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Investigation of the optical potentials for the 40Ca(α,t)41Sc reaction at 40 MeV
Mazumder U. K.,Somadder A.,Hoque E.,Das S. K. 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.80 No.7
The 40Ca(α,t)41Sc reaction has been studied at a 40 MeV incident energy. The angular distributions of the eight states of the reaction are analyzed using the full finite-range (FFR) distorted-wave Born approximation (DWBA) for both the bound and the unbound states of the 41Sc nucleus using the normal optical, Michel and molecular potentials. The spectroscopic factors that have been extracted for the three optical potentials are compared with the previous local zero-range (LZR) and local finite-range (LFR) calculations of the 40Ca(α,t)41Sc reaction for the normal optical potential. The χ2 values of all the potentials for different l transfers are calculated to estimate the quality of fits. The present analysis shows that the Michel and the molecular potentials fit the data more satisfactorily than the normal optical potential.
Gupta, M.,Mazumder, U.K.,Haldar, P.K.,Manikandan, L.,Senthilkumar, G.P.,Kander, C.C. Kyung Hee Oriental Medicine Research Center 2004 Oriental pharmacy and experimental medicine Vol.4 No.2
The plant Indigofera aspalathoides are used by a large number of tribes in India for the treatment of various hepatic disorder. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its effect on carbontetrachloride $(CCl_{4})$ induced liver damage. Biochemical parameters such as serum glutamine oxaloacetate trasaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein (TP), thiobarbituric acid reactive substances (TBRS) and glutathione content of the liver were estimated to assess liver function and metabolism. Biochemical observations suggest that methanol extract of Indigofera aspalathoides (MEIA) significantly restored the liver function and metabolism towards normal condition in $CCl_{4}$-induced hepatic damage.
Antisteroidogenic activity of Raphanus sativus seed extract in female albino mice
Haldar, P.K.,Mazumder, U.K.,Bhattacharya, Sanjib,Manikandan, L.,Bhattacharya, Siladitya Kyung Hee Oriental Medicine Research Center 2009 Oriental pharmacy and experimental medicine Vol.9 No.4
The defatted methanol extract of Raphanus sativus Linn. (Cruciferae) seed (MERS) was evaluated for its antisteroidogenic potential in mature female Swiss albino mice. The methanol extract at the doses of 100 and 200 mg/kg body weight significantly elevated the levels of cholesterol and ascorbic acid contents which serve as a precursor for the synthesis of steroid hormones in ovaries. The extract also significantly inhibited glucose-6-phosphate dehydrogenase and ${\Delta}^5-3{\beta}$-hydroxy steroid dehydrogenase, the two key enzymes involved in ovarian steroidogenesis. Hence the extract (MERS) exhibited significant antisteroidogenic activity.
Pre clinical studies of Streblus asper Lour in terms of behavioural safety and toxicity
R. B. Suresh Kumar,A. Puratchikodi,Angelene Prasanna,Narayan Dolai,Piyali Majumder,U. K. Mazumder,P. K. Haldar 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
Streblus asper Lour (Family: Moraceae) is a medicinal plant wildly grows in most part of Asian countries. It has many traditional uses like leprosy, piles,diarrhoea, dysentery, elephantiasis, cancer etc. This present study was relates in terms of behavioural safety and toxicity studies of methanol and petroleum ether extracts of S. asper. Brine Shrimps lethality bioassay method was established for the present study and cytotoxicity was reported in terms of 50% lethality concentration (LC_(50)). Different concentrations of drug solutions were added to the Brine Shrimps, surviving shrimps were counted after 24 h and 50% lethality concentration (LC_(50)) were assessed. Acute toxicity was studied on Swiss albino mice after single dose. Sub-Chronic toxicity was performed for 28 days and assessed with biochemical and histopathological parameters. On cytotoxicity studies of brine shrimps it was found methanol extract of S. asper (MESA) was weakly toxic, may be due to the presence of cardiac glycosides and bioactive compounds, however petroleum ether extract of S. asper (PESA) was non toxic. But, in case of acute and sub-acute toxicity study both extracts were found to be non-toxic.
Pre clinical studies of $Streblus$ $asper$ Lour in terms of behavioural safety and toxicity
Kumar, R.B. Suresh,Puratchikodi, A.,Prasanna, Angelene,Dolai, Narayan,Majumder, Piyali,Mazumder, U.K.,Haldar, P.K. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4
$Streblus$ $asper$ Lour (Family: Moraceae) is a medicinal plant wildly grows in most part of Asian countries. It has many traditional uses like leprosy, piles, diarrhoea, dysentery, elephantiasis, cancer etc. This present study was relates in terms of behavioural safety and toxicity studies of methanol and petroleum ether extracts of $S.$ $asper$. Brine Shrimps lethality bioassay method was established for the present study and cytotoxicity was reported in terms of 50% lethality concentration ($LC_{50}$). Different concentrations of drug solutions were added to the Brine Shrimps, surviving shrimps were counted after 24 h and 50% lethality concentration ($LC_{50}$) were assessed. Acute toxicity was studied on Swiss albino mice after single dose. Sub-Chronic toxicity was performed for 28 days and assessed with biochemical and histopathological parameters. On cytotoxicity studies of brine shrimps it was found methanol extract of $S.$ $asper$ (MESA) was weakly toxic, may be due to the presence of cardiac glycosides and bioactive compounds, however petroleum ether extract of $S.$ $asper$ (PESA) was non toxic. But, in case of acute and sub-acute toxicity study both extracts were found to be non-toxic.
