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Corté,s, M.L.,Rodriguez, W.,Doornenbal, P.,Obertelli, A.,Holt, J.D.,Lenzi, S.M.,Mené,ndez, J.,Nowacki, F.,Ogata, K.,Poves, A.,Rodrí,guez, T.R.,Schwenk, A.,Simonis, J.,Stroberg, S.R. North-Holland Pub. Co 2020 Physics letters. Section B Vol.800 No.-
<P><B>Abstract</B></P> <P>Excited states in the N = 40 isotone <SUP>62</SUP>Ti were populated via the <SUP>63</SUP>V ( p , 2 p ) <SUP>62</SUP>Ti reaction at ∼200 MeV/nucleon at the Radioactive Isotope Beam Factory and studied using <I>γ</I>-ray spectroscopy. The energies of the 2 1 + → 0 gs + and 4 1 + → 2 1 + transitions, observed here for the first time, indicate a deformed <SUP>62</SUP>Ti ground state. These energies are increased compared to the neighboring <SUP>64</SUP>Cr and <SUP>66</SUP>Fe isotones, suggesting a small decrease of quadrupole collectivity. The present measurement is well reproduced by large-scale shell-model calculations based on effective interactions, while ab initio and beyond mean-field calculations do not yet reproduce our findings. The shell-model calculations for <SUP>62</SUP>Ti show a dominant configuration with four neutrons excited across the N = 40 gap. Likewise, they indicate that the N = 40 island of inversion extends down to Z = 20 , disfavoring a possible doubly magic character of the elusive <SUP>60</SUP>Ca.</P>
Jung, Man-Young,Park, Soo-Je,Kim, So-Jeong,Kim, Jong-Geol,Sinninghe Damsté,, Jaap S.,Jeon, Che Ok,Rhee, Sung-Keun American Society for Microbiology 2014 Applied and environmental microbiology Vol.80 No.12
<P>Soil nitrification plays an important role in the reduction of soil fertility and in nitrate enrichment of groundwater. Various ammonia-oxidizing archaea (AOA) are considered to be members of the pool of ammonia-oxidizing microorganisms in soil. This study reports the discovery of a chemolithoautotrophic ammonia oxidizer that belongs to a distinct clade of nonmarine thaumarchaeal group I.1a, which is widespread in terrestrial environments. The archaeal strain MY2 was cultivated from a deep oligotrophic soil horizon. The similarity of the 16S rRNA gene sequence of strain MY2 to those of other cultivated group I.1a thaumarchaeota members, i.e., <I>Nitrosopumilus maritimus</I> and “<I>Candidatus</I> Nitrosoarchaeum koreensis,” is 92.9% for both species. Extensive growth assays showed that strain MY2 is chemolithoautotrophic, mesophilic (optimum temperature, 30°C), and neutrophilic (optimum pH, 7 to 7.5). The accumulation of nitrite above 1 mM inhibited ammonia oxidation, while ammonia oxidation itself was not inhibited in the presence of up to 5 mM ammonia. The genome size of strain MY2 was 1.76 Mb, similar to those of <I>N. maritimus</I> and “<I>Ca</I>. Nitrosoarchaeum koreensis,” and the repertoire of genes required for ammonia oxidation and carbon fixation in thaumarchaeal group I.1a was conserved. A high level of representation of conserved orthologous genes for signal transduction and motility in the noncore genome might be implicated in niche adaptation by strain MY2. On the basis of phenotypic, phylogenetic, and genomic characteristics, we propose the name “<I>Candidatus</I> Nitrosotenuis chungbukensis” for the ammonia-oxidizing archaeal strain MY2.</P>
Comeró,n, Sé,bastien,Elmegreen, Bruce G.,Knapen, Johan H.,Sheth, Kartik,Hinz, Joannah L.,Regan, Michael W.,Gil de Paz, Armando,Muñ,oz-Mateos, Juan-Carlos,Mené,ndez-Delmestre, K IOP Publishing 2011 ASTROPHYSICAL JOURNAL LETTERS - Vol.738 No.2
