Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena

Alam, MA,Nyeem, MAB,Awal, MA,Mostofa, M,Alam, MS,Subhan, N,Rahman, M Mostafizur Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.2

The hepatoprotective activity of the alcoholic extract of Rosa damascena was studied against paracetamol induced acute hepatotoxicity in rats. Liver damage was assessed by estimating serum enzyme activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and histopathology of liver tissue. Pre- and post-treatment with ethanolic extracts showed a dose-dependent reduction of paracetamol induced elevated serum levels of enzyme activity. The mechanism underlying the protective effects was assayed in vitro and the R. damascena extracts displayed dosedependent free radical activity using DPPH ($IC_{50}=162.525\;{\mu}g/ml$) and TBA method. The hepatoprotective action was confirmed by histopathological observation. The ethanolic extracts reversed paracetamol induced liver injury. These results suggest that the hepatoprotective effects of R. damascena extracts are related to its antioxidative activity.

Antioxidant and hepatoprotective action of the crude ethanolic extract of theflowering top of Rosa damascena

MA Alam,MAB Nyeem,MA Awal,M Mostofa,MS Alam,N Subhan,M MostafizurRahman 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.2

The hepatoprotective activity of the alcoholic extract of Rosa damascena was studied against paracetamol induced acute hepatotoxicity in rats. Liver damage was assessed by estimating serum enzyme activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and histopathology of liver tissue. Pre- and post-treatment with ethanolic extracts showed a dose-dependent reduction of paracetamol induced elevated serum levels of enzyme activity. The mechanism underlying the protective effects was assayed in vitro and the R. damascena extracts displayed dosedependent free radical activity using DPPH (IC50 = 162.525 μg/ml) and TBA method. The hepatoprotective action was confirmed by histopathological observation. The ethanolic extracts reversed paracetamol induced liver injury. These results suggest that the hepatoprotective effects of R. damascena extracts are related to its antioxidative activity. The hepatoprotective activity of the alcoholic extract of Rosa damascena was studied against paracetamol induced acute hepatotoxicity in rats. Liver damage was assessed by estimating serum enzyme activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and histopathology of liver tissue. Pre- and post-treatment with ethanolic extracts showed a dose-dependent reduction of paracetamol induced elevated serum levels of enzyme activity. The mechanism underlying the protective effects was assayed in vitro and the R. damascena extracts displayed dosedependent free radical activity using DPPH (IC50 = 162.525 μg/ml) and TBA method. The hepatoprotective action was confirmed by histopathological observation. The ethanolic extracts reversed paracetamol induced liver injury. These results suggest that the hepatoprotective effects of R. damascena extracts are related to its antioxidative activity.

A Randomized single blind controlled clinical trial on safety and efficacy of a Unani formulation (Itrifal-e-Sagheer) in dyslipidemia

Alam, Sazid,Alam, MD Anzar,Quamri, MA,Sofi, Ghulamuddin,Khan, Mohd. Qudratullah,Ansari, Shabnam Cellmed Orthocellular Medicine and Pharmaceutical 2020 셀메드 (CellMed) Vol.10 No.1

Aim:'Itrifal-e-Sagheer', a compound Unani formulation has been indicated in disease conditions simulating dyslipidemia. The present study was done to substantiate the efficacy of 'Itrifal-e-Sagheer' in dyslipidemia on scientific parameters. Materials and methods: A randomized, single blind, controlled, clinical trial was carried out on 30 patients of dyslipidemia who were randomly allocated into test (n = 15) or control (n = 15) groups. The test drug, Itrifal-e-Sagheer and control drug, Abana® were given to respective group for 45 days along with lifestyle modification. Results: The test drug significantly alleviated the symptoms of subjective parameters (palpitation, breathlessness and weight gain) (p<0.05). There was statistically significant reduction in lipid profile of the patients in test group (p<0.05) than control drug treatment. Conclusion: The study evidenced that Itrifal-e-Sagheer is potentially effective and safe in the treatment of dyslipidemia. However, a multicentric study with robust study design is required to generalize the results.

