel in the consumer research context. As a result, the paper not only demonstrated the importance of brand-cause fit in CRM, it also demonstrated how choice conjoint could be used to estimate dollar metric values for cause marketing and fit using the stated preferences of individuals making multiple hypothetical choices. Interestingly, these estimates of the dollar value of CRM were lower than the (somewhat high) donation amounts used. This essay attempts to (1) provide background into how the studies came about, (2) give insight into what the paper accomplished (i.e. why it achieved such high impact), (3) describe the subsequent developments in the field of fit in cause marketing by exploring a subset of the 400+ papers which have cited the original work, (4) discuss the managerial implications, and (5) discuss open research questions in this interesting area.

Directing Zeolite Structures into Hierarchically Nanoporous Architectures

Na, Kyungsu,Jo, Changbum,Kim, Jeongnam,Cho, Kanghee,Jung, Jinhwan,Seo, Yongbeom,Messinger, Robert J.,Chmelka, Bradley F.,Ryoo, Ryong American Association for the Advancement of Scienc 2011 Science Vol.333 No.6040

명시적 및 암시적 정치태도의 이해

ShantoIyengar,Solomon Messing,Kyu S. Hahn 한국언론학회 2011 한국언론학회 학술대회 발표논문집 Vol.2011 No.5-2

Risk of second cancer among young prostate cancer survivors

Hong Zhang,Andrew Yu,Andrea Baran,Edward Messing 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.2

Purpose: About 40% of men diagnosed with prostate cancer (Pca) are ≤65 years of age. This study evaluates the risk of second cancer among young Pca patients treated with surgery or radiation. Materials and Methods: This is a retrospective review of 150,915 men aged ≤65 years at Pca diagnosis treated with surgery or radiation registered in the Surveillance, Epidemiology, and End Results (SEER) database between 1973 and 2014. Incidence rates of second rectum/rectosigmoid junction (RJ), bladder, and lung cancer in each treatment group were reported with adjustment for potential confounders. Cumulative incidence functions were used to summarize the risk of second cancer after completing initial treatment. Results: Men treated with external beam radiation (BEAM), brachytherapy (SEED), or combined radiation all exhibited a statistically significant increased incidence of second bladder cancer compared to men treated with surgery (adjusted incidence rate ratio [IRR]: 2.09, 1.91, and 2.04, respectively). Incidence of rectum/RJ cancer was also significantly increased in men receiving BEAM and combined radiation (adjusted IRR: 1.58 and 1.98, respectively). There were also significant differences in the cumulative incidence of second bladder cancer after receiving any form of radiation compared to surgery. Conclusion: Pca survivors ≤65 years of age at Pca diagnosis had an increased risk of second bladder and rectum/RJ cancer after BEAM and combined radiation treatment after adjusting for confounding factors. Second bladder cancer incidence after either form of radiation treatment was increased even at 5 years after a Pca diagnosis.

분사연소합성(SCS)을 위한 평형종 계산과 용액연소공정

전병세,이상진,윤존도,권혁보,Gary L. Messing 한국세라믹학회 2001 한국세라믹학회지 Vol.38 No.6

본 연구에서는 분사연소합성(SCS)을 위한 기초단계로서 용액연소합성에 대한 거동을 살펴보고자 알루미나 합성을 모델로 하였으며 이를 위해 전구체에 대한 열분해거동, 그리고 각 온도에서의 평형종 분압 계산 및 합성과정을 조사하였다. 각각의 열중량 분석(TGA) 결과 산화제와 환원제(연료)의 열분해 이력이 서로 다르게 나타났으며, 열역학 응용 프로그램인 ChemSag에 의한 평형종 분압의 계산에서 연소속도를 저하시킬 수 있는 $CO_2$와 수증기 가스 분압이 상당부분 존재하였다. 산화제/환원제 혼합물의 열분석(DTA/TG) 결과 산화제와 환원제의 열분해 거동의 차이, 그리고 매우 작은 시료의 양으로 인해 263$^{\circ}C$에서 발열피크가 매우 작게 나타났다. 열분석 시료에 비해 발열 에너지를 높이기 위해 산화제와 환원제 혼합 전구체를 비이커에서 증기압을 조절하며 가열시켜 본 결과 27$0^{\circ}C$에서 $\alpha$-Al$_2$O$_3$생성물을 얻을 수 있었다. 따라서 분사연소합성 반응을 통해 세라믹 원료를 합성하기 위해서는 연소과정 중 열분해 거동과 평형종의 분압을 고려하여야 한다.

