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- 검색키워드
- 저자 : M. T. Amin (검색결과 17 건)
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The label free DNA sensor using a silicon nanowire array
Kulkarni, A.,Xu, Y.,Ahn, C.,Amin, R.,Park, S.H.,Kim, T.,Lee, M. Elsevier Science Publishers 2012 Journal of biotechnology Vol.160 No.3
Biosensors based on silicon nanowire (Si-NW) promise highly sensitive dynamic label free electrical detection of various biological molecules. Here we report Si-NW array electronic devices that function as sensitive and selective detectors of as synthesized 2D DNA lattices with biotins. The Si-NW array was fabricated using top-down approach consists of 250 nanowires of 20μm in length, equally spaced with an interval of 3.2μm. Measurements of photoresistivity of the Si-NW array device with streptavidin (SA) attached on biotinylated DNA lattices at different concentration were observed and analyzed.. The conductivity in the DNA lattices with protein SA shows significant change in the photoresistivity of Si-NW array device. This Si-NW based DNA sensor would be one of very efficient devices for direct, label free DNA detection and could provide a pathway to immunological assays, DNA forensics and toxin detection in modern biotechnology.
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Amin, A.R.M.R.,Karpowicz, P.A.,Carey, T.E.,Arbiser, J.,Nahta, R.,Chen, Z.G.,Dong, J.T.,Kucuk, O.,Khan, G.N.,Huang, G.S.,Mi, S.,Lee, H.Y.,Reichrath, J.,Honoki, K.,Georgakilas, A.G.,Amedei, A.,Amin, A. Saunders Scientific Publications ; Academic Press 2015 SEMINARS IN CANCER BIOLOGY Vol.35 No.suppl
The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to continue to proliferate, cancer cells must somehow uncouple themselves from the many signals that exist to slow down cell growth. Here, we define the anti-growth signaling process, and review several important pathways involved in growth signaling: p53, phosphatase and tensin homolog (PTEN), retinoblastoma protein (Rb), Hippo, growth differentiation factor 15 (GDF15), AT-rich interactive domain 1A (ARID1A), Notch, insulin-like growth factor (IGF), and Kruppel-like factor 5 (KLF5) pathways. Aberrations in these processes in cancer cells involve mutations and thus the suppression of genes that prevent growth, as well as mutation and activation of genes involved in driving cell growth. Using these pathways as examples, we prioritize molecular targets that might be leveraged to promote anti-growth signaling in cancer cells. Interestingly, naturally occurring phytochemicals found in human diets (either singly or as mixtures) may promote anti-growth signaling, and do so without the potentially adverse effects associated with synthetic chemicals. We review examples of naturally occurring phytochemicals that may be applied to prevent cancer by antagonizing growth signaling, and propose one phytochemical for each pathway. These are: epigallocatechin-3-gallate (EGCG) for the Rb pathway, luteolin for p53, curcumin for PTEN, porphyrins for Hippo, genistein for GDF15, resveratrol for ARID1A, withaferin A for Notch and diguelin for the IGF1-receptor pathway. The coordination of anti-growth signaling and natural compound studies will provide insight into the future application of these compounds in the clinical setting.
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Amin M.T.,Alazba A.A.,Shafiq M. 한국물리학회 2022 Current Applied Physics Vol.40 No.-
In the study, the layered double hydroxide (LDH) of NiZnFe and its composites with date-palm biochar (LDHDPb) and carbon nanotubes (LDH-cnt) were synthesized for adsorbing reactive black 5 (RB5) dye from aqueous solutions. In the first 5 min, rapid adsorption was followed by a gradual increase in both dye uptake and removal efficiency of up to 60 min of starting time. In the investigated pH range (3.0–8.0), the removal efficiency linearly decreased while the sorption capacity linearly increased for all three adsorbents as their doses increased to 0.3 or 0.4 g following a decreasing trend up to 0.6 g. By increasing the initial RB5 concentration from 10 to 100 mg L-1, the removal efficiency linearly decreased. A nearly perfect fitting of the pseudo-second-order kinetic model to the adsorption data was observed; however, the Elovich kinetic model showed the heterogeneous surface of adsorbents with chemisorption. At the solid–liquid interface, from a thermodynamics point of view, we obtained the nonspontaneous nature of the adsorption of RB5 dye of the studied adsorbents with an increased disorder, which supported the endothermic nature onto the studied adsorption process. Furthermore, a nearly perfect fitting of the Langmuir model was obtained to the adsorption data, thereby suggesting the monolayer adsorption of RB5 dye onto the studied adsorbents. In the Dubinin–Radushkevich model, a good agreement of the calculated adsorption capacities to the experimental values were observed and the chemical adsorption of RB5 dye on to the studied adsorbents was proposed based on E (8 – 16 kJ mol-1).
