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Haque, Md. Nazmul,Bhuiyan, Mohammad Maqueshudul Haque,Moon, Il Soo Elsevier 2018 Nutrition research Vol.56 No.-
<P>The naturally occurring phytosterol stigmasterol (ST) ameliorates scopolamine-induced memory impairment and promotes neuritogenesis and synaptogenesis. Therefore, in this study, we investigated the hypothesis that ST promotes spinogenesis and the formation of glutamatergic synapses and thus improves memory in cultured rat hippocampal neurons. Immunoblots showed that ST activated extracellular signal-regulated kinase 1/2 (Erk1/2) and cAMP response element binding protein (Creb), and upregulated actin-related protein 2 (Arp2) and cell division cycle 42 (Cdc42), central components in actin organization and spine head development. Consistently, DiO staining of live neurons showed that ST increased the densities of dendritic filopodia and mushroom-type mature spines, and immunocytochemistry showed an increase in the expressions of the GluN2A and GluN2B subunits of N-methyl-D-aspartate receptors (NMDARs) at synapses. Finally, staining the recycling membranes with FM1-43 showed that ST increased the sizes of synaptic vesicle pools at presynaptic terminals. Together, our data indicate that ST upregulates Cdc42-Arp2/3 and Erk1/2-Creb signaling and thus induces the formations of mushroom-type spines and glutamatergic excitatory synapses. (C) 2018 Elsevier Inc. All rights reserved.</P>
Haque, Md. Nazmul,Moon, Il Soo Elsevier 2018 Phytomedicine Vol.46 No.-
<P>Conclusion: The study indicates that ST upregulates genes for neuritogenesis and synaptogenesis, and suggests ST be viewed as a potential resource for improving brain functions.</P>
Md. Mohibbullah,최재석,Mohammad Maqueshudul Haque Bhuiyan,Md. Nazmul Haque,Md. Khalilur Rahman,문일수,홍용기 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.5
Exogenous neurotrophins can induce neuronal differentiation, outgrowth, survival, and synaptic function in the central nervous system. In primary cultures of rat hippocampal neurons, an ethanol extract of the red alga Gracilariopsis chorda (GCE) and its active compound arachidonic acid (AA) significantly increased the densities of dendritic filopodia and spines, promoted the expression of presynaptic vesicle protein 2 (SV2) and postsynaptic density protein 95 (PSD-95), induced robust synaptogenesis, and increased the expression of cell division control protein 42 (CDC42) and actin-related protein 2 (ARP2), which are important for actin organization in dendritic protrusions, and facilitated presynaptic plasticity by increasing the size of the synaptic vesicle pool at presynaptic nerve terminals. In addition, oral administration of GCE and AA for 10 days, at concentrations of 1 mg/g and 2.2 μg/g body weight, respectively, significantly protected against scopolamine-induced memory impairment in mice by increasing the latency time in the passive avoidance test. These results provide strong scientific evidence that these natural products can be used as neurotrophic substances and/or dietary supplements for the prevention and treatment of memory-related neurological disorders via the reconstruction of axo-dendrites and its synapses.
Analysis of analog neuron circuit using 180nm CMOS process for Brain-Inspired Neural Networks
Md Nazmul Haque,Samiur Rahman Khan,Mohammad Khaleqi Qaleh Jooq,AlaaDdin Al-Shidaifat,Hanjung Song 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.11
The investigation on biological neurons and synapses behavior in the human brain, a CMOS neuromorphic system is implemented to mimic the behavior of biological neurons. Since the basic properties of silicon neurons are fixed at the time of design and after the chip fabrication, it is impossible to change the design. it is critical to implement a circuit that is an accurate model of the real neurons while being compact, low-power, and compatible with asynchronous logic. I have implemented the proposed integrating and firing neuron circuit in the 180nm CMOS technology node using Cadence program and investigated the resulting characteristics.
Gabriel Tirtawijaya,Md. Nazmul Haque,Jae Sue Choi,Il Soo Moon,Maria Dyah Nur Meinita,Jae-Suk Choi,Yong-Ki Hong 한국식품영양과학회 2019 Preventive Nutrition and Food Science Vol.24 No.4
Neurotrophic factors promote the formation of spines and synapses in neuron development and maintenance. Synaptic connections enhance memory in the brain. In this study, the effects of Kappaphycus alvarezii ethanolic extract (EKA) and its isolated cholesterol (iCHOL) on spinogenesis and synaptogenesis of hippocampal neurons were evaluated. Compared with the vehicle, both EKA and iCHOL significantly promoted generation of dendritic filopodia (2.4- and 2.2- fold, respectively) and spine (1.7- and 1.4-fold) formations in spinogenesis; they also increased presynaptic (3.6- and 2.6- fold), postsynaptic (2.5- and 2.9-fold), and cocolonized (3.8- and 3.0-fold) puncta, which enhances synaptic function (P< 0.05). Further, EKA- and iCHOL-treated neurons showed significantly improved functional presynaptic plasticity (1.6- and 1.4-fold, respectively, at 17 days in vitro; P<0.05). These results indicate that K. alverezii facilitates neuronal development, and support its use as a functional food to reduce neurological disorders and prevent brain aging via helping to reconstruct partially damaged neural networks.
A study on different memristor model for neuromorphic applications
Samiur Rahman Khan,Md Nazmul Haque,Mohammad Khaleqi Qaleh,AlaaDdin Al-Shidaifat,Hanjung Song 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.11
Memristor provides hope of becoming an alternative for next-generation memory with several features such as logic implementation, signal processing, neuromorphic systems, and nonvolatility and low power compared to CMOS-based memories. Many memristor models that have been developed. This paper is going to discuss the mathematical model of those models and show the output results of different models and their hysteresis loops.