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Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy
Shinji Kume,Munehiro Kitada,Keizo Kanasaki,Hiroshi Maegawa,Daisuke Koya 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.2
Caloric restriction prolongs the lifespan ofmany species. Therefore, investigators have researched theusefulness of caloric restriction for healthy lifespan extension. Sirt1, an NAD?-dependent deacetylase, was identifiedas a molecule necessary for caloric restriction-related antiagingstrategies. Sirt1 functions as an intracellular energysensor to detect the concentration of NAD?, and controlsin vivo metabolic changes under caloric restriction andstarvation through its deacetylase activity to many targetsincluding histones, nuclear transcriptional factors, andenzymes. During the past decade, investigators havereported the relationship between disturbance of Sirt1activation and the onset of aging- and obesity-associateddiseases such as diabetes, cardiovascular disease and neurodegenerativedisorders. Consequently, a calorie restriction-mimetic action of Sirt1 is now expected as a newtherapy for these diseases. In addition, recent studies havegradually clarified the role of Sirt1 in the onset of kidneydisease. Its activation may also become a new target oftreatment in the patients with chronic kidney diseaseincluding diabetic nephropathy. In this article, we wouldlike to review the role of Sirt1 in the onset of kidney diseasebased on previous studies, and discuss its possibility as thetarget of treatment in diabetic nephropathy.
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