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HDAC-Targeting Epigenetic Drug Screening for Biliary Tract Cancer
( Christian Mayr ),( Tobias Kiesslich ),( Sara Erber ),( Dino Bekric ),( Heidemarie Dobias ),( Markus Ritter ),( Tarkan Jäger ),( Bettina Neumayer ),( Paul Winkelmann ),( Eckhard Klieser ),( Daniel Ne 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1
HDAC-targeting epigenetic drug screening for biliary tract cancer
Christian MAYR,Tobias KIESSLICH,Sara ERBER,Dino BEKRIC,Heidemarie DOBIAS,Markus RITTER,Tarkan JAGER,Bettina NEUMAYER,Paul WINKELMANN,Eckhard KLIESER,Daniel NEUREITER 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.-
Sub-gap optical response in the Kitaev spin-liquid candidate <i>α</i>-RuCl<sub>3</sub>
Reschke, Stephan,Mayr, Franz,Widmann, Sebastian,von Nidda, Hans-Albrecht Krug,Tsurkan, Vladimir,Eremin, Mikhail V,Do, Seung-Hwan,Choi, Kwang-Yong,Wang, Zhe,Loidl, Alois IOP 2018 Journal of physics, an Institute of Physics journa Vol.30 No.47
<P>We report detailed optical experiments on the layered compound <I>α</I>-RuCl<SUB>3</SUB> focusing on the THz and sub-gap optical response across the structural phase transition from the monoclinic high-temperature to the rhombohedral low-temperature structure, where the stacking sequence of the molecular layers is changed. This type of phase transition is characteristic for a variety of tri-halides crystallizing in a layered honeycomb-type structure and so far is unique, as the low-temperature phase exhibits the higher symmetry. One motivation is to unravel the microscopic nature of THz and spin-orbital excitations via a study of temperature and symmetry-induced changes. The optical studies are complemented by thermal expansion experiments. We document a number of highly unusual findings: A characteristic two-step hysteresis of the structural phase transition, accompanied by a dramatic change of the reflectivity. A complex dielectric loss spectrum in the THz regime, which could indicate remnants of Kitaev physics. Orbital excitations, which cannot be explained based on recent models, and an electronic excitation, which appears in a narrow temperature range just across the structural phase transition. Despite significant symmetry changes across the monoclinic to rhombohedral phase transition and a change of the stacking sequence, phonon eigenfrequencies and the majority of spin-orbital excitations are not strongly influenced. Obviously, the symmetry of a single molecular layer determines the eigenfrequencies of most of these excitations. Only one mode at THz frequencies, which becomes suppressed in the high-temperature monoclinic phase and one phonon mode experience changes in symmetry and stacking. Finally, from this combined terahertz, far- and mid-infrared study we try to shed some light on the so far unsolved low energy (<1 eV) electronic structure of the ruthenium 4<I>d</I> <SUP>5</SUP> electrons in <I>α</I>-RuCl<SUB>3</SUB>.</P>
Electronic and phonon excitations in α−RuCl3
Reschke, S.,Mayr, F.,Wang, Zhe,Do, Seung-Hwan,Choi, K.-Y.,Loidl, A. American Physical Society 2017 Physical Review B Vol.96 No.16
<P>We report on terahertz (THz), infrared reflectivity, and transmission experiments for wavenumbers from 10 to 8000 cm(-1) (similar to 1meV-1eV) and for temperatures from 5 to 295 K on the Kitaev candidate material alpha-RuCl3. As reported earlier, the compound under investigation passes through a first-order structural phase transition, from a monoclinic high-temperature to a rhombohedral low-temperature phase. The phase transition shows an extreme and unusual hysteretic behavior, which extends from 60 to 166 K. In passing this phase transition, in the complete frequency range investigated, we found a significant reflectance change, which amounts to almost a factor of two. We provide a broadband spectrum of dielectric constant, dielectric loss, and optical conductivity from the THz to the mid-infrared regime and study in detail the phonon response and the low-lying electronic density of states. We provide evidence for the onset of an optical energy gap, which is on the order of 200 meV, in good agreement with the gap derived from measurements of the dc electrical resistivity. Remarkably, the onset of the gap exhibits a strong blue shift on increasing temperatures.</P>
Kim, Sei‐,Yong,Jeong, Won‐,Ik,Mayr, Christian,Park, Young‐,Seo,Kim, Kwon‐,Hyeon,Lee, Jeong‐,Hwan,Moon, Chang‐,Ki,Brü,tting, Wolfgang,Kim, Jang‐,Joo WILEY‐VCH Verlag 2013 Advanced Functional Materials Vol.23 No.31
<P><B>Abstract</B></P><P>High‐efficiency phosphorescent organic light‐emitting diodes (OLEDs) doped with Ir(ppy)<SUB>2</SUB>(acac) [bis(2‐phenylpyridine)iridium(III)‐acetylacetonate] in an exciplex forming co‐host have been optically analyzed. This emitter has a preferred orientation with the horizontal to vertical dipole ratio of 0.77:0.23 as compared to 0.67:0.33 in the isotropic case. Theoretical analysis based on the orientation factor (<I>Θ</I>, the ratio of the horizontal dipoles to total dipoles) and the photoluminescence quantum yield (<I>q</I><SUB>PL</SUB>) of the emitter predicts that the maximum external quantum efficiency (EQE) of the OLEDs with this emitter is about 30%, which matches very well with the experimental data, indicating that the electrical loss of the OLEDs is negligible and the device structure can be utilized as a platform to demonstrate the validity of optical modeling. Based on the results, the maximum EQE achievable for a certain emitting dye in a host can be predicted by just measuring <I>q</I><SUB>PL</SUB> and <I>Θ</I> in a neat film on glass without the need to fabricate devices, which offers a universal plot of the maximum EQE as a function of <I>q</I><SUB>PL</SUB> and <I>Θ</I>.</P>
Florian Girtner,Hans-Martin Fritsche,Florian Zeman,Toni Huber,Maximilian Haider,Christoph Pickl,Maximilian Burger,Roman Mayr 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.4
Purpose: Transcutaneous tibial nerve stimulation (TTNS) has proven to be a valuable treatment option for various lower urinary tract conditions, such as overactive bladder syndrome and neurogenic detrusor overactivity. The aim of this study was to investigate acute changes in urodynamic parameters due to bilateral TTNS. Methods: Fifty-one patients (18–87 years; 61% female) with various lower urinary tract symptoms were enrolled in this study. They were single-blinded and randomly assigned to receive simultaneous bilateral TTNS either during their first urodynamic examination, followed by a second round using a placebo stimulation technique, or vice versa. Results: For subjects without signs of anatomical pathologies, the filling volume at the first desire to void (FDV) increased significantly by 54 mL (interquartile range [IQR], 26–81 mL; P<0.01) under the influence of TTNS compared to placebo. The maximum cystometric capacity increased by 41 mL (IQR, 10–65 mL; P=0.02). The median micturition volume of patients with pathological postvoid residual volumes (>100 mL) increased by 76 mL compared to patients without urinary retention (IQR, 6–166 mL; P=0.03). Conclusions: Compared to placebo, simultaneous bilateral TTNS showed significant improvements in bladder functioning, such as delayed FDV, increased maximum cystometric capacity, and reduced urinary retention. Patients with signs of anatomical pathologies did not seem to benefit from TTNS. Further studies need to be conducted to compare the effectiveness of bilateral versus unilateral TTNS.