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Satoshi Ugi,Hiroshi Maegawa,Katsutaro Morino,Yoshihiko Nishio,Toshiyuki Sato,Seiki Okada,Yasuo Kikkawa,Toshihiro Watanabe,Hiromu Nakajima,Atsunori Kashiwagi 대한당뇨병학회 2016 Diabetes and Metabolism Journal Vol.40 No.4
Background: Management of postprandial hyperglycemia is a key aspect in diabetes treatment. We developed a novel system to measure glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET) for simple monitoring of postprandial glucose excursions. In this study, we evaluated the relationship between our system and continuous glucose monitoring (CGM) by comparing glucose AUC obtained using MIET with that obtained using CGM for a long duration. Methods: Twenty diabetic inpatients wearing a CGM system were enrolled. For MIET measurement, a plastic microneedle array was applied to the skin as pretreatment, and hydrogels were placed on the pretreated area to collect interstitial fluid. Hydrogels were replaced every 2 or 4 hours and AUC was predicted on the basis of glucose and sodium ion levels. Results: AUC predicted by MIET correlated well with that measured by CGM (r=0.93). Good performances of both consecutive 2- and 4-hour measurements were observed (measurement error: 11.7%±10.2% for 2 hours and 11.1%±7.9% for 4 hours), indicating the possibility of repetitive measurements up to 8 hours. The influence of neither glucose fluctuation nor average glucose level over the measurement accuracy was observed through 8 hours. Conclusion: Our system showed good relationship with AUC values from CGM up to 8 hours, indicating that single pretreatment can cover a large portion of glucose excursion in a day. These results indicated possibility of our system to contribute to convenient monitoring of glucose excursions for a long duration.
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy
Shinji Kume,Munehiro Kitada,Keizo Kanasaki,Hiroshi Maegawa,Daisuke Koya 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.2
Caloric restriction prolongs the lifespan ofmany species. Therefore, investigators have researched theusefulness of caloric restriction for healthy lifespan extension. Sirt1, an NAD?-dependent deacetylase, was identifiedas a molecule necessary for caloric restriction-related antiagingstrategies. Sirt1 functions as an intracellular energysensor to detect the concentration of NAD?, and controlsin vivo metabolic changes under caloric restriction andstarvation through its deacetylase activity to many targetsincluding histones, nuclear transcriptional factors, andenzymes. During the past decade, investigators havereported the relationship between disturbance of Sirt1activation and the onset of aging- and obesity-associateddiseases such as diabetes, cardiovascular disease and neurodegenerativedisorders. Consequently, a calorie restriction-mimetic action of Sirt1 is now expected as a newtherapy for these diseases. In addition, recent studies havegradually clarified the role of Sirt1 in the onset of kidneydisease. Its activation may also become a new target oftreatment in the patients with chronic kidney diseaseincluding diabetic nephropathy. In this article, we wouldlike to review the role of Sirt1 in the onset of kidney diseasebased on previous studies, and discuss its possibility as thetarget of treatment in diabetic nephropathy.