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      • Genome-wide identification and characterization of miniature inverted- repeat transposable elements in Brassica rapa

        Perumal Sampath,Sang-Choon Lee,Jee Young Park,Jonghoon Lee,Nur Kholilatul Izzah,Shailendra Karki,Haejoon Joo,Tae-Jin Yang 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07

        Miniature inverted- repeat transposable elements are expected to play vital role in evolution of genes and genome of major eukaryotic organisms. However, there have been little reports on MITEs in B. rapa, a polyploidy model genome. We identified 13 novel MITE families in B. rapa genome by computational approach. Out of 13 MITEs families three, eight and two were classified under stowaway-like, tourist-like and hAT super families based on their unique structural characteristics. We characterized the members of 13 MITE families from the available 256 Mbp from whole genome draft sequences of B. rapa. We found ech MITE has high copiy number ranges from 14 to 977 which are distributed randomly along all the chromosomes. We also found more than 40% of the MITE members were associated with genes and gene rich regions. Furthermore, the polymorphism due to insertion and non-insertion of MITEs analysis suggest that MITEs are active in the genome. As, such the newly identified MITEs will provide a foundation for the further analysis of roles of MITEs in gene and genome evolution.

      • High-concentration graphene dispersion stabilized by block copolymers in ethanol

        Perumal, Suguna,Lee, Hyang Moo,Cheong, In Woo Elsevier 2017 JOURNAL OF COLLOID AND INTERFACE SCIENCE - Vol.497 No.-

        <P><B>Abstract</B></P> <P>This article describes a comprehensive study for the preparation of graphene dispersions by liquid-phase exfoliation using amphiphilic diblock copolymers; poly(ethylene oxide)-<I>block</I>-poly(styrene) (PEO-<I>b</I>-PS), poly(ethylene oxide)-<I>block</I>-poly(4-vinylpyridine) (PEO-<I>b</I>-PVP), and poly(ethylene oxide)-<I>block</I>-poly(pyrenemethyl methacrylate) (PEO-<I>b</I>-PPy) with similar block lengths. Block copolymers were prepared from PEO using the Steglich coupling reaction followed by reversible addition-fragmentation chain transfer (RAFT) polymerization. Graphite platelets (G) and reduced graphene oxide (rGO) were used as graphene sources. The dispersion stability of graphene in ethanol was comparatively investigated by on-line turbidity, and the graphene concentration in the dispersions was determined gravimetrically. Our results revealed that the graphene dispersions with PEO-<I>b</I>-PVP were much more stable and included graphene with fewer defects than that with PEO-<I>b</I>-PS or PEO-<I>b</I>-PPy, as confirmed by turbidity and Raman analyses. Gravimetry confirmed that graphene concentrations up to 1.7 and 1.8mg/mL could be obtained from G and rGO dispersions, respectively, using PEO-<I>b</I>-PVP after one week. Distinctions in adhesion forces of PS, VP, PPy block units with graphene surface and the variation in solubility of the block copolymers in ethanol medium significantly affected the stability of the graphene dispersion.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • Highly flexible memristive devices based on MoS<sub>2</sub> quantum dots sandwiched between PMSSQ layers

        Perumal Veeramalai, Chandrasekar,Li, Fushan,Guo, Tailiang,Kim, Tae Whan The Royal Society of Chemistry 2019 Dalton Transactions Vol.48 No.7

        <P>This paper reports a facile, cost effective method that uses an aqueous hydrothermal process for synthesizing two-dimensional molybdenum disulphide (MoS2) monolayer quantum dots (QDs) and their potential applications in flexible memristive devices. High-resolution transmission electron microscopy and atomic force microscopy images confirmed that the diameters of the synthesized MoS2 QDs with irregular shapes were in the range between 3 and 6 nm; their thicknesses were confirmed to lie between 1.0 and 0.8 nm, a clear indication that a monolayer of MoS2 QDs had been synthesized. Photoluminescence (PL) and time-resolved PL spectra of the MoS2 QDs revealed a strong emission in the blue region with a slower decay constant. Memristive devices fabricated by incorporating MoS2 QDs between poly(methylsilsesquioxane) ultrathin layers, which had been deposited on poly(ethylene terephthalate), demonstrated a high ON-OFF current ratio of ∼10<SUP>4</SUP>, stable retention, and excellent endurance in the relaxed state; these devices were also demonstrated to function properly during bending and in a bent state. The flexible memristive devices demonstrated an OFF state with a very low current of 10<SUP>−6</SUP> A. These results clearly show that ultrathin two-dimensional QDs have promising applications in high-performance flexible memristive devices.</P>

      • SCOPUSKCI등재SCIE
      • SCISCIESCOPUS

        Interaction of Zwitterionic and Ionic Monomers with Graphene Surfaces

        Perumal, Suguna,Raji, Atchudan,Cheong, In Woo American Chemical Society 2018 Langmuir Vol.34 No.23

