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Moon, Surk-Sik,Rahman, Md. Aziz Abdur,Manir, Md. Maniruzzaman,Ahamed, V.S. Jamal 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.8
Bioassay-directed fractionation of a methanolic extract from the seeds of Draba nemorosa (Brassicaceae) led to isolation of a new flavonol glycoside, drabanemoroside (5, kaempferol 3-O-${\alpha}$-L-rhamnopyranosyl-(1${\rightarrow}$2)-${\alpha}$-L-arabinopyranose) along with four known flavonoid derivatives (1-4), four cardenolide glycosides (6-9). Kaempferol glycosides 2 and 5 showed strong cytotoxicity against human small lung cancer cell line A549 and melanoma SK-Mel-2 with an $IC_{50}$ of 0.5 ${\mu}g/mL$ and 1.9 ${\mu}g/mL$, respectively. Cardenolide glycosides 6-9 showed potent cyto-toxicity (A549) in the range of 0.01-0.032 ${\mu}g/mL$. Their structures were characterized based on spectroscopic data (2D NMR, HRTOFMS, IR, and UV) and comparison of literature values. The carbohydrate units were also confirmed by comparing the hydrolysate of 5 with authentic monosaccharides.
노성우,Rira Seo,박중권,Md. Maniruzzaman Manir,박경석,상미경,문석식,정호원 한국식물병리학회 2017 Plant Pathology Journal Vol.33 No.4
Cyclic dipeptides (CDPs) are one of the simplest compounds produced by living organisms. Plant-growth promoting rhizobacteria (PGPRs) also produce CDPs that can induce disease resistance. Bacillus vallismortis strain BS07 producing various CDPs has been evaluated as a potential biocontrol agent against multiple plant pathogens in chili pepper. However, plant signal pathway triggered by CDPs has not been fully elucidated yet. Here we introduce four CDPs, cyclo(Gly- L-Pro) previously identified from Aspergillus sp., and cyclo(L-Ala-L-Ile), cyclo(L-Ala-L-Leu), and cyclo(LLeu- L-Pro) identified from B. vallismortis BS07, which induce disease resistance in Arabidopsis against Pseudomonas syringae infection. The CDPs do not directly inhibit fungal and oomycete growth in vitro. These CDPs require PHYTOALEXIN DEFICIENT4, SALICYLIC ACID INDUCTION DEFICIENT2, and NONEXPRESSOR OF PATHOGENESIS-RELATED PROTEINS1 important for salicylic acid-dependent defense to induce resistance. On the other hand, regulators involved in jasmonate-dependent event, such as ETHYLENE RECEPTOR1, JASMONATE RESPONSE1, and JASMONATE INSENSITIVE1, are necessary to the CDP-induced resistance. Furthermore, treatment of these CDPs primes Arabidopsis plants to rapidly express PATHOGENESIS-RELATED PROTEIN4 at early infection phase. Taken together, we propose that these CDPs from PGPR strains accelerate activation of jasmonate-related signaling pathway during infection.
Noh, Seong Woo,Seo, Rira,Park, Jung-Kwon,Manir, Md. Maniruzzaman,Park, Kyungseok,Sang, Mee Kyung,Moon, Surk-Sik,Jung, Ho Won The Korean Society of Plant Pathology 2017 Plant Pathology Journal Vol.33 No.4
Cyclic dipeptides (CDPs) are one of the simplest compounds produced by living organisms. Plant-growth promoting rhizobacteria (PGPRs) also produce CDPs that can induce disease resistance. Bacillus vallismortis strain BS07 producing various CDPs has been evaluated as a potential biocontrol agent against multiple plant pathogens in chili pepper. However, plant signal pathway triggered by CDPs has not been fully elucidated yet. Here we introduce four CDPs, cyclo(Gly-L-Pro) previously identified from Aspergillus sp., and cyclo(L-Ala-L-Ile), cyclo(L-Ala-L-Leu), and cyclo(L-Leu-L-Pro) identified from B. vallismortis BS07, which induce disease resistance in Arabidopsis against Pseudomonas syringae infection. The CDPs do not directly inhibit fungal and oomycete growth in vitro. These CDPs require PHYTOALEXIN DEFICIENT4, SALICYLIC ACID INDUCTION DEFICIENT2, and NONEXPRESSOR OF PATHOGENESIS-RELATED PROTEINS1 important for salicylic acid-dependent defense to induce resistance. On the other hand, regulators involved in jasmonate-dependent event, such as ETHYLENE RECEPTOR1, JASMONATE RESPONSE1, and JASMONATE INSENSITIVE1, are necessary to the CDP-induced resistance. Furthermore, treatment of these CDPs primes Arabidopsis plants to rapidly express PATHOGENESIS-RELATED PROTEIN4 at early infection phase. Taken together, we propose that these CDPs from PGPR strains accelerate activation of jasmonate-related signaling pathway during infection.
Park, Kyungseok,Park, Yong-Soon,Ahamed, Jamal,Dutta, Swarnalee,Ryu, Hojin,Lee, Seo-Hyun,Balaraju, Kotnala,Manir, Maniruzzaman,Moon, Surk-Sik AGRICULTURAL INSTITUTE OF CANADA 2016 Canadian journal of plant science Vol.96 No.4
<P>Cyclic lipopeptides (CLPs) derived from plant growth-promoting rhizobacteria (PGPR) are well known as potential antifungal compounds. However, the physiological function of CLPs from Bacillus vallismortis strain EXTN-1 (EXTN-1) is still poorly understood. In this study, we proposed the potential role of iturin A analogs in modulation of induced systemic resistance (ISR) of chili pepper in response to Phytophthora capsici. Seven individual iturin A analogs were identified from EXTN-1, and iturin A analogs pre-treated plants resulted in a significant reduction of disease. However, no iturins directly inhibited growth of P. capsici in vitro antibiosis assay, indicating the existence of other possibilities for suppression of disease. The expression analysis of defense-related marker genes PR1, PR4, PR10, chitinase, peroxidase, and beta-1,3-glucanase revealed that transcript levels of these genes were dramatically up-regulated in iturin A analog treated plants after inoculation of P. capsici, suggesting that iturin-triggered plant systemic defense responses were involved in attenuating the disease symptoms. Collectively, our results clearly suggest that iturin A analogs from EXTN-1 are required for alleviation of P. capsici-mediated disease incidence.</P>