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Amin M.T.,Alazba A.A.,Shafiq M. 한국물리학회 2022 Current Applied Physics Vol.40 No.-
The nanofibrous membrane of polyacrylonitrile (NMP) was successfully synthesized after NaOH and NaHCO3 treatment aiming its functionalization using electrospinning for cadmium ion (Cd2+) adsorption. Field emission scanning electron microscopy (FE-SEM) revealed that small particles attached to the surface of functionalized PAN nanofibers. Equilibrium was attained after 60 min following a rapid uptake of Cd2+ with maximum adsorption capacity and percentage removal at an optimum solution pH of 7.0. The adsorbent dose of 0.3 g and 90 mg L-1 of initial Cd2+ concentration yielded the maximum adsorption capacity. The pseudo-second-order kinetic model was the best fitted to the adsorption data, indicating that the chemisorption is the controlling mechanism of adsorption. The physisorption was proposed based on the calculated values of the mean free energy of adsorption from the D–R isotherm (E < 8 kJ mol-1). Furthermore, three-parameter isotherm models indicated the homogeneous and heterogeneous Cd2+ adsorption onto NMP adsorbent.
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Immune evasion in cancer: Mechanistic basis and therapeutic strategies
Vinay, D.S.,Ryan, E.P.,Pawelec, G.,Talib, W.H.,Stagg, J.,Elkord, E.,Lichtor, T.,Decker, W.K.,Whelan, R.L.,Kumara, H.M.C.S.,Signori, E.,Honoki, K.,Georgakilas, A.G.,Amin, A.,Helferich, W.G.,Boosani, C. Saunders Scientific Publications ; Academic Press 2015 SEMINARS IN CANCER BIOLOGY Vol.35 No.suppl
Cancer immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Although considerable progress has been made in understanding how cancers evade destructive immunity, measures to counteract tumor escape have not kept pace. There are a number of factors that contribute to tumor persistence despite having a normal host immune system. Immune editing is one of the key aspects why tumors evade surveillance causing the tumors to lie dormant in patients for years through ''equilibrium'' and ''senescence'' before re-emerging. In addition, tumors exploit several immunological processes such as targeting the regulatory T cell function or their secretions, antigen presentation, modifying the production of immune suppressive mediators, tolerance and immune deviation. Besides these, tumor heterogeneity and metastasis also play a critical role in tumor growth. A number of potential targets like promoting Th1, NK cell, γδ T cell responses, inhibiting Treg functionality, induction of IL-12, use of drugs including phytochemicals have been designed to counter tumor progression with much success. Some natural agents and phytochemicals merit further study. For example, use of certain key polysaccharide components from mushrooms and plants have shown to possess therapeutic impact on tumor-imposed genetic instability, anti-growth signaling, replicative immortality, dysregulated metabolism etc. In this review, we will discuss the advances made toward understanding the basis of cancer immune evasion and summarize the efficacy of various therapeutic measures and targets that have been developed or are being investigated to enhance tumor rejection.
