A self-powered β-Ga2O3/CsCu2I3 heterojunction photodiode responding to deep ultraviolet irradiation

Gao Ang,Jiang Weiyu,Ma Guoliang,Liu Zeng,Li Shan,Yan Zuyong,Sun Weiming,Zhang Shaohui,Tang Weihua 한국물리학회 2022 Current Applied Physics Vol.33 No.-

In this paper, a lead-free halide perovskite CsCu2I3 film with high stability was prepared by the anti-solvent assisted crystallization method. Then, we coupled it with Ga2O3 to prepare a corresponding heterojunction deep ultraviolet (UV) photodetector. After testing, we concluded that the photodetector is sensitive to 254 nm UV light. The photodetector has good reproducibility, and has an ultra-high photo-to-dark current ratio (PDCR) of more than 105. In addition, under a bias of 10 V and an illuminated intensity of 200 μW/cm2, the responsivity (R) and specific detectivity (D*) reached 20 mA/W and 107 cm Hz1/2 W 1 (Jones), and the external quantum efficiency (EQE) is 10%. Meanwhile, the prepared photodetector could operate at zero bias, i.e., self-powered operation, along with a photocurrent of about 1 nA under illumination with UV light intensity of 200 μW/cm2.

Knockdown of HMGN5 Expression by RNA Interference Induces Cell Cycle Arrest in Human Lung Cancer Cells

Chen, Peng,Wang, Xiu-Li,Ma, Zhong-Sen,Xu, Zhong,Jia, Bo,Ren, Jin,Hu, Yu-Xin,Zhang, Qing-Hua,Ma, Tian-Gang,Yan, Bing-Di,Yan, Qing-Zhu,Li, Yan-Lei,Li, Zhen,Yu, Jin-Yan,Gao, Rong,Fan, Na,Li, Bo,Yang, Jun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

HMGN5 is a typical member of the HMGN (high mobility group nucleosome-binding protein) family which may function as a nucleosomal binding and transcriptional activating protein. Overexpression of HMGN5 has been observed in several human tumors but its role in tumorigenesis has not been fully clarified. To investigate its significance for human lung cancer progression, we successfully constructed a shRNA expression lentiviral vector in which sense and antisense sequences targeting the human HMGN5 were linked with a 9-nucleotide loop. Inhibitory effects of siRNA on endogenous HMGN5 gene expression and protein synthesis were demonstrated via real-time RT-PCR and western blotting. We found HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation assessed by MTT, BrdU incorporation and colony formation assays. Furthermore, flow cytometry analysis showed that specific knockdown of HMGN5 slowed down the cell cycle at the G0/G1 phase and decreased the populations of A549 and H1299 cells at the S and G2/M phases. Taken together, these results suggest that HMGN5 is directly involved in regulation cell proliferation in A549 and H1299 cells by influencing signaling pathways involved in cell cycle progression. Thus, our finding suggests that targeting HMGN5 may be an effective strategy for human lung cancer treatment.

Microstructure and Biocompatibility of Porous Ti-Nb-Zr-CPP Composite Fabricated by Spark Plasma Sintering and Leaching Process

( Yan Hua Ma ),( Kee Do Woo ),( Dong Soo Kang ),( Sang Mi Kim ) 대한금속재료학회(구 대한금속학회) 2013 대한금속·재료학회지 Vol.51 No.5

Metallic biomaterials such as titanium and its alloys have been widely used as permanent implant materials due to their excellent corrosion resistance, fatigue property, and strength. Calcium pyrophosphate (CPP) is an attractive bioceramic for human tissue implantation due to its good biocompatibility and similar composition to human bone. High energy mechanical milling and spark plasma sintering (SPS) can be used to fabricate a sound composite of the Ti-Nb-Zr-CPP. In a biomaterial such as the Ti-6Al-4V ELI alloy, the coating property between the bioceramic and Ti-based alloy is very important. By addition of CPP to the Ti-Nb-Zr alloy, the Ti-Nb-Zr alloy can improve the wetability between the Ti alloy and bioceramic as a coating material. Also the porous surface of the biomaterials can improve the symphyseal ability with osteoblast. In this study, a porous surface can be made by using several different leaching solutions such as aqueous diluted H3PO4. Ti-Nb-Zr-CPP composite was fabricated by spark plasma sintering (SPS) at 1000 ℃ under 70 MPa using high energy mechanical milled powder. A porous surface was successfully fabricated by using a 40 vol%H3PO4+ 60 vol.%H2O leaching solution at room temperature for 24 h.

