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Acute and a 28-repeated dose toxicity study of commercial oleoresin from Copaifera sp. in rodents
Marina Alves Coelho Silva,Dorcas Fernandes dos Anjos Melo,Sayonara Ay Moré de Oliveira,Alessandro de Carvalho Cruz,Edemilson Cardoso da Conceição,José Realino de Paula,Ruy de Souza Lino Junior,Luiz Ca 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.4
Copaifera spp. (copaiba) oleoresin is traditionally used as a medicinal compound since the 16th century, which is primarily indicated for its anti-inflammatory properties being widely sold in free fairs and medicinal herbal houses in Brazil. However, copaiba oleoresin toxicity information is still limited. In this study, we aimed to investigate the acute (in mice and rats) and 28 day—repeated doses (in rats) oral toxicity of commercial copaiba oleoresin. In the acute toxicity test, copaiba oleoresin oral administration at 2000 mg/kg dose did not induce mice or rat lethality. In the subacute toxicity tests, we administered copaiba oleoresin at daily doses of 25, 50, or 100 mg/kg for 28 days. We observed no toxicological effects in body weight gain, feed and water intake, gross necropsy, relative organ weight, histopathology, hematology, or biochemistry parameters. At the three copaiba oleoresin tested doses, we observed an alkaline phosphatase reduction, which might indicate hepatic protection. In conclusion, the commercial copaiba oleoresin has a low risk of toxicity and did not induce treatment-related adverse effects after short-term daily exposures to a dose two thousand times higher than folk use, showing safety doses for further pharmacological investigations.
Handray Fernandes de Souza,Giovana Felicio Monteiro,Victor Dédalo Di Próspero Gonçalves,João Vitor dos Santos,Amanda Cristina Dias de Oliveira,Karina Nascimento Pereira,Mariana Fronja Carosia,Marina V 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.7
Mead is a fermented alcoholic beverage produced by yeast action on a diluted solution of honey. In this study, for the first time, sensory acceptance, purchase intention and color parameters of potentially probiotic mead with Saccharomyces boulardii were evaluated. The mead with S. boulardii presented yeast counts higher than 106 CFU/mL, being considered potentially probiotic, and tended to be yellow in color. About 160 tasters participated in the sensory evaluation, and 69.38% knew mead, but only 35.62% had tried the beverage. In terms of acceptance, the mead were within the acceptable range (above 5), and F2 (with initial soluble solids of 30° Brix and S. boulardii concentration of 0.030 g/L) was the most accepted, with an overall average of 7.63 ± 1.42 on the nine-point hedonic scale. In addition, F2 presented the highest purchase intention. In conclusion, the mead showed a tendency towards the color yellow and good sensory acceptance.
Juice Test for Identification of Nonerosive Reflux Disease in Heartburn Patients
Michel R Fernandes,Marina De Oliveira,Sidia M Callegari-Jacques,Gissele V R Gonçalves,Fernando Fornari 대한소화기 기능성질환∙운동학회 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.2
Background/Aims Evaluation of esophageal clearance by orange juice swallowing could be useful to identify different categories of gastroesophageal reflux disease. We determined whether a juice test at the beginning of esophageal pH monitoring can identify nonerosive reflux disease (NERD) among heartburn patients. Methods Multiple swallows of orange juice (pH 3) were performed at the beginning of esophageal pH monitoring in 71 heartburn patients off acid-suppressive therapy. The area between pH drop below 5 and recovery to 5 was calculated from pH tracings and named Delta5 (mmol·L−1·sec). Fifteen healthy subjects served to determine Delta5 cutoff (95th percentile). Patients were classified as NERD, non-NERD (a mix of reflux hypersensitivity, functional heartburn, and undetermined), and erosive disease depending on acid exposure, reflux symptom analysis, and upper endoscopy. Results Delta5 cutoff in healthy subjects was 251 mmol·L−1·sec. Among 71 patients, 23 had NERD, 26 had non-NERD, and 22 had erosive disease. Compared to non-NERD, Delta5 was higher in both NERD (median [interquartile range]: 316 [213–472] vs 165 [105–225]; P < 0.01) and erosive disease (310 [169–625] vs 165 [105–225]; P < 0.01). An elevated Delta5 (> 251 mmol·L−1·sec) showed sensitivity of 74% and specificity of 81% for identification of NERD. Positive and negative likelihood ratios were 3.84 and 0.32 respectively, whereas test accuracy was 78%. Conclusions A juice test with calculation of Delta5 helps in the identification of true NERD among heartburn patients with endoscopy-negative reflux disease. In these patients, an elevated Delta5 could make prolonged reflux testing unnecessary.
