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ASIAA EXTRAGALACTIC STUDY WITH THE SMA
MATSUSHITA SATOKI,MAO RUI-QING,MULLER SEBASTIEN,CHOU CHUEN- YI,SAWADA-SATOH SATOKO,TRUNG DINH-VAN,LIM JEREMY,HSIEH PEI-YING,PECK ALISON B. The Korean Astronomical Society 2005 Journal of The Korean Astronomical Society Vol.38 No.2
We present CO(3-2), CO(2-1), and 230 GHz (1.3 mm) continuum images of nearby galaxies taken with the Submillimeter Array (SMA). Our main topic is to study the relation between higher-J molecular gas (e.g., CO J=3-2, 2-1) and nuclear activities (e.g., active galactic nuclei [AGNs] and starbursts). The nearby Seyfert 2 galaxy M51 shows strong CO(3-2) emission from the circumnuclear molecular gas, with an intensity twice as strong as that of the CO(1-0) emission. Strong CO(3-2) emission enhancement suggests that the circum nuclear molecular gas in M51 is warm and dense, which may be related to the AGN activities. Molecular gas in the nearby moderate starburst galaxy NGC 6946 is distributed along the large-scale bar or spiral arms and along the minibar, and the multi-J CO line images show very similar distribution to each other. For this galaxy, there is no clear enhancement in higher-J lines as seen in M51, which may be because NGC 6946 does not have clear AGN activities. Based on the results of these two galaxies, the physical conditions of the circum nuclear molecular gas may be related to the AGN activities. We also observed the nearby edge-on starburst galaxy NGC 3628 and the starburst/Seyfert composite galaxy NGC 4945 with the CO(2-1) line and 230 GHz (1.3 mm) continuum emission. These information will give us some hints for understanding the relation between nuclear activities and circum nuclear molecular gas and dust.
Luciferase Assay to Screen Tumour-specific Promoters in Lung Cancer
Xu, Rong,Guo, Long-Jiang,Xin, Jun,Li, Wen-Mao,Gao, Yan,Zheng, You-Xian,Guo, You-Hong,Lin, Yang-Jun,Xie, Yong-Hua,Wu, Ya-Qing,Xu, Rui-An Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Objective: Specific promoters could improve efficiency and ensure the safety of gene therapy. The aim of our study was to screen examples for lung cancer. Methods: The firefly luciferase gene was used as a reporter, and promoters based on serum markers of lung cancer were cloned. The activity and specificity of seven promoters, comprising CEACAM5 (carcinoembryonic antigen, CEA), GRP (Gastrin-Releasing Peptide), KRT19 (cytokeratin 19, KRT), SFTPB (surfactant protein B, SP-B), SERPINB3 (Squamous Cell Carcinoma Antigen, SCCA), SELP (Selectin P, Granule Membrane Protein 140kDa, Antigen CD62, GMP) and DKK1 (Dickkopf-1) promoters were compared in lung cancer cells to obtain cancer-specific examples with strong activity. Results: The CEACAM5, DKK1, GRP, SELP, KRT19, SERPINB3 and SFTPB promoters were cloned. Furthermore, we successfully constructed recombinant vector pGL-CEACAM5 (DKK1, GRP, SELP, KRT19, SERPINB3 and SFTPB) contained the target gene. After cells were transfectedwith recombinant plasmids, we found that the order of promoter activity from high to low was SERPINB3, DKK1, SFTPB, KRT19, CEACAM5, SELP and GRP and the order for promoters regarding specificity and high potential were SERPINB3, DKK1, SELP, SFTPB, CEACAM5, KRT19 and GRP. Conclusion: The approach adopted is feasible to screen for new tumour specific promoters with biomarkers. In addition, the screened lung-specific promoters might have potential for use in lung cancer targeted gene therapy research.