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- 저자 : Hiroyuki Ishii (검색결과 9 건)
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Invasiveness Reduction of Recent Total En Bloc Spondylectomy: Assessment of the Learning Curve
Takayoshi Ishii,Hideki Murakami,Satoru Demura,Satoshi Kato,Katsuhito Yoshioka,Moriyuki Fujii,Takashi Igarashi,Hiroyuki Tsuchiya 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.3
Study Design: Case-control study. Purpose: To evaluate the surgical magnitude and learning curve of “second-generation” total en bloc spondylectomy (TES). Overview of Literature: In June 2010, we developed second-generation TES combined with tumor-induced cryoimmunology, which does not require autograft harvesting. Methods: TES was performed in 63 patients between June 2010 and September 2013. Three groups of patients were evaluated: 20 undergoing surgery in the first year of development of second-generation TES (group I), 20 in the second year (group II), and 23 in the third year (group III). Patient backgrounds showed no remarkable differences. Operating time, intraoperative blood loss, blood transfusion, and postoperative C-reactive protein and creatine phosphokinase were compared among the groups. Results: Mean±standard deviation operating time was 486±130 minutes in group I, 441±85 minutes in group II, and 396±75 minutes in group III. The time was significantly shorter in group III than in group I (p <0.05). Intraoperative blood loss was 901±646 mL in group I, 433±177 mL in group II, and 411±167 mL in group III. Blood loss was significantly lower in groups II and III than in group I (p <0.01). Transfusion was not required in 20 of 23 patients in group III, and mean C-reactive protein levels on postoperative day 3 were significantly lower in this group than in group I (6.12 mg/L vs. 10.07 mg/L; p <0.05). Postoperative creatine phosphokinase levels did not differ among the groups. Conclusions: TES is associated with a significant learning curve. Thus, second-generation TES can no longer be considered highly invasive.
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Shinji Tanishima,Hideki Nagashima,Hiroyuki Ishii,Satoru Fukata,Toshiyuki Dokai,Taiki Murakami,Yasuo Morio 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.5
Study Design: Prospective study. Purpose: To examine the changes in body sway using stabilometry in patients who underwent cervical laminoplasty for cervical myelopathy. Overview of Literature: Although the patients of cervical myelopathy complain body sway there are few report to examine body sway objectively. Methods: Patients who received treatment for cervical myelopathy between October 2010 and February 2013 were included. Twentyone patients underwent cervical laminoplasty (myelopathy group). Body sway was assessed using stabilometry, wherein patients stood on a stabilometer with their eyes closed for 30 seconds. The Romberg ratio, outer peripheral area (OPA) with eyes closed (cm2), and total locus length per unit area (L/A) with eyes closed (/cm) were examined. Examinations were performed preoperatively (at baseline) and at 8 weeks postoperatively. Examination results of patients in the myelopathy group were compared with those of 17 healthy individuals (control group). Clinical symptoms were evaluated using the Japanese Orthopaedic Association scale score (JOA score) and the timed up and go (TUG) test. Results: In the myelopathy and control groups, the mean baseline Romberg ratio, OPA, and L/A were 2.3±1.2, 8.9±5.5 cm2, and 14.2±5.3/cm and 1.4±1.0, 4.3±2.8 cm2, and 23.7±10.1/cm, respectively. Eight weeks after laminoplasty, only L/A showed significant improvement from baseline in the myelopathy group (23.2±10.1 to 16.8±7.9; p =0.03). The Romberg ratio and OPA showed improvement in the myelopathy group, but the changes were not statistically significant. JOA scores and TUG test results in this group significantly improved from baseline to 8 weeks after laminoplasty (12.7 to 13.4 and 10.8 to 8.0 seconds, respectively; both p <0.05). Conclusions: L/A is a useful parameter for measuring body sway to assess the recovery of body sway after laminoplasty.
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Recent Developments of Actuation Mechanisms for Continuum Robots: A Review
Ibrahim A. Seleem,Haitham El-Hussieny,Hiroyuki Ishii 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.5
Traditional rigid robots face significant challenges in congested and tight environments, including bulky size, maneuverability, and safety limitations. Thus, soft continuum robots, inspired by the incredible capabilities of biological appendages such as octopus arms, starfish, and worms, have shown promising performance in complex environments due to their compliance, adaptability, and safety. Different actuation techniques are implemented in soft continuum robots to achieve a smoothly bending backbone, including cable-driven actuators, pneumatic actuators, and hydraulic actuation systems. However, designing and developing efficient actuation mechanisms, motion planning approaches, and control algorithms are challenging due to the high degree of redundancy and non-linearity of soft continuum robots. This article profoundly reviews the merits and drawbacks of soft robots’ actuation systems concerning their applications to provide the readers with a brief review reference to explore the recent development of soft robots’ actuation mechanisms technology. Moreover, the authors have surveyed the recent review studies in controller design of continuum robots as a guidance for future applications.
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Nagashima, Fumiaki,Nishiyama, Ryohta,Iwao, Beniko,Kawai, Yuiko,Ishii, Chikanao,Yamanaka, Tsuyoshi,Uchino, Hiroyuki,Inazu, Masato The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.4
In this study, we examined the molecular and functional characterization of choline uptake in the human esophageal cancer cells. In addition, we examined the influence of various drugs on the transport of [$^3H$]choline, and explored the possible correlation between the inhibition of choline uptake and apoptotic cell death. We found that both choline transporter-like protein 1 (CTL1) and CTL2 mRNAs and proteins were highly expressed in esophageal cancer cell lines (KYSE series). CTL1 and CTL2 were located in the plasma membrane and mitochondria, respectively. Choline uptake was saturable and mediated by a single transport system, which is both $Na^+$-independent and pH-dependent. Choline uptake and cell viability were inhibited by various cationic drugs. Furthermore, a correlation analysis of the potencies of 47 drugs for the inhibition of choline uptake and cell viability showed a strong correlation. Choline uptake inhibitors and choline deficiency each inhibited cell viability and increased caspase-3/7 activity. We conclude that extracellular choline is mainly transported via a CTL1. The functional inhibition of CTL1 by cationic drugs could promote apoptotic cell death. Furthermore, CTL2 may be involved in choline uptake in mitochondria, which is the rate-limiting step in S-adenosylmethionine (SAM) synthesis and DNA methylation. Identification of this CTL1- and CTL2-mediated choline transport system provides a potential new target for esophageal cancer therapy.
