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Makoto Fujimoto,Koichi Tsuneyama,Yuko Nakanishi,Thucydides L. Salunga,Kazuhiro Nomoto,Yoshiyuki Sasaki,Seiichi Iizuka,Mitsunobu Nagata,Wataru Suzuki,Tsutomu Shimada,Masaki Aburada,Yutaka Shimada,M. Er 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.3
The metabolic syndrome is a major worldwide health care issue and a dominant risk factor for cardiovascular disease. The liver manifestations of this syndrome include nonalcoholic fatty liver disease (NAFLD) and its progressive variant nonalcoholic steatohepatitis (NASH). Although significant research has been performed, the basic pathogenesis of NAFLD/NASH remains controversial and effective treatments are still unavailable. We have previously reported on a murine model of NASH induced by the neonatal injection of monosodium glutamate (MSG), which includes the clinical manifestations of central obesity, diabetes, hyperlipidemia, and ultimately liver inflammation, fibrosis, and cancer. Although MSG is considered a safe food additive, its administration to pregnant rats increases the voracity and growth hormone levels in the offspring. To further understand the biology of this model, we have investigated the influence of the calorie intake on these clinical manifestations by feeding animals a restrictive diet. MSG-treated animals fed a restrictive diet continue to manifest obesity and early stage NASH but have improvements in serum lipid profiles. At 12 months of age, mice had manifestations of obesity, whether animals were fed a restricted or control diet, but animals fed a restrictive diet had a reduction in the progression of NASH. In conclusion, MSG appears to be a critical factor in the initiation of obesity, whereas calorie intake may modulate the progression of disease.
Extended supersymmetry in Dirac action with extra dimensions
Fujimoto, Yukihiro,Hasegawa, Kouhei,Nishiwaki, Kenji,Sakamoto, Makoto,Tatsumi, Kentaro,Ueba, Inori IOP 2018 JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL Vol.51 No.43
<P>We investigate a new realization of extended quantum-mechanical supersymmetry. We first show that an <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/1751-8121/51/43/435201/aaadea2ieqn001.gif'/> quantum-mechanical supersymmetry is hidden in the four-dimensional (4D) spectrum of the Kaluza–Klein decomposition for the higher dimensional Dirac field, that is, Kaluza–Klein mode functions of 4D right-handed spinors and 4D left-handed ones form <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/1751-8121/51/43/435201/aaadea2ieqn002.gif'/> supermultiplets. In addition to <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/1751-8121/51/43/435201/aaadea2ieqn003.gif'/> supersymmetry, we discover that an <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/1751-8121/51/43/435201/aaadea2ieqn004.gif'/>-extended supersymmetry (<img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/1751-8121/51/43/435201/aaadea2ieqn005.gif'/> for <I>d</I> = even (odd) extra dimensions) is further hidden in the 4D spectrum. The extended symmetry can explain additional degeneracy of the spectrum. Furthermore, we show that a superpotential can be introduced into the <img ALIGN='MIDDLE' ALT='' SRC='http://ej.iop.org/images/1751-8121/51/43/435201/aaadea2ieqn006.gif'/>-extended supercharges and clarify the condition to preserve the supersymmetry. The partial breaking of the supersymmetry is also demonstrated.</P>
Comprehensive analysis of Yukawa hierarchies onT2/ZNwith magnetic fluxes
Fujimoto, Yukihiro,Kobayashi, Tatsuo,Nishiwaki, Kenji,Sakamoto, Makoto,Tatsuta, Yoshiyuki American Physical Society 2016 Physical Review D Vol.94 No.3
<P>Based on the results of the classification by T.-h. Abe et al., Nucl. Phys. B894, 374 (2015)., we exhaustively investigate Yukawa sector of U(8) model on magnetized orbifolds T-2 / Z(2), T-2 / Z(3), T-2 / Z(4) and T-2 / Z(6) by evaluating ratios of the mass eigenvalues of the three states in all the possible configurations with one and two Higgs pairs where three generations are realized in fermions. Because of the smearing effect via kinetic mixing, one can realize a hierarchy such as 10(-2)-10(-3), but it is very difficult to achieve the mass ratio between the up and top quarks (m(up) / m(top) similar to 10(-5)) on the complicated magnetized orbifolds T-2 / Z(N) (N similar to 3,4,6).</P>
Dynamical generation of fermion mass hierarchy in an extra dimension
Fujimoto, Yukihiro,Miura, Takashi,Nishiwaki, Kenji,Sakamoto, Makoto American Physical Society 2018 Physical Review D Vol.97 No.11
