Microstructure Evolution and Mechanical Properties of AA2099 Al–Li Alloy with Tailored Li‐Containing Precipitates in Uniaxial Compression at Medium Temperature

Li Hu,Mengdi Li,Weijiu Huang,Xusheng Yang,Fei Guo,Haipeng Dong 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.5

Microstructure characteristics and mechanical behavior of AA2099 Al–Li alloy with no pre-existing Li-containing precipitates(AA2099-1 sample), pre-existing δ′ precipitates (AA2099-2 sample), pre-existing T1phase (AA2099-3 sample) andpre-existing T2phase (AA2099-4 sample) are systematically investigated via isothermal uniaxial compression at 250 °C inthe present study. Experimental results demonstrate that at the onset of plastic deformation, dynamic precipitation of smallsizedT1phase occurs rapidly within AA2099-1 sample, while it will be hindered within AA2099-2 sample. The increasingplastic strain benefits to dynamic precipitation of small-sized T1phase in AA2099-2 sample. Consequently, AA2099-1 andAA2099-2 samples possess similar and intermediate mechanical behaviors. In terms of AA2099-3 sample, the existence oflarge-sized T1phase results in the maximum yielding stress. However, some regions within these large-sized T1precipitatesare suspected to be sheared by cross-slip, leading to the destruction of crystallographic structure and the formation of Almatrix intervals. This aspect is responsible for the gradual degradation in true stress-strain curve after peak stress. As forAA2099-4 sample, dynamic precipitation rarely happens during plastic deformation and the interaction between dislocationand the pre-existing T2phase belongs to Orowan looping, resulting in the minimal mechanical response. Besides,AA2099-1 sample possesses the average minimum deviation angle (MDA) of ~ 16.5° between the loading direction and the<110> crystal direction, whereas AA2099-4 sample owns the average MDA of ~ 7.5°. The difference in MDA is mainlyattributed to δ′ phase and T1phase, which will separately accelerate and postpone the rotation of orientation towards the<110> crystal direction.

Recent advances in nano/microparticle-based oral vaccines

Li Mengdie,Kaminskas Lisa M.,Marasini Nirmal 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.4

Background Vaccines are often recognized as one of the most cost-effective public health interventions in controlling infectious diseases. Most pathogens infiltrate the body from mucosal sites, primarily from the oral and pulmonary region and reach the systemic circulation where disease manifestation starts. Traditional needle-based vaccines are usually not capable of inducing immunity at the mucosal sites where pathogen infiltrates start, but induces systemic immunity. In contrast to needle-based vaccines, mucosally administered vaccines induce immunity at both the mucosal sites and systemically. The oral route of immunization is the most convenient way to administer the vaccines. However, due to the complicated and hostile gastrointestinal structure and environment, vaccines need to overcome major hurdles while retaining their stability and immunogenicity. Area covered This review will briefly discuss different barriers to oral vaccine development. It gives a brief overview of different types of nano/microparticle-based oral vaccines and discusses how physicochemical characteristics of the particles influence overall immunity after oral immunization. Expert opinion Formulation strategies using novel lipid and polymer-based nano/microparticle platforms retain stability and antigenicity of vaccines against the harsh gastrointestinal condition. The physicochemical properties of particles can be uniquely tailored to prolong the release of antigens, and attached ligands (M-cells and APC-ligands) can precisely target uptake by immune cells. These represent viable strategies for efficient delivery of oral vaccines.

Integration of Additive Manufacturing in Casting: Advances, Challenges, and Prospects

Mengdi Gao,Lei Li,Qingyang Wang,Zhilin Ma,Xinyu Li,Zhifeng Liu 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.1

Additive manufacturing (AM) is a novel manufacturing technology that can create highly customized products with more complex geometries than traditional techniques. Despite its significant advantages, including the freedom of design, mass customization, and ability to produce complex structures, AM consumes a large amount of energy and incurs high costs. In addition, AM suffers from long production cycles and low production efficiency in the large-scale manufacturing of metal structures. This study offers a review of the existing literature focused on metal AM technology. To avoid the shortcomings of AM and highlight its bene fits, which are widely used for manufacturing in combination with casting. The current combination application of AM and casting is reviewed to provide solutions to the problem of manufacturing large metal components from the perspective of the use of different AM technology and quality control in casting. However, such integration is insufficient for producing large castings with complex shapes, structures, or multiple features. Therefore, a novel method for integrating AM into casting to enable the manufacture of large scale metal parts with complex shapes is introduced as a topic for possible future research. This method divides complex castings with multiple features into an AM processing part and the casting substrate. The complex features were processed by AM on the fabricated casting substrate. This study provides a review of the application of AM into casting and presents a novel idea for the integration application of AM and other processes. This promising method has significant value for future study.