Clinical Evaluation of Tumor Markers for Diagnosis in Patients with Non-small Cell Lung Cancer in China

Ma, Li,Xie, Xiao-Wei,Wang, Hai-Yan,Ma, Ling-Yun,Wen, Zhong-Guang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12

Background: To evaluate the value of combined detection of serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), and carbohydrateantigen 125 (CA125) for the clinical diagnosis of nonsmall cell lung cancer (NSCLC). Materials and Methods: Serum CEA, CYFRA21-1 and CA125 were assessed in 140 patients with NSCLC, 90 patients with benign lung disease and 90 normal control subjects, and differences of expression were compared in each group, and joint effects of these tumor markers in the diagnosis of NSCLC were analyzed. Results: Serum CEA, CYFRA21-1 and CA125 in patients with NSCLC were significantly higher than those with benign lung disease and normal controls (P<0.05). The sensitivity of CEA, CYFRA21-1 and CA125 were 49.45%, 59.67%, and 44.87% respectively. As expected, combinations of these tumor markers improved their sensitivity for NSCLC. The combined detection of CEA + CYFRA21-1 was the most cost-effective combination which had higher sensitivity and specificity in NSCLC. Elevation of serum CEA and CYFRA21-1 was significantly associated with pathological types (P<0.05) and elevation of serum CEA, CYFRA21-1 and CA125 was significantly associated with TNM staging (P<0.05). Conclusions: Single measurement of CEA, CYFRA21-1 and CA125 is of diagnostic value in the diagnosis of lung cancer, and a joint detection of these three tumor markers, could greatly improve the sensitivity of diagnosis on NSCLC. Combined detection of CEA + CYFRA21-1 proved to be the most economic and practical strategy in diagnosis of NSCLC, which can be used to screen the high-risk group.

Exchange Bias in the Exchange Spring-like Ising Bilayer

Yan Ma,An Du 한국자기학회 2008 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-

Differential Roles of Glycogen Synthase Kinase 3 Subtypes Alpha and Beta in Cortical Development

Ma, Yan-xia,Wang, Xiu-li,Chen, Jian-quan,Li, Bin,Hur, Eun-Mi,Saijilafu Frontiers Media S.A. 2017 Frontiers in molecular neuroscience Vol.10 No.-

<P>Glycogen synthase kinases 3 (GSK3) α and β are expressed in the nervous system, and disruption of GSK3 signaling has been implicated in a wide range of neurodevelopmental and psychiatric disorders. Although several studies have established a role of GSK3 signaling in the nervous system, much less is known about isoform-specific functions. Here, we have examined the role of GSK3α and GSK3β in the developing neocortex by performing <I>in utero</I> electroporation with specific small interfering RNAs targeting each isoform. We found that depletion of either GSK3α or GSK3β commonly promoted the proliferation of neural progenitor cells in the ventricular zone, but at later stages, knocking down of each isoform resulted in distinct outcomes. In particular, the transformation of radial progenitors to intermediate progenitor cells was promoted in GSK3α-depleted cells, but markedly prevented in GSK3β-depleted cells. Moreover, knocking down of GSK3β but not GSK3α prevented the generation of upper-layer Cux1<SUP>+</SUP> neurons. Consistent with the distinct outcomes, protein levels of c-Myc and β-catenin, well-known substrates of GSK3, were differentially affected by depletion of GSK3α and GSK3β. Together, these results suggest that GSK3α and GSK3β might play distinct roles in the genesis and differentiation of neuronal lineage cells during neocortex development by differential regulation of downstream signaling pathways.</P>

Stochastic dynamic responses of a train-track-bridge system under spatially varying ground motions

Ma, Chun Yan(마춘연),Mu, Di(모디),Choi, Dong Ho(최동호) 한국강구조학회 2021 한국강구조학회 학술대회 발표집 Vol.32 No.1

Prognostic Role of Circulating Tumor Cells in Patients with Pancreatic Cancer: a Meta-analysis

Ma, Xue-Lei,Li, Yan-Yan,Zhang, Jing,Huang, Jing-Wen,Jia, Hong-Yuan,Liu, Lei,Li, Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Background: Isolation and characterization of circulating tumor cells (CTCs) in patients suffering from a variety of different cancers have become hot biomarker topics. In this study, we evaluated the prognostic value of CTCs in pancreatic cancer. Materials and Methods: Initial literature was identified using Medline and EMBASE. The primary data were hazard ratios (HRs) with 95% confidence intervals (CIs) of survival outcomes, including overall survival (OS) and progression free survival/recurrence free survival (PFS/RFS). Results: A total of 9 eligible studies were included in this meta-analysis, published between 2002 and 2013. The estimated pooled HR and 95%CI for OS for all studies was 1.64 (95%CI 1.39-1.94, p<0.00001) and the pooled HR and 95%CI for RFS/DFS was 2.36 (95%CI 1.41-3.96, p<0.00001). The HRs and 95%CIs for OS and RFS/DFS in patients before treatment were 1.93 (95%CI 1.26-2.96, p=0.003) and 1.82 (95%CI 1.22-2.72, p=0.003), respectively. In patients receiving treatment, the HRs and 95%CI for OS and RFS/DFS were 1.37 (95%CI 1.00-1.86, p=0.05) and 1.89 (95%CI 1.01-3.51, p=0.05), respectively. Moreover, the pooled HR and 95%CI for OS in the post-treatment group was 2.20 (95%CI 0.80-6.02, p=0.13) and the pooled HR for RFS/DFS was 8.36 (95%CI 3.22-21.67, p<0.0001). Conclusions: The meta-analysis provided strong evidence supporting the proposition that CTCs detected in peripheral blood have a fine predictive role in pancreatic patients especially on the time point of post-treatment.

