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A prediction model of survival for patients with bone metastasis from uterine cervical cancer
Hiroko Matsumiya,Yukiharu Todo,Kazuhira Okamoto,Sho Takeshita,Hiroyuki Yamazaki,Katsushige Yamashiro,Hidenori Kato 대한부인종양학회 2016 Journal of Gynecologic Oncology Vol.27 No.6
Objective: The aim of the study was to establish a predictive model of survival period afterbone metastasis from cervical cancer. Methods: A total of 54 patients with bone metastasis from cervical cancer were included in thestudy. Data at the time of bone metastasis diagnosis, which included presence of extraskeletalmetastasis, performance status, history of any previous radiation or chemotherapy, thenumber of bone metastases, onset period, and treatment were collected. Survival data wereanalyzed using Kaplan-Meier method and Cox proportional hazards model. Results: The median survival period after diagnosis of bone metastasis was 22 weeks (5months). The 26- and 52-week survival rates after bone metastasis were 36.5% and 15.4%,respectively. Cox regression analysis showed that extraskeletal metastasis (hazard ratio [HR],6.1; 95% CI, 2.2 to 16.6), performance status of 3 to 4 (HR, 7.8; 95% CI, 3.3 to 18.2), previousradiation or chemotherapy (HR, 3.3; 95% CI, 1.4 to 7.8), multiple bone metastases (HR, 1.9;95% CI, 1.0 to 3.5), and a bone metastasis-free interval of <12 months (HR, 2.5; 95% CI, 1.2to 5.3) were significantly and independently related to poor survival. A prognostic score wascalculated by adding the number of each significant factor. The 26-week survival rates afterdiagnosis of bone metastasis were 70.1% in the group with a score ≤2, 46.7% in the groupwith a score of 3, and 12.5% in the group with a score ≥4 (p<0.001). Conclusion: This scoring system provided useful prognostic information on survival ofpatients with bone metastasis of cervical cancer.
Watanabe, Hiroshi,Matsumiya, Yumi,Kwon, Youngdon American Chemical Society 2018 Macromolecules Vol.51 No.16
<P>For entangled linear polymer having type A dipoles and undergoing head-to-head association and dissociation reaction, viscoelastic and dielectric behavior is theoretically analyzed on the basis of the reptation dynamics combined with the reaction kinetics. Specifically, for the dissociated unimer and associated dimer (indexed with <I>j</I> = 1 and 2, respectively), the normalized complex modulus <I>g</I><SUB><I>j</I></SUB>*(ω) and the normalized complex dielectric permittivity ε̃<SUB><I>j</I></SUB>*(ω) are analytically calculated via eigenfunction expansion of the orientational anisotropy and orientational memory defined in terms of the bond vectors <B>u</B> of entanglement segments. The reaction activates mutual conformational transfer between the unimer and dimer. Multiple coupling occurs for the anisotropy decay modes of the unimer and dimer due to this transfer, and the viscoelastic <I>g</I><SUB>1</SUB>* and <I>g</I><SUB>2</SUB>* of the unimer and dimer, respectively, exhibit considerably retarded and accelerated relaxation compared to the pure reptation case. In contrast, the memory decay modes of the unimer and dimer are only pairwisely coupled, so that the reaction-induced acceleration and retardation for the dielectric ε̃<SUB>1</SUB>* and ε̃<SUB>2</SUB>* are much weaker than those seen for the viscoelastic <I>g</I><SUB>1</SUB>* and <I>g</I><SUB>2</SUB>*. The orientational anisotropy is the tensorial, second-moment average of <B>u</B> associated with no cancellation in the conformational transfer, whereas the orientational memory is the vectorial, first-moment average accompanied by partial cancellation, which results in the difference between <I>g</I><SUB><I>j</I></SUB>* and ε̃<SUB><I>j</I></SUB>*. This difference between <I>g</I><SUB><I>j</I></SUB>* and ε̃<SUB><I>j</I></SUB>* is noted also for the associating/dissociating Rouse chains. Nevertheless, the reaction-induced retardation of the viscoelastic relaxation is stronger for the reptating unimer than for the Rouse unimer, whereas the reaction-induced acceleration is similar, in magnitude, for the reptating dimer and Rouse dimer. These features of <I>g</I><SUB><I>j</I></SUB>* of the unimer and dimer are discussed in relation to the motional coherence along the chain backbone being present and absent in the reptation and Rouse dynamics.</P> [FIG OMISSION]</BR>
Dielectric Characterization of Pigment Inks for Electrohydrodynamic Jet Printing
Lee, Ayoung,Watanabe, Hiroshi,Matsumiya, Yumi,Choi, Kyung-Hyun,Ahn, Kyung Hyun,Lee, Seung Jong American Chemical Society 2014 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.53 No.44
<P>This article presents a characterization method that could be useful for evaluating the performance of ink in electrohydrodynamic jet printing. The ink contains pigment particles and polymer (stabilizer for pigments) and has a low viscosity and a low elasticity. Depending on the medium (hydrocarbon for oil-based inks and glycol ether for polar solvent-based inks) and the type of pigment (exhibiting different colors), vast differences were found in the dielectric properties even when the viscosities of the inks were almost identical. These differences between the two series of inks were related to differences in the ion concentration <I>n</I> and ion mobility μ estimated from an analysis of the complex dielectric constant ε* (= ε′ – iε″) on the basis of Macdonald theory. These differences between the polar solvent- and oil-based inks are discussed in relation to the performances of the inks in electrohydrodynamic inkjet printing.</P>
성종환,장곡천수부,송궁지지,내산아수,하주영,이문순,허재두,Sung, Jong-Hwan,Hasegawa, Hideo,Matsumiya, Satoshi,Uchiyama, Masamori,Ha, Joo-Young,Lee, Moon-Soon,Huh, Jae-Doo 한국생약학회 1995 생약학회지 Vol.26 No.4
The metabolism of ginseng saponins by human intestinal bacteria was studied using human feces under anaerobic culture conditions. $Ginsenoside-Rb_1$, $-Rb_2$ and -Rc(protopanaxadiol type) were mainly metabolized to compound-K(C-K), $20-O-[{\alpha}-L-arabinopyranosyl(1{\rightarrow}6)-{\beta}-{_D}-glucopyranosyl]-20(S)-protopanaxadiol(compound-Y,\;C-Y)$, $20-O-[{\alpha}-L-arabinopyranosyl(1{\rightarrow}6)-{\beta}-{_D}-glucopyranosyll-20(S)-protopanaxadiol(ginsenosied-MC,{\;}MC)$, respectively, and $ginsenoside-Rg_1$ and -Re(protopanaxatriol type) to their aglycon, 20(S)-protopanaxatriol, though the pathway and rate of the metabolism were affected by fermentation medium. C-K was not decomposed any more, while C-Y and Mc were both gradually hydrolyzed to C-K.