<P>We propose a new mechanism to produce a fermion mass hierarchy dynamically in a model with a single generation of fermions. A five-dimensional gauge theory on an interval with point interactions (zero-width brans) takes responsibility for realizing three generations and each massless zero mode localizes at boundaries of the segments on the extra dimension. An extra dimension coordinate-dependent vacuum expectation value of a scalar field makes large differences in overlap integrals of the localized zero modes and then an exponential fermion mass hierarchy can appear. The positions of the point interactions control the magnitude of the fermion mass hierarchy and are determined by the minimization condition of the Casimir energy. As a result of the minimization of the Casimir energy, an exponential mass hierarchy appears dynamically. We also discuss the stability of the extra dimension.</P>
Koneri, Kenji,Hirono, Yasuo,Fujimoto, Daisuke,Sawai, Katsuji,Morikawa, Mitsuhiro,Murakami, Makoto,Goi, Takanori,Iida, Atsushi,Katayama, Kanji,Yamaguchi, Akio The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.1
Alpha-fetoprotein-producing gastric cancer is associated with poor prognosis because of frequent liver and lymph node metastasis. We present a case with synchronous liver metastasis who survived for 5 years. A 69-year-old man with upper abdominal pain was referred to our hospital. Gastrointestinal endoscopy revealed a Borrmann II-like tumor in the lower part of the stomach. Computed tomography revealed a tumor in the left lobe of the liver. Serum alpha-fetoprotein levels were markedly increased. We performed distal gastrectomy after administering oral tegafur/gimeracil/oteracil potassium and administered hepatic intra-arterial cisplatin injection. Liver metastasis showed partial response on computed tomography. Despite left hepatic lobectomy, further metastases to the liver and mediastinal lymph nodes became difficult to control. After sorafenib tosylate administration, stabilization of the disease was observed for 4 months. We conclude that hepatic intra-arterial chemotherapy and oral administration of sorafenib tosylate may potentially improve the prognosis in such cases.
Operator analysis of physical states on magnetized <sup> T 2 </sup> / <sub> Z N </sub> orbifolds
Abe, Tomo-hiro,Fujimoto, Yukihiro,Kobayashi, Tatsuo,Miura, Takashi,Nishiwaki, Kenji,Sakamoto, Makoto Elsevier 2015 Nuclear physics, B Vol.890 No.-
<P><B>Abstract</B></P> <P>We discuss an effective way for analyzing the system on the magnetized twisted orbifolds in operator formalism, especially in the complicated cases <SUP> T 2 </SUP> / <SUB> Z 3 </SUB> , <SUP> T 2 </SUP> / <SUB> Z 4 </SUB> and <SUP> T 2 </SUP> / <SUB> Z 6 </SUB> . We can obtain the exact and analytical results which can be applicable for any larger values of the quantized magnetic flux <I>M</I>, and show that the (non-diagonalized) kinetic terms are generated via our formalism and the number of the surviving physical states are calculable in a rigorous manner by simply following usual procedures in linear algebra in any case. Our approach is very powerful when we try to examine properties of the physical states on (complicated) magnetized orbifolds <SUP> T 2 </SUP> / <SUB> Z 3 </SUB> , <SUP> T 2 </SUP> / <SUB> Z 4 </SUB> , <SUP> T 2 </SUP> / <SUB> Z 6 </SUB> (and would be in other cases on higher-dimensional torus) and could be an essential tool for actual realistic model construction based on these geometries. (Note: This article is registered under preprint number: arXiv:1409.5421.)</P>
Kenji Koneri,Yasuo Hirono,Daisuke Fujimoto,Katsuji Sawai,Mitsuhiro Morikawa,Makoto Murakami,Takanori Goi,Atsushi Iida,Kanji Katayama,Akio Yamaguchi 대한위암학회 2013 Journal of gastric cancer Vol.13 No.1
Alpha-fetoprotein–producing gastric cancer is associated with poor prognosis because of frequent liver and lymph node metastasis. We present a case with synchronous liver metastasis who survived for 5 years. A 69-year-old man with upper abdominal pain was referred to our hospital. Gastrointestinal endoscopy revealed a Borrmann II-like tumor in the lower part of the stomach. Computed tomography revealed a tumor in the left lobe of the liver. Serum alpha-fetoprotein levels were markedly increased. We performed distal gastrectomy after administering oral tegafur/gimeracil/oteracil potassium and administered hepatic intra-arterial cisplatin injection. Liver metastasis showed partial response on computed tomography. Despite left hepatic lobectomy, further metastases to the liver and mediastinal lymph nodes became difficult to control. After sorafenib tosylate administration, stabilization of the disease was observed for 4 months. We conclude that hepatic intra-arterial chemotherapy and oral administration of sorafenib tosylate may potentially improve the prognosis in such cases.