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A Hypothesis on the Hen-Dragon (Gyeryong) of Silla
( Maurizio Riotto ) 서울대학교 규장각한국학연구원 2022 Seoul journal of Korean studies Vol.35 No.1
In a field such as Korean Studies, where Gyeongju is considered by many the eastern arrival point of the various “Silk Roads” (both land and maritime), and a “multicultural” approach to the various topics is strongly encouraged (although still extremely rare are the scholars able to follow this encouragement), this article is an invitation to consider the possibility, hitherto never explored, that elements of European/Mediterranean derivation may have influenced Korean mythology. In particular, the author examines the myth of the birth of Aryeong, the female progenitor of Silla, and, above all, the figure of the hen-dragon (gyeryong), whose existence in Korea seems absolutely episodic and limited to the cultural context of Silla only. Taking the cue from the fact that the hen-dragon is instead very well known in the West, where indeed it has a long history, both on a literary and an artistic level, the author therefore hypothesizes, on the basis of the concordance of various elements, that the basilisk of the Western tradition may have influenced the Korean myth of the hen-dragon, ending up creating a new version to be added to the indigenous ones.
Maurizio Di Bonito,Francesca Collina,Monica Cantile,Rosalba Camerlingo,Margherita Cerrone,Laura Marra,Giuseppina Liguori,Giuseppe Pirozzi,Gerardo Botti 한국유방암학회 2012 Journal of breast cancer Vol.15 No.1
Purpose: Prominin1/CD133 has become the ideal marker for cancer stem cells (CSCs) detection in human tumors. In this study we examined the expression of this marker in several breast cancer specimens to associate CSCs percentage with risk factor for this neoplasia. Methods: We examined specimens from 12 patients using CD133 and CD44 antibodies for CSCs immunohistochemistry detection and for flow cytometry analysis. For each patient, we also performed the immunohistochemical staining to evaluate the expression of estrogen receptor, progesterone receptor, c-erbB-2, Ki67, and E-cadherin markers. A Taqman probe for CD133 was used for mRNA quantification by realtime polymerase chain reaction. Results: Prominin-1 expression was heterogeneous in different carcinomas but was strikingly hyperexpressed in a tubulolobular variant of breast cancer. The results were confirmed by all three methods. Conclusion: Our data, although produced on a limited number of samples, showed an particularly high expression of stem cell marker CD133 in a breast cancer variant, generally with a good prognosis. Since CSCs detection by CD133 has been described as an important prognostic factor for several human cancers, we suggest the importance of detecting stem cell compartiments in all histotypes of breast carcinomas.
Normative Power and Political Dialogue: The European Union in the South Pacific
( Maurizio Carbone ) 한국EU학회 2006 Asia-Pacific Journal of EU Studies Vol.4 No.1
This paper explores the role of the European Union as a normative power in the South Pacific in the context of the EU-ACP relationship. The Cotonou Agreement provides an ideal framework since it includes political dialogue as a means for promoting ``political`` norms. Moreover, the South Pacific is a compelling case: it does not represent a direct threat to the EU`s security because of its distance; it has rather weak post-colonial links with EU Member States; it has very limited commercial relations with the EU. This paper argues that, considering the South Pacific tradition of democracy, good governance and human rights, the concept of Normative Power Europe should be re-calibrated to be more context-sensitive. Sanctions are not necessarily the best method to promote norms, yet in cases of violations of human rights and democratic principles the use of sanctions or the threat of using them is not inconsistent with the idea of normative power.
Maurizio Di Bonito,Monica Cantile,Francesca Collina,Giosuè Scognamiglio,Margherita Cerrone,Elvira La Mantia,Antonio Barbato,Giuseppina Liguori,Gerardo Botti 한국유방암학회 2012 Journal of breast cancer Vol.15 No.2
Purpose: Triple-negative breast cancer, has a significant clinical relevance being associated with a shorter median time to relapse and death and does not respond to endocrine therapy or other available targeted agents. For this reason, identifying the molecular pathways associated with increased aggressiveness, for example the presence of stem cell populations within the tumor and alteration of genes associated with cell cycle regulation represents an important objective in the clinical research into this neoplasm. Methods: To investigate the role of cell cycle progression inhibitor Geminin in triple-negative breast cancers and its potential correlation with stem-like phenotype of this neoplasm, we used tissue microarray technology to build a specific triplenegative breast cancer tissue micro-array. Geminin and cancer stem cell marker CD133 expression was further investigated at the mRNA level for selected breast tumor samples through realtime polymerase chain reaction quantification. Results: Our results showed that CD133 expression was significantly associated to high Geminin expression (p=0.017), a strong association between Ki-67 and tumor grade (p=0.020) and an inverse association between Geminin expression and lymphonode metastases (p=0.058), and a trend of statistically significance between Geminin marker expression and survival of triple-negative breast cancer patients (p=0.076). Conclusion: The strong association between the expression of CD133 and Geminin could be useful in molecular stratification of breast tumors and in particular of triple-negative breast cancers.
