Isolated Tuberculoma Mimicking Foramen Magnum Meningioma in the Absence of Primary Tuberculosis: A Case Report

Manish Kolakshyapati,Masaaki Takeda,Takafumi Mitsuhara,Satoshi Yamaguchi,Masaru Abiko,Shingo Matsuda,Kaoru Kurisu 대한척추신경외과학회 2018 Neurospine Vol.15 No.3

Central nervous system tuberculosis is a devastating complication of systemic tuberculosis. Intradural extramedullary (IDEM) tuberculoma at the foramen magnum is rare, and mimics en plaque meningioma. We report the case of a 53-year-old woman who presented with dysesthesia of the tongue and lower cranial nerve (CN) palsy, with onset 4 months prior to admission. The neurologic examination revealed left upper-limb weakness and hypoesthesia on the sole and dorsum of the left foot. Other physical examinations revealed no features of tubercular infection. Laboratory investigations likewise showed no signs of infection or inflammation. Magnetic resonance imaging of the brain showed an IDEM mass originating from the left intradural surface at the foramen magnum extending to the C2 segment and compressing the brainstem and upper cervical cord. The mass was isointense/hypointense on T1- and T2-weighted images and homogeneously-enhanced on postcontrast images. The lesion also exhibited the dural-tail sign and was preoperatively diagnosed as en plaque meningioma. The patient underwent surgery via the left transcondylar fossa approach with partial laminectomy of the atlas. Intraoperatively, the mass exhibited a dural origin and encased the vertebral artery and lower CNs, with strong adhesions. While the histopathological study of the mass was strongly suggestive of tuberculoma with multifocal granulomas, caseous necrosis, and Langerhans giant cells, extensive diagnostic studies failed to detect Mycobacterium tuberculosis itself. Although the patient had recurrence with multisystem involvement, she responded well to antitubercular treatment. IDEM tuberculoma of the foramen magnum may present as en plaque meningioma. Histopathology is required for a definitive diagnosis. Prompt surgical resection and decompression with adequate antitubercular treatment yield better neurological outcomes.

Nanocommunication Design in Graduate-Level Education and Research Training

Itoh, Tadashi,Akai, Hisazumi,Takeda, Seiji,Ogawa, Hisahito,Ichikawa, Satoshi,Geshi, Masaaki,Ara, Masato,Niioka, Hirohiko The Korean Vacuum Society 2010 Applied Science and Convergence Technology Vol.19 No.6

나노과학, 나노공학, 및 나노기술의 축적된 지식을 대중참여라는 관점을 첨가하여 대학원생이나 젊은 과학자들에게 가르치기 위하여, 오사카 대학은 2004년부터 다양한 교육 및 훈련 프로그램을 제공하고 있는데, 교학문적(交學問的) 대학원 부전공 과목, 야간 강좌, 단기 국제훈련 프로그램 등이다. 연속강의는 위성통신을 이용하여 교실에 전달되기도 한다. 또한 학생들은 현대시설을 활용한 실습을 통하여 직접, 나노소재와 나노소자를 설계, 제작, 측정, 특성분석 및 기능화 할 수 있다. 그리고 특별히 사회적, 법적, 윤리적 관계를 포함하는 나노소통에 관한 연구훈련 프로그램과 강좌 시리즈가 네 개 개설되어 있으니, "나노기술 경력 건설 강좌", "나노기술의 대중 참여", "나노기술 지도 설계", "목적과제 학습 및 훈련 프로그램(PAL)"이다. 전체 프로그램의 윤곽이 나노소통 특별 프로그램과 함께 소개되어 있다. In order to teach the accumulated knowledge of nanoscience, nanoengineering and nanotechnology to graduate school students and young scientists with the sense of public engagement, Osaka University started from 2004 to prepare and offer various kinds of education and training programs such as trans-disciplinary graduate-school minor program, evening course refresher program, short-term international research training program, etc. It offers a series of lectures, partly broadcasted live to satellite classrooms. In addition, the students can join intensive hands-on training programs using modern facilities, allowing them to design, fabricate, measure, characterize and functionalize nanomaterials and nanodevices. In addition, there are four specially designed lectures and research training programs aimed for nanocommunication including social, legal and ethical relationship: "Nanotechnology Career-up Lectures", "Social Engagement on Nanotechnology", "Road Map Design on Nanotechnology", and "Project-Aimed Learning and Training Programs (PAL)". The outline of the whole programs is described together with the specialized programs for nanocommunication.

Influence of Diabetes Mellitus on Surgical Outcomes in Patients with Cervical Myelopathy: A Prospective, Multicenter Study

Shinji Tanishima,Tokumitsu Mihara,Atsushi Tanida,Chikako Takeda,Masaaki Murata,Toshiaki Takahashi,Koji Yamane,Tsugutake Morishita,Yasuo Morio,Hiroyuki Ishii,Satoru Fukata,Yoshiro Nanjo,Yuki Hamamoto,T 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.3

