Overexpression of miR-146a and miR-155 are Potentially Biomarkers and Predict Unfavorable Relationship between Gastric Cancer and Helicobacter pylori Infection

Masoud Karimi,Abdolreza Mohammadnia,Mohammad Amin Amini,Azar Ghavimi Shamekh,Elahe Derakhshanfar,Farzaneh Hosseini 전남대학교 의과학연구소 2023 전남의대학술지 Vol.59 No.3

Gastric Cancer (GC) is one of the most dangerous malignancies in the world. This study aims to evaluate the relationship between miR-146a and miR-155 in patients with H. pylori infections with GC compared to H. pylori-infected patients and healthy subjects. Forty patients with H. pylori and GC positive diagnoses and 40 patients with H. pylori positive and GC negative diagnoses, and 40 healthy persons were selected. The expression of miR-146a and miR-155 genes in the whole blood was examined using qRT-PCR. Moreover, ROC curves were drawn to represent the sensitivity and specificity of miR-146a and miR-155 expression as biomarkers. The results showed the expression of miR-146a and miR-155 in the whole blood of patients with H. pylori and GC positive diagnoses are significantly higher than in healthy individuals and are non-significantly enhanced compared to H. pylori positive and GC negative. Also, the results stated miR-146a and miR-155 expression in the whole blood of patients who are H. pylori positive and GC negative are significantly increased compared to healthy individuals. Furthermore, the ROC curve analysis of miR-146a and miR-155 RNA level demonstrated the two miRNAs have an appropriate sensitivity and specificity for diagnostic goals. In conclusion, H. pylori infection may increase the expression of miR-146a and miR-155 in patients with H. pylori and GC positive diagnoses, which can be effective in the curbing the progression of GC. For this reason, up-regulation of miR-146a and miR-155 along with H. pylori infection might contribute to the pathogenesis of GC, and also can be suggested as biomarkers for GC diagnosis and treatment.

A Novel Approach for Energy Harvesting from Feedback Fluidic Oscillator

Masoud Alikhassi,Mahdi Nili-Ahmadabadi,Reza Tikani,Mohammad Hassan Karimi 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.6 No.4

Piezoelectric patches are widely used on a micro scale energy harvesting due to their simplicity and high flexibility. In this study a fluidic oscillator was used to effectively convert the kinetic energy of a fluid into the strain energy of the piezoelectric structure. The relationship between the input velocity and the frequency of fluid fluctuations in the fluidic oscillator was obtained and different positions for the piezoelectric beam and the effect of the input velocity on the output voltage was examined. The optimum electrical resistance was finally calculated for the maximum harvested power and the pressure drop caused by the fluidic oscillator and piezoelectric beam was investigated. The results indicated when the free end of the beam was inside the main chamber of oscillator, the beam fluctuates with its natural frequency so that the fluid oscillations frequency is close to the natural frequency at different velocity. However, when the free end of the beam was outside the main chamber, the voltage and power were maximized at the frequency of fluid oscillation equal to the natural frequency of the piezoelectric beam.

Application of high frequency ultrasound in different irradiation systems for photosynthesis pigment extraction from Chlorella microalgae

Masoud Rahimi,Elham Mohamadian,Soheil Dadari,Mohammad Moein Arbab,Naser Karimi 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.4

Microalgae are considered the biological drug factories of the future. To benefit from these microfactories, the intracellular metabolite of algae should be extracted. One of the most economically competitive methods is the ultrasound technique. This study was concerned with ultrasound-assisted extractions of useful substances from microalgae by comparing direct and indirect irradiation methods with respect to the extraction rate and yields. It is most likely that the direct and indirect irradiations had different irradiation powers. The systems were exposed to ultrasound wave (1.7 MHz) for 240min. For each system, the changes of optical density, concentration and biovolume of Chlorella were estimated. In addition, the concentration of extracted chlorophylls (a, b and a+b), carotenoid and lipid were measured. The factors were studied after 30, 60, 120, 180 and 240 min of exposure to ultrasound irradiation. Both direct and indirect irradiation systems produced cavitation in the cell membrane, and they reduced the concentration and biovolume of the Chlorella cells. The amount of lipids and chlorophylls was greater in the direct irradiation as compared to the indirect one, and it caused more cell disruption. However, the extraction of the carotenoid was less effective because direct irradiation produced more transmitted power of ultrasound, resulting in degradation of carotenoid. The results and analysis presented in this research showed that selection of the best method of irradiation is an important step, and it depends on the biomaterials to be extracted.

Lack of Evidence for a Relationship between High Risk Human Papillomaviruses and Breast Cancer in Iranian Patients

Doosti, Masoud,Bakhshesh, Mehran,Zahir, Shokouh Taghipour,Shayestehpour, Mohammad,Karimi-Zarchi, Mojgan Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

Background: Whether there is any relationship between human papilloma virus (HPV) and breast carcinoma is not clear. Some previous studies have indicated a possible role in oncogenesis in the breast. In this study, we therefore analyzed the presence of HPV infection in breast tissues of Iranian women from Yazd city. Materials and Methods: In a cross-sectional study, formalin-fixed paraffin-embedded tissues from 87 patients with breast cancer and 84 cases with breast fibrocystic lesions (control group) were selected from a tissue archive. Grade of tumors and fibrocystic tissues were determined by two pathologists. The nested-PCR method was performed for detection of HPVs in samples. HPV genotypes were determined by sequencing and the phylogenetic tree depicted by MEGA software. Results: Of the 87 women with breast cancer, 22.9% (20 isolates) had positive results for HPV DNA. In the control group no HPV was detected. The HPV genotypes in positive samples were HPV-16 (35%) HPV-18 (15%), HPV-6 (45%) and HPV-11 (5%). The data did not approved a significant correlation between tissue pathology of breast cancer and the HPV genotype frequency. Conclusions: The data did not provide any evidence for a role of high risk HPV types in oncogenesis in the breast.