Guilherme Godoy,Marina Masetto Antunes,Ingrid de Lima Fernandes,Luciana Pelissari Manin,Caroline Zappielo,Laureane Nunes Masi,Juliana Vanessa Colombo Martins Perles,Jesuı´ Vergı´lio Visentainer,Rui Cu 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.12
We evaluated whether linseed oil (LO) modulates the effects of a high-carbohydrate diet (HCD) on liver inflammation, fatty acid (FA) accumulation, and lipid distribution in periportal and perivenous hepatocytes. The control group (control high-carbohydrate diet [HCD-C]) received an HCD with lard and soybean oil as the lipid source. The L10 and L100 groups received the HCD with 10% and 100% of LO as the lipid source, respectively. The animals were killed by decapitation before (day 0) and after receiving the diets. Liver FA composition, inflammation, and fibrogenesis gene expression were evaluated. Also, the percentage of lipid-occupied area in periportal end perivenous hepatocytes were measured. The L100 group exhibited a higher (P < .05) liver amount of omega-3 polyunsaturated FA (n-3 PUFA) and lower (P < .05) amounts of saturated FA (SFA), monounsaturated FA (MUFA), and omega-6 polyunsaturated FA (n-6 PUFA) compared with L10 or HCD-C mice. On day 56, interleukin 10 and type IV collagen gene expression were significantly upregulated and downregulated, respectively in L100. Also, the L100 group showed lower (P < .05) FA accumulation (i.e., total FA, SFA, MUFA, and n-6 PUFA). Also, L10 and L100 presented lower (P < .05) percentage of high lipid-containing portion in periportal and perivenous hepatocytes. We concluded that LO attenuation of liver inflammation promoted by an HCD is associated with increased liver n-3 PUFA levels, so modulating FA composition, deposition, and distribution in periportal and perivenous hepatocytes.
Decreased Docosahexaenoic Acid Levels in Serum of HIV Carrier Patients
Guilherme Godoy,Marina Masetto Antunes,Maria Angelica Raffaini Covas Pereira da Silva,Ingrid de Lima Fernandes,Jesuí Vergílio Visentainer,Jeane Eliete Laguila Visentainer,Rui Curi,Roberto Barbosa Bazo 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.6
The study aimed to measure serum fatty acids (FAs) composition in HIV carrier patients and compare it with non-HIV carrier patients. The FAs composition was measured by gas chromatography as follows: four saturated FAs myristic acid (14:0), palmitic acid (16:0), stearic acid (18:0), and docosanoic acid (22:0); four monounsaturated FAs 7-hexadecenoic acid (16:1 n-9), palmitoleic acid (16:1 n-7), oleic acid (18:1 n-9), and vaccenic acid (18:1 n-7); and three polyunsaturated FAs linoleic acid (18:2 n-6), dihomo-γ-linolenic acid (20:3 n-6), and docosahexaenoic acid (DHA, 22:6 n-3). We reported herein lower (P < .05) DHA concentration (by 40%) in the serum of HIV carrier patients than in non-HIV carrier patients. This FA has a pivotal role as a precursor of anti-inflammatory molecules with beneficial effects on metabolism, cardiovascular system, and immunological system. Even though most clinical studies reported beneficial effects of DHA supplementation in HIV carrier patients, this issue remains under debate. Further investigations then require to fully clarify the role of DHA in preventing or alleviating the comorbidities associated with HIV infection.