<P>NGC 4013 is a nearby Sb edge-on galaxy known for its 'prodigious' Hi warp and its 'giant' tidal stream. Previous work on this unusual object shows that it cannot be fitted satisfactorily by a canonical thin+thick disk structure. We have produced a new decomposition of NGC 4013, considering three stellar flattened components (thin+thick disk plus an extra and more extended component) and one gaseous disk. All four components are considered to be gravitationally coupled and isothermal. To do so, we have used the 3.6 mu m images from the Spitzer Survey of Stellar Structure in Galaxies. We find evidence for NGC 4013 indeed having a thin and a thick disk and an extra flattened component. This smooth and extended component (scale height z(EC) similar to 3 kpc) could be interpreted as a thick disk or as a squashed ellipsoidal halo and contains similar to 20% of the total mass of all three stellar components. We argue it is unlikely to be related to the ongoing merger or due to the off-plane stars from a warp in the other two disk components. Instead, we favor a scenario in which the thick disk and the extended component were formed in a two-stage process, in which an initially thick disk has been dynamically heated by a merger soon enough in the galaxy history to have a new thick disk formed within it.</P>
THE THICK DISK IN THE GALAXY NGC 4244 FROM S<sup>4</sup>G IMAGING
Comeró,n, Sé,bastien,Knapen, Johan H.,Sheth, Kartik,Regan, Michael W.,Hinz, Joannah L.,Gil de Paz, Armando,Mené,ndez-Delmestre, Karí,n,Muñ,oz-Mateos, Juan-Carlos,Seibert, IOP Publishing 2011 The Astrophysical journal Vol.729 No.1
<P>If thick disks are ubiquitous and a natural product of disk galaxy formation and/or evolution processes, all undisturbed galaxies that have evolved during a significant fraction of a Hubble time should have a thick disk. The late-type spiral galaxy NGC 4244 has been reported as the only nearby edge-on galaxy without a confirmed thick disk. Using data from the Spitzer Survey of Stellar Structure in Galaxies (S(4)G) we have identified signs of two disk components in this galaxy. The asymmetries between the light profiles on both sides of the mid-plane of NGC 4244 can be explained by a combination of the galaxy not being perfectly edge-on and a certain degree of opacity of the thin disk. We argue that the subtlety of the thick disk is a consequence of either a limited secular evolution in NGC 4244, a small fraction of stellar material in the fragments which built the galaxy, or a high amount of gaseous accretion after the formation of the galaxy.</P>
A Bacterial Tyrosine Phosphatase Inhibits Plant Pattern Recognition Receptor Activation
Macho, Alberto P.,Schwessinger, Benjamin,Ntoukakis, Vardis,Brutus, Alexandre,Segonzac, Cé,cile,Roy, Sonali,Kadota, Yasuhiro,Oh, Man-Ho,Sklenar, Jan,Derbyshire, Paul,Lozano-Durá,n, Rosa,Mal American Association for the Advancement of Scienc 2014 Science Vol.343 No.6178
<P><B>Move and Countermove</B></P><P>Receptors on plant cell surfaces are tuned to recognize molecular patterns associated with pathogenic bacteria. <B>Macho <I>et al.</I></B> (p. 1509; published online 13 March) found that activation of one of these receptors in <I>Arabidopsis</I> results in phosphorylation of a specific tyrosine residue, which in turn triggers the plant's immune response to the phytopathogen <I>Pseudomonas syringae. P. syringae</I> counters by secreting a specifically targeted phosphatase, thus stalling the plant's immune response.</P>
Milne, Roger L.,Burwinkel, Barbara,Michailidou, Kyriaki,Arias-Perez, Jose-Ignacio,Zamora, M. Pilar,Mené,ndez-Rodrí,guez, Primitiva,Hardisson, David,Mendiola, Marta,Gonzá,lez-Neira, A IRL Press 2014 Human molecular genetics Vol.23 No.22