The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review

Mohammad Amin Amini,Masoud Karimi,Seyed Saman Talebi,Hossein Piri,Jamshid Karimi 전남대학교 의과학연구소 2022 전남의대학술지 Vol.58 No.3

Infertility is one of the disorders that worries many couples around the world, although novel and molecular methods can be used to cure this disease in different stages. One of the factors that causes infertility in men and women is the increased oxidative stress within the cells, which can lead to damage in zygote formation. ROMO1 is one of the most important proteins in the production of reactive oxygen species. This protein can enhance oxidative stress in the cells and body through cellular pathways, such as TNF-a and NF-kB routes, which will eventually lead to many diseases, especially infertility. We engage several international databases by using keywords; ROMO1, Infertility, and Reactive Oxygen Species, and gained a great quantity of information about ROMO1, Infertility, and Oxidative Stress. Although not proven, it is hypothesized that ROMO1 might elevate oxidative stress by activating NF-kB pathway in the cells, furthermore, TNF-a can arouse ROMO1 that can end up with apoptosis and cell death, which consequently can have a lot of disturbing effects on the body, especially the reproductive system. To sum up, revealing the exact cellular and molecular mechanisms of ROMO1-dependent TNF-a and NF-kB pathways in the pathogenesis of infertility might find interesting therapeutic and management strategies for this disorder.

Design of an H∞ PID Controller Using Particle Swarm Optimization

Majid Zamani,Nasser Sadati,Masoud Karimi Ghartemani 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.2

This paper proposes a novel method to designing an H∞ PID controller with robust stability and disturbance attenuation. This method uses particle swarm optimization algorithm to minimize a cost function subject to H∞ -norm to design robust performance PID controller. We propose two cost functions to design of a multiple-input, multiple-output (MIMO) and single-input, single-output (SISO) robust performance PID controller. We apply this method to a SISO flexible-link manipulator and a MIMO super maneuverable F18/HARV fighter aircraft system as two challenging examples to il-lustrate the design procedure and to verify performance of the proposed PID controller design method-ology. It is shown with the MIMO super maneuverable F18/HARV fighter system that PSO performs well for parametric optimization functions and performance of the PSO-based method without prior domain knowledge is superior to those of existing GA-based and OSA-based methods for designing H∞ PID controllers.

Transient thermoelastic analysis of carbon/carbon composite multidisc brake using finite element method

Ghashochi-Bargh, Hadi,Goodarzi, Mohammad-Saeed,Karimi, Masoud,Salamat-Talab, Mazaher Techno-Press 2020 Advances in aircraft and spacecraft science Vol.7 No.2

In the current paper, a generalization of the results of Zhao et al. (2008) on a new design of C/C composite multidisc brake system is presented. The purpose of this paper is to study the effect of thermal sensitivity of Carbon/Carbon (C/C) composite material on the temperature distributions, deformation, and stress during braking. In this regard, a transient temperature-displacement coupled analysis for C/C composite brake discs with frictional heat generation under simulated operating conditions is performed. An axisymmetric model for brake system is used for the finite element analysis according to the theory of energy transformation and transportation. The transient temperature distributions on the friction surfaces, deformation, and stress are obtained. To check the validity, the results are corroborated with other solutions available in the literature, wherever possible. The current study could be used as a guide in the initial design of a high performance multidisc brake system.

A simple one Step Thermochemical Approach for Synthesis of ZnS:Mn Nanocrystals (NCs)

Mehdi Molaei,Ahmad Lotfiani,Fatemeh Karimi maskon,Masoud Karimipour,Mohammd Khanzadeh 대한전자공학회 2014 Journal of semiconductor technology and science Vol.14 No.1

In this work we have synthesized ZnS:Mn nanocrystals (NCs) using a simple one step thermochemical method. Zn(NO3)2 and Na2S2O3 were used as the precursors and Mn(NO3)2 was the source of impurity. Thioglycolic acid (TGA) was used as the capping agent and the catalyst of the reaction. The structure and optical property of the NCs were characterized by means of X- ray diffraction (XRD), HRTEM, UV-visible optical spectroscopy and photoluminescence (PL). X-ray diffraction (XRD) and transmission electron microscopy (TEM) analyses demonstrated cubic phase ZnS:Mn NCs with an average size around 3 nm. Synthesized NCs exhibited band gap of about 4 eV. Photoluminescence spectra showed a yellow-orange emission with a peak located at 585 nm, demonstrating the Mn incorporation inside the ZnS particles.

Intrinsic kinetics of the Fischer-Tropsch synthesis over an impregnated cobalt-potassium catalyst

Hossein Atashi,Mohsen Mansouri,Seyyed Hossein Hosseini,Mohammad Khorram,Ali Akbar Mirzaei,Masoud Karimi,Ghobad Mansouri 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.3

The optimal amount of 15 wt%Co/10 wt%K/Al2O3 catalyst was prepared using the impregnation technique in order to study the kinetics of the Fischer-Tropsch synthesis. The rate of synthesis was measured in a fixed-bed micro reactor with H2/CO feed ratio of 1-3 and space velocity in the range of 2,700-5,200 h−1 under reactor pressure of 8 bar and a temperature range of 210-240 oC. The experimental data were best fitted by a Langmuir-Hinshelwood-Hougen-Watson (LHHW) approach rate in the form of −rCO=(k2K1PCOPH2)/(1+K1PCO). Furthermore, the data were fitted fairly well by a power law equation in the form of −rCO=kPCO 1.32PH21.42. The activation energies for LHHW approach model and power law equation were obtained as 138.5 kJ/mol and 87.39 kJ/mol, respectively.