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        Prevalence of Dyslipidemia and Hypertension in Indian Type 2 Diabetic Patients with Metabolic Syndrome and its Clinical Significance

        Dhananjay Yadav,Meerambika Mishra,Arvind Tiwari,Prakash Singh Bisen,Hari Mohan Goswamy,G.B.K.S. Prasad 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.3

        Objectives: The present study was designed to estimate the prevalence of dyslipidemia and hypertension based on the National Cholesterol Educational Programme Adult Treatment Panel III definition of metabolic syndrome (MetS). The study also focuses on prevalence for MetS with respect to the duration of disease in GwalioreChambal region of Madhya Pradesh, India. Methods: Type 2 diabetic patients (n = 700) were selected from a crosssectional study that is regularly being conducted in the School of Studies in Biochemistry, Jiwaji University Gwalior, India. The period of our study was from January 2007 to October 2009. Dyslipidemia and hypertension were determined in type 2 diabetic patients with MetS as per National Cholesterol Educational Programme Adult Treatment Panel III criteria. Results: The mean age of the study population was 54±9.3 years with 504 (72%) males and 196 (28%) females. The prevalence of MetS increased with increased duration of diabetes in females; however, almost constant prevalence was seen in the males. Notable increase in the dyslipidemia (64.1%) and hypertension (49%) in type 2 diabetic patients were seen. The steep increase in dyslipidemia and hypertension could be the reason for the growing prevalence of diabetes worldwide. The study also noted a close association between age and occurrence of MetS. Conclusion: Individual variable of MetS appears to be highly rampant in diabetic population. Despite treatment, almost half of patients still met the criteria for MetS. Effective treatment of MetS components is required to reduce cardiovascular risk in diabetes mellitus hence accurate and early diagnosis to induce effective treatment of MetS in Indian population will be pivotal in the prevention of cardiovascular disease and type 2 diabetes.

      • Evaluation of Cucurbita ficifolia Juice as a Hepatoprotective Drug in Human Type 2 Diabetes

        ( Dhananjay Yadav ),( Amita Jain ),( Meerambika Mishra ),( Arvind Tiwari ),( Gbks Prasad ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Aims: The present study has been undertaken to analyze the hepatoprotective potential of Cucurbita ficifolia juice in type 2 diabetic subjects. Methods: A total 34 subjects were selected for the study out of which 14 subjects were with type 2 diabetes mellitus, 10 subjects were selected as a normal control group and 10 subjects were selected as a normal treated group. The patients had type 2 diabetes for more than 2 years, their mean age was less than 45 years, and subjects were then asked to start the Cucurbita ficifolia juice therapy starting at day 0 and continuing up to 40 day both for diabetic and normal subjects. Liver enzymes such as. serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), and bilirubin were measured. Results: After 40 days of Cucurbita ficifolia juice therapy, there was a decrease of 9.45% and 27.85% (P<0.01) for SGPT and total serum bilirubin, while the SGOT levels increased by 2.02% in the case of diabetic treated subjects that was not found to be significant. Conclusions: The liver enzymes measured in our study ameliorated in type 2 diabetic patients. The results suggest that the Cucurbita ficifolia juice therapy could be used as a hepatoprotective drug in type 2 diabetes.

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