        <P>Measurement of the interaction force between two materials provides important information on various properties, such as adsorption, binding, or compatibility for coatings, adhesion, and composites. The interaction forces of zwitterionic and ionic monomers with graphite platelets (G) and reduced graphene oxide (rGO) surfaces were systematically investigated by atomic force microscopy (AFM) in air and water. The monomers examined were 2-(methacryloyloxy)ethyl 2-(trimethylammonio)ethyl phosphate (MPC), [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBE), [2-(acryloyloxy)ethyl]trimethylammonium chloride (ATC), and 2-methyl-2-propene-1-sulfonic acid sodium (MSS). The AFM studies revealed that MSS and SBE monomers with sulfonate units have stronger interaction forces with G surface in air and that MPC and ATC monomers with quaternary ammonium units have higher interaction forces in water. In the case of rGO surface, the monomers with quaternary ammonium units showed stronger interactions regardless of the medium. These interactions could be rationalized by the interaction mechanism between the monomers with graphene surfaces, such as cation−π for MPC and ATC and anion−π for MSS and SBE. Overall, cation−π interactions were effective in water, whereas anion−π interactions are effective in air with G surface. The adhesion values of MPC, SBE, ATC, and MSS on rGO were lower than the values measured on G surface. Among the monomers, MPC showed the highest dispersibility for aqueous graphene dispersions. Further, the adsorption of MPC on G and rGO surfaces was verified by high-resolution transmission electron microscopy and X-ray diffraction patterns.</P> [FIG OMISSION]</BR>

      • Effect of bimetal coated membrane electrode divided Clarks cell for online air pollutant sensor: A study by electrochemical removal at electroscrubbing plant

        ( Perumal Silambarasan ),( G. Muthuraman ),문일식 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0

        In the present investigation, Ag and Ag-Ni or Ag-Co metal ions coated Nafioni324 membrane electrode divided cell was developed and compared in amperometric detection of air pollutants. Ag and Ag-Ni or Ag-Co were chemically coated on the Nafion324 membrane and used in filter press technique to make a cell with one side having 0.1 M KOH electrolyte and gas phase cathodic half-cell. Based on the cyclic voltammetry and linear sweep voltammetry analyses, the gas phase redox peak was fixed for detection of selected gas pollutants. Then sense a selected air pollutants by amperometric method at different suitable applied voltage. The current with different feed concentration were compared with in-situ FTIR gas analyzer concentration and derived calibration plot.

      • Spherical Chitosan/Gelatin Hydrogel Particles for Removal of Multiple Heavy Metal Ions from Wastewater

        Perumal, Suguna,Atchudan, Raji,Yoon, Dong Ho,Joo, Jin,Cheong, In Woo American Chemical Society 2019 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.58 No.23

        <P>This article describes a simple preparation of chitosan/gelatin (CG) spherical hydrogel particles for the effective removal of multiple heavy metal ions. The CG hydrogel particles were prepared by inverse emulsion from the aqueous solutions of chitosan, gelatin, and glutaraldehyde. The oven-dried C2G1 hydrogel particles showed a maximum removal efficiency of 98% for Hg(II) ions in a single metal ion solution and which was higher than C1G1 (85%) and C1G2 (58%) particles. This result was affected by the composition of the hydrogels rather than the pore size or degree of swelling. Remarkably, the removal efficiencies for the Pb(II), Cd(II), Hg(II), and Cr(III) ions reached about 73%-94% in a multiple metal ion solution. The results indicate that the CG hydrogel particles can be used to remove coexisting heavy metal ions from wastewater, providing a versatile method to remove multiple metal ions from natural or industrial wastes.</P> [FIG OMISSION]</BR>

      • KCI등재후보

        Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer

        Perumal Elumalai,Jagadeesan Arunakaran 한국유전체학회 2014 Genomics & informatics Vol.12 No.4

        Cancer is the most dreaded disease in human and also major health problem worldwide. Despite its high occurrence, theexact molecular mechanisms of the development and progression are not fully understood. The existing cancer therapybased on allopathic medicine is expensive, exhibits side effects; and may also alter the normal functioning of genes. Thus, anon-toxic and effective mode of treatment is needed to control cancer development and progression. Some medicinal plantsoffer a safe, effective and affordable remedy to control the cancer progression. Nimbolide, a limnoid derived from the neem(Azadirachta indica) leaves and flowers of neem, is widely used in traditional medical practices for treating various humandiseases. Nimbolide exhibits several pharmacological effects among which its anticancer activity is the most promising. Theprevious studies carried out over the decades have shown that nimbolide inhibits cell proliferation and metastasis of cancercells. This review highlights the current knowledge on the molecular targets that contribute to the observed anticanceractivity of nimbolide related to induction of apoptosis and cell cycle arrest; and inhibition of signaling pathways related tocancer progression.

      • SCISCIESCOPUS

        Adhesion force measurement between the stamp and the resin in ultraviolet nanoimprint lithography—an investigative approach

        Perumal, Jayakumar,Yoon, Tae Ho,Jang, Hwan Soo,Lee, Jae Jong,Kim, Dong Pyo IOP Pub 2009 Nanotechnology Vol.20 No.5

        <P>In the ultraviolet nanoimprint lithography (UV-NIL) process, the surface interaction between the mold and the resist is essential along with molecularly clean separation of the mold from the surface of the cured resist for repeated use of the mold. In our present study, various mold–resin combinations have been examined by a tensile strength method to determine the adhesion force between a mold with a relief pattern and a photocurable resin. The adhesion force of polymer molds of the fluorine-containing polymers perfluoropolyether dimethacrylate (PFPE) and polydimethylsiloxane (PDMS) were compared to those of hard molds such as Si and quartz against several commercial UV-NIL resins. Eventually, PFPE with higher molecular weight—AMONIL—was found to be an excellent UV-NIL mold–resin combination with the lowest adhesion force per unit area (20 kPa). In particular, the 36-fold repeated imprinting with a high molecular weight PFPE mold showed only a slight increase of adhesion force by 36 kPa with molecularly clean release from the AMONIL resin, whereas a surface-modified PDMS mold revealed highly increased adhesion from an initial 20 kPa to 120 kPa after repeated use. </P>

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