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HIGH PERFORMANCE SOLVERS FOR SEMIDEFINITE PROGRAMS
Makoto Yamashita,Katsuki Fujisawa,Kazuhiro Kobayashi,Mituhiro Fukuda,Kazuhide Nakata,Maho Nakata 한국산업응용수학회 2011 한국산업응용수학회 학술대회 논문집 Vol.6 No.2
Semidefinite program (SDP) is one of important problems in mathematical optimization, since it covers many applications. To solve SDPs, we have developed SDPA (SemiDefinite Programming Algorithms) and its family. SDPARA can solve extremely large-scale SDPs in a short time by parallel computing, and SDPA-GMP can obtain highly accurate solutions of SDPs.
Evaluation of machinability in milling by controlling chip thickness using NC simulation
Makoto Nikawa,Masato Okada,Hiroki Mori,Yasuhiro Fujii,Minoru Yamashita 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.10
In this study, the machinability of the machining method for controlling chip thickness during the cutting operation was evaluated using simulation based on NC data. A comparative three-dimensional cutting test with a ball end mill was performed using both original and modified NC data. The modified NC data was created for the purpose of controlling the chip thickness generated when cutting with a constant rotation value and changing the feed rate of the original NC data. The results indicated that the actual chip thickness exceeded that of the calculated value although the thickness fluctuation was suppressed. The results revealed that the maximum cutting force and the fluctuation range of cutting force were low, and tool wear after cutting was suppressed using the modified NC data. The application of the method to the cutting of complicated shapes with high removing volume led to reductions in the cutting time by 31 %.
Shinji Yamashita,Arima Fukunishi,Haruki Higashino,Makoto Kataoka,Koichi Wada 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.2
Telmisartan is a biopharmaceutics drug classification system class II drug having a low solubility at neutral pH region. The purpose of this study is to clarify the process of dissolution and precipitation of telmisartan in the gastrointestinal tract from its oral formulation containing meglumine, a pH modifier (alkalizer). Granules of telmisartan containing different amount of meglumine were prepared, and its dissolution and precipitation profiles were investigated under various pH conditions in vitro. It was demonstrated that meglumine induced a supersaturation of telmisartan both at pH 5.0 and pH 6.8. Dissolved amount of telmisartan fluctuated over time and the pattern of dissolved concentration differed depending on the pH and the amount of meglumine. Powder X-ray diffraction analysis and differential scanning calorimetry analysis on precipitates from supersaturated solutions showed that pH of the dissolution medium profoundly affects the crystalline form of telmisartan. Furthermore, the effect of meglumine on oral absorption of telmisartan was investigated with dissolution/ permeation System in vitro. At pH 6.8, permeated amount was significantly higher with the formulation which contains larger amount of meglumine. Therefore, despite the very low solubility of telmisartan at neutral pH, meglumine significantly provided high solubility of telmisartan by induction and maintenance of its supersaturation.
Olanzapine Attenuates Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve Ligation
( Taeko Fukuda ),( Soichiro Yamashita ),( Setsuji Hisano ),( Makoto Tanaka ) 대한통증학회 2015 The Korean Journal of Pain Vol.28 No.3
Background: Neuropathic pain is a global clinical problem; nevertheless, nerve injury treatment methods remain limited. Olanzapine has antinociceptive and anti-nueropathic properties; however, its preventive effects have not been assessed in nerve injury models. Methods: We prepared a partial sciatic nerve ligation (Seltzer model) or sham-operated model in male Sprague-Dawley rats under isoflurane anesthesia. In a pre-treatment study, we administered olanzapine (10 mg/kg) intraperitoneally 1 h before nerve ligation. In post-treatment and dose-dependent studies, we injected 3 different doses of olanzapine intraperitoneally 1 h after nerve ligation. Mechanical allodynia was measured before and 7 days after surgery. Immunohistochemical analysis using anti-Iba-1 antibody was used to assess the effect of olanzapine at the spinal level. Results: In the pre-treatment study, median withdrawal thresholds of the normal saline groups were significantly lower than those of the sham-operated groups; however, those of the olanzapine (10 mg/kg) and sham-operated groups were not different. In the post-treatment and dose-dependent studies, the median withdrawal thresholds of the olanzapine (2.5 mg/kg) and normal saline groups were not different; however, those of the olanzapine (10 and 50 mg/kg) groups were significantly higher than those of the normal saline groups. Olanzapine did not have a significant effect on the density of Iba-1 staining. Conclusions: Olanzapine attenuated mechanical allodynia dose-dependently in the Seltzer model. This anti-allodynic effect of olanzapine was observed even when injected 1 h after nerve ligation. This effect of olanzapine appeared to be unrelated to microglia activation in the ipsilateral dorsal horn of the lumbar spinal cord. (Korean J Pain 2015; 28: 185-192)
Tagawa, Hiroyuki,Miyamura, Tomoshi,Yamashita, Takuzo,Kohiyama, Masayuki,Ohsaki, Makoto Council on Tall Building and Urban Habitat Korea 2015 International journal of high-rise buildings Vol.4 No.1
Detailed finite element (FE) analyses of a full-scale four-story steel frame structure, subjected to consecutive 60% and 100% excitations from the JR Takatori records during the 1995 Hyogoken-Nanbu earthquake, are conducted using E-Simulator. The four-story frame was tested at the largest shake-table facility in the world, E-Defense, in 2007. E-Simulator is a parallel FE analysis software package developed to accurately simulate structural behavior up to collapse by using a fine mesh of solid elements. To reduce computational time in consecutive dynamic time history analyses, static analysis with gravity force is introduced to terminate the vibration of the structure during the analysis of 60% excitation. An overall sway mechanism when subjected to 60% excitation and a story mechanism resulting from local buckling of the first-story columns when subjected to 100% excitation are simulated by using E-Simulator. The story drift response to the consecutive 60% and 100% excitations is slightly smaller than that for the single 100% excitation.
Collective Forest Management System in Japan: a Case Study in Osawa Property Ward Forest
Mangala Premakumara De Zoysa,Makoto Inoue,Utako Yamashita,Okuda Hironori 강원대학교 산림과학연구소 2013 Journal of Forest Science Vol.29 No.1
Iriai an Indigenous forest management system in Japan from the viewpoint of “common pool resources” was a success resilient institution and resulted with sustainable production system and environmental conservation. This study was conducted in Osawa of the Nagano prefecture through group discussions, field observations and an in-depth field survey. Osawa Property Ward Forest is managed under the concept very much similarly to raditional “Iriai”. This study firstly examined the changes of collective forest management system in terms of awareness and interest in forest management; forest management activities; role of forest; and collection of forest products. Then it analyzed the current threats for collective forest management have been identified as: land abandonment due to loss of benefits and lack of active community participation; deterioration of forest environment particularly the micro-climate and aesthetic values; conflict with local government authorities restraining the use of money in property ward forest and conflict with outsiders on damping of the garbage. Community cantered forestry management rules; livelihood contribution; protection of environment; local initiatives for protection and economic activities are the prevailing opportunities for collective forest management. The main requirements for revitalization of collective forest management are explained as local reciprocity; imposition of community based forest rules; encouraging local innovations; and building partnerships with stakeholders. Collective forest management system addresses the limitations of conventional forestry models, which had invalidated traditional ‘iriai’ institutions, and key to restoring sustainable use of forest and environmental resources. Cross-institutional collaborations together with responsibilities of local communities would ensure the revitalization of forest resources.