R Sambath Kumar,T Sivakumar,V Senthil,N Venkateswara Murthy,V Balasubramaniam,R Kanaga Sabi,R. Shanmuga Sundram,P Perumal,U K Mazumder,M Gupta 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.2
The methanol extract of stem barks of Careya arborea Roxb. (MECA) (Family- Myrtaceae) was evaluated for antitumor activity and antioxidant status against Ehrlich’s Ascites Carcinoma (EAC) bearing Swiss albino mice. After 24 h of tumor inoculation the MECA was administered at the doses of 50, 100 and 200 mg/kg body weight/mice/day for 14 days. After the last dose and 18 h fasting mice were sacrificed. The effect of MECA on the growth of transplantable murine tumor, life span of EAC bearing hosts, hematological profiles, serum and liver biochemical parameters were estimated. The MECA showed significant (P < 0.01) decrease in ascites volume, packed cell volume and viable cell count and prolonged the life span of EAC tumor bearing mice. Hematological profiles reverted to more or less normal levels in extract treated mice. The MECA also produced protective effect by decreasing the activity of serum enzymes, bilirubin and increase the protein and uric acid levels. MECA significantly (P < 0.05) decreased the levels of lipid peroxidation, while significantly (P < 0.05) increased the levels of glutathione content, vitamin C, vitamin E, superoxide dismutase and catalase CAT. The results indicate that MECA exhibited significant antitumor and antioxidant activity in EAC bearing mice. The methanol extract of stem barks of Careya arborea Roxb. (MECA) (Family- Myrtaceae) was evaluated for antitumor activity and antioxidant status against Ehrlich’s Ascites Carcinoma (EAC) bearing Swiss albino mice. After 24 h of tumor inoculation the MECA was administered at the doses of 50, 100 and 200 mg/kg body weight/mice/day for 14 days. After the last dose and 18 h fasting mice were sacrificed. The effect of MECA on the growth of transplantable murine tumor, life span of EAC bearing hosts, hematological profiles, serum and liver biochemical parameters were estimated. The MECA showed significant (P < 0.01) decrease in ascites volume, packed cell volume and viable cell count and prolonged the life span of EAC tumor bearing mice. Hematological profiles reverted to more or less normal levels in extract treated mice. The MECA also produced protective effect by decreasing the activity of serum enzymes, bilirubin and increase the protein and uric acid levels. MECA significantly (P < 0.05) decreased the levels of lipid peroxidation, while significantly (P < 0.05) increased the levels of glutathione content, vitamin C, vitamin E, superoxide dismutase and catalase CAT. The results indicate that MECA exhibited significant antitumor and antioxidant activity in EAC bearing mice.
Kumar, R Sambath,Sivakumar, T,Senthil, V,Murthy, N Venkateswara,Balasubramaniam, V,Sabi, R Kanaga,Sundram, R. Shanmuga,Perumal, P,Mazumder, U K,Gupta, M Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.2
The methanol extract of stem barks of Careya arborea Roxb. (MECA) (Family- Myrtaceae) was evaluated for antitumor activity and antioxidant status against Ehrlich's Ascites Carcinoma (EAC) bearing Swiss albino mice. After 24 h of tumor inoculation the MECA was administered at the doses of 50, 100 and 200 mg/kg body weight/mice/day for 14 days. After the last dose and 18 h fasting mice were sacrificed. The effect of MECA on the growth of transplantable murine tumor, life span of EAC bearing hosts, hematological profiles, serum and liver biochemical parameters were estimated. The MECA showed significant (P < 0.01) decrease in ascites volume, packed cell volume and viable cell count and prolonged the life span of EAC tumor bearing mice. Hematological profiles reverted to more or less normal levels in extract treated mice. The MECA also produced protective effect by decreasing the activity of serum enzymes, bilirubin and increase the protein and uric acid levels. MECA significantly (P < 0.05) decreased the levels of lipid peroxidation, while significantly (P < 0.05) increased the levels of glutathione content, vitamin C, vitamin E, superoxide dismutase and catalase CAT. The results indicate that MECA exhibited significant antitumor and antioxidant activity in EAC bearing mice.