Defect Probability Estimation for Hardness-Optimised Parts by Selective Laser Melting
Maurizio Galetto,Gianfranco Genta,Giacomo Maculotti,Elisa Verna 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.9
The development of reliable additive manufacturing (AM) technologies to process metallic materials, e.g. selective laser melting (SLM), has allowed their adoption for manufacturing final components. To date, ensuring part quality and process control for low-volume AM productions is still critical because traditional statistical techniques are often not suitable. To this aim, extensive research has been carried out on the optimisation of material properties of SLM parts to prevent defects and guarantee part quality. Amongst all material properties, defects in surface hardness are of particular concern as they may result in an inadequate tribological and wear resistance behaviour. Despite this general interest, a major void still concerns the quantification of their extent in terms of probability of defects occurring during the process, although it is optimised. Considering these issues, this paper proposes a novel approach to quantify the probability of occurrence of defects in hardness-optimised parts by SLM. First, three process variables, i.e. laser power, scan speed and hatching distance, are studied considering their effect on hardness. Design of Experiments and Response Surface Methodology are exploited to achieve hardness optimisation by controlling process variables. Then, hardness defect probability is estimated by composing the uncertainty affecting both process variables and their relationship with the hardness. The overall procedure is applied to AlSi10Mg alloy, which is relevant for both aerospace and automotive applications. The approach this study proposes may be of assistance to inspection designers to effectively and efficiently set up quality inspections in early design phases of inspection planning.
Maurizio Di Bonito,Francesca Collina,Rosalba Camerlingo,Margherita Cerrone,Laura Marra,Giuseppina Liguori,Giuseppe Pirozzi,Gerardo Botti,Monica Cantile 한국유방암학회 2013 Journal of breast cancer Vol.16 No.1
Purpose Prominin1/CD133 has become the ideal marker for cancer stem cells (CSCs) detection in human tumors. In this study we examined the expression of this marker in several breast cancer specimens to associate CSCs percentage with risk factor for this neoplasia. Methods We examined specimens from 12 patients using CD133 and CD44 antibodies for CSCs immunohistochemistry detection and for flow cytometry analysis. For each patient, we also performed the immunohistochemical staining to evaluate the expression of estrogen receptor, progesterone receptor, c-erbB-2, Ki67, and E-cadherin markers. A Taqman probe for CD133 was used for mRNA quantification by real-time polymerase chain reaction. Results Prominin-1 expression was heterogeneous in different carcinomas but was strikingly hyperexpressed in a tubulolobular variant of breast cancer. The results were confirmed by all three methods. Conclusion Our data, although produced on a limited number of samples, showed an particularly high expression of stem cell marker CD133 in a breast cancer variant, generally with a good prognosis. Since CSCs detection by CD133 has been described as an important prognostic factor for several human cancers, we suggest the importance of detecting stem cell compartiments in all histotypes of breast carcinomas.
Maurizio Cremonte,Davide Sisti,Ilaria Maraucci,Simona Giribone,Evelin Colombo,Marco Bruno Luigi Rocchi,Stefano Scoglio 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.12
Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobiological condition with onset in childhood. The disorder is characterized by inattention, impulsivity, and/or motor hyperactivity, which often affect the development and social integration of affected subjects. Phenylethylamine (PEA), naturally contained in the Klamath Lake microalgae and concentrated in the Klamin® extract, is an endogenous molecule with a general neuromodulatory activity. It functions as an activator for the neurotransmission of dopamine and other catecholamines, and very low concentrations of PEA may be associated with specific psychological disorders such as ADHD. The aim of our study was to evaluate the efficacy of the Klamin extract in treating a group of subjects diagnosed with ADHD. Thirty subjects, aged 6–15, who had been diagnosed with ADHD according to the DSM-IV TR criteria, were enrolled. The supplement was administered to all the subjects, who reported to an ADHD clinic for routine follow-up visits. Observations were made and data collected over a 6-month period. After 6 months of therapy the subjects appeared to show significant improvements based on assessments of their overall functioning, behavioral aspects related to inattention and hyperactivity–impulsivity, attention functions in both the selective and sustained component and executive functions. The study appears to confirm the initial hypothesis that the Klamin extract may positively affect the expression of ADHD symptoms. Additional larger studies on the effects of Klamin on ADHD are needed to further investigate the potential of this extract in ADHD treatment.