Differential evolution algorithm with improved crossover operation for combined heat and power economic dynamic dispatch problem with wind power

Li Mengdi,Zou Dexuan,Ouyang Haibin 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.4

This paper proposes a differential evolution algorithm with improved crossover operation (ICRDE) to deal with combined heat and power dynamic economic dispatch (CHPDED) problems with wind power. First, the improved crossover operation is used to maintain the population diversity by using original individuals, first mutated individuals, and second mutated individuals. Second, the scaling factor and weighted factor are incorporated into the mutation operation to improve the convergence efficiency of the algorithm. Third, adaptive control parameters are introduced to balance local exploitation and global exploration. Moreover, after being updated by the mutation and crossover operation of ICRDE at each generation, the solutions of ICRDE will be further amended using a constraint handling method, which improves the chance of acquiring feasible solutions. Experimental results demonstrate that ICRDE has strong global optimization ability and surpasses the compared algorithms for the CEC2017 benchmark functions, the combined heat and power economic dispatch problems, and the CHPDED problem with and without wind power.

A Review on Energy Consumption and Efficiency of Selective Laser Melting Considering Support: Advances and Prospects

Qingyang Wang,Mengdi Gao,Qiang Li,Conghu Liu,Lei Li,Xinyu Li,Zhifeng Liu 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.11 No.1

Selective laser melting (SLM) exhibits excellent manufacturing accuracy and forming ability. However, the laser beam layering process is characterized by high specific energy consumption, long manufacturing cycle, and low energy efficiency. The use of supports increases the SLM building quality and eliminates defects caused by thermal and residual stresses; however, an improper support structural design increases the process energy consumption for manufactured parts. To control energy consumption and building quality during SLM, this study first discusses the main challenges related to energy saving and improving the building quality by performing an energy consumption analysis, process energy consumption optimization, and supporting structure optimization. The obtained results reveal that it is difficult to achieve high building quality only by controlling the process parameters and energy consumption by the SLM equipment. Next, the effect of supporting structures on the process energy consumption is examined to enable the construction of an SLM energy consumption model that considers the presence of supports. Finally, the effect of supports on the building quality is elucidated by studying the influence of supporting structures on thermal and residual stresses. By identifying the most energy-efficient support, the process energy efficiency and building quality may be simultaneously optimized. The proposed method represents a new approach to reducing energy consumption and improving the building quality during SLM. This study establishes a theoretical foundation for the subsequent industrial applications, providing a thorough literature review and describing the existing challenges in the SLM manufacturing field.

Transparent, Flexible Heater Based on Hybrid 2D Platform of Graphene and Dry-Spun Carbon Nanotubes

Li, Luhe,Hong, Soon Kyu,Jo, Yeongsu,Tian, Mengdi,Woo, Chae Young,Kim, Soo Hyung,Kim, Jong-Man,Lee, Hyung Woo American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.17

<P>A high-performance, flexible, and transparent heater based on a hybrid of dry-spun carbon nanotubes (CNT), which is pulled out directly from a super vertically aligned CNT forest, and graphene is fabricated. The electrical, optical, and electromechanical properties of two different kinds of hybrid devices, graphene above or below the CNT film, and simple CNT film heating devices that are made of one or two layers of CNTs, are studied. The results prove that the hybrid structured film heaters are superior to the simple CNT film heaters. The simple single-layer CNT film and double-layer CNT film heaters attain maximum temperatures of 48 and 64 °C with transmittances of 73 and 64% at a wavelength of 550 nm, respectively, whereas the single-layer CNT sheet/graphene/PET and graphene/single-layer CNT sheet/PET hybrid heaters attain maximum temperatures of 81 and 85 °C with transmittances of 68 and 71%, respectively. The 10 000 bending cycle test suggests that the graphene/single-layer CNT sheet/PET heater has good mechanical and thermal stability. Further, defrost test and portable heating with a 9 V battery prove the possibility of using the hybrid heater for vehicle defrosting, portable heating, and wearable devices.</P> [FIG OMISSION]</BR>

Energy Efficiency and Dynamic Analysis of a Novel Hydraulic System with Double Actuator

Mengdi Gao,Lei Li,Qingyang Wang,Conghu Liu 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.3