Impact of a long-lasting adult liquid diet on female reproductive performance in the Mediterranean fruit fly, Ceratitis capitata (Diptera: Tephritidae)

Angelo Canale,Gabriele Gennari,Valeria Leoni,Russell H. Messing,Giovanni Benelli 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.2

Researchers in many countries have devoted great effort to the development and validation of the sterile insect technique (SIT) against a number of tephritid species. To improve SIT cost-effectiveness and applicability against these serious economic pests, itwould be useful to improve currentmass-rearing procedures. While the benefits of using liquid larval diets have beenwidely tested, liquid diets for adult feeding have received far less attention. Here, we report on the impact of low-cost adult liquid diets with a range of sugar:protein ratios on female reproductive performance (i.e. pre-oviposition period, female egg load, larval–pupal developmental rate, adult emergence, sex ratio and longevity of offspring) in the Mediterranean fruit fly, Ceratitis capitata. Protein-deprived females required longer pre-oviposition time and had reduced egg load. No differences were found in the reproductive performance of females fed with liquid vs. solid diet. The proposed liquid diet is readily available to the feeding behaviour of tephritid flies and lasts three times longer than the solid diet composed of the same ingredients.

Insectary production and synopsis of Fopius caudatus (Hymenoptera: Braconidae), parasitoid of tephritid fruit flies indigenous to Africa

Aimé H. Bokonon-Ganta,Mohsen M. Ramadan,Russell H. Messing 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.1

Fopius caudatus (Szépligeti) is an endophagous koinobiont egg-larval parasitoid native to Africa. It has recently been noted as a candidate for augmentative biological control of several Dacinae fruit fly pests (Diptera: Tephritidae), due to its ability to parasitize the egg stage. Previous attempts to establish this parasitoid in Hawaii, Guatemala, and Costa Rica were unsuccessful due to inability to maintain parasitoid colonies under laboratory conditions. A cohort of F. caudatus collected from Kenyan fruit flies infesting Coffea arabica was successfully colonized in Hawaii at 28 °C and 60–80% RH, resulting in the development of a laboratory-adapted colony amenable for mass production. The parasitoid was successfully developed from eggs of Ceratitis capitata and Bactrocera latifrons as a factitious host. The wasps were propagated for 15 weeks until the rearing stabilized, at which point > 10,500 adults were produced with an overall sex ratio of 0.52 females and a mean host parasitism rate of 17.3%. It could parasitize Medfly eggs in fruits other than coffee, including papaya, mango, pear, squash, and sweet pepper. Female F. caudatus oviposited mainly in 24–48 h old Medfly eggs, although occasionally a few individuals eclosed when first instar fly larvae were exposed. Mean developmental time from egg to adult was 19.8 d for males and 21.5 d for females. Mean longevity was 5.2 d for males and 14.2 d for hostdeprived females. This study enabled us to maintain a colony of F. caudatus for research and redistribution to other countries for biocontrol programs against Medfly.

Sequence Comparison of Orthologous Regions in the Sorghum and Maize Genomes

Y. J. Park,C. Y. Kim,E. Linton,O. Y. Jeong,J. Messing,J. Bennetzen,S. J. Seok 한국육종학회 2003 한국육종학회 학술발표회 발표요지 Vol.35 No.3