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RISS 인기검색어
- 검색키워드
- 저자 : Md. Nazmul Hasan Zilani (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Bioactivities of leaf and root extract of Ceriscoids turgida (Roxb.)
Md. Nazmul Hasan Zilani,Nazneen Ahmeda Sultana,Monjurul Kader Bakshi,Israt Jahan Shampa,Samia Jaman Sumi,Ohidul Islam 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.2
In traditional medicine leaf and root of Ceriscoides turgida (Roxb.) are commonly used to treat indigestion in child, leucorrhoea, dog bite, snake bite, scorpion string, epilepsy, stomachache and a number of ailments. The present study was carried out to investigate antioxidant, analgesic, antibacterial and cytotoxic activities of methanol extract of leaves and roots of C. turgida. Total flavonoids content was spectrophotometrically determined using aluminum chloride colorimetric assay while total phenolic and tannin content by Folin Chiocalteu’s reagent. Antioxidant activity was determined by DPPH free radical scavenging and reducing power assay. Analgesic activity was assessed by acetic acid induced writhing method. Antibacterial activity was evaluated by disc diffusion assay while brine shrimp lethality bioassay was carried out to verify the cytotoxic potential. Root extract contains greater amount of total phenolic (79.99 mg GAE/g dry extract) and flavonids content (35.27 mg QE/g dry extract) in comparison to leaf extract (30.75 mg GAE/g and 25.93 mg QE/g dry extract respectively). Root extracts showed DPPH scavenging (157.45 μg/mL) that was comparable to standard ascorbic acid (14.15 μg/mL). Reducing power of root extract was prominent than leaf extract in comparison to ascorbic acid. Both extract showed significant (P < 0.01) analgesic activity. In disc diffusion assay leaf extract showed greater antibacterial activity than root extract. Furthermore, extracts showed moderate cytotoxic effect. The present study demonstrates that methanol extract of C. turgida leaf and root has significant antioxidant and analgesic effect. The extracts also showed moderate antibacterial and cytotoxic activities.
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Chemical characterization and bioactivity of Trichosanthes dioica edible shoot extract
Md. Nazmul Hasan Zilani,Shaikh Jamal Uddin,Hemayet Hossain,Hazrina Hazni,Jamil A. Shilpi,Md. Golam Hossain 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.2
Present investigation was aimed to evaluate the traditional use of edible part of soft shoots of Trichosanthes dioica Roxb. (Cucurbitaceae) as an antidiabetic in mice model. In addition, antioxidant activity and chemical profiling of this plant part were also performed to support its observed activity. The extract was subjected to oral glucose tolerance test in normal and alloxan induced diabetic mice to explore its antihyperglycemic activity. Antioxidant capacity was analyzed by a number of in vitro assays. Quantification of bioactive polyphenols was done by HPLC. Liquid Chromatography coupled with Mass Spectrometry (LCMS) was used to identify chemical constituents present in the extract. Total polyphenol and flavonoids content were found in significant quantity. In DPPH radical scavenging assay the IC50 value of the extract was found to be 148.62 µg/mL. Reducing power of the extract was comparable with that of butylatedhydroxytoluene (BHT). HPLC analysis indicated that quercetin, rutin, p-coumaric acid and kaempferol were the major bioactive polyphenols present in the extract. Further chemical profiling using LCMS analysis was identified a total of nine compounds with different chemical classes. In OGTT, extract (400 mg/kg BW) showed a 31.13% decrease (p < 0.05) in blood glucose levels at 30 min compared to the normal control. In alloxan induced diabetic mice the extract at the doses of 200 mg and 400 mg/kg, showed significant decrease (p < 0.05) of blood glucose level compared to diabetic control. The extract showed oral glucose tolerance potential and antioxidant capacity which might be due to the presence of different compounds such as quercetin, rutin, kaempferol, oleanolic acid, β-sitosterol. The results support the scientific basis of it ethnobotanical uses in traditional medicinal practices of Bangladesh.
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Sarkar Kishore Kumar,Rahman Md. Muzibar,Shahriar Abdullah Al Ehsan,Mitra Trina,Golder Mimi,Zilani Md. Nazmul Hasan,Biswas Biswajit 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.3
Mimusops elengi Linn. is traditionally used as antianxiety, cytotoxic, antimicrobial, antioxidants etc. Also, conventionally, Alstonia scholaris Linn. is used in treating cancer, psychosis, nociception etc. The present study was designed to appraise neuropharmacological and cytotoxic potential of M. elengi and A. scholaris leaves. Hole cross and hole board tests were conducted for assessing sedative effect, thiopental sodium induced sleeping time test for hypnotic property, elevated plus maze (EPM) test for anxiolytic potential, tail suspension test for antidepressant effect and finally brine shrimp lethality bioassay for evaluating cytotoxic potential of both extracts. In both hole cress and hole board tests, M. elengi leaves (MEL) displayed greater locomotion reduction compared to A. scholaris leaves (ASL). Besides, in thiopental sodium induced sleeping time and EPM test, both extracts confirmed significant (p < 0.05) hypnotic and anxiolytic potential where MEL showed better effectiveness than ASL. Moreover, an increase in the duration of immobility after oral administration of extracts in tail suspension test depicts no antidepressant effect rather a depressing action. Finally, both extracts exhibited potent cytotoxic property in brine shrimp lethality bioassay where the LC50 values for ASL and MEL were 61.85 and 67.2 µg/ml, respectively. So, ASL and MEL extracts revealed significant neuropharmacological impact as well as impressive cytotoxic potential that justify the traditional uses of both plants.
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