Alcalde, Murilo Priori,Vivan, Rodrigo Ricci,Marciano, Marina Angelica,Duque, Jussaro Alves,Fernandes, Samuel Lucas,Rosseto, Mariana Bailo,Duarte, Marco Antonio Hungaro The Korean Academy of Conservative Dentistry 2018 Restorative Dentistry & Endodontics Vol.43 No.2
Objectives: This study evaluated the effect of ultrasonic agitation of mineral trioxide aggregate (MTA), calcium silicate-based cement (CSC), and Sealer 26 (S26) on adaptation at the cement/dentin interface and push-out bond strength. Materials and Methods: Sixty maxillary canines were divided into 6 groups (n = 10): MTA, S26, and CSC, with or without ultrasonic activation (US). After obturation, the apical portions of the teeth were sectioned, and retrograde cavities were prepared and filled with cement by hand condensation. In the US groups, the cement was activated for 60 seconds: 30 seconds in the mesio-distal direction and 30 seconds in the buccal-lingual direction, using a mini Irrisonic insert coupled with the ultrasound transducer. After the materials set, 1.5-mm thick sections were obtained from the apexes. The presence of gaps and the bond between cement and dentin were analyzed using low-vacuum scanning electron microscopy. Push-out bond strength was measured using a universal testing machine. Results: Ultrasonic agitation increased the interfacial adaptation of the cements. The S26 US group showed a higher adaptation value than MTA (p < 0.05). US improved the push-out bond strength for all the cements (p < 0.05). Conclusions: The US of retrograde filling cements enhanced the bond to the dentin wall of the root-end filling materials tested.
Fibre reinforcement in a structurally compromised endodontically treated molar: a case report
Soares, Renita,Ataide, Ida de Noronha de,Fernandes, Marina,Lambor, Rajan The Korean Academy of Conservative Dentistry 2016 Restorative Dentistry & Endodontics Vol.41 No.2
The reconstruction of structurally compromised posterior teeth is a rather challenging procedure. The tendency of endodontically treated teeth (ETT) to fracture is considerably higher than vital teeth. Although posts and core build-ups followed by conventional crowns have been generally employed for the purpose of reconstruction, this procedure entails sacrificing a considerable amount of residual sound enamel and dentin. This has drawn the attention of researchers to fibre reinforcement. Fibrereinforced composite (FRC), designed to replace dentin, enables the biomimetic restoration of teeth. Besides improving the strength of the restoration, the incorporation of glass fibres into composite resins leads to favorable fracture patterns because the fibre layer acts as a stress breaker and stops crack propagation. The following case report presents a technique for reinforcing a badly broken-down ETT with biomimetic materials and FRC. The proper utilization of FRC in structurally compromised teeth can be considered to be an economical and practical measure that may obviate the use of extensive prosthetic treatment.
Fibre reinforcement in a structurally compromised endodontically treated molar: a case report
Renita Soares,Ida de Noronha de Ataide,Marina Fernandes,Rajan Lambor 대한치과보존학회 2016 Restorative Dentistry & Endodontics Vol.41 No.2
The reconstruction of structurally compromised posterior teeth is a rather challenging procedure. The tendency of endodontically treated teeth (ETT) to fracture is considerably higher than vital teeth. Although posts and core build-ups followed by conventional crowns have been generally employed for the purpose of reconstruction, this procedure entails sacrificing a considerable amount of residual sound enamel and dentin. This has drawn the attention of researchers to fibre reinforcement. Fibre-reinforced composite (FRC), designed to replace dentin, enables the biomimetic restoration of teeth. Besides improving the strength of the restoration, the incorporation of glass fibres into composite resins leads to favorable fracture patterns because the fibre layer acts as a stress breaker and stops crack propagation. The following case report presents a technique for reinforcing a badly broken-down ETT with biomimetic materials and FRC. The proper utilization of FRC in structurally compromised teeth can be considered to be an economical and practical measure that may obviate the use of extensive prosthetic treatment.
Erbium on MgO(100)/Ag(100) as candidate for single-atom-qubit
Stefano Reale,Jiyoon Hwang,Jeongmin Oh,Aparajita Singha,Safa L. Ahmed,Denis Krylov,Luciano Colazzo,Christoph Wolf,Carlo S. Casari,Alessandro Barla,Edgard Fernandes,Francois Patthey,Marina Pivetta,Stef 한국자기학회 2023 한국자기학회 학술연구발표회 논문개요집 Vol.33 No.1