Study Design: Multicenter, prospective study. Purpose: To investigate the effects of diabetes mellitus (DM) on surgical outcomes in patients with cervical myelopathy. Overview of Literature: To date, few studies have investigated the influence of postoperative blood glucose or glycated hemoglobin (HbA1c) levels on surgical outcomes. Methods: The participants were patients who underwent surgery for the treatment of cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament. The 61 cases were evaluated preoperatively and 1 year postoperatively using the Japanese Orthopaedic Association (JOA) scores and the JOA Cervical Myelopathy Evaluation Questionnaire (JOACMEQ). The study variables included fasting blood glucose and HbA1c levels measured preoperatively and at 1 week, 4 weeks, and 1 year postoperatively; the F-wave conduction velocity, latency, rate of occurrence, and M-wave latency in the ulnar and tibial nerves were measured preoperatively and at 1 year postoperatively. The patients were divided into a group without diabetes (N group, 42 patients) and a group with diabetes (DM group, 19 patients). We then assessed the associations between the surgical outcomes and each of the study variables. Results: JOA scores significantly improved in both groups; however, no significant between-group differences were found. There was no significant improvement in the JOACMEQ scores, which assessed cervical function, upper and lower limb function, and bladder function in both groups. We then subdivided the DM group into those with a good control of HbA1c after 1 year (DMG group, 12 patients) and those with HbA1c deterioration after 1 year (DMB group, seven patients), prior to comparing the surgical outcomes. The JOACMEQ scores for upper and lower limb function significantly improved in the DMG group (p<0.01). Compared with the DMB group, there were no significant increases in upper or lower limb function scores in the DMG group. Conclusions: Poor glycemic control might prevent postoperative functional recovery of the spinal cord.

Nanocommunication Design in Graduate-Level Education and Research Training

Tadashi Itoh,Hisazumi Akai,Seiji Takeda,Hisahito Ogawa,Satoshi Ichikawa,Masaaki Geshi,Masato Ara,Hirohiko Niioka 한국진공학회 2010 Applied Science and Convergence Technology Vol.19 No.6

In order to teach the accumulated knowledge of nanoscience, nanoengineering and nanotechnology to graduate school students and young scientists with the sense of public engagement, Osaka University started from 2004 to prepare and offer various kinds of education and training programs such as trans-disciplinary graduate-school minor program, evening course refresher program, short-term international research training program, etc. It offers a series of lectures, partly broadcasted live to satellite classrooms. In addition, the students can join intensive hands-on training programs using modern facilities, allowing them to design, fabricate, measure, characterize and functionalize nanomaterials and nanodevices. In addition, there are four specially designed lectures and research training programs aimed for nanocommunication including social, legal and ethical relationship: “Nanotechnology Career-up Lectures”, “Social Engagement on Nanotechnology”, “Road Map Design on Nanotechnology”, and “Project- Aimed Learning and Training Programs (PAL)”. The outline of the whole programs is described together with the specialized programs for nanocommunication.

Plenary Session lI : Ex Vivo Induction of IFN-l3 by a TLR7 Agonist Determines Response to Peg-IFN/Ribavirin Therapy in Chronic Hepatitis C Patients

( Kazumoto Murata ),( Masaya Sugiyama ),( Tatsuji Kimura ),( Sachiyo Yoshio ),( Tatsuya Kanto ),( Mai Asano ),( Yoshihiko Aoki ),( Tsutomu Takeda ),( Masaaki Korenaga ),( Masatoshi Imamura ),( Naohiko 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Genetic variation of interleukin-28B (IL28B), encoding IFN-l3, predict non-responders to pegylated interferon-α/ ribavirin (Peg-IFN/RBV) therapy in chronic hepatitis C (CHC). However, it remains unknown whether IL28B is a functional phenotype, and why it failed to predict treatment responses at 20%. Methods: Message and protein levels of IFN-l3 induced by ex vivo stimulation of peripheral blood mononuclear cells (PBMC) with toll-like receptor agonists (TLR3; poly I: C, TLR7; R-837) were measured by quantitative real-time PCR and our newly developed chemiluminescence enzyme immunoassays, and compared with the clinical data. BDCA-3 or -4+dendritic cells (DC) was negatively or positively selected by Magnet-Associated Cell Sorting. Results: We firstly found that BDCA-4+DCs were the main producers of IFN-ls when stimulated with R-837 whereas BDCA-3+DCs were main producers of IFN-ls when stimulated with poly I: C, using PBMC from healthy volunteers. We also found that detectable levels of IFN-ls were inducible using small amount of PBMC by R-837, not poly I: C. When stimulated with R-837, IFN-l3 was more robustly up-regulated in the PBMC from CHC patients with favorable genotype (TT in rs8099917, n = 59) for the response to Peg-IFN/RBV than non-TT (n = 41) whereas no differences was observed in IFN-l1 or IFNl2, which may support our GWAS data. Importantly, protein levels of IFN-l3 induced by R-837 clearly differentiated the response to Peg-IFN/RBV treatment (p = 1.0×10-10), including discrepant cases such as VR in patients with TG/GG or NVR in TT genotype. Our method more accurately predicted treatment efficacies (95.7%) than IL28B genotyping (65.2%) did. Conclusions: Genetic variations in IL28B basically affect IFNl3 production, but different amount of IFN-l3 production determines the outcomes of Peg-IFN/RBV treatment. This study, for the first time, presents compelling evidence that genetic variations in IL28B confer a functional phenotype. Our method may provide more accurate prediction for the efficacy of Peg-IFN/RBV.