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Amin, H.H.,Meghani, N.M.,Oh, K.T.,Choi, H.,Lee, B.J. Association de pharmacie galénique industri 2017 Journal of drug delivery science and technology Vol.41 No.-
In this study, apotransferrin (Tf)-stearic acid conjugate was newly synthesized via ''fattigation method'' to form self-assembled nanoparticles (NPs) containing a hydrophobic model drug, paclitaxel (PAC). Then, physicochemical properties and cellular behaviors such as transferrin receptor-driven targeting and cytotoxic efficiencies were evaluated. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) studies showed that the NPs had spherical shape and smooth surface. The particle size of PAC-loaded NPs was 326.97 +/- 2.03 nm with a loading and encapsulation efficiency of 7.94 +/- 1.60% (w/w) and 71.10 +/- 4.12% (w/w), respectively. In comparison to free PAC, PAC-loaded NPs showed a 7-fold reduction in the LC50 value in breast carcinoma cells (MCF-7), which indicated an increase in cytotoxicity owing to the effective targeting of cells. This observation was confirmed via confocal microscopy images that showed that transferrin receptor blocking inhibited NP uptake. This was further confirmed via flow cytometry data which showed the time-dependent uptake of NPs and their inhibition by transferrin receptor blockage. The results of this study reveal the advantages of NP-based drug delivery systems consisting of Tf as a core of NP for the receptor-driven targeting and subsequent killing of cancer cells.
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Terahertz emission in quantum dots by sum frequency generation
M. Abdullah,Farah T. Mohammed Noori,Amin H. Al-Khursan 한국물리학회 2016 Current Applied Physics Vol.16 No.7
The second-order nonlinear susceptibility (SONS) in self-assembled InAs quantum dots (QDs), in the form of quantum disks, under applied electric field was studied. Using Feynman diagram, the relation of SONS for sum frequency generation was stated. Two cases were studied, which are the interband (IB) and intersubband (ISB) transitions with the consideration of the QD inhomogeneity, which is shown to be important in SONS calculations. For the ISB case, a resonance near 92 mm was predicted, which is important for infrared applications. Energy subbands and momentum matrix elements are shown as the main factors controlling SONS. It was found that adding some detuning to the pump will extend the wavelength by 45 mm which might applicable for Terahertz (THz) applications. Double resonance was shown to blue shifts the wavelength.
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F. T. Z. Toma,I. N. Esha,Md. Al-Amin,M. N. I. Khan,Kazi Hanium Maria 한양대학교 세라믹연구소 2017 Journal of Ceramic Processing Research Vol.18 No.10
The structural, electrical and magnetic properties have been investigated for Ca and Sr substituted Ba1-x(Ca0.5Sr0.5)xFe0.5Ti0.5O3(where x = 0.0, 0.1 0.2, 0.3, 0.4) which have been synthesized by a solid state reaction technique and sintered at 1200 oC for 3 hours. In this study BaTiO3 is modified with Fe in lattice B-site. The X-ray diffraction pattern of the prepared samples have indicated single phase cubic perovskite structure. Lattice constant of the samples have decreased with the increasing Ca and Sr contents which follows Vegard’s law. The microstructure of the samples showed that the grain growth rate was greately changed by doping contents. Doping contents have influenced the dielectric constant within the frequency range of 1 kHz to 120 MHz. It is observed that AC resistivities of the prepared samples have been decreased with increasing frequency while DC resistivities have been decreased with increasing temperature confirming the semiconductor behavior of the prepared ceramics. The magnetic hysteresis loops had also been observed by VSM at room temperarure. The initial permeability followed decreasing trend with increasing doping contents. The structural, electrical and magnetic properties have been investigated for Ca and Sr substituted Ba1- (Ca0.5Sr0.5)xFe0.5Ti0.5O3(where x = 0.0, 0.1 0.2, 0.3, 0.4) which have been synthesized by a solid state reaction technique and sintered at 1200 oC for 3 hours. In this study BaTiO3 is modified with Fe in lattice B-site. The X-ray diffraction pattern of the prepared samples have indicated single phase cubic perovskite structure. Lattice constant of the samples have decreased with the increasing Ca and Sr contents which follows Vegard’s law. The microstructure of the samples showed that the grain growth rate was greately changed by doping contents. Doping contents have influenced the dielectric constant within the frequency range of 1 kHz to 120 MHz. It is observed that AC resistivities of the prepared samples have been decreased with increasing frequency while DC resistivities have been decreased with increasing temperature confirming the semiconductor behavior of the prepared ceramics. The magnetic hysteresis loops had also been observed by VSM at room temperarure. The initial permeability followed decreasing trend with increasing doping contents.
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