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- 저자 : M.K. Kundu (검색결과 6 건)
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Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer
Lee, K-S,Lee, Y-S,Lee, J-M,Ito, K,Cinghu, S,Kim, J-H,Jang, J-W,Li, Y-H,Goh, Y-M,Chi, X-Z,Wee, H,Lee, H-W,Hosoya, A,Chung, J-H,Jang, J-J,Kundu, J K,Surh, Y-J,Kim, W-J,Ito, Y,Jung, H-S,Bae, S-C Macmillan Publishers Limited 2010 Oncogene Vol.29 No.23
Human lung adenocarcinoma, the most prevalent form of lung cancer, is characterized by many molecular abnormalities. K-ras mutations are associated with the initiation of lung adenocarcinomas, but K-ras-independent mechanisms may also initiate lung tumors. Here, we find that the runt-related transcription factor Runx3 is essential for normal murine lung development and is a tumor suppressor that prevents lung adenocarcinoma. Runx3−/− mice, which die soon after birth, exhibit alveolar hyperplasia. Importantly, Runx3−/− bronchioli exhibit impaired differentiation, as evidenced by the accumulation of epithelial cells containing specific markers for both alveolar (that is SP-B) and bronchiolar (that is CC10) lineages. Runx3−/− epithelial cells also express Bmi1, which supports self-renewal of stem cells. Lung adenomas spontaneously develop in aging Runx3+/− mice (∼18 months after birth) and invariably exhibit reduced levels of Runx3. As K-ras mutations are very rare in these adenomas, Runx3+/− mice provide an animal model for lung tumorigenesis that recapitulates the preneoplastic stage of human lung adenocarcinoma development, which is independent of K-Ras mutation. We conclude that Runx3 is essential for lung epithelial cell differentiation, and that downregulation of Runx3 is causally linked to the preneoplastic stage of lung adenocarcinoma.
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Yoo, J.M.,Lee, Y.R.,Kim, D.,Jeong, M.J.,Stockwell, W.R.,Kundu, P.K.,Oh, S.M.,Shin, D.B.,Lee, S.J. Pergamon Press ; Elsevier [distribution] 2014 Atmospheric environment Vol.82 No.-
The washout effect of summertime rain on surface air pollutants (O<SUB>3</SUB>, CO, NO<SUB>2</SUB>, SO<SUB>2</SUB>, and PM<SUB>10</SUB>) has been investigated over South Korea during 2002-2012 using routinely available air-monitored and meteorological data. Three new washout indices for PM<SUB>10</SUB>, SO<SUB>2</SUB>, NO<SUB>2</SUB>, and CO are developed to express the effect of precipitation scavenging on these pollutants. All of these pollutants show statistically significant negative correlations between their concentrations and rain intensity due to washout or convection. The washout effect is estimated for precipitation episodes classified by rain intensity (one set included all episodes and another included a subset of moderate intensity episodes that exclude Changma and typhoons), based on the log-transformed hourly data. The most sensitive air pollutant to the rain onset among these five air pollutants is PM<SUB>10</SUB>. The relative effect of the rainfall washout on the air pollutant concentrations is estimated to be: PM<SUB>10</SUB> > SO<SUB>2</SUB> > NO<SUB>2</SUB> > CO > O<SUB>3</SUB>, indicating that PM<SUB>10</SUB> is most effectively scavenged by rainfall. The analysis suggests that the O<SUB>3</SUB> concentrations may increase due to vertical mixing leading to its downward transport from the lower stratosphere/upper troposphere. The concentrations of CO are reduced, probably due to both the washout and convection. The concentrations of NO<SUB>2</SUB> are affected by the opposing influences of lightning-generation and washout and this are discussed as well.
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Secrecy performance of a-k-u shadowed fading channel
A.S.M. Badrudduza,S.H. Islam,M.K. Kundu,I.S. Ansari 한국통신학회 2023 ICT Express Vol.9 No.2
In this paper, the physical layer security aspects of a wireless framework over shadowed (AKMS) fading channel are examined by acquiring closed-form novel expressions of average secrecy capacity, secure outage probability (SOP), and strictly positive secrecy capacity. The lower bound of SOP is derived along with the asymptotic expression of SOP at the high signal-to-noise ratio regime in order to achieve secrecy diversity gain. Capitalizing on these expressions, the consequences due to the simultaneous occurrence of fading and shadowing are quantified. Finally, Monte-Carlo simulations are demonstrated to assess the correctness of the expressions.
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A sub-decadal trend in diacids in atmospheric aerosols in eastern Asia
Kundu, S.,Kawamura, K.,Kobayashi, M.,Tachibana, E.,Lee, M.,Fu, P. Q.,Jung, J. Copernicus GmbH 2016 Atmospheric Chemistry and Physics Vol.16 No.2
<P>Abstract. Change in secondary organic aerosols (SOAs) has been predicted to be highly uncertain in the future atmosphere in Asia. To better quantify the SOA change, we examine the sub-decadal (2001-2008) trend in major surrogate compounds (C2-C10 diacids) of SOA in atmospheric aerosols from Gosan site on Cheju Island, South Korea. The Gosan site is influenced by pollution outflows from eastern Asia. The molecular distributions of diacids were characterized by the predominance of oxalic (C2) acid followed by malonic (C3) and succinic (C4) acids in each year. The seasonal variations in diacids in each year were characterized by the highest concentrations of saturated diacids in spring and unsaturated diacids in winter. The consistent molecular distributions and seasonal variations along with significantly similar air mass transport patterns are indicative of similar pollution sources for diacids in eastern Asia on a sub-decadal scale. However, the intensity of the pollution sources has increased as evidenced by the increases in major diacids at the rate of 3.9-47.4 % per year, particularly in April. The temporal variations in atmospheric tracer compounds (carbon monoxide, levoglucosan, 2-methyltetrols, pinic acid, glyoxylic acid, glyoxal and methylglyoxal) suggest that the increases in diacids are due to enhanced precursor emissions associated with more anthropogenic than biogenic activities followed by the compounds' chemical processing in the atmosphere. The trends in diacids contrast with the reported decreases in sulfate, nitrate and ammonium in recent years in eastern Asia. This study demonstrates that recent pollution control strategies in eastern Asia were not able to decrease organic acidic species in the atmosphere. The increases in water-soluble organic acid fraction could modify the aerosol organic composition and its sensitivity to climate relevant physical properties. </P>
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P. Nayek,S. Ghosh,S. Kundu,T. Pal Majumder,S.K. Roy,N. Bennis,J.M. Otón,R. Dabrowski 한국물리학회 2010 Current Applied Physics Vol.10 No.2
The electro-optical behavior of the orthoconic antiferroelectric liquid crystal mixture W-182 has been studied. Surface-stabilized, low thickness cells of this mixture give a perfect double hysteresis loop with 1 Hz triangular signal, reaching different transmission levels for different voltages amplitudes. These levels can be stabilized with a single holding voltage, making it possible for the material to be passively multiplexed at video rate. With the application of bias field at three different temperatures, we have observed the field-induced Fréedericksz transition from SmI*A–SmC*A, antiferroelectric to ferroelectric, and ferroelectric to paraelectric transition. Such Fréedericksz transition point is decreased with the increase of temperature.
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