Effectiveness of some selected insecticides and botanicals against okra shoot and fruit borer

Mazed, MA,Alam, MZ,Miah, MRU,Hossain, MS,Awal, MA Bangladesh Journals Online 2017 Bangladesh journal of agricultural research Vol.42 No.2

<P>An experiment was conducted to evaluate the effectiveness of some selected insecticides and botanicals against okra shoot and fruit borer Earias vittella F. under field conditions. The insecticides tested were Relothrin 10EC @ 1ml l-1, Marshal 20EC @ 2ml l-1and Riva 2.5 EC @ ml l-1; and the botanicals were NSKE @ 50g l-1, Neem leaf extract @ 100g l-1 and Bishkatali leaf extract @ 100g l-1. An additional treatment of Mechanical control (hand picking) and an untreated control were maintained in the experiment for comparison. All treatments were applied at 15 days interval. Shoot infestation was the lowest in Marshal 20EC treated plot (4.34% at pre-fruiting and 3.55% at fruiting stage) and the highest was in untreated control plot (21.4%). The lowest fruit infestation by okra shoot and fruit borer was obtained with Marshal 20EC (5.07% n/n and 3.65% w/w) followed by Relothrin 10EC (5.43% n/n and 4.27% w/w) and the highest infestation was observed under untreated control plot (19.67% n/n and 19.81% w/w). The reduction of fruit infestation over untreated control ranged from 56.93-81.55% by number and 43.47-74.22% by weight. The highest marketable yield (10.46 t ha-1) was obtained in Marshal 20EC treated plot followed by in Relothrin 10EC 10.30 t ha-1 with the maximum benefit cost ratio (BCR) 6.72.Bangladesh J. Agril. Res. 42(2): 353-362, June 2017</P>

Anesthetics or anesthetic techniques and cancer surgical outcomes: a possible link

Alam Azeem,Rampes Sanketh,Patel Sonam,Hana Zac,Ma Daqing 대한마취통증의학회 2021 Korean Journal of Anesthesiology Vol.74 No.3

As of 2018 cancer is responsible for almost 9.6 million deaths annually and, with an aging population, the incidence of cancer is expected to continue to rise. Surgery is an important treatment modality for patients with solid organ cancers. It has been postulated that, due to potentially overlapping processes underlying the development of malignancy and the therapeutic pathways of various anesthetic agents, the choice of anesthetic type and method of administration may affect post-operative outcomes in patients with cancer. This is a literature review of the most recent evidence extracted from various databases including PubMed, EMBASE, and the Cochrane, as well as journals and book reference lists. The review highlights the pathophysiological processes underpinning cancer development and the molecular actions of anesthetic agents, pre-clinical and retrospective studies investigating cancer and anesthetics, as well as ongoing clinical trials. Overall, there are conflicting results regarding the impact of regional vs. general anesthesia on cancer recurrence, whilst the majority of data suggest a benefit of the use of intravenous propofol over inhalational volatile anesthetics. The biological changes associated with the surgical inflammatory response offer a unique opportunity to intervene to counteract any potentially cancer-promoting effects.

Identification of okra shoot and fruit borer infesting okra and their distribution in Bangladesh

Mazed, MA,Alam, MZ,Miah, MRU,Hossain, MS,Mian, MIH Bangladesh Journals Online 2016 Bangladesh journal of agricultural research Vol.41 No.4