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MACHINE LEARNING APPLICATION TO PREDICT COMBUSTION PHASE OF A DIRECT INJECTION SPARK IGNITION ENGINE
Rio Asakawa,Keisuke Yokota,Iku Tanabe,Kyohei Yamaguchi,Ratnak Sok,Hiroyuki Ishii,Jin Kusaka 한국자동차공학회 2022 International journal of automotive technology Vol.23 No.1
Lean-diluted combustion can enhance thermal efficiency and reduce exhaust gas emissions from spark-ignited (SI) gasoline engines. However, excessive lean mixture with external dilution leads to combustion instability due to high cycle-to-cycle variations (CCV). The CCV should be controlled as low as possible to achieve stable combustion, high engine performance, and low emissions. Therefore, a stable combustion control function is required to predict the combustion phase with a low calculation load. A machine learning-based function is developed in this work to predict the 50 % mass fraction burn location (MFB50). Input parameters to the machine learning model consist of 1-, 2-, 3-, and 4-cycle from a three-cylinder production-based gasoline engine operated under stoichiometric to the lean-burn mixture. The results show that the MFB50 prediction model achieves high accuracy when 2-cycle data are used relative to 1-cycle data, which implies that the previous cycle data affects the predicted MFB50 of the next cycle. As a result, the neural network model can predict the cyclic MFB50 error within ± 3 oCA CCV and ± 5 oCA CCV with 70 % and 90 % accuracy, respectively. However, an increasing number of cycle data worsens the prediction accuracy due to model over-learning.
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Fumiaki Nagashima,Ryohta Nishiyama,Beniko Iwao,Yuiko Kawai,Chikanao Ishii,Tsuyoshi Yamanaka,Hiroyuki Uchino,Masato Inazu 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.4
In this study, we examined the molecular and functional characterization of choline uptake in the human esophageal cancer cells. In addition, we examined the influence of various drugs on the transport of [3H]choline, and explored the possible correlation between the inhibition of choline uptake and apoptotic cell death. We found that both choline transporter-like protein 1 (CTL1) and CTL2 mRNAs and proteins were highly expressed in esophageal cancer cell lines (KYSE series). CTL1 and CTL2 were located in the plasma membrane and mitochondria, respectively. Choline uptake was saturable and mediated by a single transport system, which is both Na+-independent and pH-dependent. Choline uptake and cell viability were inhibited by various cationic drugs. Furthermore, a correlation analysis of the potencies of 47 drugs for the inhibition of choline uptake and cell viability showed a strong correlation. Choline uptake inhibitors and choline deficiency each inhibited cell viability and increased caspase-3/7 activity. We conclude that extracellular choline is mainly transported via a CTL1. The functional inhibition of CTL1 by cationic drugs could promote apoptotic cell death. Furthermore, CTL2 may be involved in choline uptake in mitochondria, which is the rate-limiting step in S-adenosylmethionine (SAM) synthesis and DNA methylation. Identification of this CTL1- and CTL2-mediated choline transport system provides a potential new target for esophageal cancer therapy.
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Shinji Tanishima,Tokumitsu Mihara,Atsushi Tanida,Chikako Takeda,Masaaki Murata,Toshiaki Takahashi,Koji Yamane,Tsugutake Morishita,Yasuo Morio,Hiroyuki Ishii,Satoru Fukata,Yoshiro Nanjo,Yuki Hamamoto,T 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.3
Study Design: Multicenter, prospective study. Purpose: To investigate the effects of diabetes mellitus (DM) on surgical outcomes in patients with cervical myelopathy. Overview of Literature: To date, few studies have investigated the influence of postoperative blood glucose or glycated hemoglobin (HbA1c) levels on surgical outcomes. Methods: The participants were patients who underwent surgery for the treatment of cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament. The 61 cases were evaluated preoperatively and 1 year postoperatively using the Japanese Orthopaedic Association (JOA) scores and the JOA Cervical Myelopathy Evaluation Questionnaire (JOACMEQ). The study variables included fasting blood glucose and HbA1c levels measured preoperatively and at 1 week, 4 weeks, and 1 year postoperatively; the F-wave conduction velocity, latency, rate of occurrence, and M-wave latency in the ulnar and tibial nerves were measured preoperatively and at 1 year postoperatively. The patients were divided into a group without diabetes (N group, 42 patients) and a group with diabetes (DM group, 19 patients). We then assessed the associations between the surgical outcomes and each of the study variables. Results: JOA scores significantly improved in both groups; however, no significant between-group differences were found. There was no significant improvement in the JOACMEQ scores, which assessed cervical function, upper and lower limb function, and bladder function in both groups. We then subdivided the DM group into those with a good control of HbA1c after 1 year (DMG group, 12 patients) and those with HbA1c deterioration after 1 year (DMB group, seven patients), prior to comparing the surgical outcomes. The JOACMEQ scores for upper and lower limb function significantly improved in the DMG group (p<0.01). Compared with the DMB group, there were no significant increases in upper or lower limb function scores in the DMG group. Conclusions: Poor glycemic control might prevent postoperative functional recovery of the spinal cord.
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