At present, increased attention has been given to energy effi ciency promotion and energy saving of manufacturing equipment and systems. Hydraulic system is widely used in engineering machinery industries; however, the high energy consumption and low energy effi ciency of which limit its development and application. On the basis of previous research on hydraulic system, an energy-effi cient hydraulic system with double actuator is proposed in this study. This hydraulic system can reduce the energy consumption by reusing the potential energy loss of the system. In this novel hydraulic system, the chambers of two actuators are connected with rod by pipes and valves. During the operating processes, the falling operation of one cylinder and the returning operation of the other are synchronized. That is, one actuator remains at the top point performing the demanded operation, whereas the other one remains at the bottom performing the corresponding operation. System models are developed to address the energy consumption and dynamic performance of the proposed hydraulic system. This hydraulic system is applied into a press to study its energy-saving mechanism and dynamic performance during transient under various working conditions. On the basis of the simulation and experimental results, energy and production effi ciency are compared and discussed. Results show that in comparison with the energy and time consumption of the original 630 kN hydraulic press, the energy-saving potential has reached 17.34%, and the production effi ciency can be improved by 18.85%.

Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ

Hongming Li,Yumei Qiu,Mengdie Xie,Changsheng Ouyang,Xiaoyun Ding,Hao Zhang,Wei Dong,Yinhua Xiong,Xilan Tang 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.1

This study aimed to observe the protective effect of momordicine I, a triterpenoid compound extracted from momordica charantia L., on isoproterenol (ISO)-induced hypertrophy in rat H9c2 cardiomyocytes and investigate its potential mechanism. Treatment with 10 μM ISO induced cardiomyocyte hypertrophy as evidenced by increased cell surface area and protein content as well as pronounced upregulation of fetal genes including atrial natriuretic peptide, β-myosin heavy chain, and α-skeletal actin; however, those responses were markedly attenuated by treatment with 12.5 μg/ml momordicine I. Transcriptome experiment results showed that there were 381 and 447 differentially expressed genes expressed in comparisons of model/control and momordicine I intervention/model, respectively. GO enrichment analysis suggested that the anti-cardiomyocyte hypertrophic effect of momordicine I may be mainly associated with the regulation of metabolic processes. Based on our transcriptome experiment results as well as literature reports, we selected glycerophospholipid metabolizing enzymes group VI phospholipase A2 (PLA2G6) and diacylglycerol kinase ζ (DGK-ζ) as targets to further explore the potential mechanism through which momordicine I inhibited ISO-induced cardiomyocyte hypertrophy. Our results demonstrated that momordicine I inhibited ISO-induced upregulations of mRNA levels and protein expressions of PLA2G6 and DGK-ζ. Collectively, momordicine I alleviated ISO-induced cardiomyocyte hypertrophy, which may be related to its inhibition of the expression of glycerophospholipid metabolizing enzymes PLA2G6 and DGK-ζ.

질소 플라즈마로 표면 처리한 그래핀 전극 기반 유기태양전지 제작

조영수,우채영,Li Luhe,Tian Mengdi,홍순규,이형우 한국에너지학회 2018 한국에너지공학회 학술발표회 Vol.2018 No.04

Analysis and Optimization of Energy Consumption for Multi-part Printing Using Selective Laser Melting and Considering the Support Structure

Zhilin Ma,Mengdi Gao,Kai Guo,Qingyang Wang,Lei Li,Conghu Liu,Guang Zhu,Zhifeng Liu 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.3

Selective laser melting (SLM) can form complex and precise metal parts simultaneously and is widely used in medical and aerospace fields. The support structure plays an important role in SLM process, including supporting the overhanging structure, dissipating heat, and minimizing geometric deformation caused by internal stress. However, a non-optimal support structure causes increased energy and material consumption during processing and must be removed afterward to allow for utilization of the parts. Existing support structure design methods only consider reducing the support of a single part, and research on the support and energy consumption of simultaneous multi-part printing is lacking. Therefore, to reduce the energy and material consumption of simultaneous multi-part printing by SLM and improve processing efficiency, an energy consumption analysis and optimization method is proposed in this study from the perspective of the support structure. Based on previous studies on energy consumption distribution of the additive manufacturing process, a multi-component SLM energy consumption and material consumption model was established. Furthermore, a shared-support optimization strategy for simultaneous multi-part processing is proposed. For optimization, the method selects the appropriate printing direction of one part, and then combines multiple parts to form a shared support structure to minimize energy consumption. Finally, under the constraint of minimizing the mass, an optimization strategy of the SLM multi-part shared support combination is established, and the purpose of reducing the energy consumption and material consumption of the SLM is achieved under the premise of ensuring the geometric accuracy of the parts. The method was applied to the manufacturing process of a group of parts with a beam structure. Compared with the printing method using independent support, the shared support structure method reduced energy consumption more than 5.5%, material consumption for the support structure more than 17.2%, and printing time to a certain extent. This method effectively improves SLM production efficiency and sustainability and provides strategic support for additive manufacturing designers and producers.