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RISS 인기검색어
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- 저자 : Shahriar Abdullah Al Ehsan (검색결과 1 건)
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Sarkar Kishore Kumar,Rahman Md. Muzibar,Shahriar Abdullah Al Ehsan,Mitra Trina,Golder Mimi,Zilani Md. Nazmul Hasan,Biswas Biswajit 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.3
Mimusops elengi Linn. is traditionally used as antianxiety, cytotoxic, antimicrobial, antioxidants etc. Also, conventionally, Alstonia scholaris Linn. is used in treating cancer, psychosis, nociception etc. The present study was designed to appraise neuropharmacological and cytotoxic potential of M. elengi and A. scholaris leaves. Hole cross and hole board tests were conducted for assessing sedative effect, thiopental sodium induced sleeping time test for hypnotic property, elevated plus maze (EPM) test for anxiolytic potential, tail suspension test for antidepressant effect and finally brine shrimp lethality bioassay for evaluating cytotoxic potential of both extracts. In both hole cress and hole board tests, M. elengi leaves (MEL) displayed greater locomotion reduction compared to A. scholaris leaves (ASL). Besides, in thiopental sodium induced sleeping time and EPM test, both extracts confirmed significant (p < 0.05) hypnotic and anxiolytic potential where MEL showed better effectiveness than ASL. Moreover, an increase in the duration of immobility after oral administration of extracts in tail suspension test depicts no antidepressant effect rather a depressing action. Finally, both extracts exhibited potent cytotoxic property in brine shrimp lethality bioassay where the LC50 values for ASL and MEL were 61.85 and 67.2 µg/ml, respectively. So, ASL and MEL extracts revealed significant neuropharmacological impact as well as impressive cytotoxic potential that justify the traditional uses of both plants.
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