<P>A survey was conducted during July 2009 to October 2010 to know the occurrence of okra shoot and fruit borer species that infest okra in Bangladesh. Infested okra fruits were collected from eleven selected locations representing 11 Agro-ecological Zones of Bangladesh and reared in the laboratory. A total of 423 adult individuals consisting of 188 male and 235 female moths emerged from the infested fruits. The male and female ratio was 1.00?1.25. The morphological characteristics of adult moths were recorded. Head and thorax of adults are ochreous white; forewings are pale white with a wedge shaped horizontal green patch in the middle and hind wings are silvery creamy white in color. The males are smaller than the females in size and the females are Vshaped at the end of the anal part but the males have thick hairs at the end of the anal part. Pupae are chocolate brown, bluntly rounded and enclosed in grey colored inverted boat shaped cocoon formed in the fruit or in the sand. Full grown caterpillars measured 1.64 cm in length and their color is brownish with white streaks dorsally and pale yellow ventrally, without finger tipped process. The recorded morphological characteristics ware compared with standard key and the insects were identified as Earias vittella belonging to the family Noctuidae.Bangladesh J. Agril. Res. 41(4): 657-665, December 2016</P>

Effect of some new generation insecticides on the population abundance of aphid and different beneficial insects in mustard crop

Dutta, NK,Alam, SN,Sarkar, MA,Rahman, AKMZ,Kwon, YJ Bangladesh Journals Online 2017 Bangladesh journal of agricultural research Vol.42 No.3

<P>The present study evaluated the efficacy of some new generation insecticides namely Clothianidin 48 SC, Fenpyroximate 5 SC, Pyridaben 20 WP and Methoxyphenozide 24 SC along with a synthetic pyrethroid insecticide, Fenpropathrin 20 EC against mustard aphid and their effects on beneficial insects i.e. syrphid flies and foraging honeybees during 2015 - 2016 in Bangladesh Agricultural Research Institute, Gazipur, Bangladesh. Tested six treatments were: Clothianidin 48 SC 1ml l-1, Fenpyroximate 5 SC 0.25 ml l-1, Pyridaben 20 WP 1g l-1, Methoxyphenozide 24 SC 1ml l-1 , Fenpropathrin 20 EC 1ml l-1 and an untreated control, replicated three times in RCBD. It was found that, Methoxyphenozide 24 SC was found to be the most effective against aphid offering lower aphid population (1.42/ top 10 cm central twig) at 7 days after spraying (DAS) which was statistically identical to Clothianidin 48 SC (1.50/top 10 cm central twig). Among the insecticides, Methoxyphenozide 24 SC was also found to be safer to the populations of syrphid flies revealing flight activity of 6.85 adults (plot/5 min) and honeybees of 8.82 workers (plot/5 min), respectively at 7 DAS. Whereas, Clothianidin 48 SC and Pyridaben 25 WP treated plots were found to be highly toxic to these beneficial insects. Consequently, the highest yield was obtained from Methoxyphenozide 24 SC (1.55 t/ha) followed by Fenpyroximate 5 SC (1.42 t/ha) treated plots.Bangladesh J. Agril. Res. 42(3): 563-570, September 2017</P>

Screening a Panel of Acid-producing Strains by Developing a High-throughput Method

Lijuan Zhu,Hui Zhang,Shiyuan Wang,Anqi Zhao,Lingbo Qu,Wenlong Xiong,Md. Asraful Alam,Wenlong Ma,Yongkun Lv,Jingliang Xu 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.5

Organic acids are natural cellular metabolites, which are widely used in food, pharmaceutical, and chemical industries. Among them, L-lactic acid is of special interest, because it is widely used in food and pharmaceutical industries and its monopolymer (poly (lactic acid)) is a green, renewable, biodegradable, and biocompatible alternative to the petroleum-based polymers. Currently, organic acids are predominantly produced by microbial fermentation. Their productions have been substantially improved by genetic modifications, metabolic engineering, and fermentation optimizations. However, the commonly used microbial producers still suffer from low acidic tolerance. Screening higher tolerant acid-producing microorganisms from the nature is relatively less explored. The traditional fermented foods are good resources for the screening of acid-producing and probiotic microorganisms. However, they are relatively less explored, especially those foods in developing countries. To speed up the acid-producing microorganism screening, we developed and validated a high-throughput method in this study. By using this method, we screened 1,296 colonies in 4 days and obtained a panel of acid-producing microorganisms. Among them, a Lacticaseibacillus rhamnosus showed the potential for organic acid production and probiotics applications.