An Octree-Based Two-Step Method of Surface Defects Detection for Remanufacture

Yan He,Wen Ma,Yufeng Li,Chuanpeng Hao,Yulin Wang,Yan Wang 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.2

Accurate and quick detection has a significant bearing on overall productivity of remanufacture. 3D scanning technologies have been widely applied in defects detection by comparing the damaged model with the nominal model. In this process, a huge amount of point cloud data is required to ensure detection accuracy whereas resulting in large storage space and long processing time of detection. This paper proposed an efficient two-step method based on octree to detect defects accurately and quickly for remanufacturing. In this method, the damaged point cloud and the nominal point cloud are first registered. Then a two-step detection approach is developed to extract the surface defects, coarse detection and detailed extraction, where the octree method is applied to create an effective topology of discrete points and perform the Boolean operation for defects extraction. In coarse detection, rough location and size information of the defects are acquired from the whole point cloud data. Based on coarse detected boundary box containing defects, the detailed extraction step is applied to extract corresponding defects shape accurately. The feasibility of proposed method was validated by using a case to detect defects of a damaged turbine blade and the detection results can be used to generate restoration tool path. The results show that the proposed method outperforms state-of-art defects detection methods, which can reduce time by 74.03% and reduce error by 36.86%, respectively.

China’s Legislative Trend on Cruise Carrier’s Liability –Focus on the first draft of Proposal for Revising the Maritime Law-

Yan-Qiu MA 한국해사법학회 2018 해사법연구 Vol.30 No.3

중국은 현재 해상법 개정작업을 시작하여, 개정안초안에 대한 전문가의견수렴단계에 있다. 해상여객운송인의 책임에 대하여, 개정안초안은 아테네협약 2002년 의정서의 일부 원칙을 수용하였는데, 크루즈운송인의 의무와 책임에 관한 내용을 증가하였다. 이종책임체계, 크루즈운송인의 의무, 강제보험과 직접 청구권 등 규정을 신설하였는바, 이는 크루즈여객에 대하여 강력한 보호를 제공하고자 하고 있으며, 여객으로 하여금 권리의 존재여부를 쉽게 알도록 하고 있다. 그러나 개정안초안의 크루즈운송인책임제도는 아직 미흡한 점이 있는바 이를 보완할 필요가 있다. 본 고는 해상법개정안초안의 크루즈운송인책임제도와 현행 해상법 및 <아테네협약 2002년 의정서> 내용에 대한 비교연구를 통하여 중점적으로 크루즈운송인의 책임기간과 의무, 크루즈운송중 부동한 운송기간운송인의 책임에 대한 법률적용, 책임기초, 책임제한, 강제책임보험 및 강제책임보험인에 대한 직접 청구권 등 문제를 규명하고자 한다. China initiated the revision of the Maritime Law and the first draft of the Proposal is soliciting opinions from law field as well as shipping field. The Ministry of Transport of the People’s Republic of China has been continuously carrying out revision research on the Maritime law. It has organized two systematic studies in 2000 and 2013 respectively, with certain basic accumulation. Considering the professional and the complexity of maritime law, a research program is formed again in 2017 and, after nearly two years of hard work, a first draft proposal was ultimately finished. The Proposal borrows some general principles from the 2002 Athens Protocol for the passenger carrier’s liability regime. What’s more, some provisions specific for cruise carrier’s duties and liabilities are added in such as network liability system, cruise carrier’s duties, compulsory insurance and direct action against liability insurers, thus providing a cruise passenger with stronger protection and making it easier for him/her to understand just which his/her rights are. However, the regime of cruise carrier’s liability in this paper still needs some improvement because of some slight imperfections. This article aims to give a somewhat comprehensive study on the liability framework of the cruise carrier in the Proposal and, where necessary, compare with the current Maritime Law and the 2002 Athens Protocol, focus on the responsibility period of the cruise carrier, the relevant obligations, the application of the laws in various sections of the cruise journey, the grounds for responsibility, the limit of liability, compulsory insurance and direct claims against liability insurers.