<P>Candidate variant association studies have been largely unsuccessful in identifying common breast cancer susceptibility variants, although most studies have been underpowered to detect associations of a realistic magnitude. We assessed 41 common non-synonymous single-nucleotide polymorphisms (nsSNPs) for which evidence of association with breast cancer risk had been previously reported. Case-control data were combined from 38 studies of white European women (46 450 cases and 42 600 controls) and analyzed using unconditional logistic regression. Strong evidence of association was observed for three nsSNPs: <I>ATXN7-</I>K264R at 3p21 [rs1053338, per allele OR = 1.07, 95% confidence interval (CI) = 1.04–1.10, <I>P</I> = 2.9 × 10<SUP>−6</SUP>], <I>AKAP9-</I>M463I at 7q21 (rs6964587, OR = 1.05, 95% CI = 1.03–1.07, <I>P</I> = 1.7 × 10<SUP>−6</SUP>) and <I>NEK10-</I>L513S at 3p24 (rs10510592, OR = 1.10, 95% CI = 1.07–1.12, <I>P</I> = 5.1 × 10<SUP>−17</SUP>). The first two associations reached genome-wide statistical significance in a combined analysis of available data, including independent data from nine genome-wide association studies (GWASs): for <I>ATXN7-</I>K264R, OR = 1.07 (95% CI = 1.05–1.10, <I>P</I> = 1.0 × 10<SUP>−8</SUP>); for <I>AKAP9-</I>M463I, OR = 1.05 (95% CI = 1.04–1.07, <I>P</I> = 2.0 × 10<SUP>−10</SUP>). Further analysis of other common variants in these two regions suggested that intronic SNPs nearby are more strongly associated with disease risk. We have thus identified a novel susceptibility locus at 3p21, and confirmed previous suggestive evidence that rs6964587 at 7q21 is associated with risk. The third locus, rs10510592, is located in an established breast cancer susceptibility region; the association was substantially attenuated after adjustment for the known GWAS hit. Thus, each of the associated nsSNPs is likely to be a marker for another, non-coding, variant causally related to breast cancer risk. Further fine-mapping and functional studies are required to identify the underlying risk-modifying variants and the genes through which they act.</P>
Ji, Seungwon,Lee, Jin-Young,Schrö,r, Jan,Mazumder, Aloran,Jang, Dong Man,Chateauvieux, Sé,bastien,Schnekenburger, Michael,Hong, Che Ry,Christov, Christo,Kang, Hyoung Jin,Lee, Youngjo,Han, By Elsevier 2018 Cancer letters Vol.416 No.-
<P><B>Abstract</B></P> <P>Stemphol (STP) is a novel druggable phytotoxin triggering mixed apoptotic and non-apoptotic necrotic-like cell death in human acute myeloid leukemia (AML). Use of several chemical inhibitors highlighted that STP-induced non-canonical programmed cell death was Ca<SUP>2+</SUP>-dependent but independent of caspases, poly (ADP-ribose) polymerase-1, cathepsin, or calpains. Similar to thapsigargin, STP led to increased cytosolic Ca<SUP>2+</SUP> levels and computational docking confirmed binding of STP within the thapsigargin binding pocket of the sarco/endoplasmic reticulum (ER) Ca<SUP>2+</SUP>-ATPase (SERCA). Moreover, the inositol 1,4,5-trisphosphate receptor is implicated in STP-modulated cytosolic Ca<SUP>2+</SUP> accumulation leading to ER stress and mitochondrial swelling associated with collapsed cristae as observed by electron microscopy. Confocal fluorescent microscopy allowed identifying mitochondrial Ca<SUP>2+</SUP> overload as initiator of STP-induced cell death insensitive to necrostatin-1 or cycloheximide. Finally, we observed that STP-induced necrosis is dependent of mitochondrial permeability transition pore (mPTP) opening. Importantly, the translational immunogenic potential of STP was validated by HMGB1 release of STP-treated AML patient cells. STP reduced colony and <I>in vivo</I> tumor forming potential and impaired the development of AML patient-derived xenografts in zebrafish.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Stemphol induces cell death by disrupting calcium homeostasis. </LI> <LI> Stemphol induces necrosis by mediating mPTP opening. </LI> <LI> Stemphol triggers immunogenic cell death markers ER stress and HMGB1 release. </LI> <LI> Stemphol impairs development of leukemia patient-derived zebrafish xenografts. </LI> </UL> </P>